JP5639058B2 - 造血前駆細胞の増殖 - Google Patents

造血前駆細胞の増殖 Download PDF

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JP5639058B2
JP5639058B2 JP2011524142A JP2011524142A JP5639058B2 JP 5639058 B2 JP5639058 B2 JP 5639058B2 JP 2011524142 A JP2011524142 A JP 2011524142A JP 2011524142 A JP2011524142 A JP 2011524142A JP 5639058 B2 JP5639058 B2 JP 5639058B2
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cells
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hematopoietic
anemia
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JP2012501968A (ja
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イテシュ,シルヴィウ
シュースター,マイケル,デーヴィッド
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メソブラスト,インコーポレーテッド
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JP2011524142A 2008-09-03 2009-09-03 造血前駆細胞の増殖 Active JP5639058B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19096708P 2008-09-03 2008-09-03
US61/190,967 2008-09-03
PCT/AU2009/001145 WO2010025506A1 (en) 2008-09-03 2009-09-03 Expansion of haemopoietic precursors

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JP2012501968A JP2012501968A (ja) 2012-01-26
JP2012501968A5 JP2012501968A5 (https=) 2012-06-28
JP5639058B2 true JP5639058B2 (ja) 2014-12-10

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US (2) US8828375B2 (https=)
EP (1) EP2324109B1 (https=)
JP (1) JP5639058B2 (https=)
KR (1) KR101708067B1 (https=)
CN (1) CN102144028B (https=)
AU (3) AU2009290134B2 (https=)
CA (1) CA2735800C (https=)
SG (1) SG193888A1 (https=)
WO (1) WO2010025506A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102651433B1 (ko) 2006-04-14 2024-03-25 아스텔라스 인스티튜트 포 리제너러티브 메디슨 혈관 콜로니 형성 세포
JP6041456B2 (ja) * 2006-07-12 2016-12-07 メゾブラスト,インコーポレーテッド 過剰新生血管形成の治療
CA2735800C (en) * 2008-09-03 2018-05-01 Angioblast Systems, Inc. Expansion of haemopoietic precursors
CA2803641A1 (en) 2010-07-02 2012-01-05 Mesoblast, Inc. Treatment of t-cell mediated immune disorders
WO2012162754A1 (en) * 2011-06-03 2012-12-06 Mesoblast, Inc Methods of treating or preventing neurological diseases
KR101786862B1 (ko) 2011-07-04 2017-10-18 메소블라스트, 아이엔씨. 류마티즘성 질환을 치료 또는 예방하는 방법
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
KR102246369B1 (ko) 2011-11-30 2021-04-29 아스텔라스 인스티튜트 포 리제너러티브 메디슨 중간엽 간질 세포 및 이에 관련된 용도
US9745551B2 (en) 2012-07-12 2017-08-29 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
CN103816183A (zh) * 2012-11-16 2014-05-28 臻景生物技术(上海)有限公司 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用
CN115919901A (zh) * 2012-12-12 2023-04-07 麦瑟布莱斯特公司 治疗或预防呼吸病症的方法
CA3177929A1 (en) 2012-12-21 2014-06-26 Astellas Institute For Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
EP3130668B1 (en) * 2014-04-07 2019-07-17 IUCF-HYU (Industry-University Cooperation Foundation Hanyang University) In-vitro expansion of erythroid cells
KR101980169B1 (ko) * 2016-04-06 2019-05-21 가톨릭대학교 산학협력단 중간엽 기질세포-기반 세포 치료에서의 이질적인 니치 활성
JP6963555B2 (ja) * 2016-09-02 2021-11-10 タカラバイオ株式会社 多能性幹細胞からミクログリアを得る方法
AU2020301413A1 (en) * 2019-06-24 2022-02-10 Children's Hospital Los Angeles BCL11B overexpression to enhance human thymopoiesis T cell function
CN115361960A (zh) * 2020-02-19 2022-11-18 迈索布拉斯特国际有限公司 用于治疗慢性移植物抗宿主病的方法
CN113750220B (zh) * 2020-06-02 2023-11-03 南京大学 间充质干细胞联合tpo及其类似物在治疗慢性髓性白血病中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
AR051573A1 (es) * 2004-09-22 2007-01-24 Sds Digger Tools Pty Ltd Diseno de piston para martillo de fondo
CA2866468C (en) * 2004-09-24 2019-09-03 Mesoblast, Inc. Generating multipotential expanded mesenchymal precursor cell progeny (memp) from mesenchymal progenitor cells (mpc) and stimulation factor
WO2006113881A2 (en) * 2005-04-19 2006-10-26 The Johns Hopkins University Method of using stroma cells from cord blood to expand and engraft nucleated cells from cord blood
AU2006252363A1 (en) * 2005-06-02 2006-12-07 Stemcyte, Inc. Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use
JP2007202506A (ja) * 2006-02-03 2007-08-16 Toshiba Ceramics Co Ltd ヒト造血幹細胞または造血前駆細胞の培養方法
CA2735800C (en) * 2008-09-03 2018-05-01 Angioblast Systems, Inc. Expansion of haemopoietic precursors

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Publication number Publication date
JP2012501968A (ja) 2012-01-26
EP2324109B1 (en) 2016-10-26
US20150202232A1 (en) 2015-07-23
SG193888A1 (en) 2013-10-30
EP2324109A4 (en) 2013-06-12
EP2324109A1 (en) 2011-05-25
AU2016204920A1 (en) 2016-08-04
KR101708067B1 (ko) 2017-02-17
AU2009290134A1 (en) 2010-03-11
AU2018217219A1 (en) 2018-08-30
CN102144028A (zh) 2011-08-03
CA2735800C (en) 2018-05-01
US8828375B2 (en) 2014-09-09
WO2010025506A1 (en) 2010-03-11
AU2009290134B2 (en) 2016-04-14
AU2016204920B2 (en) 2018-05-17
KR20110063640A (ko) 2011-06-13
CN102144028B (zh) 2017-12-26
US9415072B2 (en) 2016-08-16
CA2735800A1 (en) 2010-03-11
US20110217263A1 (en) 2011-09-08

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