WO2023120447A1 - Sterilization composition and sterilization method - Google Patents

Sterilization composition and sterilization method Download PDF

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Publication number
WO2023120447A1
WO2023120447A1 PCT/JP2022/046565 JP2022046565W WO2023120447A1 WO 2023120447 A1 WO2023120447 A1 WO 2023120447A1 JP 2022046565 W JP2022046565 W JP 2022046565W WO 2023120447 A1 WO2023120447 A1 WO 2023120447A1
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Prior art keywords
disinfecting composition
present disclosure
mass
skin
copolymer
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PCT/JP2022/046565
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French (fr)
Japanese (ja)
Inventor
梓 鷲見
圭 佐藤
真佐夫 原
俊輔 櫻井
Original Assignee
日油株式会社
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Publication of WO2023120447A1 publication Critical patent/WO2023120447A1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • TECHNICAL FIELD The present disclosure relates to a disinfecting composition, in particular a disinfecting composition before using an electronic device, more particularly a disinfecting composition for smooth use of electronic devices (particularly keyboards) immediately after application to the skin. about things.
  • This application claims priority from Japanese Application No. 2021-210026, which is incorporated herein by reference.
  • Disinfectant compositions have the advantage of being able to sterilize and disinfect hands simply by applying them, and are widely used.
  • the disinfecting composition contains a high content of a monohydric alcohol with 1 to 5 carbon atoms such as ethanol for the purpose of maintaining sterilizing power and improving the feeling of use such as quick drying and non-stickiness. Ingenuity has been made such as adjusting the type of thickening agent and adjusting the pH of the composition to a specific range.
  • a carboxyvinyl polymer is neutralized with an alkali metal hydroxide, and a polyethylene glycol having a specific molecular weight has been proposed to prevent the composition from becoming cloudy.
  • the disinfecting composition does not have a neutral pH and contains a relatively large amount of monohydric alcohol having 1 to 5 carbon atoms. If it is used frequently, it may cause rough hands.
  • an object of the present invention is to provide a disinfecting composition that can be used smoothly.
  • a disinfecting composition containing a copolymer (P) having a specific structure, a monohydric alcohol having 1 to 5 carbon atoms, and a fatty acid triglyceride
  • P copolymer having a specific structure
  • monohydric alcohol having 1 to 5 carbon atoms a monohydric alcohol having 1 to 5 carbon atoms
  • a fatty acid triglyceride The product should provide the user with a non-sticky and moist feeling on the skin after application, and should also provide a smooth feeling when using electronic devices (especially keyboards) immediately after application.
  • the present inventors have confirmed that the present invention can be provided, have found that the above problems can be solved, and have completed the present disclosure.
  • a disinfecting composition comprising: (In formula (1), R 1 represents a hydrogen atom or a methyl group.)
  • R 2 represents a hydrogen atom or a methyl group
  • R 3 represents an alkyl group having 4 to 22 carbon atoms.) 2.
  • the disinfecting composition according to item 1 wherein the monohydric alcohol having 1 to 5 carbon atoms is one or more selected from the group consisting of ethanol and isopropanol. 3. 3. The disinfecting composition according to any one of the preceding items 1 and 2, wherein the fatty acid triglyceride is one or more selected from the group consisting of glyceryl triisooctanoate and glyceryl tricaprylate. 4. 4. The disinfecting composition according to any one of the preceding items 1 to 3, further comprising an organic acid. 5. The disinfecting composition according to the preceding item 1, wherein the monohydric alcohol having 1 to 5 carbon atoms is ethanol, and the fatty acid triglyceride is glyceryl tricaprylate. 6.
  • a disinfection method comprising: comprising the step of contacting the disinfecting composition with the subject of use;
  • the disinfecting composition comprises 1) A structural unit (1) based on 2-(meth)acryloyloxyethylphosphorylcholine having a weight average molecular weight of 1,000 to 1,000,000 and represented by the following formula (1), and the following formula (2) Containing a structural unit (2) based on the alkyl group-containing (meth)acrylic monomer represented, the content ratio of the structural unit (1) to the structural unit (2) is 15:85 in terms of molar ratio 0.001% by mass to 10% by mass of a copolymer (P) that is ⁇ 45:55; 2) 55% to 90% by mass of monohydric alcohol having 1 to 5 carbon atoms, and 3) 0.001% to 1% by mass of
  • R 1 represents a hydrogen atom or a methyl group.
  • R 2 represents a hydrogen atom or a methyl group, and R 3 represents an alkyl group having 4 to 22 carbon atoms.
  • 8. 8 The disinfection method according to item 7, wherein the monohydric alcohol having 1 to 5 carbon atoms is one or more selected from the group consisting of ethanol and isopropanol. 9. 9. The disinfection method according to any one of the preceding items 7 to 8, wherein the fatty acid triglyceride is one or more selected from the group consisting of glyceryl triisooctanoate and glyceryl tricaprylate. 10. 10. 10.
  • the disinfection method according to any one of the preceding items 7 to 9, further containing an organic acid. 11.
  • a disinfecting composition that provides a user with a non-sticky and moist skin feeling after application, and can provide smooth use of electronic devices (especially keyboards) immediately after application. can provide things. Specifically, users who use the disinfectant composition of the present disclosure on their fingers or the like feel a non-sticky and moist feeling on the skin, and use electronic devices (especially keyboards) immediately after application. In some cases, the electronic device can be used smoothly.
  • Disinfectant compositions of the present disclosure include: 1) A structural unit (1) having a weight average molecular weight of 1,000 to 1,000,000 and based on 2-(meth)acryloyloxyethylphosphorylcholine represented by formula (1) and represented by formula (2) containing a structural unit (2) based on an alkyl group-containing (meth)acrylic monomer, wherein the ratio of the content of the structural unit (1) to the structural unit (2) is 15:85 to 45 in terms of molar ratio : 55 copolymer (P) 0.001% by mass to 10% by mass 2) 55% to 90% by mass of monohydric alcohol having 1 to 5 carbon atoms 3) Fatty acid triglyceride 0.001% by mass to 1% by mass
  • “(meth)acryl” means acrylic or methacrylic (methacryl)
  • (meth)acryloyl” means acryloyl or methacryloyl (methacryloyl).
  • each lower limit and upper limit can be independently combined.
  • preferably 10 to 100, more preferably 20 to 90 “preferable lower limit: 10” and “more preferred upper limit: 90” can be combined to “10 to 90”.
  • the copolymer (P) contained in the disinfecting composition of the present disclosure includes a structural unit based on 2-(meth)acryloyloxyethylphosphorylcholine and a structural unit based on an alkyl group-containing (meth)acrylic monomer. It is a copolymer containing
  • a structural unit based on 2-(meth)acryloyloxyethylphosphorylcholine is represented by the following formula (1).
  • R 1 represents a hydrogen atom or a methyl group.
  • 2-Methacryloyloxyethylphosphorylcholine (MPC) in which R 1 in the above formula (1) is a methyl group is preferred.
  • a structural unit based on an alkyl group-containing (meth)acrylic monomer is represented by the following formula (2).
  • R 2 represents a hydrogen atom or a methyl group
  • R 3 represents an alkyl group having 4 to 22 carbon atoms.
  • the alkyl group represented by R 3 is a linear or branched alkyl group having 4 to 22 carbon atoms, such as butyl, pentyl, hexyl, octyl, 2-ethylhexyl, decyl, dodecyl, tetradecyl, hexadecyl. , octadecyl, docosyl, lauryl, tridecyl, stearyl and the like.
  • structural units based on alkyl group-containing (meth)acrylic monomers represented by formula (2) include butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, and lauryl (meth)acrylate. , tridecyl (meth)acrylate, stearyl (meth)acrylate, docosyl (meth)acrylate, and the like, and particularly preferred is butyl (meth)acrylate.
  • the ratio of the content of structural units based on 2-(meth)acryloyloxyethylphosphorylcholine and structural units based on alkyl group-containing (meth)acrylic monomers has a molar ratio of 15:85 to 45:55, preferably 20:80 to 40. :60, more preferably 25:75 to 35:65.
  • a structural unit means the unit of the compound contained in the polymer based on each monomer or derived from each monomer.
  • the copolymer (P) is a structural unit based on 2-(meth)acryloyloxyethylphosphorylcholine and an alkyl group-containing (meth)acrylic monomer within a range that does not affect the effects of the disinfecting composition of the present disclosure.
  • Structural units other than the structural units based on can be contained.
  • Styrenic monomers include styrene, methylstyrene, and chloromethylstyrene.
  • Vinyl ether monomers include methyl vinyl ether and butyl vinyl ether.
  • Vinyl ester monomers include vinyl acetate and vinyl propionate.
  • Hydrophilic hydroxyl group-containing (meth)acrylates include polyethylene glycol (meth)acrylate, polypropylene glycol (meth)acrylate, N-vinylpyrrolidone, 2-hydroxyethyl (meth)acrylate, 2-hydroxybutyl (meth)acrylate, 4 - hydroxybutyl (meth)acrylate.
  • Acid group-containing monomers include (meth)acrylic acid, styrenesulfonic acid, and (meth)acryloyloxyphosphonic acid.
  • Nitrogen-containing group-containing monomers include aminoethyl (meth)acrylate.
  • Amino group-containing monomers include aminoethyl methacrylate, dimethylaminoethyl (meth)acrylate, and N,N-dimethylaminopropyl (meth)acrylamide.
  • Cationic group-containing monomers include 2-hydroxy-3-(meth)acryloyloxypropyltrimethylammonium chloride.
  • the copolymer (P) contained in the disinfecting composition of the present disclosure has a weight average molecular weight of 1,000 to 1,000,000, preferably 5,000 to 500,000, more preferably , from 10,000 to 150,000. If the weight-average molecular weight of the copolymer (P) is less than 1,000, the film properties may deteriorate, and the effect of improving smoothness during use may not be expected. Larger sizes may impair the ease of use of the disinfecting composition. In addition, the weight average molecular weight of the copolymer (P) is measured by gel permeation chromatography (GPC) and is indicated by the molecular weight in terms of pullulan.
  • GPC gel permeation chromatography
  • the polymerization form of the copolymer (P) is not particularly limited, and may be a random copolymer or a block copolymer, but a random copolymer is preferred.
  • Copolymer (P) can be produced by a known production method.
  • a monomer mixture containing MPC and an alkyl group-containing (meth)acrylic monomer is polymerized by a known method such as solution polymerization in the presence of a radical polymerization initiator in an inert gas atmosphere such as nitrogen.
  • the content ratio of each monomer may be a ratio corresponding to the content ratio of each structural unit in the copolymer (P).
  • the copolymer (P) can be used after being produced by the polymerization method described above, but it is also possible to use products commercially available as solutions or dispersions of water or polyhydric alcohols.
  • the disinfecting composition of the present disclosure may contain one of the copolymers (P) described above, or may contain two or more of them in combination.
  • the form of the copolymer (P) contained in the disinfecting composition of the present disclosure may be solid such as powder or liquid such as solution or dispersion.
  • the content of the copolymer (P) in the disinfecting composition of the present disclosure can be appropriately selected in the range of 0.001% by mass to 10% by mass (or 0.001% by mass to 9% by mass), From the viewpoint of smoothness of use, it is preferable to select in the range of 0.005% by mass to 5% by mass. If the content of the copolymer (P) in the disinfecting composition of the present disclosure is less than 0.001% by mass, smoothness of use may not be sufficient in the disinfecting composition, and the copolymer (P ) content of more than 10% by mass may conversely impair the smoothness of use.
  • the monohydric alcohol having 1 to 5 carbon atoms contained in the disinfecting composition of the present disclosure is usually an alcohol having 5 or less carbon atoms, and can dissolve the copolymer (P) and fatty acid triglycerides. As long as it can be used on the skin, it can be used without any particular limitation. Furthermore, monohydric alcohols having 3 or less carbon atoms are preferred, and monohydric alcohols having 2 or 3 carbon atoms are more preferred. Monohydric alcohols having 1 to 5 carbon atoms preferably used in the present disclosure include ethanol, 1-propanol, isopropanol and the like, with ethanol and isopropanol being more preferably used. In the present disclosure, monohydric alcohols having 1 to 5 carbon atoms may be used singly or in combination of two or more.
  • the antiseptic composition of the present disclosure contains a monohydric alcohol having 1 to 5 carbon atoms
  • the interfacial tension of the antiseptic composition is reduced, and the composition tends to spread over uneven areas of the skin, resulting in film formation.
  • the uniformity of time is improved, it becomes easier to evenly apply to the skin, and the smoothness of use is improved.
  • the content of the monohydric alcohol having 1 to 5 carbon atoms in the disinfecting composition of the present disclosure is 55% to 90% by mass (or 55% to 89% by mass), preferably 60% to 85% by mass. % by mass, more preferably 65 to 80% by mass. If the content of the monohydric alcohol having 1 to 5 carbon atoms is less than 55% by mass, the bactericidal activity may be poor. On the other hand, even if the monohydric alcohol having 1 to 5 carbon atoms is contained in an amount exceeding 90% by mass, the effect corresponding to the content may not be obtained.
  • Fatty acid triglycerides contained in the disinfecting composition of the present disclosure are preferably liquid at 25° C. and 1013.25 hPa.
  • the fatty acid portion of the fatty acid triglyceride is preferably a linear or branched fatty acid having 6 to 18 carbon atoms, more preferably 6 to 10 carbon atoms.
  • Specific examples include fatty acid triglycerides in which the fatty acid moiety is selected from caproic acid, caprylic acid, capric acid, isooctanoic acid, isopalmitic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid and the like.
  • the fatty acid moiety is preferably caproic acid, caprylic acid, capric acid or isooctanoic acid, more preferably isooctanoic acid.
  • the same fatty acid may be used for all three fatty acid moieties of the fatty acid triglyceride, or a combination of multiple types of fatty acids may be used.
  • Specific examples of such fatty acid triglycerides include glyceryl tricaprylate, glyceryl triisooctanoate, glyceryl dicaprylate monocaprate, etc. Glyceryl triisooctanoate and glyceryl tricaprylate are more preferred.
  • fatty acid triglycerides can be used singly or in combination of two or more.
  • the content of fatty acid triglycerides in the disinfecting composition of the present disclosure is generally 0.001% to 1% by mass, preferably 0.01% to 1% by mass. If the content of fatty acid triglyceride is less than 0.001% by mass, the moist feeling after drying may be poor, and if it exceeds 1% by mass, stickiness and sliminess may increase when rubbed into fingers.
  • the disinfecting composition of the present disclosure may contain a disinfectant as necessary from the viewpoint of disinfecting effect.
  • the disinfectant is an agent that can kill or inhibit the growth of pathogenic microorganisms and can be used for disinfecting the skin, and the copolymer (P) and Any substance that does not inhibit the effect of fatty acid triglyceride can be used without particular limitation.
  • cationic surfactants such as benzalkonium chloride, benzethonium chloride and cetylpyridinium chloride
  • amphoteric surfactants such as alkyldiaminoethylglycine hydrochloride
  • biguanide compounds such as chlorhexidine gluconate and chlorhexidine hydrochloride
  • halogen (iodine) compounds such as , povidone-iodine
  • silver-based inorganic compounds such as silver ions
  • phenol-based compounds such as cresol and isopropylmethylphenol.
  • Benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, and the like are preferably used from the viewpoint of bactericidal activity and mild skin irritation.
  • one type of disinfectant may be used alone, or two or more types may be selected and used in combination.
  • the content of the disinfectant in the disinfectant composition of the present disclosure can be appropriately set depending on the type of disinfectant and the like, but is preferably 0.01% by mass to 5% by mass, more preferably 0.01% by mass to It is 0.05% by mass.
  • the disinfecting composition of the present disclosure may contain an organic acid, if necessary, from the viewpoint of improving the feeling of use.
  • the organic acid is not particularly limited as long as it is an agent that improves moistness and does not inhibit the effects of the copolymer (P) and fatty acid triglyceride. and citric acid, malic acid, lactic acid, and the like. Lactic acid or the like is preferably used from the viewpoint of moist feeling and low irritation to the skin.
  • one type of organic acid may be used alone, or two or more types may be selected and used in combination.
  • the content of the organic acid in the disinfecting composition of the present disclosure can be appropriately set depending on the type of organic acid, etc., but is usually 0.01% by mass to 10% by mass, preferably 1% by mass to 10% by mass. be.
  • the disinfecting compositions of the present disclosure typically contain water as a base.
  • the adhesion of the copolymer (P) and fatty acid triglycerides to the skin is improved.
  • the reason for the improvement in adhesion is that when the composition dries, the evaporation rate of monohydric alcohols with 1 to 5 carbon atoms differs from that of water. This is because it can be oriented effectively.
  • the water contained in the disinfecting composition of the present disclosure water generally used for cosmetics or pharmaceuticals can be used, and it is preferable to use ion-exchanged water, purified water, water for injection, and the like.
  • the water content of the disinfecting composition of the present disclosure is 10% to 35% by weight, preferably 15% to 30% by weight. If the water content is less than 3% by mass or more than 45% by mass, the sterilizing power may be inferior, which is not preferable.
  • the disinfecting composition of the present disclosure can contain a humectant to the extent that the effect of the composition is not impaired.
  • Wetting agents include, for example, ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, pentylene glycol, hexylene glycol, isoprene glycol, 2-ethyl-1,3- Dihydric alcohols such as hexanediol and isopentyldiol; glycerin; glycerin condensates such as diglycerin and polyglycerin; sugar alcohols such as sorbitol, xylitol, maltitol, mannitol and erythritol;
  • the species can be used singly or as mixtures of two or more species.
  • propylene glycol, dipropylene glycol, 1,3-butylene glycol and glycerin are more preferably used because of their good compatibility with the skin.
  • the content of the humectant in the disinfecting composition of the present disclosure is selected within a range that does not impair the effects of the composition, and is preferably 0.01% by mass to 10% by mass.
  • the disinfecting composition of the present disclosure may further contain additives commonly used in external preparations such as known disinfecting compositions, as long as they do not impair the effects of the composition.
  • additives include nonionic surfactants, thickeners, foaming agents, propellants, organic acids, antioxidants, stabilizers, preservatives, sequestering agents, fragrances, pigments, colorants, and the like. is mentioned. One or two or more of these additives may be selected and contained depending on the purpose.
  • the disinfecting composition of the present disclosure can be manufactured according to conventional methods. For example, to the above-mentioned copolymer (P), monohydric alcohol having 1 to 5 carbon atoms, fatty acid triglyceride, etc., if necessary, bactericide, water, wetting agent and other general additives are added and mixed appropriately. It can be manufactured by making it uniform.
  • the disinfecting composition of the present disclosure can be used, for example, as pharmaceuticals, quasi-drugs, or components thereof.
  • the disinfecting composition of the present disclosure can be provided in the form of liquid, semi-solid such as paste, and the like. From the viewpoint of ease of use, safety, etc., the disinfecting composition of the present disclosure is preferably in a liquid form.
  • the disinfecting compositions of the present disclosure can be contained in pump or spray containers. Specifically, liquid discharge type filled in a container with a dispenser pump, spray type filled in a container with a spray pump, foam discharge type filled in a container with a foamer pump or an aerosol container, impregnation type with a cleaning wipe impregnated, etc. A product is preferred.
  • the disinfecting composition of the present disclosure when it is used for disinfecting fingers, take an appropriate amount (about 1 mL to 3 mL) of the disinfecting composition of the present disclosure, apply it while rubbing it on the hand, and then dry it. can be used
  • impregnating a cleaning wipe with the disinfecting composition of the present disclosure impregnate about 10 parts by mass to 400 parts by mass of the disinfecting composition of the present disclosure with respect to 100 parts by mass of the cleaning wipe. , can be used to clean the skin and medical instruments.
  • the disinfecting composition of the present disclosure provides a non-sticky and moist skin feeling after application, and further provides a smooth feeling when using electronic devices immediately after application. can be done.
  • users who use the disinfecting composition of the present disclosure on their hands and fingers have a good feeling of non-sticky and moist feeling of use, as well as rough hands due to the fatty acid triglycerides contained in the composition. etc., and furthermore, when using electronic devices (for example, keyboards, tablet terminals, smartphones, medical devices) immediately after application, the electronic devices can be used smoothly.
  • One embodiment of the present disclosure is directed to a disinfecting method comprising contacting a subject of use (eg, a mammal, including a human) with a disinfecting composition of the present disclosure as described above.
  • a subject of use eg, a mammal, including a human
  • the target of use includes not only users who disinfect their hands and fingers, but also media (eg, cleaning wipes, etc.) for providing the disinfecting composition of the present disclosure to the users.
  • Contacting can be exemplified by application, spraying, immersion, etc., but is not particularly limited.
  • One embodiment of the present disclosure is also directed to the use of the above-described copolymer (P), C1-C5 monohydric alcohol and fatty acid triglyceride as the manufacture of a disinfecting composition of the present disclosure.
  • the disinfecting composition of the present disclosure will be specifically described below with reference to Examples and Comparative Examples, but the present disclosure is not limited to these.
  • Various evaluations and tests of the disinfecting composition of the present disclosure were conducted as follows.
  • Glyceryl triisooctanoate "Panathate 800B" manufactured by NOF Corporation
  • Glycerin tricaprylate "Panathate 810S” manufactured by NOF Corporation As glycerin: Concentrated g
  • GPC measurement GPC measurement of the above MPC copolymer was carried out under the following conditions.
  • GPC system EcoSEC system (manufactured by Tosoh Corporation)
  • Developing solvent 20 mM sodium phosphate buffer (pH 7.4)
  • Detector Differential refractive index detector
  • Molecular weight standard EasiVial PEG/PEO (manufactured by Agilent Technologies)
  • Flow rate 0.5 mL/min
  • Injection volume 100 ⁇ L
  • the stickiness of the skin after application For each of the disinfecting compositions of the above examples and comparative examples, the stickiness of the skin after application, the moistness of the skin after application, and the smoothness of use when using the keyboard immediately after application to the skin are as follows. evaluated.
  • Table 1 also shows the evaluation results for the stickiness of the skin after application, the moistness of the skin after application, and the smoothness of use.
  • the skin after application was evaluated to have little or no sticky feeling, and to have a moist or sufficient feeling. and was rated moderately good or excellent in smoothness of use.
  • the antiseptic compositions of Examples 2, 3, 4, 6, 7, 8, 9 and 10 containing 0.5% by mass or more of fatty acid triglyceride were evaluated as sufficiently moist to the skin after application.
  • the disinfecting compositions of Examples 4, 8 and 9 containing lactic acid were rated as having excellent moisturizing properties. Since the disinfecting compositions of Comparative Examples 1 and 2 did not contain fatty acid triglycerides, they were evaluated as lacking smoothness of use.
  • the disinfecting composition of Comparative Example 3 does not contain an MPC copolymer, it was evaluated as lacking smoothness of use. Since the disinfecting composition of Comparative Example 4 contained glycerin instead of fatty acid triglycerides, it was evaluated as giving a sticky feeling to the skin after application and lacking smoothness in use.
  • the disinfecting composition of Comparative Example 5 does not form a clear and colorless liquid because the content ratio of the structural unit (1) and the structural unit (2) in the MPC copolymer is not appropriate, and is not suitable for evaluation. It was confirmed. Since the disinfecting composition of Comparative Example 6 contained a large amount of glyceryl triisooctanoate, the skin felt sticky after application, and was evaluated as lacking smoothness in use.
  • the disinfecting composition of the present disclosure has no sticky and moist skin after application compared to the disinfecting composition of the Comparative Example. It can provide a feeling and furthermore, it can provide smooth use of the electronic device.

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Abstract

[Problem] To provide a sterilization composition with which it is possible to provide a moist usage feel without stickiness of the skin after application, and with which it is furthermore possible, when using a keyboard or another electronic device immediately after application to the skin of the fingers or the like, to provide smooth use of the electronic device. [Solution] A sterilization composition according to the present disclosure was realized upon verifying that a sterilization composition containing a copolymer (P) having a specific structure, a C1-5 monohydric alcohol, and a fatty acid triglyceride provides a user with a moist usage feel without stickiness of the skin after application, and furthermore provides the user with a smooth usage feel during use of an electronic device (particularly a keyboard) immediately after application.

Description

消毒用組成物及び消毒方法Disinfectant composition and disinfection method
　本開示は、消毒用組成物に関し、詳しくは、電子機器使用前の消毒用組成物、より詳しくは、皮膚に塗布した直後に電子機器（特に、キーボード）を円滑に用い得るための消毒用組成物に関する。
　本出願は、参照によりここに援用されるところの日本出願2021-210026号優先権を請求する。 TECHNICAL FIELD The present disclosure relates to a disinfecting composition, in particular a disinfecting composition before using an electronic device, more particularly a disinfecting composition for smooth use of electronic devices (particularly keyboards) immediately after application to the skin. about things.
This application claims priority from Japanese Application No. 2021-210026, which is incorporated herein by reference.
　近年、病原性ウイルスや細菌類による感染症の拡大が懸念されており、各種感染防止関連製品の開発が行われている。消毒用組成物は、手指に塗布するだけで殺菌消毒できる利点を有し、広く普及されている。
　消毒用組成物は、殺菌力を維持するとともに、速乾性やべたつきのなさといった使用感の改良を目的として、エタノール等の炭素数1～5の1価アルコールを高含有量で含有し、さらに、増粘剤の種類や、組成物のｐＨを特定領域に調整するといった工夫がなされている。たとえば、カルボキシビニルポリマーをアルカリ金属水酸化物で中和し、特定の分子量を有するポリエチレングリコールにより、組成物の白濁を防止したゲル状の手指殺菌剤が提案されている（特許文献１）。
　しかし、該消毒用組成物は、中性領域のｐＨではなく、炭素数1～5の1価アルコールを比較的多量に含有したりするために、医療関係者のように、消毒用組成物を使用する頻度が高い場合には、手荒れを生じるおそれがあった。 In recent years, there has been concern about the spread of infectious diseases caused by pathogenic viruses and bacteria, and various infection prevention-related products have been developed. Disinfectant compositions have the advantage of being able to sterilize and disinfect hands simply by applying them, and are widely used.
The disinfecting composition contains a high content of a monohydric alcohol with 1 to 5 carbon atoms such as ethanol for the purpose of maintaining sterilizing power and improving the feeling of use such as quick drying and non-stickiness. Ingenuity has been made such as adjusting the type of thickening agent and adjusting the pH of the composition to a specific range. For example, a carboxyvinyl polymer is neutralized with an alkali metal hydroxide, and a polyethylene glycol having a specific molecular weight has been proposed to prevent the composition from becoming cloudy.
However, the disinfecting composition does not have a neutral pH and contains a relatively large amount of monohydric alcohol having 1 to 5 carbon atoms. If it is used frequently, it may cause rough hands.
　手荒れ防止効果を消毒用組成物に付与するために、グリセリン、プロピレングリコール、ソルビトール等の保湿剤を配合する（特許文献２）、水溶性多価アルコールと脂肪酸トリグリセリドを配合する（特許文献３）、ＭＰＣ共重合体と無水マレイン酸含有重合体を配合する（特許文献４）など、さらなる工夫が知られている。
　上記特許文献にて提案された工夫により、べたつきがなくかつしっとりとした使用感を付与できる消毒用組成物の提供が可能となった。 In order to impart an anti-roughness effect to the disinfecting composition, moisturizing agents such as glycerin, propylene glycol, and sorbitol are blended (Patent Document 2), water-soluble polyhydric alcohols and fatty acid triglycerides are blended (Patent Document 3), Further devices such as blending an MPC copolymer and a maleic anhydride-containing polymer (Patent Document 4) are known.
The ideas proposed in the above-mentioned patent documents have made it possible to provide a disinfecting composition that is non-sticky and can impart a moist feeling when used.
特開２０１１－１４４１４６号公報JP 2011-144146 A 特開２００４－１５５７１２号公報JP 2004-155712 A 特開２０１１－２１９４１０号公報JP 2011-219410 A 特開２００８－１１５１２５号公報JP 2008-115125 A
　しっとりとした使用感を使用者に付与できる消毒用組成物を用いると、その使用直後に、電子カルテシステムなどの電子機器（キーボード）を使用する場合には、キーボードがべたつき、使用し難くなるといった問題があった。医療機関に勤務する医師や看護師等から、皮膚に塗布した直後にも、キーボードを円滑に使用できる消毒用組成物が強く要望されている。
　そこで、本開示は、塗布後の皮膚のべたつきがなくかつしっとりとした使用感を提供し、さらに、手指等の皮膚に塗布した直後に、電子機器等のキーボードを使用する際において、電子機器の使用を円滑に行うことを提供できる消毒用組成物の提供を課題とする。 When using a disinfecting composition that can impart a moist feeling to the user, the keyboard becomes sticky and difficult to use when using an electronic device (keyboard) such as an electronic medical record system immediately after use. I had a problem. There is a strong demand from doctors, nurses, etc. working in medical institutions for a disinfecting composition that allows smooth use of keyboards immediately after being applied to the skin.
Therefore, the present disclosure provides a moist feeling of use without stickiness on the skin after application, and further, when using a keyboard such as an electronic device immediately after applying to the skin such as fingers, An object of the present invention is to provide a disinfecting composition that can be used smoothly.
　本発明者らは、上記課題を解決するために鋭意検討を進めた結果、特定の構造を有する共重合体（Ｐ）、炭素数1～5の1価アルコールおよび脂肪酸トリグリセリドを含有する消毒用組成物は、使用者に、塗布後の皮膚のべたつきがなくかつしっとりとした使用感を提供し、さらに、塗布直後に電子機器（特に、キーボード）を使用する際の使用感も円滑に行うことを提供できることを確認して、上記課題を解決し得ることを見出し、本開示を完成するに至った。 As a result of intensive studies to solve the above problems, the present inventors have found that a disinfecting composition containing a copolymer (P) having a specific structure, a monohydric alcohol having 1 to 5 carbon atoms, and a fatty acid triglyceride The product should provide the user with a non-sticky and moist feeling on the skin after application, and should also provide a smooth feeling when using electronic devices (especially keyboards) immediately after application. The present inventors have confirmed that the present invention can be provided, have found that the above problems can be solved, and have completed the present disclosure.
　すなわち、本開示は以下に関する。
　１．１）重量平均分子量１，０００～１，０００，０００であり、下記式（１）で表される２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位（１）と、下記式（２）で表されるアルキル基含有（メタ）アクリル系単量体に基づく構成単位（２）を含み、該構成単位（１）と該構成単位（２）の含有量の比がモル比にて１５：８５～４５：５５である共重合体（Ｐ）　０．００１質量％～１０質量％と、
　２）炭素数1～5の1価アルコール　５５質量％～９０質量％と、及び
　３）脂肪酸トリグリセリド　０．００１質量％～１質量％
　を含む消毒用組成物。
Figure JPOXMLDOC01-appb-C000003
 （式（１）中、Ｒ１は水素原子またはメチル基を示す。）
Figure JPOXMLDOC01-appb-C000004
 （式（２）中、Ｒ２は水素原子またはメチル基を示し、Ｒ３は炭素数４～２２のアルキル基を示す。）
　２．炭素数1～5の1価アルコールが、エタノールおよびイソプロパノールからなる群より選択される１種以上である、前項１に記載の消毒用組成物。
　３．脂肪酸トリグリセリドが、トリイソオクタン酸グリセリンおよびトリカプリル酸グリセリンからなる群より選択される１種以上である、前項１～２のいずれか１項に記載の消毒用組成物。
　４．さらに、有機酸を含有する、前項１～３のいずれか１項に記載の消毒用組成物。
　５．前記炭素数1～5の1価アルコールがエタノールであり、かつ、前記脂肪酸トリグリセリドがトリカプリル酸グリセリンである、前項１に記載の消毒用組成物。
　６．前記炭素数1～5の1価アルコールがエタノールであり、かつ、前記脂肪酸トリグリセリドがトリイソオクタン酸グリセリンである、前項１に記載の消毒用組成物。
　７．消毒方法であって、
　消毒用組成物を使用対象に接触させる工程を含み、
　該消毒用組成物は、
　１）重量平均分子量１，０００～１，０００，０００であり、下記式（１）で表される２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位（１）と、下記式（２）で表されるアルキル基含有（メタ）アクリル系単量体に基づく構成単位（２）を含み、該構成単位（１）と該構成単位（２）の含有量の比がモル比にて１５：８５～４５：５５である共重合体（Ｐ）　０．００１質量％～１０質量％と、
　２）炭素数1～5の1価アルコール　５５質量％～９０質量％と、及び
　３）脂肪酸トリグリセリド　０．００１質量％～１質量％を含む、
消毒方法。
Figure JPOXMLDOC01-appb-C000005
 （式（１）中、Ｒ１は水素原子またはメチル基を示す。）
Figure JPOXMLDOC01-appb-C000006
 （式（２）中、Ｒ２は水素原子またはメチル基を示し、Ｒ３は炭素数４～２２のアルキル基を示す。）
　８．炭素数1～5の1価アルコールが、エタノールおよびイソプロパノールからなる群より選択される１種以上である、前項７に記載の消毒方法。
　９．脂肪酸トリグリセリドが、トリイソオクタン酸グリセリンおよびトリカプリル酸グリセリンからなる群より選択される１種以上である、前項７～８のいずれか１項に記載の消毒方法。
　１０．さらに、有機酸を含有する、前項７～９のいずれか１項に記載の消毒方法。
　１１．以下の１）～３）を消毒用組成物の製造としての使用。
　１）重量平均分子量１，０００～１，０００，０００であり、下記式（１）で表される２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位（１）と、下記式（２）で表されるアルキル基含有（メタ）アクリル系単量体に基づく構成単位（２）を含み、該構成単位（１）と該構成単位（２）の含有量の比がモル比にて１５：８５～４５：５５である共重合体（Ｐ）
　２）炭素数1～5の1価アルコール
　３）脂肪酸トリグリセリド
Figure JPOXMLDOC01-appb-C000007
 （式（１）中、Ｒ１は水素原子またはメチル基を示す。）
Figure JPOXMLDOC01-appb-C000008
 （式（２）中、Ｒ２は水素原子またはメチル基を示し、Ｒ３は炭素数４～２２のアルキル基を示す。）
　１２．炭素数1～5の1価アルコールが、エタノールおよびイソプロパノールからなる群より選択される１種以上である、前項１１に記載の消毒用組成物の製造としての使用。
　１３．脂肪酸トリグリセリドが、トリイソオクタン酸グリセリンおよびトリカプリル酸グリセリンからなる群より選択される１種以上である、前項１１～１２のいずれか１項に記載の消毒用組成物の製造としての使用。
　１４．さらに、有機酸を含有する、前項１１～１３のいずれか１項に記載の消毒用組成物の製造としての使用。 That is, the present disclosure relates to:
1.1) A structural unit (1) based on 2-(meth)acryloyloxyethylphosphorylcholine represented by the following formula (1) having a weight average molecular weight of 1,000 to 1,000,000, and the following formula (2 ) containing a structural unit (2) based on an alkyl group-containing (meth)acrylic monomer represented by the molar ratio of the structural unit (1) to the structural unit (2) is 15 0.001% by mass to 10% by mass of the copolymer (P), which is :85 to 45:55,
2) 55% to 90% by mass of monohydric alcohol having 1 to 5 carbon atoms, and 3) 0.001% to 1% by mass of fatty acid triglyceride
A disinfecting composition comprising:
Figure JPOXMLDOC01-appb-C000003
 (In formula (1), R 1 represents a hydrogen atom or a methyl group.)
Figure JPOXMLDOC01-appb-C000004
 (In formula (2), R 2 represents a hydrogen atom or a methyl group, and R 3 represents an alkyl group having 4 to 22 carbon atoms.)
2. 2. The disinfecting composition according to item 1, wherein the monohydric alcohol having 1 to 5 carbon atoms is one or more selected from the group consisting of ethanol and isopropanol.
3. 3. The disinfecting composition according to any one of the preceding items 1 and 2, wherein the fatty acid triglyceride is one or more selected from the group consisting of glyceryl triisooctanoate and glyceryl tricaprylate.
4. 4. The disinfecting composition according to any one of the preceding items 1 to 3, further comprising an organic acid.
5. The disinfecting composition according to the preceding item 1, wherein the monohydric alcohol having 1 to 5 carbon atoms is ethanol, and the fatty acid triglyceride is glyceryl tricaprylate.
6. The disinfecting composition according to the preceding item 1, wherein the monohydric alcohol having 1 to 5 carbon atoms is ethanol, and the fatty acid triglyceride is glyceryl triisooctanoate.
7. A disinfection method comprising:
comprising the step of contacting the disinfecting composition with the subject of use;
The disinfecting composition comprises
1) A structural unit (1) based on 2-(meth)acryloyloxyethylphosphorylcholine having a weight average molecular weight of 1,000 to 1,000,000 and represented by the following formula (1), and the following formula (2) Containing a structural unit (2) based on the alkyl group-containing (meth)acrylic monomer represented, the content ratio of the structural unit (1) to the structural unit (2) is 15:85 in terms of molar ratio 0.001% by mass to 10% by mass of a copolymer (P) that is ~45:55;
2) 55% to 90% by mass of monohydric alcohol having 1 to 5 carbon atoms, and 3) 0.001% to 1% by mass of fatty acid triglyceride,
disinfection method.
Figure JPOXMLDOC01-appb-C000005
 (In formula (1), R 1 represents a hydrogen atom or a methyl group.)
Figure JPOXMLDOC01-appb-C000006
 (In formula (2), R 2 represents a hydrogen atom or a methyl group, and R 3 represents an alkyl group having 4 to 22 carbon atoms.)
8. 8. The disinfection method according to item 7, wherein the monohydric alcohol having 1 to 5 carbon atoms is one or more selected from the group consisting of ethanol and isopropanol.
9. 9. The disinfection method according to any one of the preceding items 7 to 8, wherein the fatty acid triglyceride is one or more selected from the group consisting of glyceryl triisooctanoate and glyceryl tricaprylate.
10. 10. The disinfection method according to any one of the preceding items 7 to 9, further containing an organic acid.
11. Use of the following 1) to 3) for manufacturing a disinfecting composition.
1) A structural unit (1) based on 2-(meth)acryloyloxyethylphosphorylcholine having a weight average molecular weight of 1,000 to 1,000,000 and represented by the following formula (1), and the following formula (2) Containing a structural unit (2) based on the alkyl group-containing (meth)acrylic monomer represented, the content ratio of the structural unit (1) to the structural unit (2) is 15:85 in terms of molar ratio Copolymer (P) that is ~45:55
2) C1-C5 monohydric alcohol 3) Fatty acid triglyceride
Figure JPOXMLDOC01-appb-C000007
 (In formula (1), R 1 represents a hydrogen atom or a methyl group.)
Figure JPOXMLDOC01-appb-C000008
 (In formula (2), R 2 represents a hydrogen atom or a methyl group, and R 3 represents an alkyl group having 4 to 22 carbon atoms.)
12. 12. Use for producing a disinfecting composition according to 11 above, wherein the monohydric alcohol having 1 to 5 carbon atoms is one or more selected from the group consisting of ethanol and isopropanol.
13. 13. Use for producing a disinfecting composition according to any one of the preceding items 11 to 12, wherein the fatty acid triglyceride is one or more selected from the group consisting of glyceryl triisooctanoate and glyceryl tricaprylate.
14. 14. Further, use for producing a disinfecting composition according to any one of the preceding items 11 to 13, which contains an organic acid.
　塗布後の皮膚のべたつきがなくかつしっとりとした使用感を使用者に提供し、さらに、塗布直後に電子機器（特に、キーボード）を使用する際の使用を円滑に行うことを提供できる消毒用組成物を提供することができる。
　詳しくは、本開示の消毒用組成物を手指等に使用した使用者は、皮膚にべたつきがなくかつしっとりとした使用感を感じるとともに、さらに、塗布直後に電子機器（特に、キーボード）を使用する際には、電子機器の使用を円滑に行うことができる。 A disinfecting composition that provides a user with a non-sticky and moist skin feeling after application, and can provide smooth use of electronic devices (especially keyboards) immediately after application. can provide things.
Specifically, users who use the disinfectant composition of the present disclosure on their fingers or the like feel a non-sticky and moist feeling on the skin, and use electronic devices (especially keyboards) immediately after application. In some cases, the electronic device can be used smoothly.
　以下の本開示を詳細に説明する。
　本開示の消毒用組成物は、以下を含む。
　１）重量平均分子量１，０００～１，０００，０００であり、式（１）で表される２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位（１）と、式（２）で表されるアルキル基含有（メタ）アクリル系単量体に基づく構成単位（２）を含み、該構成単位（１）と該構成単位（２）の含有量の比がモル比にて１５：８５～４５：５５である共重合体（Ｐ）　０．００１質量％～１０質量％
　２）炭素数1～5の1価アルコール　５５質量％～９０質量％
　３）脂肪酸トリグリセリド　０．００１質量％～１質量％
　なお、本開示において「（メタ）アクリル」は、アクリルまたはメタアクリル（メタクリル）を意味し、「（メタ）アクリロイル」は、アクリロイルまたはメタアクリロイル（メタクリロイル）を意味する。
　また、本明細書において、好ましい数値範囲（例えば、含有量や重量平均分子量の範囲）を段階的に記載した場合、各下限値及び上限値は、それぞれ独立して組み合わせることができる。例えば、「好ましくは１０～１００、より好ましくは２０～９０」という記載において、「好ましい下限値：１０」と「より好ましい上限値：９０」とを組み合わせて「１０～９０」とすることができる。 The present disclosure is described in detail below.
Disinfectant compositions of the present disclosure include:
1) A structural unit (1) having a weight average molecular weight of 1,000 to 1,000,000 and based on 2-(meth)acryloyloxyethylphosphorylcholine represented by formula (1) and represented by formula (2) containing a structural unit (2) based on an alkyl group-containing (meth)acrylic monomer, wherein the ratio of the content of the structural unit (1) to the structural unit (2) is 15:85 to 45 in terms of molar ratio : 55 copolymer (P) 0.001% by mass to 10% by mass
2) 55% to 90% by mass of monohydric alcohol having 1 to 5 carbon atoms
3) Fatty acid triglyceride 0.001% by mass to 1% by mass
In the present disclosure, "(meth)acryl" means acrylic or methacrylic (methacryl), and "(meth)acryloyl" means acryloyl or methacryloyl (methacryloyl).
Further, in the present specification, when preferred numerical ranges (for example, content and weight-average molecular weight ranges) are described stepwise, each lower limit and upper limit can be independently combined. For example, in the statement "preferably 10 to 100, more preferably 20 to 90", "preferable lower limit: 10" and "more preferred upper limit: 90" can be combined to "10 to 90". .
　本開示の消毒用組成物に含有される共重合体（Ｐ）は、２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位と、アルキル基含有（メタ）アクリル系単量体に基づく構成単位を含む共重合体である。 The copolymer (P) contained in the disinfecting composition of the present disclosure includes a structural unit based on 2-(meth)acryloyloxyethylphosphorylcholine and a structural unit based on an alkyl group-containing (meth)acrylic monomer. It is a copolymer containing
　２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位は、下記の式（１）で表される。 A structural unit based on 2-(meth)acryloyloxyethylphosphorylcholine is represented by the following formula (1).
Figure JPOXMLDOC01-appb-C000009
Figure JPOXMLDOC01-appb-C000009
　上記式（１）中、Ｒ１は水素原子またはメチル基を示す。上記式（１）中のＲ１がメチル基である２－メタクリロイルオキシエチルホスホリルコリン（ＭＰＣ）が好ましい。 In formula (1) above, R 1 represents a hydrogen atom or a methyl group. 2-Methacryloyloxyethylphosphorylcholine (MPC) in which R 1 in the above formula (1) is a methyl group is preferred.
　アルキル基含有（メタ）アクリル系単量体に基づく構成単位は、下記の式（２）で表される。
Figure JPOXMLDOC01-appb-C000010
 A structural unit based on an alkyl group-containing (meth)acrylic monomer is represented by the following formula (2).
Figure JPOXMLDOC01-appb-C000010
　上記式（２）中、Ｒ２は水素原子またはメチル基を示し、Ｒ３は炭素数４～２２のアルキル基を示す。 In formula (2) above, R 2 represents a hydrogen atom or a methyl group, and R 3 represents an alkyl group having 4 to 22 carbon atoms.
　式（２）中、Ｒ３で示されるアルキル基は、炭素数４～２２の直鎖または分岐のアルキル基であり、ブチル、ペンチル、ヘキシル、オクチル、２－エチルヘキシル、デシル、ドデシル、テトラデシル、ヘキサデシル、オクタデシル、ドコシル、ラウリル、トリデシル、ステアリル等が例示される。 In formula (2), the alkyl group represented by R 3 is a linear or branched alkyl group having 4 to 22 carbon atoms, such as butyl, pentyl, hexyl, octyl, 2-ethylhexyl, decyl, dodecyl, tetradecyl, hexadecyl. , octadecyl, docosyl, lauryl, tridecyl, stearyl and the like.
　従って、式（２）で表されるアルキル基含有（メタ）アクリル系単量体に基づく構成単位としては、（メタ）アクリル酸ブチル、（メタ）アクリル酸２－エチルヘキシル、（メタ）アクリル酸ラウリル、（メタ）アクリル酸トリデシル、（メタ）アクリル酸ステアリル、（メタ）アクリル酸ドコシル等に基づく構成単位が挙げられるが、特に好ましいのは（メタ）アクリル酸ブチルである。 Therefore, structural units based on alkyl group-containing (meth)acrylic monomers represented by formula (2) include butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, and lauryl (meth)acrylate. , tridecyl (meth)acrylate, stearyl (meth)acrylate, docosyl (meth)acrylate, and the like, and particularly preferred is butyl (meth)acrylate.
　共重合体（Ｐ）において、２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位とアルキル基含有（メタ）アクリル系単量体に基づく構成単位の含有量の比（［２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位］：［アルキル基含有（メタ）アクリル系単量体に基づく構成単位］）は、モル比にて１５：８５～４５：５５であり、好ましくは２０：８０～４０：６０であり、より好ましくは２５：７５～３５：６５である。
　なお、構成単位とは、各モノマーに基づく又は各モノマーから誘導される重合体に含まれる化合物の単位を意味する。 In the copolymer (P), the ratio of the content of structural units based on 2-(meth)acryloyloxyethylphosphorylcholine and structural units based on alkyl group-containing (meth)acrylic monomers ([2-(meth)acryloyl Structural unit based on oxyethylphosphorylcholine]:[structural unit based on alkyl group-containing (meth)acrylic monomer]) has a molar ratio of 15:85 to 45:55, preferably 20:80 to 40. :60, more preferably 25:75 to 35:65.
In addition, a structural unit means the unit of the compound contained in the polymer based on each monomer or derived from each monomer.
　共重合体（Ｐ）は、本開示の消毒用組成物の効果に影響与えない範囲で、２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位とアルキル基含有（メタ）アクリル系単量体に基づく構成単位以外のその他の構成単位を含有させることができる。
　例えば、スチレン系単量体、ビニルエーテル単量体、ビニルエステル単量体、親水性の水酸基含有（メタ）アクリレート、酸基含有単量体、窒素含有基含有単量体、アミノ基含有単量体、カチオン性基含有単量体に基づく構成単位等を例示することができる。
　スチレン系単量体としては、スチレン、メチルスチレン、クロロメチルスチレンが挙げられる。
　ビニルエーテル単量体としては、メチルビニルエーテル、ブチルビニルエーテルが挙げられる。
　ビニルエステル単量体としては、酢酸ビニル、プロピオン酸ビニルが挙げられる。
　親水性の水酸基含有（メタ）アクリレートとしては、ポリエチレングリコール（メタ）アクリレート、ポリプロピレングリコール（メタ）アクリレート、N-ビニルピロリドン、２－ヒドロキシエチル（メタ）アクリレート、２－ヒドロキシブチル（メタ）アクリレート、４－ヒドロキシブチル（メタ）アクリレートが挙げられる。
　酸基含有単量体としては、（メタ）アクリル酸、スチレンスルホン酸、（メタ）アクリロイルオキシホスホン酸が挙げられる。
　窒素含有基含有単量体としては、アミノエチル（メタ）アクリレートが挙げられる。
　アミノ基含有単量体としては、アミノエチルメタクリレート、ジメチルアミノエチル（メタ）アクリレート、N,N-ジメチルアミノプロピル（メタ）アクリルアミドが挙げられる。
　カチオン性基含有単量体としては、2-ヒドロキシ-3-(メタ)アクリロイルオキシプロピルトリメチルアンモニウムクロライドが挙げられる。 The copolymer (P) is a structural unit based on 2-(meth)acryloyloxyethylphosphorylcholine and an alkyl group-containing (meth)acrylic monomer within a range that does not affect the effects of the disinfecting composition of the present disclosure. Structural units other than the structural units based on can be contained.
For example, styrene-based monomers, vinyl ether monomers, vinyl ester monomers, hydrophilic hydroxyl group-containing (meth)acrylates, acid group-containing monomers, nitrogen-containing group-containing monomers, amino group-containing monomers , structural units based on cationic group-containing monomers, and the like.
Styrenic monomers include styrene, methylstyrene, and chloromethylstyrene.
Vinyl ether monomers include methyl vinyl ether and butyl vinyl ether.
Vinyl ester monomers include vinyl acetate and vinyl propionate.
Hydrophilic hydroxyl group-containing (meth)acrylates include polyethylene glycol (meth)acrylate, polypropylene glycol (meth)acrylate, N-vinylpyrrolidone, 2-hydroxyethyl (meth)acrylate, 2-hydroxybutyl (meth)acrylate, 4 - hydroxybutyl (meth)acrylate.
Acid group-containing monomers include (meth)acrylic acid, styrenesulfonic acid, and (meth)acryloyloxyphosphonic acid.
Nitrogen-containing group-containing monomers include aminoethyl (meth)acrylate.
Amino group-containing monomers include aminoethyl methacrylate, dimethylaminoethyl (meth)acrylate, and N,N-dimethylaminopropyl (meth)acrylamide.
Cationic group-containing monomers include 2-hydroxy-3-(meth)acryloyloxypropyltrimethylammonium chloride.
　本開示の消毒用組成物に含有される共重合体（Ｐ）の重量平均分子量は１，０００～１，０００，０００であり、好ましくは、５，０００～５００，０００であり、より好ましくは、１０，０００～１５０，０００である。
　共重合体（Ｐ）の重量平均分子量が１，０００未満であると、皮膜性が低下し、使用時の円滑さの改善効果が望めない場合があり、重量平均分子量が１，０００，０００より大きいと、消毒用組成物の使用の円滑さを損なう場合がある。
　なお、共重合体（Ｐ）の重量平均分子量は、ゲル浸透クロマトグラフィー（ＧＰＣ）によって測定され、プルラン換算の分子量で示される。 The copolymer (P) contained in the disinfecting composition of the present disclosure has a weight average molecular weight of 1,000 to 1,000,000, preferably 5,000 to 500,000, more preferably , from 10,000 to 150,000.
If the weight-average molecular weight of the copolymer (P) is less than 1,000, the film properties may deteriorate, and the effect of improving smoothness during use may not be expected. Larger sizes may impair the ease of use of the disinfecting composition.
In addition, the weight average molecular weight of the copolymer (P) is measured by gel permeation chromatography (GPC) and is indicated by the molecular weight in terms of pullulan.
　共重合体（Ｐ）の重合形態は特に限定されず、ランダム共重合体であっても、ブロック共重合体であってもよいが、ランダム共重合体が好ましい。 The polymerization form of the copolymer (P) is not particularly limited, and may be a random copolymer or a block copolymer, but a random copolymer is preferred.
　共重合体（Ｐ）は、公知の製造方法により製造することができる。
　たとえば、ＭＰＣおよびアルキル基含有（メタ）アクリル系単量体を含む単量体混合物を、ラジカル重合開始剤の存在下、窒素等の不活性ガス雰囲気下において、溶液重合等の公知の方法により重合させて製造することができる。
　各単量体の含有量比は、共重合体（Ｐ）中における各構成単位の含有量比に相当する比とすればよい。
　共重合体（Ｐ）は、上記した重合方法により製造して用いることもできるが、水や多価アルコールの溶液もしくは分散液として市販されている製品を用いることもできる。 Copolymer (P) can be produced by a known production method.
For example, a monomer mixture containing MPC and an alkyl group-containing (meth)acrylic monomer is polymerized by a known method such as solution polymerization in the presence of a radical polymerization initiator in an inert gas atmosphere such as nitrogen. can be produced by
The content ratio of each monomer may be a ratio corresponding to the content ratio of each structural unit in the copolymer (P).
The copolymer (P) can be used after being produced by the polymerization method described above, but it is also possible to use products commercially available as solutions or dispersions of water or polyhydric alcohols.
　本開示の消毒用組成物は、上記した共重合体（Ｐ）は１種を選択し、単独で含有してもよく、２種以上を選択し、組み合わせて含有してもよい。
　本開示の消毒用組成物に含有させる共重合体（Ｐ）の形態としては、粉末等の固形状、溶液、分散液等の液状のいずれでもよい。 The disinfecting composition of the present disclosure may contain one of the copolymers (P) described above, or may contain two or more of them in combination.
The form of the copolymer (P) contained in the disinfecting composition of the present disclosure may be solid such as powder or liquid such as solution or dispersion.
　本開示の消毒用組成物の共重合体（Ｐ）の含有量は、０．００１質量％～１０質量％（又は０．００１質量％～９質量％）の範囲で適宜選定することができ、使用の円滑さの観点から、０．００５質量％～５質量％の範囲で選択することが好ましい。
　本開示の消毒用組成物の共重合体（Ｐ）の含有量が０．００１質量％未満であると、該消毒用組成物において使用の円滑さが十分でない場合があり、共重合体（Ｐ）の含有量が１０質量％を超えると、逆に使用の円滑さを損なう場合がある。 The content of the copolymer (P) in the disinfecting composition of the present disclosure can be appropriately selected in the range of 0.001% by mass to 10% by mass (or 0.001% by mass to 9% by mass), From the viewpoint of smoothness of use, it is preferable to select in the range of 0.005% by mass to 5% by mass.
If the content of the copolymer (P) in the disinfecting composition of the present disclosure is less than 0.001% by mass, smoothness of use may not be sufficient in the disinfecting composition, and the copolymer (P ) content of more than 10% by mass may conversely impair the smoothness of use.
　本開示の消毒用組成物に含有される炭素数1～5の1価アルコールは、通常炭素数が５以下であるアルコールであり、共重合体（Ｐ）や脂肪酸トリグリセリドを溶解させることができ、皮膚に対して使用可能なものであれば、特に制限なく用いることができる。さらに、炭素数が３以下である一価アルコールが好ましく、炭素数が２または３である一価アルコールがより好ましい。
　本開示において好適に用いられる炭素数1～5の1価アルコールとしては、エタノール、１－プロパノール、イソプロパノール等が挙げられ、エタノールおよびイソプロパノールがより好適に用いられる。
　本開示において、炭素数1～5の1価アルコールは１種を単独で用いてもよく、または２種以上を混合して用いてもよい。 The monohydric alcohol having 1 to 5 carbon atoms contained in the disinfecting composition of the present disclosure is usually an alcohol having 5 or less carbon atoms, and can dissolve the copolymer (P) and fatty acid triglycerides. As long as it can be used on the skin, it can be used without any particular limitation. Furthermore, monohydric alcohols having 3 or less carbon atoms are preferred, and monohydric alcohols having 2 or 3 carbon atoms are more preferred.
Monohydric alcohols having 1 to 5 carbon atoms preferably used in the present disclosure include ethanol, 1-propanol, isopropanol and the like, with ethanol and isopropanol being more preferably used.
In the present disclosure, monohydric alcohols having 1 to 5 carbon atoms may be used singly or in combination of two or more.
　本開示の消毒用組成物に炭素数1～5の1価アルコールを含有させると、消毒用組成物の界面張力が低下して、皮膚の凹凸部位に該組成物が広がりやすくなるため、皮膜形成時の均一性が向上し、皮膚に対して均一に塗布しやすくなり、使用の円滑さが良好となる。
　本開示の消毒用組成物中の炭素数1～5の1価アルコールの含有量は、５５質量％～９０質量％（又は５５質量％～８９質量％）であり、好ましくは６０質量％～８５質量％であり、より好ましくは６５質量％～８０質量％である。
　炭素数1～5の1価アルコールの含有量が５５質量％未満であると、殺菌力に劣る場合がある。一方、炭素数1～5の1価アルコールを、９０質量％を超えて含有させても、含有量に見合う効果が得られない場合がある。 When the antiseptic composition of the present disclosure contains a monohydric alcohol having 1 to 5 carbon atoms, the interfacial tension of the antiseptic composition is reduced, and the composition tends to spread over uneven areas of the skin, resulting in film formation. The uniformity of time is improved, it becomes easier to evenly apply to the skin, and the smoothness of use is improved.
The content of the monohydric alcohol having 1 to 5 carbon atoms in the disinfecting composition of the present disclosure is 55% to 90% by mass (or 55% to 89% by mass), preferably 60% to 85% by mass. % by mass, more preferably 65 to 80% by mass.
If the content of the monohydric alcohol having 1 to 5 carbon atoms is less than 55% by mass, the bactericidal activity may be poor. On the other hand, even if the monohydric alcohol having 1 to 5 carbon atoms is contained in an amount exceeding 90% by mass, the effect corresponding to the content may not be obtained.
　本開示の消毒用組成物に含有される脂肪酸トリグリセリドとしては、２５℃、１０１３．２５ｈＰａで液体のものが好ましい。脂肪酸トリグリセリドの脂肪酸部分としては、炭素数６～１８の直鎖脂肪酸又は分岐脂肪酸が好ましく、炭素数６～１０のものがより好ましい。
　具体的には、脂肪酸部分がカプロン酸、カプリル酸、カプリン酸、イソオクタン酸、イソパルミチン酸、イソステアリン酸、オレイン酸、リノール酸、リノレン酸等から選ばれる脂肪酸トリグリセリドが挙げられる。これらのうち、特に脂肪酸部分がカプロン酸、カプリル酸、カプリン酸、イソオクタン酸であることが好ましく、イソオクタン酸であることがより好ましい。脂肪酸トリグリセリドの脂肪酸部分は３つとも同じ脂肪酸を用いてもよく、又は複数の種類の脂肪酸を組み合わせて用いてもよい。かかる脂肪酸トリグリセリドの具体例としては、例えば、トリカプリル酸グリセリン、トリイソオクタン酸グリセリン、ジカプリル酸モノカプリン酸グリセリン等が挙げられ、トリイソオクタン酸グリセリンおよびトリカプリル酸グリセリンがより好ましい。
　本開示の消毒用組成物には、脂肪酸トリグリセリドは、１種を選択して単独で、または２種以上を組み合わせて用いることができる。 Fatty acid triglycerides contained in the disinfecting composition of the present disclosure are preferably liquid at 25° C. and 1013.25 hPa. The fatty acid portion of the fatty acid triglyceride is preferably a linear or branched fatty acid having 6 to 18 carbon atoms, more preferably 6 to 10 carbon atoms.
Specific examples include fatty acid triglycerides in which the fatty acid moiety is selected from caproic acid, caprylic acid, capric acid, isooctanoic acid, isopalmitic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid and the like. Among these, the fatty acid moiety is preferably caproic acid, caprylic acid, capric acid or isooctanoic acid, more preferably isooctanoic acid. The same fatty acid may be used for all three fatty acid moieties of the fatty acid triglyceride, or a combination of multiple types of fatty acids may be used. Specific examples of such fatty acid triglycerides include glyceryl tricaprylate, glyceryl triisooctanoate, glyceryl dicaprylate monocaprate, etc. Glyceryl triisooctanoate and glyceryl tricaprylate are more preferred.
For the disinfecting composition of the present disclosure, fatty acid triglycerides can be used singly or in combination of two or more.
　本開示の消毒用組成物における脂肪酸トリグリセリドの含有量は、通常０．００１質量％～１質量％であり、好ましくは０．０１質量％～１質量％である。
　脂肪酸トリグリセリドの含有量が０．００１質量％未満では、乾いた後のしっとり感に劣る場合があり、１質量％を超えると、手指に擦り込む際にべたつきやぬめりが増大する恐れがある。 The content of fatty acid triglycerides in the disinfecting composition of the present disclosure is generally 0.001% to 1% by mass, preferably 0.01% to 1% by mass.
If the content of fatty acid triglyceride is less than 0.001% by mass, the moist feeling after drying may be poor, and if it exceeds 1% by mass, stickiness and sliminess may increase when rubbed into fingers.
　本開示の消毒用組成物には、消毒効果の観点から必要に応じて、殺菌剤を含有させることができる。
　本開示の消毒用組成物において、殺菌剤としては、病原性を有する微生物を死滅させ、または増殖を抑制し得る薬剤であり、皮膚の消毒に使用することができ、共重合体（Ｐ）および脂肪酸トリグリセリドの効果を阻害しないものであれば、特に制限されることなく用いることができる。
　例えば、塩化ベンザルコニウム、塩化ベンゼトニウム、塩化セチルピリジニウム等のカチオン性界面活性剤；塩酸アルキルジアミノエチルグリシン等の両性界面活性剤；クロルヘキシジングルコン酸塩、塩酸クロルヘキシジン等のビグアナイド系化合物；ヨウ素イオン、ヨードホルム、ポビドンヨード等のハロゲン（ヨウ素）化合物；銀イオン等の銀系無機化合物；クレゾール、イソプロピルメチルフェノール等のフェノール系化合物等が挙げられる。
　殺菌活性と皮膚に対する低刺激性等の観点からは、塩化ベンザルコニウム、塩化ベンゼトニウム、クロルヘキシジングルコン酸塩等が好ましく用いられる。
　本開示の消毒用組成物には、殺菌剤は１種を単独で用いてもよく、２種以上を選択し、組み合わせて用いてもよい。
　本開示の消毒用組成物における殺菌剤の含有量は、殺菌剤の種類等により適宜設定され得るが、好ましくは０．０１質量％～５質量％であり、より好ましくは０．０１質量％～０．０５質量％である。 The disinfecting composition of the present disclosure may contain a disinfectant as necessary from the viewpoint of disinfecting effect.
In the disinfecting composition of the present disclosure, the disinfectant is an agent that can kill or inhibit the growth of pathogenic microorganisms and can be used for disinfecting the skin, and the copolymer (P) and Any substance that does not inhibit the effect of fatty acid triglyceride can be used without particular limitation.
For example, cationic surfactants such as benzalkonium chloride, benzethonium chloride and cetylpyridinium chloride; amphoteric surfactants such as alkyldiaminoethylglycine hydrochloride; biguanide compounds such as chlorhexidine gluconate and chlorhexidine hydrochloride; halogen (iodine) compounds such as , povidone-iodine; silver-based inorganic compounds such as silver ions; phenol-based compounds such as cresol and isopropylmethylphenol.
Benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, and the like are preferably used from the viewpoint of bactericidal activity and mild skin irritation.
In the disinfectant composition of the present disclosure, one type of disinfectant may be used alone, or two or more types may be selected and used in combination.
The content of the disinfectant in the disinfectant composition of the present disclosure can be appropriately set depending on the type of disinfectant and the like, but is preferably 0.01% by mass to 5% by mass, more preferably 0.01% by mass to It is 0.05% by mass.
　本開示の消毒用組成物には、使用感向上の観点から必要に応じて、有機酸を含有させることができる。
　本開示の消毒用組成物において、有機酸としては、しっとり感を向上させる薬剤であり、共重合体（Ｐ）および脂肪酸トリグリセリドの効果を阻害しないものであれば、特に制限されることなく用いることができ、クエン酸、リンゴ酸、乳酸等が挙げられる。
　しっとり感と皮膚に対する低刺激性等の観点からは、乳酸等が好ましく用いられる。
　本開示の消毒用組成物には、有機酸は１種を単独で用いてもよく、２種以上を選択し、組み合わせて用いてもよい。
　本開示の消毒用組成物における有機酸の含有量は、有機酸の種類等により適宜設定され得るが、通常０．０１質量％～１０質量％であり、好ましくは１質量％～１０質量％である。 The disinfecting composition of the present disclosure may contain an organic acid, if necessary, from the viewpoint of improving the feeling of use.
In the disinfectant composition of the present disclosure, the organic acid is not particularly limited as long as it is an agent that improves moistness and does not inhibit the effects of the copolymer (P) and fatty acid triglyceride. and citric acid, malic acid, lactic acid, and the like.
Lactic acid or the like is preferably used from the viewpoint of moist feeling and low irritation to the skin.
For the disinfecting composition of the present disclosure, one type of organic acid may be used alone, or two or more types may be selected and used in combination.
The content of the organic acid in the disinfecting composition of the present disclosure can be appropriately set depending on the type of organic acid, etc., but is usually 0.01% by mass to 10% by mass, preferably 1% by mass to 10% by mass. be.
　本開示の消毒用組成物は、通常水を基材として含有する。
　本開示の消毒用組成物の調製に際し、上記した炭素数1～5の1価アルコールを、水との混合溶媒として用いることにより、皮膚に対する共重合体（Ｐ）および脂肪酸トリグリセリドの密着性を向上させることができる。密着性の向上の理由は、組成物の乾燥時において、炭素数1～5の1価アルコールと水の蒸散速度が異なることから、共重合体（Ｐ）および脂肪酸トリグリセリドの疎水性基を皮膚表面に効果的に配向させることができるためである。
　本開示の消毒用組成に含まれる水としては、化粧品用または医薬品用等として一般的に用いられる水を用いることができ、イオン交換水、精製水、注射用水等を用いることが好ましい。
　本開示の消毒用組成物の水の含有量は、１０質量％～３５質量％であり、好ましくは１５質量％～３０質量％である。
　水の含有量が３質量％未満である場合、もしくは４５質量％を超える場合には、殺菌力に劣る可能性があるため、好ましくない。 The disinfecting compositions of the present disclosure typically contain water as a base.
In the preparation of the disinfecting composition of the present disclosure, by using the above monohydric alcohol having 1 to 5 carbon atoms as a mixed solvent with water, the adhesion of the copolymer (P) and fatty acid triglycerides to the skin is improved. can be made The reason for the improvement in adhesion is that when the composition dries, the evaporation rate of monohydric alcohols with 1 to 5 carbon atoms differs from that of water. This is because it can be oriented effectively.
As the water contained in the disinfecting composition of the present disclosure, water generally used for cosmetics or pharmaceuticals can be used, and it is preferable to use ion-exchanged water, purified water, water for injection, and the like.
The water content of the disinfecting composition of the present disclosure is 10% to 35% by weight, preferably 15% to 30% by weight.
If the water content is less than 3% by mass or more than 45% by mass, the sterilizing power may be inferior, which is not preferable.
　本開示の消毒用組成物は、該組成物の効果を損なわない範囲で、湿潤剤を含有することができる。
　湿潤剤としては、例えば、エチレングリコール、プロピレングリコール、ジプロピレングリコール、１，３－ブチレングリコール、１，４－ブチレングリコール、ペンチレングリコール、ヘキシレングリコール、イソプレングリコール、２－エチル－１，３－ヘキサンジオール、イソペンチルジオール等の二価アルコール；グリセリン；ジグリセリン、ポリグリセリン等のグリセリン縮合物；ソルビトール、キシリトール、マルチトール、マンニトール、エリスリトール等の糖アルコール等、ポリオール系化合物類が挙げられ、１種を単独で、または２種以上の混合物として用いることができる。
　これら湿潤剤の中でも、皮膚への馴染みの良さから、プロピレングリコール、ジプロピレングリコール、１，３－ブチレングリコールおよびグリセリンがより好ましく用いられる。
　本開示の消毒用組成物の湿潤剤の含有量は、該組成物の効果を損なうことのない範囲で選択され、０．０１質量％～１０質量％とすることが好ましい。 The disinfecting composition of the present disclosure can contain a humectant to the extent that the effect of the composition is not impaired.
Wetting agents include, for example, ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, pentylene glycol, hexylene glycol, isoprene glycol, 2-ethyl-1,3- Dihydric alcohols such as hexanediol and isopentyldiol; glycerin; glycerin condensates such as diglycerin and polyglycerin; sugar alcohols such as sorbitol, xylitol, maltitol, mannitol and erythritol; The species can be used singly or as mixtures of two or more species.
Among these humectants, propylene glycol, dipropylene glycol, 1,3-butylene glycol and glycerin are more preferably used because of their good compatibility with the skin.
The content of the humectant in the disinfecting composition of the present disclosure is selected within a range that does not impair the effects of the composition, and is preferably 0.01% by mass to 10% by mass.
　本開示の消毒用組成物には、該組成物の効果を損なわない範囲で、さらに、公知の消毒用組成物等である外用剤に一般的に使用される添加剤を含有させてもよい。
　該添加剤としては、例えば、ノニオン性界面活性剤、増粘剤、起泡剤、噴射剤、有機酸、酸化防止剤、安定剤、防腐剤、金属イオン封鎖剤、香料、色素、色材等が挙げられる。これらの添加剤は、目的に応じて、１種または２種以上を選択し、含有させることができる。 The disinfecting composition of the present disclosure may further contain additives commonly used in external preparations such as known disinfecting compositions, as long as they do not impair the effects of the composition.
Examples of such additives include nonionic surfactants, thickeners, foaming agents, propellants, organic acids, antioxidants, stabilizers, preservatives, sequestering agents, fragrances, pigments, colorants, and the like. is mentioned. One or two or more of these additives may be selected and contained depending on the purpose.
　本開示の消毒用組成物は、常法に従って製造することができる。例えば、上記した共重合体（Ｐ）、炭素数1～5の1価アルコール、脂肪酸トリグリセリド等に、必要に応じて殺菌剤、水、湿潤剤や一般的な他の添加剤を加えて適宜混合し、均一とすることで製造することができる。
　また、本開示の消毒用組成物は、例えば、医薬品や医薬部外品又はそれらの成分として用いることができる。 The disinfecting composition of the present disclosure can be manufactured according to conventional methods. For example, to the above-mentioned copolymer (P), monohydric alcohol having 1 to 5 carbon atoms, fatty acid triglyceride, etc., if necessary, bactericide, water, wetting agent and other general additives are added and mixed appropriately. It can be manufactured by making it uniform.
In addition, the disinfecting composition of the present disclosure can be used, for example, as pharmaceuticals, quasi-drugs, or components thereof.
　本開示の消毒用組成物は、液状、ペースト状等の半固形状等の形態で提供され得る。
　使用時の簡便さや安全性等の観点からは、本開示の消毒用組成物は、液状の形態とすることが好ましい、
　本開示の消毒用組成物は、ポンプ容器もしくはスプレー容器に収容することができる。詳しくは、ディスペンサーポンプ付き容器に充填した液吐出型、スプレーポンプ付き容器に充填した噴霧型、フォーマーポンプ付き容器またはエアゾール容器に充填した泡吐出型、清拭ワイプに含浸させた含浸型等の製品とすることが好ましい。
　本開示の消毒用組成物の使用例として、手指の消毒に用いる場合には、本開示の消毒用組成物を適量（１　ｍＬ～３　ｍＬ程度）取り、手に擦り込みながら塗布した後、乾燥させて使用することができる。
　本開示の消毒用組成物を清拭ワイプに含浸させる場合には、清拭ワイプ１００質量部に対して本開示の消毒用組成物を１０質量部～４００質量部程度含浸させ、該ワイプにて、皮膚や医療器具を清拭して使用することができる。 The disinfecting composition of the present disclosure can be provided in the form of liquid, semi-solid such as paste, and the like.
From the viewpoint of ease of use, safety, etc., the disinfecting composition of the present disclosure is preferably in a liquid form.
The disinfecting compositions of the present disclosure can be contained in pump or spray containers. Specifically, liquid discharge type filled in a container with a dispenser pump, spray type filled in a container with a spray pump, foam discharge type filled in a container with a foamer pump or an aerosol container, impregnation type with a cleaning wipe impregnated, etc. A product is preferred.
As an example of use of the disinfecting composition of the present disclosure, when it is used for disinfecting fingers, take an appropriate amount (about 1 mL to 3 mL) of the disinfecting composition of the present disclosure, apply it while rubbing it on the hand, and then dry it. can be used
When impregnating a cleaning wipe with the disinfecting composition of the present disclosure, impregnate about 10 parts by mass to 400 parts by mass of the disinfecting composition of the present disclosure with respect to 100 parts by mass of the cleaning wipe. , can be used to clean the skin and medical instruments.
　本開示の消毒用組成物は、塗布後の皮膚のべたつきがなくかつしっとりとした使用感を提供し、さらに、塗布直後に電子機器を使用する際の使用感を円滑にすることを提供することができる。
　詳しくは、本開示の消毒用組成物を手指等に使用した使用者は、皮膚にべたつきがなくかつしっとりとした使用感の感じである良好な感触とともに、該組成物に含有する脂肪酸トリグリセリドにより手荒れ等を防止することができ、さらに、塗布直後に電子機器（例えば、キーボード、タブレット端末、スマートフォン、医療機器）を使用する際には、電子機器の使用を円滑に行うことができる。 The disinfecting composition of the present disclosure provides a non-sticky and moist skin feeling after application, and further provides a smooth feeling when using electronic devices immediately after application. can be done.
Specifically, users who use the disinfecting composition of the present disclosure on their hands and fingers have a good feeling of non-sticky and moist feeling of use, as well as rough hands due to the fatty acid triglycerides contained in the composition. etc., and furthermore, when using electronic devices (for example, keyboards, tablet terminals, smartphones, medical devices) immediately after application, the electronic devices can be used smoothly.
（消毒方法）
　本開示の一実施形態は、上記記載の本開示の消毒用組成物を使用対象（例えば、ヒトを含む哺乳類）に接触させる工程を含む、消毒方法を対象とする。
　使用対象とは、手指等の消毒をする使用者だけでなく、該使用者に本開示の消毒用組成物を提供するための媒体（例、清拭ワイプ等）も対象とする。
　接触とは、塗布、噴霧、浸漬等を例示することができるが、特に限定されない。 (Disinfection method)
One embodiment of the present disclosure is directed to a disinfecting method comprising contacting a subject of use (eg, a mammal, including a human) with a disinfecting composition of the present disclosure as described above.
The target of use includes not only users who disinfect their hands and fingers, but also media (eg, cleaning wipes, etc.) for providing the disinfecting composition of the present disclosure to the users.
Contacting can be exemplified by application, spraying, immersion, etc., but is not particularly limited.
（消毒用組成物の製造としての使用）
　本開示の一実施形態は、上記記載の共重合体（Ｐ）、炭素数1～5の1価アルコール及び脂肪酸トリグリセリドを、本開示の消毒用組成物の製造としての使用も対象とする。 (Use for production of disinfecting composition)
One embodiment of the present disclosure is also directed to the use of the above-described copolymer (P), C1-C5 monohydric alcohol and fatty acid triglyceride as the manufacture of a disinfecting composition of the present disclosure.
（本開示の消毒用組成物の構成例）
　本開示の消毒用組成物の各構成の組み合わせを以下に例示するが、限定されない。
　１）共重合体（Ｐ）、エタノール、トリカプリル酸グリセリン
　２）共重合体（Ｐ）、エタノール、トリカプリル酸グリセリン、乳酸
　３）共重合体（Ｐ）、エタノール、トリイソオクタン酸グリセリン
　４）共重合体（Ｐ）、エタノール、トリイソオクタン酸グリセリン、乳酸
　５）共重合体（Ｐ）、エタノール、トリカプリル酸グリセリン、塩化ベンザルコニウム
　６）共重合体（Ｐ）、エタノール、トリイソオクタン酸グリセリン、塩化ベンザルコニウム
　加えて、上記各組合せの構成は、それぞれ、他の組み合わせの構成単位と変更して、本開示の消毒用組成物を構成しても良い。 (Configuration example of the disinfecting composition of the present disclosure)
Non-limiting examples of combinations of each component of the disinfecting composition of the present disclosure are provided below.
1) Copolymer (P), ethanol, glyceryl tricaprylate 2) Copolymer (P), ethanol, glyceryl tricaprylate, lactic acid 3) Copolymer (P), ethanol, glyceryl triisooctanoate 4) Copolymer (P), ethanol, glyceryl triisooctanoate, lactic acid 5) Copolymer (P), ethanol, glyceryl triisooctanoate, benzalkonium chloride 6) Copolymer (P), ethanol, glyceryl triisooctanoate, benzalkonium chloride In addition, the constituents of each of the above combinations may be replaced with constituent units of other combinations to constitute the disinfecting composition of the present disclosure.
　以下、実施例及び比較例により、本開示の消毒用組成物について具体的に説明するが、本開示はこれらに限定されるものではない。また、本開示の消毒用組成物の各種評価、試験は以下の通りに実施した。 The disinfecting composition of the present disclosure will be specifically described below with reference to Examples and Comparative Examples, but the present disclosure is not limited to these. Various evaluations and tests of the disinfecting composition of the present disclosure were conducted as follows.
　［実施例１～１０及び比較例１～６］
　以下の表１に示す処方に従って、実施例１～１０および比較例１～６の各消毒用組成物を下記の通り調製した。
　ＭＰＣ共重合体（１）：ＭＰＣ・メタクリル酸ブチル共重合体（ＭＰＣおよびメタクリル酸ブチルの共重合組成比［ＭＰＣ／メタクリル酸ブチル］（モル比）＝３０／７０、重量平均分子量＝１００，０００）
　ＭＰＣ共重合体（２）：ＭＰＣ・メタクリル酸ブチル共重合体（ＭＰＣおよびメタクリル酸ブチルの共重合組成比［ＭＰＣ／メタクリル酸ブチル］（モル比）＝８０／２０、重量平均分子量＝６００，０００）
　トリイソオクタン酸グリセリン：日油株式会社製の「パナセート８００Ｂ」
　トリカプリル酸グリセリン：日油株式会社製の「パナセート８１０Ｓ」
　グリセリンとして：濃グリセリン（「日局濃グリセリン－Ｓ」、日油株式会社製）
　塩化ベンザルコニウム：日油株式会社製の「ニッサンカチオンＭ２－１００」
　エタノール、乳酸、水：外用剤の市販品
　精製水１０ｇにエタノールを加え、脂肪酸トリグリセリドを加え、次いで、ＭＰＣ共重合体を添加し、必要に応じて、他成分を添加し、攪拌、混合して均一とした。合計量が１００ｇとなるように精製水を添加し、実施例１～１０および比較例１～６の各消毒用組成物を調製した。 [Examples 1 to 10 and Comparative Examples 1 to 6]
According to the formulation shown in Table 1 below, disinfecting compositions of Examples 1 to 10 and Comparative Examples 1 to 6 were prepared as follows.
MPC copolymer (1): MPC/butyl methacrylate copolymer (copolymer composition ratio of MPC and butyl methacrylate [MPC/butyl methacrylate] (molar ratio) = 30/70, weight average molecular weight = 100,000 )
MPC copolymer (2): MPC/butyl methacrylate copolymer (copolymer composition ratio of MPC and butyl methacrylate [MPC/butyl methacrylate] (molar ratio) = 80/20, weight average molecular weight = 600,000 )
Glyceryl triisooctanoate: "Panathate 800B" manufactured by NOF Corporation
Glycerin tricaprylate: "Panathate 810S" manufactured by NOF Corporation
As glycerin: Concentrated glycerin (“JP Concentrated Glycerin-S”, manufactured by NOF Corporation)
Benzalkonium chloride: "Nissan Cation M2-100" manufactured by NOF Corporation
Ethanol, lactic acid, water: commercially available products for external use Ethanol is added to 10 g of purified water, fatty acid triglyceride is added, then MPC copolymer is added, and if necessary, other ingredients are added, stirred and mixed. made uniform. Purified water was added so that the total amount was 100 g, and disinfecting compositions of Examples 1 to 10 and Comparative Examples 1 to 6 were prepared.
（ＧＰＣ測定）
　上記のＭＰＣ共重合体のＧＰＣ測定は以下の条件で実施した。
　ＧＰＣシステム：ＥｃｏＳＥＣシステム（東ソー株式会社製）
　カラム：Ｓｈｏｄｅｘ　ＯＨｐａｋ　ＳＢ－８０２．５ＨＱ（昭和電工株式会社製）、及びＳＢ－８０６ＨＱ（昭和電工株式会社製）を直列に接続
　展開溶媒：２０ｍＭ　りん酸ナトリウム緩衝液（ｐＨ　７．４）
　検出器：示差屈折率検出器
　分子量標準：ＥａｓｉＶｉａｌ　ＰＥＧ／ＰＥＯ（Ａｇｉｌｅｎｔ　Ｔｅｃｈｎｏｌｏｇｉｅｓ社製）
　流速：０．５ｍＬ／分
　カラム温度：４０℃
　サンプル：得られた各ＭＰＣ共重合体を終濃度０．１重量％となるよう展開溶媒で希釈
　注入量：１００μＬ (GPC measurement)
GPC measurement of the above MPC copolymer was carried out under the following conditions.
GPC system: EcoSEC system (manufactured by Tosoh Corporation)
Column: Shodex OHpak SB-802.5HQ (manufactured by Showa Denko KK) and SB-806HQ (manufactured by Showa Denko KK) connected in series Developing solvent: 20 mM sodium phosphate buffer (pH 7.4)
Detector: Differential refractive index detector Molecular weight standard: EasiVial PEG/PEO (manufactured by Agilent Technologies)
Flow rate: 0.5 mL/min Column temperature: 40°C
Sample: Dilute each MPC copolymer obtained with a developing solvent to a final concentration of 0.1% by weight Injection volume: 100 μL
　上記実施例および比較例の各消毒用組成物について、塗布後の皮膚のべたつき感、塗布後の皮膚のしっとり感及び皮膚に塗布した直後にキーボードを使用した際の使用の円滑さを下記の通り評価した。 For each of the disinfecting compositions of the above examples and comparative examples, the stickiness of the skin after application, the moistness of the skin after application, and the smoothness of use when using the keyboard immediately after application to the skin are as follows. evaluated.
　（１）塗布後の皮膚のべたつき感（「乾いた後のべたつき」）の評価
　実施例および比較例の各消毒用組成物を皮膚に塗布した後の皮膚のべたつき感については、２５才～５７才の男女パネラー３０名による官能評価により評価した。
　室温＝２５℃、相対湿度＝６０％の環境下で、各パネラーに消毒用組成物のそれぞれを３ｍＬ手に取らせ、手指に１０回擦り込ませた後、手指のべたつき感を、下記評価基準により評価させた。パネラー３０名の評価点の合計点を算出し、下記判定基準により、べたつき感の判定を行った。
　＜評価基準＞
　　べたつき感がない：３点
　　ややべたつき感がない：２点
　　ややべたつき感がある：１点
　　べたつき感がある：０点
　＜判定基準＞
　　６１点～９０点：＋＋；塗布後の皮膚のべたつき感がない消毒用組成物である
　　３１点～６０点：＋；塗布後の皮膚のべたつき感がややない消毒用組成物である
　　３０点以下：－；塗布後の皮膚のべたつき感のある消毒用組成物である (1) Evaluation of skin stickiness after application (“stickiness after drying”) Skin stickiness after applying each of the disinfecting compositions of Examples and Comparative Examples to the skin was evaluated in subjects aged 25 to 57. Sensory evaluation was performed by 30 male and female panelists of all ages.
In an environment of room temperature = 25 ° C. and relative humidity = 60%, each panelist took 3 mL of each disinfectant composition and rubbed it on their fingers 10 times, and then evaluated the stickiness of their fingers according to the following evaluation criteria. evaluated. The total score of the evaluation points of 30 panelists was calculated, and the stickiness was judged according to the following judgment criteria.
<Evaluation Criteria>
No sticky feeling: 3 points Somewhat no sticky feeling: 2 points Somewhat sticky feeling: 1 point Sticky feeling: 0 points <Judgment Criteria>
61 points to 90 points: ++; It is a disinfecting composition with no sticky feeling on the skin after application 31 points to 60 points: +; It is a disinfecting composition with a little sticky feeling on the skin after application 30 points or less :-; It is a disinfecting composition that leaves a sticky feeling on the skin after application.
　（２）塗布後の皮膚のしっとり感（「乾いた後のしっとり感」）の評価
　実施例および比較例の各消毒用組成物を皮膚に塗布した後の皮膚のしっとり感については、２５才～５７才の男女パネラー３０名による官能評価により評価した。
　室温＝２５℃、相対湿度＝６０％の環境下で、各パネラーに消毒用組成物のそれぞれを３ｍＬ手に取らせ、手指に１０回擦り込ませた後、手指のしっとり感を、下記評価基準により評価させた。パネラー３０名の評価点の合計点を算出し、下記判定基準により、しっとり感の判定を行った。
　＜評価基準＞　
　　しっとり感がある：３点
　　ややしっとり感がある：２点
　　ややしっとり感がない：１点
　　しっとり感がない：０点
　＜判定基準＞
　　６１点～９０点：＋＋；塗布後の皮膚のしっとり感が十分ある消毒用組成物である
　　３１点～６０点：＋；塗布後の皮膚のしっとり感がある消毒用組成物である
　　３０点以下：－；塗布後の皮膚のしっとり感のない消毒用組成物である (2) Evaluation of skin moist feeling after application (“moist feeling after drying”) The moist feeling of the skin after applying each disinfecting composition of Examples and Comparative Examples to the skin was evaluated from 25 years old and up. Sensory evaluation was performed by 30 57-year-old male and female panelists.
In an environment of room temperature = 25 ° C. and relative humidity = 60%, each panelist took 3 mL of each disinfectant composition and rubbed it on their fingers 10 times. evaluated. The total score of the 30 panelists' evaluation points was calculated, and the moist feeling was determined according to the following criteria.
<Evaluation Criteria>
Moist feeling: 3 points Slightly moist feeling: 2 points Slightly not moist feeling: 1 point No moist feeling: 0 point <Judgment criteria>
61 points to 90 points: ++; a disinfecting composition with sufficient skin moistness after application 31 points to 60 points: +; a disinfecting composition with moist skin after application 30 points or less :-; It is a disinfecting composition that does not leave the skin feeling moist after application.
　（３）皮膚に塗布した後にキーボードを使用する際の使用の円滑さ（「使用の円滑さ」）の評価
　実施例および比較例の各消毒用組成物について、使用の円滑さは、２５才～５７才の男女パネラー３０名による官能評価により評価した。
　室温＝２５℃、相対湿度＝６０％の環境下で、各パネラーに消毒用組成物のそれぞれを３ｍＬ手に取らせ、手指に１０回擦り込ませた後、直ちにキーボード（「ＴＫ－ＦＣＭ０６４ＷＨ／ＲＳ」エレコム株式会社製）を使用させ、使用の円滑さを下記評価基準により評価させた。パネラー３０名の評価点の合計点を算出し、下記判定基準により、使用の円滑さの判定を行った。
　＜評価基準＞
　　キーボードの使用を円滑に行うことができる；３点
　　キーボードの使用をやや円滑に行うことができる；２点
　　キーボードの使用をやや円滑に行うことができない；１点
　　キーボードの使用を円滑に行うことができない；０点
　＜判定基準＞　
　　６１点～９０点：＋＋；使用の円滑さに優れる消毒用組成物である
　　３１点～６０点：＋；使用の円滑さにやや優れる消毒用組成物である
　　３０点以下：－；使用の円滑さに欠ける消毒用組成物である (3) Evaluation of smoothness of use when using the keyboard after application to the skin ("smoothness of use") Sensory evaluation was performed by 30 57-year-old male and female panelists.
Under the environment of room temperature = 25 ° C. and relative humidity = 60%, let each panelist pick up 3 mL of each of the disinfecting compositions and rub them 10 times on their fingers, then immediately press the keyboard ("TK-FCM064WH/RS" Elecom Co., Ltd.) was used, and smoothness of use was evaluated according to the following evaluation criteria. The total score of the evaluation points of 30 panelists was calculated, and smoothness of use was determined according to the following criteria.
<Evaluation Criteria>
Able to use the keyboard fluently; 3 Able to use the keyboard somewhat fluently; 2 Able to use the keyboard somewhat fluently; 1 Able to use the keyboard fluently Impossible; 0 points <judgment criteria>
61 points to 90 points: ++; a disinfecting composition that is excellent in smoothness of use 31 points to 60 points: +; a disinfecting composition that is slightly excellent in smoothness of use 30 points or less: -; It is a sanitizing composition lacking
　塗布後の皮膚のべたつき感、塗布後の皮膚のしっとり感及び使用の円滑さについての評価結果を、表１に併せて示した。 Table 1 also shows the evaluation results for the stickiness of the skin after application, the moistness of the skin after application, and the smoothness of use.
Figure JPOXMLDOC01-appb-T000011
Figure JPOXMLDOC01-appb-T000011
　表１に示されるように、本開示の実施例１～１０の各消毒用組成物については、塗布後の皮膚は、べたつき感がややない若しくはないと評価され、しっとり感がある若しくは十分あると評価され、かつ使用の円滑さにやや優れる若しくは優れると評価された。
　脂肪酸トリグリセリドを０．５質量％以上含有する実施例２、３、４、６、７、８、９および１０の消毒用組成物は、塗布後の皮膚はしっとり感が十分あると評価された。
　乳酸を含有する実施例４、８および９の消毒用組成物は、優れたしっとり感があると評価された。
　比較例１、２の消毒用組成物は、脂肪酸トリグリセリドを含有しないので、使用の円滑さに欠けると評価された。
　比較例３の消毒用組成物は、ＭＰＣ共重合体を含有しないので、使用の円滑さに欠けると評価された。
　比較例４の消毒用組成物は、脂肪酸トリグリセリドの代わりにグリセリンを含有しているので、塗布後の皮膚のべたつき感があり、使用の円滑さに欠けると評価された。
　比較例５の消毒用組成物は、ＭＰＣ共重合体中の構成単位（１）と構成単位（２）の含有量の比が適切でないため、無色澄明の液にはならず、評価に適さないことを確認した。
　比較例６の消毒用組成物は、トリイソオクタン酸グリセリンの含有量が多いので、塗布後の皮膚のべたつき感があり、使用の円滑さに欠けると評価された。 As shown in Table 1, for each of the disinfecting compositions of Examples 1 to 10 of the present disclosure, the skin after application was evaluated to have little or no sticky feeling, and to have a moist or sufficient feeling. and was rated moderately good or excellent in smoothness of use.
The antiseptic compositions of Examples 2, 3, 4, 6, 7, 8, 9 and 10 containing 0.5% by mass or more of fatty acid triglyceride were evaluated as sufficiently moist to the skin after application.
The disinfecting compositions of Examples 4, 8 and 9 containing lactic acid were rated as having excellent moisturizing properties.
Since the disinfecting compositions of Comparative Examples 1 and 2 did not contain fatty acid triglycerides, they were evaluated as lacking smoothness of use.
Since the disinfecting composition of Comparative Example 3 does not contain an MPC copolymer, it was evaluated as lacking smoothness of use.
Since the disinfecting composition of Comparative Example 4 contained glycerin instead of fatty acid triglycerides, it was evaluated as giving a sticky feeling to the skin after application and lacking smoothness in use.
The disinfecting composition of Comparative Example 5 does not form a clear and colorless liquid because the content ratio of the structural unit (1) and the structural unit (2) in the MPC copolymer is not appropriate, and is not suitable for evaluation. It was confirmed.
Since the disinfecting composition of Comparative Example 6 contained a large amount of glyceryl triisooctanoate, the skin felt sticky after application, and was evaluated as lacking smoothness in use.
　実施例および比較例の各消毒用組成物の上記評価結果より、本開示の消毒用組成物は、比較例の消毒用組成物に比べて、塗布後の皮膚のべたつきがなくかつしっとりとした使用感を提供することができ、さらに、電子機器の使用を円滑に行うことも提供できる。 From the above evaluation results of the disinfecting compositions of Examples and Comparative Examples, the disinfecting composition of the present disclosure has no sticky and moist skin after application compared to the disinfecting composition of the Comparative Example. It can provide a feeling and furthermore, it can provide smooth use of the electronic device.
　塗布後の皮膚のべたつきがなくかつしっとりとした使用感を提供することができ、さらに、電子機器の使用を円滑に行うことも提供できる消毒用組成物を提供することができる。 It is possible to provide a disinfecting composition that can provide a non-sticky and moist feel to the skin after application, and can also provide smooth use of electronic devices.

Claims (6)

  1. 　１）重量平均分子量１，０００～１，０００，０００であり、下記式（１）で表される２－（メタ）アクリロイルオキシエチルホスホリルコリンに基づく構成単位（１）と、下記式（２）で表されるアルキル基含有（メタ）アクリル系単量体に基づく構成単位（２）を含み、該構成単位（１）と該構成単位（２）の含有量の比がモル比にて１５：８５～４５：５５である共重合体（Ｐ）　０．００１質量％～１０質量％と、
    　２）炭素数1～5の1価アルコール　５５質量％～９０質量％と、及び
    　３）脂肪酸トリグリセリド　０．００１質量％～１質量％
    　を含む消毒用組成物。
    Figure JPOXMLDOC01-appb-C000001
     （式（１）中、Ｒ１は水素原子またはメチル基を示す。）
    Figure JPOXMLDOC01-appb-C000002
     （式（２）中、Ｒ２は水素原子またはメチル基を示し、Ｒ３は炭素数４～２２のアルキル基を示す。）
    1) A structural unit (1) based on 2-(meth)acryloyloxyethylphosphorylcholine having a weight average molecular weight of 1,000 to 1,000,000 and represented by the following formula (1), and the following formula (2) Containing a structural unit (2) based on the alkyl group-containing (meth)acrylic monomer represented, the content ratio of the structural unit (1) to the structural unit (2) is 15:85 in terms of molar ratio 0.001% by mass to 10% by mass of a copolymer (P) that is ~45:55;
    2) 55% to 90% by mass of monohydric alcohol having 1 to 5 carbon atoms, and 3) 0.001% to 1% by mass of fatty acid triglyceride
    A disinfecting composition comprising:
    Figure JPOXMLDOC01-appb-C000001
     (In formula (1), R 1 represents a hydrogen atom or a methyl group.)
    Figure JPOXMLDOC01-appb-C000002
     (In formula (2), R 2 represents a hydrogen atom or a methyl group, and R 3 represents an alkyl group having 4 to 22 carbon atoms.)
  2. 　炭素数1～5の1価アルコールが、エタノールおよびイソプロパノールからなる群より選択される１種以上である、請求項１に記載の消毒用組成物。
    The disinfecting composition according to claim 1, wherein the monohydric alcohol having 1 to 5 carbon atoms is one or more selected from the group consisting of ethanol and isopropanol.
  3. 　脂肪酸トリグリセリドが、トリイソオクタン酸グリセリンおよびトリカプリル酸グリセリンからなる群より選択される１種以上である、請求項１～２のいずれか１項に記載の消毒用組成物。
    The disinfecting composition according to any one of claims 1 and 2, wherein the fatty acid triglyceride is one or more selected from the group consisting of glyceryl triisooctanoate and glyceryl tricaprylate.
  4. 　さらに、有機酸を含有する、請求項１～３のいずれか１項に記載の消毒用組成物。
          The disinfecting composition according to any one of claims 1 to 3, further comprising an organic acid.
  5. 　前記炭素数1～5の1価アルコールがエタノールであり、かつ、前記脂肪酸トリグリセリドがトリカプリル酸グリセリンである、請求項１に記載の消毒用組成物。
          The disinfecting composition according to claim 1, wherein the monohydric alcohol having 1 to 5 carbon atoms is ethanol and the fatty acid triglyceride is glyceryl tricaprylate.
  6. 　前記炭素数1～5の1価アルコールがエタノールであり、かつ、前記脂肪酸トリグリセリドがトリイソオクタン酸グリセリンである、請求項１に記載の消毒用組成物。
          The disinfecting composition according to claim 1, wherein the monohydric alcohol having 1 to 5 carbon atoms is ethanol and the fatty acid triglyceride is glyceryl triisooctanoate.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11246329A (en) * 1998-02-27 1999-09-14 Shiseido Co Ltd Skin preparation for external use
JP2002080401A (en) * 2000-06-21 2002-03-19 Nof Corp Gel composition for external preparation
JP2008115125A (en) * 2006-11-07 2008-05-22 Nof Corp Quick-drying transparent lotion for sterilization
JP2011219410A (en) * 2010-04-08 2011-11-04 Kao Corp Hand disinfectant composition
JP2019104719A (en) * 2017-12-14 2019-06-27 日油株式会社 disinfectant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11246329A (en) * 1998-02-27 1999-09-14 Shiseido Co Ltd Skin preparation for external use
JP2002080401A (en) * 2000-06-21 2002-03-19 Nof Corp Gel composition for external preparation
JP2008115125A (en) * 2006-11-07 2008-05-22 Nof Corp Quick-drying transparent lotion for sterilization
JP2011219410A (en) * 2010-04-08 2011-11-04 Kao Corp Hand disinfectant composition
JP2019104719A (en) * 2017-12-14 2019-06-27 日油株式会社 disinfectant

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