JP5607304B2 - 電界を発生させる高インピーダンスシステムおよび使用方法 - Google Patents

電界を発生させる高インピーダンスシステムおよび使用方法 Download PDF

Info

Publication number
JP5607304B2
JP5607304B2 JP2008539011A JP2008539011A JP5607304B2 JP 5607304 B2 JP5607304 B2 JP 5607304B2 JP 2008539011 A JP2008539011 A JP 2008539011A JP 2008539011 A JP2008539011 A JP 2008539011A JP 5607304 B2 JP5607304 B2 JP 5607304B2
Authority
JP
Japan
Prior art keywords
electric field
fluid
dielectric
electrode
electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008539011A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009515168A (ja
JP2009515168A5 (enExample
Inventor
メイ，ウェイン，エー．
ルーベン，ピーター
Original Assignee
メイ−ルーベン テクノロジーズ，インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メイ−ルーベン テクノロジーズ，インク． filed Critical メイ−ルーベン テクノロジーズ，インク．
Publication of JP2009515168A publication Critical patent/JP2009515168A/ja
Publication of JP2009515168A5 publication Critical patent/JP2009515168A5/ja
Application granted granted Critical
Publication of JP5607304B2 publication Critical patent/JP5607304B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/042—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A61N1/0424—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44713—Particularly adapted electric power supply
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H05H1/2443—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the plasma fluid flowing through a dielectric tube
    • H05H1/246—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the plasma fluid flowing through a dielectric tube the plasma being activated using external electrodes

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2008539011A 2005-11-02 2006-10-31 電界を発生させる高インピーダンスシステムおよび使用方法 Expired - Fee Related JP5607304B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73288805P 2005-11-02 2005-11-02
US60/732,888 2005-11-02
US11/551,584 2006-10-20
US11/551,584 US8226811B2 (en) 2005-11-02 2006-10-20 High impedance system for generating electric fields and method of use
PCT/US2006/042712 WO2007056027A1 (en) 2005-11-02 2006-10-31 High impedance system for generating electric fields and method of use

Publications (3)

Publication Number Publication Date
JP2009515168A JP2009515168A (ja) 2009-04-09
JP2009515168A5 JP2009515168A5 (enExample) 2013-10-17
JP5607304B2 true JP5607304B2 (ja) 2014-10-15

Family

ID=37994810

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008539011A Expired - Fee Related JP5607304B2 (ja) 2005-11-02 2006-10-31 電界を発生させる高インピーダンスシステムおよび使用方法

Country Status (11)

Country Link
US (2) US8226811B2 (enExample)
EP (1) EP1952133B1 (enExample)
JP (1) JP5607304B2 (enExample)
KR (1) KR101361498B1 (enExample)
AU (1) AU2006311979B2 (enExample)
BR (1) BRPI0618420A2 (enExample)
CA (1) CA2628407C (enExample)
NZ (1) NZ603542A (enExample)
RU (1) RU2408006C2 (enExample)
UA (1) UA95262C2 (enExample)
WO (1) WO2007056027A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10996210B2 (en) 2018-01-02 2021-05-04 Transportation Ip Holdings, Llc Vehicle system with sensor probe assembly for monitoring oil health
US8821365B2 (en) 2009-07-29 2014-09-02 Thoratec Corporation Rotation drive device and centrifugal pump apparatus using the same
JP5969979B2 (ja) 2011-03-28 2016-08-17 ソーラテック コーポレイション 回転駆動装置およびそれを用いた遠心式ポンプ装置
CN102720490B (zh) * 2012-06-29 2014-11-26 西南石油大学 一种直井随钻钻井液油气信息测量方法及测量仪器
CN102691498B (zh) * 2012-06-29 2014-11-26 西南石油大学 一种水平井随钻泥浆电参数测量仪
US20140221877A1 (en) * 2013-02-01 2014-08-07 Moshe Ein-Gal Pressure-assisted irreversible electroporation
US10052420B2 (en) 2013-04-30 2018-08-21 Tc1 Llc Heart beat identification and pump speed synchronization
US9623161B2 (en) 2014-08-26 2017-04-18 Tc1 Llc Blood pump and method of suction detection
EP3256183B1 (en) 2015-02-11 2025-08-13 Tc1 Llc Heart beat identification and pump speed synchronization
US10371152B2 (en) 2015-02-12 2019-08-06 Tc1 Llc Alternating pump gaps
WO2016130944A1 (en) 2015-02-12 2016-08-18 Thoratec Corporation System and method for controlling the position of a levitated rotor
US10245361B2 (en) 2015-02-13 2019-04-02 Tc1 Llc Impeller suspension mechanism for heart pump
US10117983B2 (en) 2015-11-16 2018-11-06 Tc1 Llc Pressure/flow characteristic modification of a centrifugal pump in a ventricular assist device
US10835734B1 (en) 2017-08-21 2020-11-17 Wayne May High and low impedance systems and methods for the generation and use of constant intensity electric fields
EP3666882A1 (en) 2018-12-12 2020-06-17 AIT Austrian Institute of Technology GmbH Specific electroporation and lysis of eukaryotic cells
CN113281380B (zh) * 2021-05-20 2024-06-11 重庆大学 一种摩擦纳米发电机驱动的电介质陷阱态测量和成像系统及方法
ES2991715B2 (es) * 2024-03-22 2025-06-27 Gil Daniel Serrano Electrodo con proteccion frente a arco electrico

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2919235A (en) * 1956-11-06 1959-12-29 Paul S Roller Electrolytic method and apparatus for the production of metal hydroxide
GB8621948D0 (en) * 1986-09-11 1986-10-15 Gibbs R W Destroying bacteria
US4822470A (en) * 1987-10-09 1989-04-18 Baylor College Of Medicine Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses
US5134070A (en) * 1990-06-04 1992-07-28 Casnig Dael R Method and device for cell cultivation on electrodes
US5234555A (en) * 1991-02-05 1993-08-10 Ibbott Jack Kenneth Method and apparatus for ionizing fluids utilizing a capacitive effect
US5983131A (en) * 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5690978A (en) * 1996-09-30 1997-11-25 Ohio State University High voltage pulsed electric field treatment chambers for the preservation of liquid food products
US6090617A (en) * 1996-12-05 2000-07-18 Entremed, Inc. Flow electroporation chamber with electrodes having a crystalline metal nitride coating
GB9908681D0 (en) * 1999-04-16 1999-06-09 Central Research Lab Ltd Apparatus for, and method of, introducing a substance into an object
US6455014B1 (en) * 1999-05-14 2002-09-24 Mesosystems Technology, Inc. Decontamination of fluids or objects contaminated with chemical or biological agents using a distributed plasma reactor
US6689380B1 (en) * 1999-05-17 2004-02-10 Kevin S. Marchitto Remote and local controlled delivery of pharmaceutical compounds using electromagnetic energy
CA2376368C (en) * 1999-06-08 2009-08-11 Altea Technologies, Inc. Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US7192553B2 (en) * 1999-12-15 2007-03-20 Plasmasol Corporation In situ sterilization and decontamination system using a non-thermal plasma discharge
GB9930718D0 (en) * 1999-12-24 2000-02-16 Central Research Lab Ltd Apparatus for and method of making electrical measurements on objects
AU2001228841A1 (en) * 2000-01-27 2001-08-07 The Mollennium Laboratories Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method
US6868289B2 (en) * 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US6928318B2 (en) 2000-05-22 2005-08-09 Merck & Co., Inc. System and method for assessing the performance of a pharmaceutical agent delivery system
US6911225B2 (en) * 2001-05-07 2005-06-28 Regents Of The University Of Minnesota Method and apparatus for non-thermal pasteurization of living-mammal-instillable liquids
US6562386B2 (en) 2001-05-07 2003-05-13 Regents Of The University Of Minnesota Method and apparatus for non-thermal pasteurization
US7011790B2 (en) * 2001-05-07 2006-03-14 Regents Of The University Of Minnesota Non-thermal disinfection of biological fluids using non-thermal plasma
KR20040077658A (ko) 2001-11-02 2004-09-06 플라스마솔 코포레이션 플라스마 방전 및 필터를 이용한 살균 및 오염제거 시스템
ATE412447T1 (de) 2002-05-23 2008-11-15 Gendel Ltd Ablationsvorrichtung
RU26004U1 (ru) * 2002-05-29 2002-11-10 Общество с ограниченной ответственностью Центр по изготовлению медицинской техники "Экстратерм" Устройство для высокочастотной терапии и система ориентации электродов для него
JP2004202086A (ja) 2002-12-26 2004-07-22 Teikoku Seiyaku Co Ltd エレクトロポレーション用薬物投与部、エレクトロポレーション用薬物投与システム、及びエレクトロポレーション用薬物投与方法
JP4037258B2 (ja) * 2002-12-26 2008-01-23 株式会社吉野工業所 櫛付き容器
JP2004248653A (ja) 2003-02-22 2004-09-09 Minoru Seki 流通型エレクトロポレーション用電極装置およびそれを用いた細胞への物質導入方法
JP4319427B2 (ja) * 2003-02-28 2009-08-26 株式会社東芝 医用超音波照射装置
WO2007021994A2 (en) 2005-08-12 2007-02-22 Maxcyte, Inc. Electrode shielding for electroporation
CA2678450A1 (en) * 2007-03-01 2008-09-04 Queen's University At Kingston Planar electroporation apparatus and method

Also Published As

Publication number Publication date
KR101361498B1 (ko) 2014-02-12
WO2007056027A1 (en) 2007-05-18
US8221596B2 (en) 2012-07-17
CA2628407C (en) 2014-08-05
EP1952133B1 (en) 2016-03-30
US20070095648A1 (en) 2007-05-03
JP2009515168A (ja) 2009-04-09
RU2008121962A (ru) 2009-12-10
AU2006311979A1 (en) 2007-05-18
CA2628407A1 (en) 2007-05-18
US8226811B2 (en) 2012-07-24
AU2006311979B2 (en) 2013-01-24
UA95262C2 (uk) 2011-07-25
RU2408006C2 (ru) 2010-12-27
NZ603542A (en) 2013-03-28
BRPI0618420A2 (pt) 2012-10-30
EP1952133A4 (en) 2011-08-31
US20110139608A1 (en) 2011-06-16
EP1952133A1 (en) 2008-08-06
KR20080080518A (ko) 2008-09-04

Similar Documents

Publication Publication Date Title
JP5607304B2 (ja) 電界を発生させる高インピーダンスシステムおよび使用方法
JP2009515168A5 (enExample)
Gowrishankar et al. Microdosimetry for conventional and supra-electroporation in cells with organelles
US5326530A (en) Energy-efficient electromagnetic elimination of noxious biological organisms
Movahed et al. Microfluidics cell electroporation
Pakhomov et al. Excitation and electroporation by MHz bursts of nanosecond stimuli
US4923814A (en) High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
US4906576A (en) High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
EP0553377A1 (en) Energy-efficient electromagnetic elimination of noxious biological organisms
Novickij et al. Pulsed electromagnetic field assisted in vitro electroporation: a pilot study
JPS6331675A (ja) 経皮薬剤アプリケ−タ・システム
Milestone et al. Modeling coupled single cell electroporation and thermal effects from nanosecond electric pulse trains
US10835734B1 (en) High and low impedance systems and methods for the generation and use of constant intensity electric fields
US20240131513A1 (en) Method and device for high field strength electrotransfection of microvescicles and cells
CN101331392B (zh) 用于产生电场的高阻抗系统及所使用的方法
DK2528460T3 (en) Devices and method for the treatment of high voltage pulse in ring spalte
Meir et al. Alternating electric field capacitively coupled micro-electroporation
Hui et al. In vitro and ex vivo gene delivery to cells by electroporation
MX2008005673A (es) Sistema de alta impedancia que genera campos electricos y metodo de uso
AU695048B2 (en) Apparatus and method for separating a charged substance from a conductive fluid
Murauskas et al. Electroporation cuvette with integrated electrodes for high gradient electric field generation
Gaynor et al. Physical modelling of electroporation in close cell-to-cell proximity environments
Teissié et al. Cell Membrane Electropermeabilization
Chou et al. Electrodeless dielectrophoretic trapping and separation of cells
Arslan et al. Finite element analysis of electric field for in-vitro electropermeabilization

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091030

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20091030

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20091106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091222

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20111202

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120410

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120517

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120524

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20121010

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130604

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20130902

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140415

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140710

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20140805

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140828

R150 Certificate of patent or registration of utility model

Ref document number: 5607304

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees