JP5565902B2 - Hand sanitizer composition - Google Patents
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- JP5565902B2 JP5565902B2 JP2010089769A JP2010089769A JP5565902B2 JP 5565902 B2 JP5565902 B2 JP 5565902B2 JP 2010089769 A JP2010089769 A JP 2010089769A JP 2010089769 A JP2010089769 A JP 2010089769A JP 5565902 B2 JP5565902 B2 JP 5565902B2
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- 239000000203 mixture Substances 0.000 title claims description 41
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000000645 desinfectant Substances 0.000 claims description 26
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 19
- 229930195729 fatty acid Natural products 0.000 claims description 19
- 239000000194 fatty acid Substances 0.000 claims description 19
- 150000004665 fatty acids Chemical class 0.000 claims description 19
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 14
- 150000005846 sugar alcohols Polymers 0.000 claims description 12
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229940105990 diglycerin Drugs 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 229940009714 erythritol Drugs 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 description 16
- 230000000694 effects Effects 0.000 description 12
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical group CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 3
- 206010011409 Cross infection Diseases 0.000 description 3
- 229960003260 chlorhexidine Drugs 0.000 description 3
- -1 fatty acid triglycerides Chemical class 0.000 description 3
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- OEOIWYCWCDBOPA-UHFFFAOYSA-N 6-methyl-heptanoic acid Chemical compound CC(C)CCCCC(O)=O OEOIWYCWCDBOPA-UHFFFAOYSA-N 0.000 description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- CYDRXTMLKJDRQH-UHFFFAOYSA-N benzododecinium Chemical class CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 CYDRXTMLKJDRQH-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 229960002446 octanoic acid Drugs 0.000 description 2
- 238000011012 sanitization Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- ZONJATNKKGGVSU-UHFFFAOYSA-N 14-methylpentadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCC(O)=O ZONJATNKKGGVSU-UHFFFAOYSA-N 0.000 description 1
- COPFWAGBXIWZNK-UHFFFAOYSA-N 2,3-bis(6-methylheptanoyloxy)propyl 6-methylheptanoate Chemical compound CC(C)CCCCC(=O)OCC(OC(=O)CCCCC(C)C)COC(=O)CCCCC(C)C COPFWAGBXIWZNK-UHFFFAOYSA-N 0.000 description 1
- OXBFEJBBKCRANO-UHFFFAOYSA-N 2,3-di(octanoyloxy)propyl decanoate Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC OXBFEJBBKCRANO-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960001716 benzalkonium Drugs 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
- 229960001755 resorcinol Drugs 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- PMBRBOODEWULOI-UHFFFAOYSA-N trichloromethanide Chemical compound Cl[C-](Cl)Cl PMBRBOODEWULOI-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003357 wound healing promoting agent Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
本発明は、手指消毒剤組成物に関し、さらに詳しくは、エタノール及び／又はイソプロパノールを含有し、手指に擦り込むだけで簡便に消毒を行うことができる手指消毒剤組成物に関する。 The present invention relates to a hand disinfectant composition, and more particularly, to a hand disinfectant composition containing ethanol and / or isopropanol, which can be easily disinfected by simply rubbing on the finger.
病院内において、医師や看護師等の医療従事者、さらに入院又は外来患者が種々の感染症にかかる、いわゆる院内感染が問題となっている。病院には種々のルートで病原体が持ち込まれ、院内感染を引き起こす要因となり得る。また、病院内に限らず、在宅医療現場においても同様の感染を引き起こしかねない。このような院内感染は、かかる医療従事者や患者が充分な手洗いを励行することによってある程度防ぐことができるが、手洗いだけで完全に病原菌を除去することは難しい。２００２年に公表された米国ＣＤＣの「医療施設における手指衛生のためのＣＤＣガイドライン」では、アルコール含有手指消毒剤によるラビング法（擦式法）が推奨されており、現在ではエタノールを主成分とした速乾性のラビング剤が手指消毒の主流となっている。即ち、病院のナースステーション、病棟入口、ＩＣＵ、各病室入口等にアルコール消毒剤を配備し、これを患者の治療や介護の前後に使用して手指の消毒を行っている。 In hospitals, so-called nosocomial infections, in which medical personnel such as doctors and nurses, as well as hospitalized or outpatients, suffer from various infectious diseases, have become a problem. Pathogens are brought into hospitals through various routes and can cause nosocomial infections. Moreover, the same infection may be caused not only in a hospital but also in a home medical field. Such nosocomial infections can be prevented to some extent by enforcing sufficient hand washing by such medical staff and patients, but it is difficult to completely remove pathogenic bacteria by hand washing alone. The US CDC's “CDC Guidelines for Hand Hygiene in Medical Facilities” published in 2002 recommended a rubbing method (rubbing method) with alcohol-containing hand sanitizers, and is currently based on ethanol. Quick-drying rubbing agents are the mainstream of hand sanitization. In other words, alcohol disinfectants are deployed at hospital nurse stations, ward entrances, ICUs, hospital room entrances, etc., and these are used before and after patient treatment and care to disinfect fingers.
本発明でいう手指消毒剤は、医師や看護師等の医療従事者、入院あるいは通院患者等に対する病院内用途だけでなく、一般用途として、例えば、老人ホームや在宅医療現場など家庭内での手指の消毒、レストランや飲食店などを含む食品加工業従事者等あらゆるところで使用されうる手指消毒剤をさす。 The hand disinfectant referred to in the present invention is not only used in hospitals for medical workers such as doctors and nurses, hospitalized or outpatients, etc., but also as a general use, for example, fingers in homes such as nursing homes and home medical sites. Hand sanitizer that can be used everywhere such as food processing workers including restaurants and restaurants.
速乾性の手指消毒剤は、１日のうちに頻繁に使用するとエタノールやイソプロパノールの蛋白変性作用によって手荒れを誘発する。また、手荒れ状態の手指は菌の付着が多くなり、二次感染を引き起こしやすくなる。 Quick-drying hand sanitizers, when used frequently within a day, induce hand roughness due to the protein-denaturing action of ethanol and isopropanol. In addition, the hands in rough hands are more likely to adhere to the bacteria and easily cause secondary infection.
特許文献１にはエタノールとグルコン酸クロルヘキシジンと特定のエモリエント剤を含有する手指消毒用組成物が記載されている。また、特許文献２にはエタノール、クロルヘキシジン、グルコン酸と脂肪酸トリグリセライドを特定量含有する手荒れ防止消毒用組成物が記載されている。しかしながら、十分な手荒れ抑制効果は得られておらず、前記の課題は解決できていない。 Patent Document 1 describes a hand sanitizing composition containing ethanol, chlorhexidine gluconate and a specific emollient. Further, Patent Document 2 describes a hand-roughing antiseptic composition containing specific amounts of ethanol, chlorhexidine, gluconic acid and fatty acid triglyceride. However, sufficient hand-roughness suppressing effect has not been obtained, and the above-mentioned problems have not been solved.
手荒れを抑制するには、エタノールを主成分とした手指消毒剤に湿潤剤である水溶性多価アルコールを添加する方法がある。水溶性多価アルコールには皮膚を豊潤に保つ作用がある。しかしながら、水溶性多価アルコールを添加すると乾いた後に手指にべたついた感触が残り、また作業に支障をきたすことにもなる。そのため、乾いた後にべたつきがない速乾性の手指消毒剤は得られていないのが現状であった。 In order to suppress the rough hand, there is a method of adding a water-soluble polyhydric alcohol as a wetting agent to a hand sanitizer mainly composed of ethanol. Water-soluble polyhydric alcohol has the effect of keeping the skin rich. However, when a water-soluble polyhydric alcohol is added, it feels sticky to the fingers after it dries, and it also hinders work. Therefore, the present situation is that a quick-drying hand disinfectant that does not become sticky after drying has not been obtained.
従って、本発明の課題は、手荒れ抑制効果が十分であり、かつ乾いた後にべたつきがない使用感に優れた手指消毒剤組成物であって、十分な殺菌効果を有する手指消毒剤組成物を提供することにある。 Therefore, an object of the present invention is to provide a hand disinfectant composition that has a sufficient hand-fouling-suppressing effect and is excellent in a feeling of use that is not sticky after drying, and has a sufficient bactericidal effect. There is to do.
そこで本発明者らは、上記課題を解決するべく、種々の成分を検討したところ、エタノールを主成分とした手指消毒剤に水溶性多価アルコールと脂肪酸トリグリセリドを添加し、それぞれの含有量を０．２〜３質量％と０．０１〜０．１５質量％とすることによって、使用頻度の高い場合でも手荒れ抑制効果が十分であり、かつ乾いた後にべたつきがない使用感に優れた手指消毒剤組成物を得ることができることを見出し、しかも、公知の殺菌消毒剤を添加することなく、医療従事者向けの病院での用途、介護施設、食品加工業等の公共施設での用途等に十分な殺菌効果を発揮することを見出し、本発明を完成した。 Therefore, the present inventors have studied various components in order to solve the above-mentioned problems. As a result, a water-soluble polyhydric alcohol and a fatty acid triglyceride are added to a hand disinfectant mainly composed of ethanol, and the respective contents are reduced to 0. 2. Hand disinfectant excellent in feeling of use that has a sufficient effect of suppressing hand roughness even when it is frequently used, and has no stickiness after drying, by adjusting the content to 2-3% by mass and 0.01 to 0.15% by mass. It is found that the composition can be obtained, and it is sufficient for use in public facilities such as hospitals, care facilities, food processing industries, etc. for medical workers without adding known disinfectants. The present invention was completed by finding that it exhibits a bactericidal effect.
即ち、本発明の要旨は、
次の成分（Ａ）、成分（Ｂ）及び成分（Ｃ）：
（Ａ）：エタノール及び／又はイソプロパノール ４０〜９５質量％、
（Ｂ）：水溶性多価アルコール ０．２〜３質量％
（Ｃ）：脂肪酸トリグリセリド ０．０１〜０．１５質量％
を含有する手指消毒剤組成物、に関するものである。
That is, the gist of the present invention is as follows.
The following component (A), component (B) and component (C):
(A): Ethanol and / or isopropanol 40-95 mass%,
(B): Water-soluble polyhydric alcohol 0.2-3 mass%
(C): Fatty acid triglyceride 0.01-0.15 mass%
The present invention relates to a hand sanitizer composition containing
本発明の手指消毒剤組成物は、手荒れ抑制効果が十分であり、かつべたつきがなく使用感に優れている。しかも、本発明の手指消毒剤組成物は公知の殺菌消毒剤を添加することなく十分な殺菌効果を発揮するため、より安全性が高い。従って、本発明の手指消毒剤組成物を、医師や看護師等の医療従事者、入院患者や通院患者等に対する病院での用途だけでなく、介護施設、レストランや飲食店を含む食品加工業等の公共施設での用途や、さらには一般用途として在宅医療現場等家庭内での手指の消毒等、あらゆるところで使用することができる。 The hand disinfectant composition of the present invention has a sufficient effect of suppressing hand roughness, and is excellent in usability without stickiness. Moreover, since the hand sanitizer composition of the present invention exhibits a sufficient sterilizing effect without adding a known disinfectant, it is safer. Therefore, the hand sanitizer composition of the present invention is not only used in hospitals for medical workers such as doctors and nurses, inpatients and outpatients, but also in food processing industries including nursing homes, restaurants and restaurants, etc. It can be used in various places such as disinfection of fingers in homes such as home medical sites as a general use.
本発明で使用する成分（Ａ）のエタノール及び／又はイソプロパノールの含有量は、消毒効果や液だれの観点から本発明の手指消毒剤組成物の４０〜９５質量％であり、４５〜９０質量％であることがより好ましく、５５〜７５質量％であることがさらに好ましい。エタノール及びイソプロパノールを併用する場合、その混合比としては所望の効果が得られる限り限定されるわけではないが、例えばエタノール／イソプロパノール（質量比）が５０／５０〜９９／１であることが好ましく、８０／２０〜９９／１であることがより好ましい。 The content of the component (A) ethanol and / or isopropanol used in the present invention is 40 to 95% by mass of the hand sanitizer composition of the present invention from the viewpoint of the disinfection effect and dripping, and 45 to 90% by mass. It is more preferable that it is 55-75 mass%. When ethanol and isopropanol are used in combination, the mixing ratio is not limited as long as the desired effect is obtained. For example, ethanol / isopropanol (mass ratio) is preferably 50/50 to 99/1, More preferably, it is 80/20 to 99/1.
本発明で使用する成分（Ｂ）の水溶性多価アルコールは、グリセリン、ジグリセリン、エチレングリコール、プロピレングリコール、１，３−プロパンジオール、ブチレングリコール、エリスリトール、ソルビトール、ポリエチレングリコール等が挙げられる。これらのうち、特にグリセリン、１，３−プロパンジオールが好ましい。 Examples of the water-soluble polyhydric alcohol of component (B) used in the present invention include glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, sorbitol, polyethylene glycol and the like. Of these, glycerin and 1,3-propanediol are particularly preferable.
これらの水溶性多価アルコールは、１種又は２種以上を組み合わせて用いることができ、含有量は、本発明の組成物の０．２〜３質量％であり、０．３〜２質量％であることがより好ましい。組成物中における水溶性多価アルコールの含有量は、０．２質量％以上では手荒れを抑制することができ、３質量％以下では乾いた後にべたつき感を残さないので好ましい。 These water-soluble polyhydric alcohols can be used alone or in combination of two or more, and the content is 0.2 to 3% by mass of the composition of the present invention, and 0.3 to 2% by mass. It is more preferable that When the content of the water-soluble polyhydric alcohol in the composition is 0.2% by mass or more, hand roughness can be suppressed, and when it is 3% by mass or less, a sticky feeling is not left after drying.
本発明で使用する成分（Ｃ）の脂肪酸トリグリセリドは、２５℃、１０１３．２５ｈＰａで液体のものが好ましい。脂肪酸トリグリセリドの脂肪酸部分としては、炭素数６〜１８の直鎖脂肪酸又は分岐脂肪酸が好ましく、炭素数６〜１０のものがより好ましい。具体的には、脂肪酸部分がカプロン酸、カプリル酸、カプリン酸、イソオクタン酸、イソパルミチン酸、イソステアリン酸、オレイン酸、リノール酸、リノレン酸等から選ばれる脂肪酸トリグリセリドが挙げられる。これらのうち、特に脂肪酸部分がカプロン酸、カプリル酸、カプリン酸、イソオクタン酸であることが好ましい。脂肪酸トリグリセリドの脂肪酸部分は３つとも同じ脂肪酸を用いてもよく、又は複数の種類の脂肪酸を組み合わせて用いてもよい。かかる脂肪酸トリグリセリドの具体例としては、例えば、トリカプリル酸グリセリン、トリイソオクタン酸グリセリン、ジカプリル酸モノカプリン酸グリセリン等が挙げられる。 The fatty acid triglyceride of component (C) used in the present invention is preferably liquid at 25 ° C. and 101.25 hPa. As a fatty-acid part of fatty-acid triglyceride, a C6-C18 linear fatty acid or branched fatty acid is preferable, and a C6-C10 thing is more preferable. Specific examples include fatty acid triglycerides in which the fatty acid moiety is selected from caproic acid, caprylic acid, capric acid, isooctanoic acid, isopalmitic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid and the like. Of these, the fatty acid moiety is particularly preferably caproic acid, caprylic acid, capric acid, and isooctanoic acid. The same fatty acid may be used for all three fatty acid portions of the fatty acid triglyceride, or a plurality of types of fatty acids may be used in combination. Specific examples of such fatty acid triglycerides include glycerin tricaprylate, glycerin triisooctanoate, glycerin dicaprylate monocaprate.
これらの脂肪酸トリグリセリドは、１種又は２種以上を組み合わせて用いることができ、含有量は、本発明の組成物の０．０１〜０．１５質量％であり、０．０３〜０．１２質量％であることが好ましく、０．０５〜０．１質量％であることがより好ましい。 These fatty acid triglycerides can be used alone or in combination of two or more, and the content is 0.01 to 0.15% by mass of the composition of the present invention, and 0.03 to 0.12% by mass. % Is preferable, and 0.05 to 0.1% by mass is more preferable.
本発明において、水溶性多価アルコールを含有するエタノールを主成分とした手指消毒剤に特定量の脂肪酸トリグリセリドを添加することによって、当業者にとって予期されないような、水溶性多価アルコールによるべたつきを抑制することができる。組成物中における脂肪酸トリグリセリドの含有量は、０．０１質量％以上でべたつきを抑制することができ、０．１５質量％以下では油っぽさやべたつきが感じられないので好ましい。 In the present invention, by adding a specific amount of fatty acid triglyceride to a hand sanitizer mainly composed of ethanol containing a water-soluble polyhydric alcohol, stickiness due to the water-soluble polyhydric alcohol, which is not expected by those skilled in the art, is suppressed. can do. The content of fatty acid triglyceride in the composition is preferably 0.01% by mass or more, and stickiness can be suppressed, and 0.15% by mass or less is preferable because oiliness and stickiness are not felt.
本発明の組成物には、使用感の観点から、成分（Ｂ）と成分（Ｃ）とを質量比で（Ｂ）／（Ｃ）＝４〜４０の割合で配合することが好ましく、５〜３０の割合で配合することがより好ましく、１０〜２０の割合で配合することがさらに好ましい。 From the viewpoint of usability, the composition of the present invention preferably contains the component (B) and the component (C) in a mass ratio of (B) / (C) = 4 to 40. It is more preferable to mix | blend in the ratio of 30, and it is further more preferable to mix | blend in the ratio of 10-20.
本発明の組成物は手指消毒剤として十分な殺菌効果を有するので、本技術分野で公知の殺菌消毒剤を配合することは必須ではない。即ち、例えば下記の殺菌消毒剤を含まない態様も、本発明の組成物の一つの好ましい態様である。なお、殺菌効果を増強するために、必要に応じて、本発明の効果を損なわない範囲で殺菌消毒剤を配合しても良い。ここで、殺菌消毒剤としては、例えば、塩化ベンザルコニウム、アルキルリン酸ベンザルコニウム等のベンザルコニウム塩、塩化ベンゼトニウム、トリクロサン、イソプロピルメチルフェノール、塩化セチルピリジニウム、レゾルシン、トリクロロカルバニド、塩化クロルヘキシジン、グルコン酸クロルヘキシジン、過酸化水素、ポピドンヨード、ヨードチンキ等が挙げられる。これらの殺菌剤は、単独で用いても２種類以上を組み合わせて用いてもよい。殺菌消毒剤の含有量は本発明の組成物の０．０１〜１０質量％が好ましい。 Since the composition of the present invention has a sufficient bactericidal effect as a hand disinfectant, it is not essential to add a disinfectant known in the art. That is, for example, an embodiment that does not contain the following disinfectant is also a preferred embodiment of the composition of the present invention. In order to enhance the bactericidal effect, a bactericidal disinfectant may be blended as necessary within a range not impairing the effects of the present invention. Here, examples of the disinfectant include benzalkonium salts such as benzalkonium chloride and benzalkonium alkyl phosphate, benzethonium chloride, triclosan, isopropylmethylphenol, cetylpyridinium chloride, resorcin, trichlorocarbanide, chlorhexidine chloride. Chlorohexidine gluconate, hydrogen peroxide, popidone iodine, iodine tincture and the like. These bactericides may be used alone or in combination of two or more. The content of the disinfectant is preferably 0.01 to 10% by mass of the composition of the present invention.
本発明の組成物には、上述した各成分の他に、必要に応じて手指消毒剤組成物に用いられる各種任意成分を配合することができる。ここで用いられる各種任意成分としては、特に制限されないが、例えば、油脂類、多糖類、界面活性剤、抗炎症剤、清涼剤、血行促進剤、創傷治癒剤、粘度調整剤、ｐＨ調整剤（有機又は無機の酸、有機又は無機のアルカリ）、キレート剤、酸化防止剤、防腐剤、粉体、香料、色素等が挙げられ、本発明の効果を損なわない範囲で配合することができる。本発明の組成物を用いた場合、乾いた後のべたつきが抑制されているので、べたつきを抑制する目的でシリコーン類を配合しなくてもよい。 In addition to the above-described components, the composition of the present invention may contain various optional components used in the hand sanitizer composition as necessary. The various optional components used here are not particularly limited. For example, fats and oils, polysaccharides, surfactants, anti-inflammatory agents, refreshing agents, blood circulation promoters, wound healing agents, viscosity modifiers, pH adjusters ( Organic or inorganic acids, organic or inorganic alkalis), chelating agents, antioxidants, preservatives, powders, fragrances, pigments and the like can be mentioned, and they can be blended within a range that does not impair the effects of the present invention. When the composition of the present invention is used, the stickiness after drying is suppressed, so it is not necessary to add silicones for the purpose of suppressing the stickiness.
本発明の手指消毒剤組成物は、希釈剤として水を含有してもよい。即ち、水を含有する場合、上述した各成分及びその他の任意成分を除くその残余量が水の含有量となる。水の含有量は、本発明の組成物の４〜５８質量％が好ましく、９〜５４質量％がより好ましい。 The hand sanitizer composition of the present invention may contain water as a diluent. That is, when it contains water, the remaining amount except each component mentioned above and other arbitrary components becomes water content. The content of water is preferably 4 to 58% by mass, more preferably 9 to 54% by mass of the composition of the present invention.
実施例１〜４及び比較例１〜３
表１に示す組成の手指消毒剤組成物を常法に従って調製し、それらの乾いた後のべたつき、乾いた後のしっとり感、手荒れ抑制効果について、下記の方法で評価した。なお、表中の組成の数値はいずれも質量％である。
Examples 1-4 and Comparative Examples 1-3
Hand disinfectant compositions having the compositions shown in Table 1 were prepared according to a conventional method, and their stickiness after drying, moist feeling after drying, and the effect of suppressing hand roughness were evaluated by the following methods. In addition, all the numerical values of the composition in the table are mass%.
［方法１：乾いた後のべたつきの評価］
１０名のパネラーが、各手指消毒剤組成物を手指に３ｍＬ噴霧し、両手で塗布し、そのまま自然乾燥させた。５分経過毎に、この操作を３回繰り返し、乾いた後のべたつきについて、べたつかないことが良く、べたつくことが良くないとした評価を行った。
[Method 1: Evaluation of stickiness after drying]
Ten panelists sprayed 3 mL of each hand disinfectant composition on the fingers, applied with both hands, and allowed to dry naturally. This operation was repeated 3 times every 5 minutes, and the stickiness after drying was evaluated as not sticky and not sticky.
［方法２：乾いた後のしっとり感の評価］
１０名のパネラーが、各手指消毒剤組成物を手指に３ｍＬ噴霧し、両手で塗布し、そのまま自然乾燥させた。５分経過毎に、この操作を３回繰り返し、乾いた後のしっとり感について、しっとりすることが良く、しっとりしないことが良くないとした評価を行った。
[Method 2: Evaluation of moist feeling after drying]
Ten panelists sprayed 3 mL of each hand disinfectant composition on the fingers, applied with both hands, and allowed to dry naturally. This operation was repeated 3 times every 5 minutes, and the moist feeling after drying was evaluated to be moist and not moist.
［方法３：手荒れ抑制効果の評価］
１０名のパネラーが、各手指消毒剤組成物を手指に３ｍＬ噴霧し、両手で塗布し、そのまま自然乾燥させた。５分経過毎に、この操作を１０回繰り返し、これを３日間連続して行い、手荒れの状態を観察して、手荒れ抑制効果について、手荒れがないことが良く、手荒れすることが良くないとした評価を行った。
[Method 3: Evaluation of hand roughening effect]
Ten panelists sprayed 3 mL of each hand disinfectant composition on the fingers, applied with both hands, and allowed to dry naturally. This operation is repeated 10 times every 5 minutes, and this operation is performed continuously for 3 days, and the state of rough hand is observed. Evaluation was performed.
各パネラーによる評価を、次の基準で行った。
５：非常に良い
４：良い
３：どちらともいえない
２：あまり良くない
１：良くない
Evaluation by each panel was performed according to the following criteria.
5: Very good 4: Good 3: Not good 2: Not very good 1: Not good
各評価項目に関して、１０名の平均値を、表１に結果として示した。 For each evaluation item, the average value of 10 persons is shown in Table 1 as a result.
表１に示すように、本発明の手指消毒剤組成物は、手荒れ抑制効果が十分であり、かつ乾いた後にべたつきがない使用感に優れるものであった。一方、比較例１では、成分（Ｃ）が含まれないのでべたつきが強いことが、比較例２では成分（Ｂ）が含まれないのでしっとり感が悪化していることが分かった。さらに比較例３では、成分（Ｃ）の量が多すぎるので、実施例２及び３よりもべたつきが強くなり、しっとり感も悪化した。 As shown in Table 1, the hand disinfectant composition of the present invention has a sufficient effect of suppressing hand roughness and has an excellent feeling of use with no stickiness after drying. On the other hand, in Comparative Example 1, it was found that the component (C) was not included, and thus the stickiness was strong. In Comparative Example 2, the component (B) was not included, and the moist feeling was deteriorated. Furthermore, in Comparative Example 3, since the amount of the component (C) was too large, the stickiness became stronger than in Examples 2 and 3, and the moist feeling was also deteriorated.
なお、実施例１〜４のもの、比較例１〜３のものは共に、大腸菌及び黄色ブドウ球菌に対する殺菌活性に優れたものであり、殺菌消毒剤の有無による殺菌効果に違いは見られなかった。 In addition, the thing of Examples 1-4 and the thing of Comparative Examples 1-3 were both excellent in bactericidal activity with respect to colon_bacillus | E._coli and Staphylococcus aureus, and the difference was not looked at by the bactericidal effect by the presence or absence of a bactericidal disinfectant. .
本発明の手指消毒剤組成物は、手荒れ抑制効果が十分であり、かつ乾いた後にべたつきがなく使用感に優れているため、医療従事者向けの病院での用途、介護施設、食品加工業等の公共施設での用途等に好適に用いられる。 The hand disinfectant composition of the present invention has sufficient hand-roughness suppression effect, and has no stickiness after drying and is excellent in feeling of use, so that it is used in hospitals for healthcare professionals, care facilities, food processing industries, etc. It is suitably used for applications in public facilities.
Claims (5)
（Ａ）：エタノール及び／又はイソプロパノール ４０〜９５質量％、
（Ｂ）：水溶性多価アルコール ０．２〜３質量％
（Ｃ）：脂肪酸トリグリセリド ０．０１〜０．１５質量％
を含有する手指消毒剤組成物であって、
該成分（Ｂ）と該成分（Ｃ）との質量比が（Ｂ）／（Ｃ）＝１０〜４０である、手指消毒剤組成物。 The following component (A), component (B) and component (C):
(A): Ethanol and / or isopropanol 40-95 mass%,
(B): Water-soluble polyhydric alcohol 0.2-3 mass%
(C): Fatty acid triglyceride 0.01-0.15 mass%
A disinfectant composition containing,
The hand sanitizer composition whose mass ratio of this component (B) and this component (C) is (B) / (C) = 10-40 .
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