JP5574967B2 - チゲサイクリン塩酸塩の結晶型 - Google Patents

チゲサイクリン塩酸塩の結晶型 Download PDF

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Publication number
JP5574967B2
JP5574967B2 JP2010533564A JP2010533564A JP5574967B2 JP 5574967 B2 JP5574967 B2 JP 5574967B2 JP 2010533564 A JP2010533564 A JP 2010533564A JP 2010533564 A JP2010533564 A JP 2010533564A JP 5574967 B2 JP5574967 B2 JP 5574967B2
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Japan
Prior art keywords
type
tigecycline
crystal
tigecycline hydrochloride
hydrochloride
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Active
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JP2010533564A
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English (en)
Japanese (ja)
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JP2011503142A5 (enExample
JP2011503142A (ja
Inventor
ビーザー，ヨーゼフ
ホツター，アンドレアス
ピヒラー，アルトウール
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Sandoz AG
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Sandoz AG
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Publication of JP2011503142A5 publication Critical patent/JP2011503142A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2010533564A 2007-11-14 2008-11-12 チゲサイクリン塩酸塩の結晶型 Active JP5574967B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07120732 2007-11-14
EP07120732.8 2007-11-14
PCT/EP2008/065398 WO2009062963A1 (en) 2007-11-14 2008-11-12 Crystalline forms of tigecycline hydrochloride

Publications (3)

Publication Number Publication Date
JP2011503142A JP2011503142A (ja) 2011-01-27
JP2011503142A5 JP2011503142A5 (enExample) 2014-05-01
JP5574967B2 true JP5574967B2 (ja) 2014-08-20

Family

ID=39186791

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010533564A Active JP5574967B2 (ja) 2007-11-14 2008-11-12 チゲサイクリン塩酸塩の結晶型

Country Status (9)

Country Link
US (2) US8252946B2 (enExample)
EP (1) EP2220033B1 (enExample)
JP (1) JP5574967B2 (enExample)
CN (1) CN101861300B (enExample)
CA (1) CA2704536C (enExample)
ES (1) ES2532880T3 (enExample)
IL (1) IL205451A0 (enExample)
SI (1) SI2220033T1 (enExample)
WO (1) WO2009062963A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102285898A (zh) * 2011-06-29 2011-12-21 赵军旭 替加环素盐酸盐的晶型及其制备方法
CN106431963B (zh) * 2015-08-13 2019-03-05 江苏豪森药业集团有限公司 替加环素的新晶型及其制备方法
WO2017219994A1 (zh) * 2016-06-22 2017-12-28 山东亨利医药科技有限责任公司 9-氨基甲基取代的四环素类化合物的晶型及其制备方法
CN111060641B (zh) * 2019-12-27 2020-10-23 瀚晖制药有限公司 一种注射用替加环素中9-硝基米诺环素的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
DE202007019460U1 (de) 2006-04-24 2012-10-24 Teva Pharmaceutical Industries Ltd. Kristalline Tigecyclin-Formen
WO2008066935A2 (en) 2006-11-29 2008-06-05 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
EP2178827A1 (en) 2007-06-21 2010-04-28 Sandoz AG Crystalline solid forms
CN101386582A (zh) * 2007-09-14 2009-03-18 上海来益生物药物研究开发中心有限责任公司 替加环素盐及其制备方法

Also Published As

Publication number Publication date
WO2009062963A1 (en) 2009-05-22
CA2704536A1 (en) 2009-05-22
IL205451A0 (en) 2010-12-30
CN101861300A (zh) 2010-10-13
SI2220033T1 (sl) 2015-07-31
US20110105772A1 (en) 2011-05-05
US8252946B2 (en) 2012-08-28
EP2220033B1 (en) 2014-12-17
CN101861300B (zh) 2014-07-09
US20130012481A1 (en) 2013-01-10
ES2532880T3 (es) 2015-04-01
CA2704536C (en) 2017-04-25
JP2011503142A (ja) 2011-01-27
EP2220033A1 (en) 2010-08-25

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