JP5568471B2 - 抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤 - Google Patents
抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤 Download PDFInfo
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- JP5568471B2 JP5568471B2 JP2010516297A JP2010516297A JP5568471B2 JP 5568471 B2 JP5568471 B2 JP 5568471B2 JP 2010516297 A JP2010516297 A JP 2010516297A JP 2010516297 A JP2010516297 A JP 2010516297A JP 5568471 B2 JP5568471 B2 JP 5568471B2
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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| US94936507P | 2007-07-12 | 2007-07-12 | |
| US60/949,365 | 2007-07-12 | ||
| PCT/US2008/069974 WO2009009793A2 (en) | 2007-07-12 | 2008-07-14 | Inhibitors of akt/pkb with anti-tumor activity |
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| JP2010533206A JP2010533206A (ja) | 2010-10-21 |
| JP2010533206A5 JP2010533206A5 (OSRAM) | 2011-09-01 |
| JP5568471B2 true JP5568471B2 (ja) | 2014-08-06 |
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| AU (1) | AU2008274956B2 (OSRAM) |
| BR (1) | BRPI0815563A2 (OSRAM) |
| CA (1) | CA2695330C (OSRAM) |
| MX (1) | MX2010000474A (OSRAM) |
| WO (1) | WO2009009793A2 (OSRAM) |
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| CA2576765C (en) * | 2004-09-03 | 2013-05-28 | Applied Research Systems Ars Holding N.V. | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors |
| JP5568471B2 (ja) * | 2007-07-12 | 2014-08-06 | ユニヴァーシティ オブ サウス フロリダ | 抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤 |
| EP2300011A4 (en) | 2008-05-27 | 2012-06-20 | Dmi Life Sciences Inc | THERAPEUTIC PROCESSES AND COMPOUNDS |
| JP2013537195A (ja) | 2010-09-07 | 2013-09-30 | ディエムアイ アクイジション コーポレイション | 疾患の治療 |
| WO2012158197A2 (en) * | 2010-11-11 | 2012-11-22 | Lyndor Biosciences L.L.C. | Compounds useful as akt/pkb modulators and uses thereof |
| RS56759B2 (sr) | 2011-04-01 | 2024-10-31 | Genentech Inc | Kombinacija akt inhibitor jedinjenja i abiraterona za upotrebu pri terapeutskim tretiranjima |
| RU2635193C2 (ru) * | 2011-04-01 | 2017-11-09 | Дженентек, Инк. | Биомаркеры для прогнозирования чувствительности к противоопухолевой терапии |
| CN102225067B (zh) * | 2011-04-29 | 2012-10-03 | 济南环肽医药科技有限公司 | 一种治疗胃癌的药物组合物 |
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| US4559157A (en) * | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) * | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US5167649A (en) * | 1988-08-22 | 1992-12-01 | Zook Gerald P | Drug delivery system for the removal of dermal lesions |
| US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| JP4407008B2 (ja) * | 2000-05-11 | 2010-02-03 | パナソニック株式会社 | カラー画像形成装置 |
| UA72612C2 (en) * | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
| AU2003232071A1 (en) * | 2002-05-06 | 2003-11-17 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| AU2005228410A1 (en) * | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| WO2008094321A2 (en) * | 2006-10-04 | 2008-08-07 | Universtiy Of South Florida | Akt sensitization of cancer cells |
| JP5568471B2 (ja) | 2007-07-12 | 2014-08-06 | ユニヴァーシティ オブ サウス フロリダ | 抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤 |
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| CA2695330A1 (en) | 2009-01-15 |
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| EP2173352A2 (en) | 2010-04-14 |
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| BRPI0815563A2 (pt) | 2015-02-18 |
| MX2010000474A (es) | 2010-06-23 |
| CN101743007B (zh) | 2015-04-08 |
| EP2173352B1 (en) | 2016-09-07 |
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