CN106380502A - G蛋白偶联受体5(tgr5)调节剂及其使用方法 - Google Patents
G蛋白偶联受体5(tgr5)调节剂及其使用方法 Download PDFInfo
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- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
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| EP08169460 | 2008-11-19 | ||
| EP08169460.6 | 2008-11-19 | ||
| CN200980154703.7A CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
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| CN200980154703.7A Division CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
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| CN201610680498.XA Pending CN106380502A (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
| CN200980154703.7A Expired - Fee Related CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
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| CN200980154703.7A Expired - Fee Related CN102282157B (zh) | 2008-11-19 | 2009-11-19 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
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| EP (2) | EP3150620B1 (enExample) |
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| ES (2) | ES2592452T3 (enExample) |
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| WO (1) | WO2010059859A1 (enExample) |
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| US8940716B2 (en) | 2010-05-06 | 2015-01-27 | Bristol-Myers Squibb Company | Bicyclic heteroaryl compounds as GPR119 modulators |
| TW201247627A (en) | 2011-04-28 | 2012-12-01 | Bristol Myers Squibb Co | Novel bicyclic nitrogen containing heteroaryl TGR5 receptor modulators |
| KR102068381B1 (ko) * | 2012-10-26 | 2020-01-20 | 인터셉트 파마슈티컬즈, 인크. | 담즙산 유도체의 제조 방법 |
| CA2891348C (en) * | 2012-11-28 | 2020-04-28 | Intercept Pharmaceuticals, Inc. | Treatment of pulmonary disease |
| CN105636984A (zh) | 2013-06-13 | 2016-06-01 | 法斯特弗沃德制药有限公司 | 用于治疗慢性炎症和预防胃肠道癌或纤维化的cd40信号转导抑制剂和其他化合物，该其他化合物是胆汁酸、胆汁酸衍生物、tgr5受体激动剂、fxr激动剂或其组合 |
| EP3149019B1 (en) | 2014-05-29 | 2019-12-04 | Bar Pharmaceuticals S.r.l. | Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases |
| CN107108688B (zh) * | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 |
| TWI688571B (zh) * | 2014-11-19 | 2020-03-21 | 英商Ｎｚｐ英國有限公司 | 化合物（四） |
| PL3221331T3 (pl) * | 2014-11-19 | 2020-03-31 | NZP UK Limited | Steroidy, 6-alkilo-7-hydroksy-4-en-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr |
| WO2016079518A1 (en) * | 2014-11-19 | 2016-05-26 | Dextra Laboratories Limited | 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal fxr modulators |
| MX2017006833A (es) * | 2014-11-26 | 2018-02-13 | Enanta Pharm Inc | Análogos de ácido biliar como agonistas de fxr/tgr5 y métodos para el uso de los mismos. |
| CN105348365A (zh) * | 2014-12-03 | 2016-02-24 | 四川百利药业有限责任公司 | 一种胆酸衍生物及其制备方法、药物组合物和用途 |
| CN104523703A (zh) * | 2014-12-24 | 2015-04-22 | 聂飚 | 一种游离脂肪酸转运蛋白小分子抑制物的应用 |
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| CN105985396A (zh) | 2015-02-16 | 2016-10-05 | 苏州泽璟生物制药有限公司 | 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物 |
| US10800807B2 (en) * | 2015-06-19 | 2020-10-13 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| CN106854229A (zh) * | 2015-12-08 | 2017-06-16 | 陈剑 | 一类脂肪酸盐,其制备及其在医药上的应用 |
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| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| WO2018054300A1 (zh) * | 2016-09-20 | 2018-03-29 | 江苏豪森药业集团有限公司 | 胆酸衍生物游离碱，晶型及其制备方法和应用 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
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| BR112022017039A2 (pt) | 2020-02-28 | 2022-11-16 | Kallyope Inc | Agonistas de gpr40 |
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| FR2696934B1 (fr) | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir. |
| EP1591120A4 (en) | 2003-01-28 | 2009-06-10 | Takeda Chemical Industries Ltd | RECEPTOR AGONISTS |
| CA2928178C (en) | 2007-01-19 | 2019-09-10 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
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| CN102282157B (zh) | 2017-02-22 |
| AU2009316484A1 (en) | 2010-05-27 |
| JP2012509349A (ja) | 2012-04-19 |
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| US20110263555A1 (en) | 2011-10-27 |
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| EP2373673A1 (en) | 2011-10-12 |
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| CA2744135A1 (en) | 2010-05-27 |
| IL212970A (en) | 2017-07-31 |
| ES2774368T3 (es) | 2020-07-20 |
| EP3150620B1 (en) | 2020-01-08 |
| CA2744135C (en) | 2017-07-04 |
| BRPI0921992B1 (pt) | 2021-12-14 |
| ES2592452T3 (es) | 2016-11-30 |
| CN102282157A (zh) | 2011-12-14 |
| AU2009316484B2 (en) | 2015-04-16 |
| JP5639073B2 (ja) | 2014-12-10 |
| IL212970A0 (en) | 2011-07-31 |
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