JP5623682B2 - 微量元素製剤 - Google Patents
微量元素製剤 Download PDFInfo
- Publication number
- JP5623682B2 JP5623682B2 JP2001054370A JP2001054370A JP5623682B2 JP 5623682 B2 JP5623682 B2 JP 5623682B2 JP 2001054370 A JP2001054370 A JP 2001054370A JP 2001054370 A JP2001054370 A JP 2001054370A JP 5623682 B2 JP5623682 B2 JP 5623682B2
- Authority
- JP
- Japan
- Prior art keywords
- manganese
- trace element
- element preparation
- administered
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
下記第1表に示す組成のガラスアンプル入り製剤を作成した。すなわち、同表に示す成分のうち、コンドロイチン硫酸ナトリウムを注射用蒸留水に溶解し、これに攪拌下塩化第二鉄水溶液を加え水酸化ナトリウム溶液でpHを6〜8に調整して鉄コロイド液を調製した。この鉄コロイド液に注射用蒸留水を加え攪拌しながら塩化マンガン、硫酸亜鉛、硫酸銅およびヨウ化カリウムを加えて溶かした後、水酸化ナトリウム水溶液にてpHを4.5〜6.0に調整した。このようにして調製した微量元素製剤をBaO含量が0.01%以下の実質的にBaOが含まれていないガラスアンプル20本に各2ml宛充填し、高圧蒸気滅菌装置にて滅菌してアンプル入りの最終製品(製剤)とした。
実施例1で調製の溶液剤2mlを、先端にブチルゴム製の摺動可能な密閉栓有するプランジャーと、端部に充填液を用時に排出可能な密閉部を有する環状ポリオレフィン製(エチレン・テトラシクロドデセンコポリマー製)のバレル内に充填後、滅菌処理しプレフィルドシリンジに充填されたマンガン、鉄、亜鉛、銅およびヨウ素の各元素を含有する微量元素製剤を製造した。
注射用蒸留水にその2ml中に塩化マンガン0.1979mg(マンガン元素量として2ml中に1μmol)を含むように塩化マンガンを溶解して塩化マンガン水溶液を調製し、ガラスアンプルに各2ml宛充填し、高圧蒸気滅菌装置にて滅菌してアンプル入りの、微量元素としてマンガンのみを配合した製品(製剤)を調製した。
Claims (4)
- マンガンを投与したときにマンガン排泄機能が正常に働き、且つ経口および経腸管栄養補給が不能、不充分で高カロリー静脈栄養に頼らざるを得ない肝機能が正常な患者用の塩化マンガン、塩化第二鉄、硫酸亜鉛及びコンドロイチン硫酸ナトリウムを含む微量元素製剤であって、前記微量元素製剤が環状ポリオレフィン製樹脂を用いた容器に収容され、且つ加熱滅菌処理された溶液剤であり、高カロリー輸液のマンガン量を分析したうえで、2,000〜3,000ml中のマンガンの含有量が0.2μmol未満である場合に、高カロリー輸液に混合して投与する、マンガンをマンガン元素量として1日当り0.2〜1.5μmolの量で投与することを特徴とする前記患者の血液中のマンガン濃度を正常に維持するための微量元素製剤。
- マンガンを投与したときにマンガン排泄機能が正常に働き、且つ経口および経腸管栄養補給が不能、不充分で高カロリー静脈栄養に頼らざるを得ない肝機能が正常な患者用の塩化マンガン、塩化第二鉄、硫酸亜鉛及びコンドロイチン硫酸ナトリウムを含む微量元素製剤であって、前記微量元素製剤がBaOを含有しないガラス容器に収容され、且つ加熱滅菌処理された溶液剤であり、高カロリー輸液のマンガン量を分析したうえで、2,000〜3,000ml中のマンガンの含有量が0.2μmol未満である場合に、高カロリー輸液に混合して投与する、マンガンをマンガン元素量として1日当り0.2〜1.5μmolの量で投与することを特徴とする前記患者の血液中のマンガン濃度を正常に維持するための微量元素製剤。
- ヨウ素をさらに含む請求項1または2に記載の微量元素製剤。
- 1容器あたり、マンガンをマンガン元素量として0.2〜1.5μmolの量を含有することを特徴とする請求項1〜3のいずれか1項に記載の微量元素製剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001054370A JP5623682B2 (ja) | 2001-02-28 | 2001-02-28 | 微量元素製剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001054370A JP5623682B2 (ja) | 2001-02-28 | 2001-02-28 | 微量元素製剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012121528A Division JP5922496B2 (ja) | 2012-05-29 | 2012-05-29 | 微量元素製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002255830A JP2002255830A (ja) | 2002-09-11 |
JP5623682B2 true JP5623682B2 (ja) | 2014-11-12 |
Family
ID=18914716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001054370A Expired - Lifetime JP5623682B2 (ja) | 2001-02-28 | 2001-02-28 | 微量元素製剤 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP5623682B2 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4968800B2 (ja) * | 2008-08-28 | 2012-07-04 | 裕和 芝原 | 患者の予後健康状態改善度合の予測方法 |
JP5252425B2 (ja) * | 2008-08-28 | 2013-07-31 | 裕和 芝原 | 患者の健康状態評価方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3484689B2 (ja) * | 1998-12-18 | 2004-01-06 | ニプロ株式会社 | 微量元素製剤 |
-
2001
- 2001-02-28 JP JP2001054370A patent/JP5623682B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2002255830A (ja) | 2002-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1288346C (en) | Use of n-acetylglucosamine for the therapy of degenerative joint disease and related diseases | |
RU2001110097A (ru) | Терапевтические композиции (ii) | |
MX2012007775A (es) | Composiciones nutritivas y metodos para utilizar las mismas. | |
CN109789213B (zh) | T4甲状腺激素的高稳定性包装解决方案 | |
JP2007137836A (ja) | 末梢静脈栄養輸液 | |
Heizer et al. | Parenteral nutrition at home for 5 years via arteriovenous fistulae: Supplemental intravenous feedings for a patient with severe short bowel syndrome | |
CN114191425A (zh) | 2,4-二羟基苯甲酸在治疗铁过载疾病食品药品中的应用 | |
CN109044968A (zh) | 氨酚右美肾素口服液及其制备方法 | |
JP5623682B2 (ja) | 微量元素製剤 | |
JP5922496B2 (ja) | 微量元素製剤 | |
JPH0670718A (ja) | 栄養組成物 | |
JP5669408B2 (ja) | 鉄を含有しない微量元素製剤 | |
JP2000178181A (ja) | 微量元素製剤 | |
JPH03135918A (ja) | 免疫賦活剤 | |
JPH0959150A (ja) | 経静脈用輸液製剤 | |
EP0990441A1 (en) | A drug for treating diabetic nephrosis | |
JPH0283327A (ja) | 高カロリー輸液用ブドウ糖電解質製剤 | |
JP5769354B2 (ja) | 中心静脈投与用輸液 | |
CN102258507A (zh) | 含有布洛芬的药物组合物及其制备方法和应用 | |
JP2002193816A (ja) | 微量元素配合製剤 | |
EP2085091B1 (en) | Use of hydrochloric acid in manufacture of medicament for treating diabetes | |
JPH06256186A (ja) | 癌用アミノ酸製剤 | |
JPH06172191A (ja) | ブドウ糖加電解質輸液 | |
Friend | Iron ascorbate in the treatment of anemia | |
CN107595829B (zh) | 一种防治肾性骨营养不良的组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20050628 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071017 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110411 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110608 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110608 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120229 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20120413 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20120505 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120529 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20120806 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20120824 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20130701 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20130701 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130719 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20130719 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140804 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140925 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5623682 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |