JP6210481B2 - Tackiness reducing composition for gloves - Google Patents

Description

  The present invention relates to a tackiness reducing composition for gloves.

  When medical personnel are treated in hospitals, disposable gloves are worn to prevent nosocomial infections. However, there are opportunities to use various adhesive products such as adhesive bandages (cloth adhesive bandages, paper bonds, plastic bandages), suture tapes (surgical tape), dressings, waterproof films, etc. in the medical field. When processing using a tape is performed, there is a problem that the adhesive tape adheres to the glove and takes time and effort. Therefore, in the medical field, there has been a demand for a glove that does not adhere an adhesive product or a technique for preventing adhesion.

  In particular, not only gloves made of different materials such as natural rubber (latex), nitrile rubber, and polyvinyl chloride are used as medical gloves, but also adhesive products such as rubber and acrylic are different. Adhesives are used, and the solution is required to be applicable to any combination of these.

Patent Document 1 includes a resin film layer mainly composed of a silicone aqueous emulsion on the surface of a fiber glove body as a glove excellent in operability and suitable for handling an adhesive. Gloves are disclosed.
Patent Document 2 discloses a medical glove coated with polyisoprene as an elastomeric glove having reduced adhesion / stickiness on the surface.

  However, these known gloves are provided in a state in which the surface of the glove is coated in advance, and are not techniques that can be individually applied to disposable gloves widely used in the medical field. In addition, these documents do not describe whether or not they are effective against a plurality of different pressure-sensitive adhesives.

By the way, a gel-like or liquid quick-drying rubbing hand sanitizer is known.
In Patent Document 3, “the following component (A), component (B) and component (C):
(A): Ethanol and / or isopropanol 40-95 mass%,
(B): Water-soluble polyhydric alcohol 0.2-3 mass% (preferably 0.2-2 mass%)
(C): Fatty acid triglyceride 0.01-0.15 mass%
Disclosed is a hand sanitizer composition containing (Claim 1). In Patent Document 3, the water-soluble polyhydric alcohol is selected from the group consisting of glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butylene glycol, erythritol, sorbitol, and polyethylene glycol. (Claim 2), the content of the water-soluble polyhydric alcohol is more preferably 0.3 to 2% by mass (paragraph [0014]).

  Patent Document 4 states that “an external sterilizing disinfectant characterized in that isopropanol is added to ethanol as an active ingredient, and the content thereof is 80 to 85 vol% Japanese pharmacopoeia ethanol and 3.7 to 10 vol% isopropanol”. (Claim 1) is disclosed. Patent Document 4 can further contain one or more moisturizing components of glycerin, propylene glycol, sorbitol, 1,3-butylene glycol, polyethylene glycol, hyaluronate, urea for preventing rough hand. (Claim 2) is described, and as a specific disinfectant, “Japanese pharmacopoeia ethanol 83 vol%, isopropanol 4.9 vol% as an active ingredient, and glycerin 0.9 w / v% as a humectant are added to purified water. Is described in Example 3.

  Each of the disinfectants described in Patent Document 3 and Patent Document 4 contains a trace amount of glycerin or the like as a moisturizing agent for preventing hand roughness because of the harshness of hand with only alcohol for disinfection. This is different from the present invention. In addition, these disinfectants are intended to be applied directly to the skin and are not intended to be used while wearing gloves, since they are intended to prevent rough hands.

JP2012-154001A Japanese translation of PCT publication 2010-520927 JP 2011-219410 A JP 2004-155712 A

  An object of the present invention is to reduce the adhesive composition for gloves, which can prevent the adhesive product from adhering to the glove without affecting the work operation when the adhesive product is handled in the state of wearing the glove. To provide things.

Said subject is the following ingredients according to the invention:
(A) Disinfecting alcohol 60-90% by volume
(B) Water-soluble polyhydric alcohol 3-30% by volume
It can be solved by a tackiness-reducing composition for gloves.

  According to the adhesiveness-reducing composition of the present invention, when an adhesive product is handled while wearing a glove, the adhesive product can be prevented from adhering to the glove. Moreover, since the adhesiveness-reducing composition of the present invention has negligible influence on the lubricity of the glove or is extremely mild, it does not hinder the work operation in which the glove is worn. Furthermore, the present invention is also applicable to any combination of gloves made of different materials such as natural rubber (latex), nitrile rubber, and polyvinyl chloride, and different adhesives such as rubber and acrylic. An adhesive reduction effect can be obtained.

FIG. 1 is a graph showing the traction force in the traction force experiment of Example 3 when the glycerin concentration is changed at 80% by volume of ethanol using a rubber-based and acrylic adhesive tape.

The tackiness reducing composition of the present invention can be applied to gloves made of various materials. The glove may be a disposable glove or a glove that is used repeatedly, and examples thereof include a surgical glove, a dental glove, and an examination / diagnosis glove that are used as a medical glove. . Examples of the material for the glove include various materials used for the glove, such as natural rubber (latex), nitrile rubber, and polyvinyl chloride.
Since the adhesiveness-reducing composition of the present invention contains a disinfecting alcohol at a concentration having a disinfecting effect, a sterilizing effect on the glove surface can be obtained at the same time by applying to the glove, and there is no need to prepare a disinfecting alcohol separately. .

  The pressure-sensitive adhesive product in which the pressure-sensitive adhesive composition of the present invention exhibits a pressure-reducing effect includes various pressure-sensitive adhesive products coated with various pressure-sensitive adhesives, such as adhesive bandages (cloth bond plaster, paper bond, plastic). (Adhesive bandage), suture tape (surgical tape), dressing, waterproof film and the like. Examples of the pressure-sensitive adhesive include a rubber-based pressure-sensitive adhesive and an acrylic pressure-sensitive adhesive.

  The disinfecting alcohol blended in the tackiness-reducing composition of the present invention is not particularly limited as long as it is a disinfecting alcohol used for medical purposes, and examples thereof include ethanol and isopropanol (2-propanol). be able to. The tackiness-reducing composition of the present invention can contain one disinfecting alcohol alone or in combination of two or more.

  Examples of the water-soluble polyhydric alcohol blended in the tackiness-reducing composition of the present invention include glycerin, polyethylene glycol, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, pentaerythritol, Examples include erythritol, sorbitol, and xylitol, and glycerin, polyethylene glycol, and ethylene glycol are more preferable. The adhesiveness-reducing composition of the present invention can contain one water-soluble polyhydric alcohol alone or in combination of two or more.

The adhesiveness-reducing composition of the present invention has a content of 60 to 90% by volume as a total amount of alcohol for disinfection and 3 to 30% by volume as a total amount of water-soluble polyhydric alcohol, based on the total weight of the composition. Can be contained.
When the content of the alcohol for disinfection is less than 60% by volume or exceeds 90% by volume, the disinfection effect is lowered. In the Japanese Pharmacopoeia, the concentration of ethanol for disinfection is defined as 76.9 vol% to 81.4 vol% (15 ° C). The lower limit of the alcohol for disinfection is preferably 65% by volume or more, more preferably 70% by volume or more, and further preferably 75% by volume or more. As an upper limit of alcohol for disinfection, 85 volume% or less is preferable and 80 volume% or less is more preferable.

  If the content of the water-soluble polyhydric alcohol is less than 3% by volume, a sufficient adhesive reduction effect cannot be obtained. The lower limit of the water-soluble polyhydric alcohol is preferably 4% by volume or more, more preferably 5% by volume or more, still more preferably 6% by volume or more, still more preferably 7% by volume or more, still more preferably 8% by volume or more, 9% by volume or more is more preferable, and 10% by volume or more is more preferable. If the content of the water-soluble polyhydric alcohol exceeds 30% by volume, the lubricity of the glove increases more than necessary, which may cause inconveniences such as requiring attention to fingers. The upper limit of the water-soluble polyhydric alcohol is preferably 25% by volume or less, and more preferably 20% by volume or less.

  The tackiness-reducing composition of the present invention may be composed of only a disinfecting alcohol and a water-soluble polyhydric alcohol, or may further contain water and / or other additional components. Examples of the additional component include various components that can be added to the disinfecting alcohol or the disinfecting composition. For example, various components described in Patent Document 3 mentioned above, specifically, a disinfectant. (For example, benzalkonium salts such as benzalkonium chloride, benzalkonium alkyl phosphate, benzethonium chloride, triclosan, isopropylmethylphenol, cetylpyridinium chloride, resorcin, trichlorocarbanide, chlorhexidine chloride, chlorhexidine gluconate, hydrogen peroxide , Popidone iodine, iodine tincture), oils and fats, polysaccharides, surfactants, anti-inflammatory agents, refreshing agents, blood circulation promoters, wound healing agents, viscosity modifiers, pH regulators (organic or inorganic acids, organic or inorganic alkalis) ), Chelating agents, antioxidants, preservatives, powders, fragrances, pigments, etc. It can be added in amounts not detrimental to the light effect.

  The tackiness-reducing composition of the present invention preferably consists essentially of a disinfecting alcohol and a water-soluble polyhydric alcohol, or consists essentially of only a disinfecting alcohol, a water-soluble polyhydric alcohol, and water. . In this specification, “consisting essentially of only” means that the component is contained in 98% or more (preferably 99% or more) with respect to the total volume of the tackiness reducing composition.

  EXAMPLES Hereinafter, the present invention will be specifically described by way of examples, but these do not limit the scope of the present invention.

<< Example 1: Preparation of tackiness reducing solution >>
Each solution shown in Table 1 was prepared as an adhesive reduction solution. Ethanol or isopropanol was used as the disinfecting alcohol, and glycerin, polyethylene glycol, and ethylene glycol were used as the water-soluble polyhydric alcohol. In addition, the composition ratio shown in Table 1 is capacity%. Further, as a comparative example, urea exemplified in Patent Document 4 as a moisturizing component was used.

<< Example 2: Evaluation of adhesiveness reduction effect (sensory test) >>
In the following experiments, three types of gloves made of natural rubber (latex), nitrile rubber, and polyvinyl chloride, which are most widely used in the medical field, were used as medical gloves.
1. Made of natural rubber: Ansel Examination Glove (Powder Free)
JM Corporation 2. Made of nitrile rubber: SensiCare Ice (registered trademark) Powder-Free Nitrile Exam Gloves
Medline Industries, Inc.
3. Made of polyvinyl chloride: TORAY, VG2.5 NP Vinyl Gloves
Toray Medical Co., Ltd.

In the medical field, various adhesive tapes are used. However, since these are mainly tapes coated with rubber adhesive and acrylic adhesive, experiments were conducted using the following two tapes.
1. Rubber adhesive: Nichiban cloth tape cloth adhesive tape NO.102N 50mm × 25M
2. Acrylic adhesive: 3M ^TM Micropore ^TM Surgical Tape

After wearing the gloves, 0.1 to 0.2 mL of each solution shown in Table 1 prepared in Example 1 was dropped onto the fingers, and the fingers were scraped and applied to the entire fingers.
A state in which the solution was not applied was used as a control, and a commercially available gel-like quick-drying rubbing hand sterilizer / disinfectant “GoJo (registered trademark) MHS” (GoJo Japan Co., Ltd.) was used as a comparative example. GoJo (registered trademark) MHS contains 78.89 mL of ethanol as an active ingredient in 100 mL, and propylene glycol and isopropyl myristate as additives.

Gloves were worn and the solution was applied, and then an adhesive tape (5 cm wide x 7 cm long) was affixed to the fingers. The ease of peeling of the tape was divided into the following three stages and scored.
Level 1: Tackiness is markedly reduced and peels easily (1 point).
Level 2: Although the adhesiveness was lowered, it took a little time to peel (two points).
Level 3: Decrease in tackiness is poor and effort is required for the peeling operation (3 points).
Table 2 shows the evaluation results (n = 3) using the rubber adhesive tape, and Table 3 shows the evaluation results (n = 3) using the acrylic adhesive tape. The meaning of each symbol in the table is as follows:
Eta: ethanol iso: isopropanol Gly: glycerin PG: polyethylene glycol EG: ethylene glycol

As a result of the sensory test, the tackiness was reduced even when the average value was 2, but it took a little time to peel off, so it was determined that an average value of 1.8 or less had an effect of reducing the tackiness. For those judged to be ineffective, they were shaded in the table.
In the medical field, a wide variety of hand sterilization disinfectants have been used so far, but no glove adhesive reduction effect was obtained as in the comparative example. In this experiment, it was confirmed that a mere hand disinfectant could not provide an adhesive reduction effect.

<< Example 3: Evaluation of adhesiveness reduction effect (traction force measurement) >>
After wearing the gloves, 0.1 to 0.2 mL of each solution shown in Table 1 prepared in Example 1 was dropped onto the fingers, and the fingers were scraped and applied to the entire fingers. Controls and comparative examples were the same as in Example 2, and the same medical gloves and adhesive tape as in Example 2 were used.
After applying the solution, stick one end of the adhesive tape (5 cm wide x 15 cm long) to your finger, and the other end to the suspension-indicating spring-type cylindrical hand balance (Sanko Seisakusho Co., Ltd., hand balance 1 kg, 10 kg) Affixed. The force required for the tape to peel from the fingers (the traction force required for the tape to peel off was evaluated as the weight measured on the scale) was measured.

  The evaluation results (n = 3) using the rubber adhesive tape are shown in Table 4, and the evaluation results (n = 3) using the acrylic adhesive tape are shown in Table 5, respectively. Those having an average value of 300 g or less were determined to have an effect of reducing tackiness. For those judged to be ineffective, they were shaded in the table.

When the adhesive reduction solution was not used (control) and when no additive was added to the alcohol, the tape was so strong that the gloves were broken during towing, making it impossible to measure. When the pulling force was 1 kg or more, the error increased. . In consideration of this, data indicating 1 kg or more is uniformly written as “> 1 kg”.
Judgment of the adhesiveness reduction effect based on the traction force is slightly different from the sensory test, but actually, the result of the sensory test is closer to the actual feeling of use.

<< Example 4: Evaluation of the influence of the tackiness reducing solution on work (lubricity) >>
By applying the tackiness reducing solution to the glove, the lubricity of the glove is increased, and there is a possibility that the end operation of the treatment instrument or the like may be hindered. Therefore, the effect of the lubricity imparted when using the tackiness reducing solution on the work using gloves was examined.
Gloves were put on and after application of the solution, various small instruments were gripped or manipulated and scored in the following three stages by sensory test.
Level 1: Lubricity is negligible (1 point).
Level 2: Mild lubricity is recognized, but there is no effect on the work of fingers (2 points).
Level 3: Because of increased lubricity, attention must be paid to the work of fingers (3 points).

Table 6 shows the evaluation results (n = 3) using the rubber adhesive tape, and Table 7 shows the evaluation results (n = 3) using the acrylic adhesive tape.
As a result of the sensory test, if the average value was 2.5 or less, the work was not hindered. However, from the viewpoint of placing more emphasis on safety, work with gloves having an average value of 2.0 or less It was determined that it would not affect The average value exceeding 2.0 was shaded in the table.

<< Example 5: Examination of a solution exhibiting an adhesive reduction effect >>
Table 8 shows solutions determined to have an effect of reducing tackiness according to the materials of the gloves of Example 2 and Example 3 (no shading in Tables 2 and 3). Further, in Table 4, the determination was made that the tackiness-reducing solution had an influence on the work, and the shading was performed in Table 8.
From Table 8, it became clear that additives such as glycerin, polyethylene glycol, and ethylene glycol and their concentrations affect the reduction in tackiness, not the concentration of alcohol in the solution.

<< Example 6: Examination of compounding ratio of additives showing effect of reducing tackiness >>
Since it became clear from Example 5 that additives, such as glycerin, polyethyleneglycol, and ethyleneglycol, affect adhesiveness reduction, the optimal density | concentration of the additive was examined. Of the traction force experiment of Example 3, FIG. 1 shows the traction force when the glycerin concentration is changed at 80% ethanol using a rubber-based and acrylic adhesive tape.
As in Example 3, when a traction force of 300 g or less was used as the determination value for the adhesiveness reduction effect, the glycerin concentration required for the adhesiveness reduction effect was 4 for each rubber adhesive and acrylic adhesive. It became volume% or more and 3 volume% or more, and it was confirmed that a required amount changes with kinds of adhesive. In the present invention, it is particularly preferable to include an additive in an amount showing an adhesive reduction effect for any combination of materials (adhesive and gloves), but there is also a usage situation with only one type of material in mind. An aspect that includes an additive in an amount that is sufficiently assumed and exhibits an effect of reducing the adhesiveness to one kind of material is also included in the present invention.
In addition, the determination value used for determination of the adhesiveness reduction effect is not limited to the determination value used in each of the above-described embodiments, and can be appropriately changed according to the assumed use situation.

<< Example 7: Examination of clinical adhesiveness reduction effect >>
For 5 surgeons, a glove-reducing solution (10-15%) is applied to a glove when the wound is treated with an acrylic adhesive tape (3M ^TM Micropore ^TM Surgical Tape). In the case where 0.1 to 0.2 mL of glycerin and a solution containing 70 to 80% ethanol (sterilized water if necessary) were applied and not applied, the degree of adhesion of the tape to the gloves was evaluated.
All five patients who were examined in the clinic found that when the solution was applied, the tape did not stick to the gloves, and the operation of applying the tape to the patient was extremely easy.

  The present invention can be applied to medical gloves.

Claims (4)

The following ingredients:
(A) Disinfecting alcohol 60-90% by volume
(B) Water-soluble polyhydric alcohol 3-30% by volume
A composition for reducing adhesiveness for gloves, wherein the adhesive reduction for the glove adheres to the glove when the adhesive product is handled while wearing the glove. Said composition, which is to prevent.   The composition according to claim 1, wherein the water-soluble polyhydric alcohol is one or two or more selected from the group consisting of glycerin, polyethylene glycol, and ethylene glycol. The following ingredients:
(A) Disinfecting alcohol 60-90% by volume
(B) Water-soluble polyhydric alcohol 3-30% by volume
A method for reducing adhesiveness for gloves comprising applying a composition containing the adhesive to a glove, wherein the adhesiveness reduction for gloves is used when handling an adhesive product while wearing gloves And the method of preventing the adhesive product from adhering to the glove.   The method according to claim 3, wherein the water-soluble polyhydric alcohol is one or more selected from the group consisting of glycerin, polyethylene glycol, and ethylene glycol.

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