JP5639058B2 - 造血前駆細胞の増殖 - Google Patents
造血前駆細胞の増殖 Download PDFInfo
- Publication number
- JP5639058B2 JP5639058B2 JP2011524142A JP2011524142A JP5639058B2 JP 5639058 B2 JP5639058 B2 JP 5639058B2 JP 2011524142 A JP2011524142 A JP 2011524142A JP 2011524142 A JP2011524142 A JP 2011524142A JP 5639058 B2 JP5639058 B2 JP 5639058B2
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- cells
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- anemia
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Addiction (AREA)
- Neurology (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19096708P | 2008-09-03 | 2008-09-03 | |
| US61/190,967 | 2008-09-03 | ||
| PCT/AU2009/001145 WO2010025506A1 (en) | 2008-09-03 | 2009-09-03 | Expansion of haemopoietic precursors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012501968A JP2012501968A (ja) | 2012-01-26 |
| JP2012501968A5 JP2012501968A5 (https=) | 2012-06-28 |
| JP5639058B2 true JP5639058B2 (ja) | 2014-12-10 |
Family
ID=41796639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524142A Active JP5639058B2 (ja) | 2008-09-03 | 2009-09-03 | 造血前駆細胞の増殖 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8828375B2 (https=) |
| EP (1) | EP2324109B1 (https=) |
| JP (1) | JP5639058B2 (https=) |
| KR (1) | KR101708067B1 (https=) |
| CN (1) | CN102144028B (https=) |
| AU (3) | AU2009290134B2 (https=) |
| CA (1) | CA2735800C (https=) |
| SG (1) | SG193888A1 (https=) |
| WO (1) | WO2010025506A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102651433B1 (ko) | 2006-04-14 | 2024-03-25 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 혈관 콜로니 형성 세포 |
| JP6041456B2 (ja) * | 2006-07-12 | 2016-12-07 | メゾブラスト,インコーポレーテッド | 過剰新生血管形成の治療 |
| CA2735800C (en) * | 2008-09-03 | 2018-05-01 | Angioblast Systems, Inc. | Expansion of haemopoietic precursors |
| CA2803641A1 (en) | 2010-07-02 | 2012-01-05 | Mesoblast, Inc. | Treatment of t-cell mediated immune disorders |
| WO2012162754A1 (en) * | 2011-06-03 | 2012-12-06 | Mesoblast, Inc | Methods of treating or preventing neurological diseases |
| KR101786862B1 (ko) | 2011-07-04 | 2017-10-18 | 메소블라스트, 아이엔씨. | 류마티즘성 질환을 치료 또는 예방하는 방법 |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| KR102246369B1 (ko) | 2011-11-30 | 2021-04-29 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
| US9745551B2 (en) | 2012-07-12 | 2017-08-29 | Imstem Biotechnology, Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| CN103816183A (zh) * | 2012-11-16 | 2014-05-28 | 臻景生物技术(上海)有限公司 | 间质血管层细胞和间充质祖细胞在预防或治疗骨性关节炎中的应用 |
| CN115919901A (zh) * | 2012-12-12 | 2023-04-07 | 麦瑟布莱斯特公司 | 治疗或预防呼吸病症的方法 |
| CA3177929A1 (en) | 2012-12-21 | 2014-06-26 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| EP3130668B1 (en) * | 2014-04-07 | 2019-07-17 | IUCF-HYU (Industry-University Cooperation Foundation Hanyang University) | In-vitro expansion of erythroid cells |
| KR101980169B1 (ko) * | 2016-04-06 | 2019-05-21 | 가톨릭대학교 산학협력단 | 중간엽 기질세포-기반 세포 치료에서의 이질적인 니치 활성 |
| JP6963555B2 (ja) * | 2016-09-02 | 2021-11-10 | タカラバイオ株式会社 | 多能性幹細胞からミクログリアを得る方法 |
| AU2020301413A1 (en) * | 2019-06-24 | 2022-02-10 | Children's Hospital Los Angeles | BCL11B overexpression to enhance human thymopoiesis T cell function |
| CN115361960A (zh) * | 2020-02-19 | 2022-11-18 | 迈索布拉斯特国际有限公司 | 用于治疗慢性移植物抗宿主病的方法 |
| CN113750220B (zh) * | 2020-06-02 | 2023-11-03 | 南京大学 | 间充质干细胞联合tpo及其类似物在治疗慢性髓性白血病中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
| AR051573A1 (es) * | 2004-09-22 | 2007-01-24 | Sds Digger Tools Pty Ltd | Diseno de piston para martillo de fondo |
| CA2866468C (en) * | 2004-09-24 | 2019-09-03 | Mesoblast, Inc. | Generating multipotential expanded mesenchymal precursor cell progeny (memp) from mesenchymal progenitor cells (mpc) and stimulation factor |
| WO2006113881A2 (en) * | 2005-04-19 | 2006-10-26 | The Johns Hopkins University | Method of using stroma cells from cord blood to expand and engraft nucleated cells from cord blood |
| AU2006252363A1 (en) * | 2005-06-02 | 2006-12-07 | Stemcyte, Inc. | Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use |
| JP2007202506A (ja) * | 2006-02-03 | 2007-08-16 | Toshiba Ceramics Co Ltd | ヒト造血幹細胞または造血前駆細胞の培養方法 |
| CA2735800C (en) * | 2008-09-03 | 2018-05-01 | Angioblast Systems, Inc. | Expansion of haemopoietic precursors |
-
2009
- 2009-09-03 CA CA2735800A patent/CA2735800C/en active Active
- 2009-09-03 KR KR1020117005959A patent/KR101708067B1/ko active Active
- 2009-09-03 US US13/061,693 patent/US8828375B2/en active Active
- 2009-09-03 SG SG2013071717A patent/SG193888A1/en unknown
- 2009-09-03 AU AU2009290134A patent/AU2009290134B2/en active Active
- 2009-09-03 JP JP2011524142A patent/JP5639058B2/ja active Active
- 2009-09-03 EP EP09810917.6A patent/EP2324109B1/en active Active
- 2009-09-03 WO PCT/AU2009/001145 patent/WO2010025506A1/en not_active Ceased
- 2009-09-03 CN CN200980134570.7A patent/CN102144028B/zh active Active
-
2014
- 2014-09-03 US US14/476,467 patent/US9415072B2/en active Active
-
2016
- 2016-07-14 AU AU2016204920A patent/AU2016204920B2/en active Active
-
2018
- 2018-08-14 AU AU2018217219A patent/AU2018217219A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012501968A (ja) | 2012-01-26 |
| EP2324109B1 (en) | 2016-10-26 |
| US20150202232A1 (en) | 2015-07-23 |
| SG193888A1 (en) | 2013-10-30 |
| EP2324109A4 (en) | 2013-06-12 |
| EP2324109A1 (en) | 2011-05-25 |
| AU2016204920A1 (en) | 2016-08-04 |
| KR101708067B1 (ko) | 2017-02-17 |
| AU2009290134A1 (en) | 2010-03-11 |
| AU2018217219A1 (en) | 2018-08-30 |
| CN102144028A (zh) | 2011-08-03 |
| CA2735800C (en) | 2018-05-01 |
| US8828375B2 (en) | 2014-09-09 |
| WO2010025506A1 (en) | 2010-03-11 |
| AU2009290134B2 (en) | 2016-04-14 |
| AU2016204920B2 (en) | 2018-05-17 |
| KR20110063640A (ko) | 2011-06-13 |
| CN102144028B (zh) | 2017-12-26 |
| US9415072B2 (en) | 2016-08-16 |
| CA2735800A1 (en) | 2010-03-11 |
| US20110217263A1 (en) | 2011-09-08 |
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