WO2022080197A1

WO2022080197A1 - Disinfecting composition

Info

Publication number: WO2022080197A1
Application number: PCT/JP2021/036897
Authority: WO
Inventors: 真佐夫原; 俊輔櫻井
Original assignee: 日油株式会社
Priority date: 2020-10-13
Filing date: 2021-10-06
Publication date: 2022-04-21
Also published as: JPWO2022080197A1

Abstract

According to the present invention, it is possible to provide a disinfecting composition which makes skin gloss improved after application to skin, and by which, when wearing a protective tool such as gloves after the composition is used on the skin such as that on the fingers, the protective tool can be put on and off with ease.　A disinfecting composition according to the present invention contains 0.001-10 mass% of proteoglycan, 40-90 mass% of a lower grade alcohol, and 0.0001-1 mass% of an anionic polymer surfactant.

Description

Disinfectant composition

The present invention relates to a disinfectant composition, and more particularly to a disinfectant composition capable of smoothly attaching and detaching a protective device when the protective device is used, that is, when the protective device is attached after being applied to the skin or the like.

In recent years, there are concerns about the spread of infectious diseases caused by pathogenic viruses and bacteria, and various infection control-related products are being developed. Among them, the disinfectant composition has an advantage that it can be sterilized and disinfected just by using it on the fingers, and is widely used.
In the disinfecting composition, in order to have a wide bactericidal spectrum and to enhance the bactericidal activity, measures have been taken such as blending a specific bactericidal component or adjusting the pH of the composition to a specific range. For example, there is disclosed a fungicide composition in which an alkaline agent is contained in a fungicide composition containing a polyalkylene biguanide compound and the pH of the composition is 12.5 or higher (Patent Document 1).
In addition, in the bactericidal composition containing a high content of lower alcohol such as ethanol for the purpose of maintaining the bactericidal activity and improving the usability such as quick-drying and non-stickiness, the type and composition of the thickener. Some measures have been taken to adjust the pH of the object to a specific range. For example, a gel-like hand sterilizer has been proposed in which a carboxyvinyl polymer is neutralized with an alkali metal hydroxide and polyethylene glycol having a specific molecular weight is used to prevent white turbidity of the composition (Patent Document 2).

However, since the above-mentioned disinfectant composition does not have a pH in the neutral region or contains a relatively large amount of lower alcohol, the disinfectant composition is frequently used like medical personnel. In some cases, there was a risk of rough hands.
Therefore, in order to impart the effect of preventing rough hands to the disinfectant composition, a moisturizer such as glycerin, propylene glycol or sorbitol is blended (Patent Document 3), or a water-soluble polyhydric alcohol and a fatty acid triglyceride are blended (Patent). Further ingenuity has been made, such as Document 4).
The device proposed in the above patent document has made it possible to provide a disinfectant composition that is not sticky and can give a moist feeling.
However, if the ethanol content is increased in order to enhance the disinfecting power, there is a problem that the glossiness of the fingers is lost due to the high degreasing power and the appearance of the skin deteriorates. It was strongly requested.
In addition, when the disinfectant composition is frequently used, such as in medical personnel, and when protective equipment such as plastic or rubber gloves is attached to the fingers after use, it is highly moisturizing for disinfection. When the composition is used, there is a problem that it becomes difficult to put on and take off the protective equipment, and even when the protective equipment is put on the skin after being used on the skin by doctors and nurses working at medical institutions, the protective equipment can be put on and taken off smoothly. There has been a strong demand for a disinfectant composition that can be used in.

Japanese Unexamined Patent Publication No. 2016-160245 Japanese Unexamined Patent Publication No. 2011-144146 Japanese Unexamined Patent Publication No. 2004-155712 Japanese Unexamined Patent Publication No. 2011-219410

Therefore, the present invention is a disinfectant that has an excellent glossiness of the skin after use and can smoothly put on and take off the protective device when wearing a protective device such as gloves after using it on the skin such as fingers. The subject is the provision of a composition for use.

As a result of diligent studies to solve the above problems, the present inventors have made a disinfectant composition containing proteoglycan, a lower alcohol and an anionic polymer surfactant, thereby glossing the skin after use. It has been found that the above-mentioned problems can be solved by excellent feeling and smooth attachment / detachment when the protective device is attached after the disinfectant composition is used on the skin, and the present invention has been completed.

That is, the present invention relates to the following.
[1] Disinfectant composition containing 0.001% by mass to 10% by mass of proteoglycan, 40% by mass to 90% by mass of lower alcohol, and 0.001% by mass to 1% by mass of anionic polymer surfactant. ..
[2] The disinfectant composition according to [1], wherein the proteoglycan is a plant-derived proteoglycan.
[3] The disinfectant composition according to [1] or [2], wherein the lower alcohol is at least one selected from the group consisting of ethanol and isopropanol.
[4] The anionic polymer surfactant is at least one selected from the group consisting of an ethylene / maleic anhydride copolymer and a methyl vinyl ether / maleic anhydride copolymer, [1] to [3]. The disinfectant composition according to any one of.
[5] The disinfectant composition according to any one of [1] to [4], further containing a bactericidal agent.
[6] The disinfectant composition according to any one of [1] to [5], further containing a copolymer containing a structural unit based on 2- (meth) acryloyloxyethyl phosphorylcholine.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a disinfectant composition which is excellent in the glossiness of the skin after use and is excellent in the smoothness of attachment and detachment when the protective device is attached to the skin.
When the disinfectant composition of the present invention is used for fingers and the like, it is possible to give a good appearance with a glossy feeling to the skin and prevent rough hands, and further, after using the disinfectant composition, gloves and the like. When the protective equipment is attached, the protective equipment can be smoothly attached and detached.

The disinfectant composition of the present invention contains proteoglycan, a lower alcohol and an anionic polymer surfactant.

The proteoglycan contained in the disinfectant composition of the present invention is a complex of sugar and protein having a special structure, and animal and vegetable proteoglycans are present.
Animal proteoglycan is a glycoprotein in which multiple glycosaminoglycans such as chondroitin sulfate and keratan sulfate are covalently bonded to one core protein, and as a component of extracellular matrix, organs, brain, skin, and cartilage. It is widely distributed in the body.
Plant-derived proteoglycan is a combination of arabinogalactan and core protein in a certain manner, officially called arabinogalactan-protein (AGP), as an extracellular matrix on the cell wall and sap of plants. exist.

As the animal proteoglycan, water-soluble proteoglycan obtained by extracting and purifying from salmon nasal cartilage, shark fin cartilage, squid head cartilage and the like is preferably used.
In the present invention, the animal proteoglycan may be used in any of a liquid form such as an aqueous solution and a dispersion, and a solid form such as a powder.
As the animal proteoglycan, it may be manufactured and used by extracting and purifying it from animal tissues such as salmon nasal cartilage, shark fin cartilage and squid head cartilage, but commercially available products provided by each company should be used. Can be done.

As the plant-derived proteoglycan, those made from gum arabic (Acacia senegal Wildenow) belonging to the genus Acacia of the subfamily Mimosoideae of the family Leguminosae, or gum arabic obtained from a plant closely related to the same genus are preferably used. Here, gum arabic is a dried secretion liquid exuding from a wound on the bark of the plant.
Since it is possible to obtain a substance having a physiological activity equal to or higher than that of animal proteoglycan, the object of the present invention is to obtain gum arabic obtained from gum arabic (Acacia senegal Wildenow) or its seyal species, Acacia serial Delile. Those made of a raw material are more preferable, and those made of gum arabic obtained from gum arabic (Acacia senegal Wildenow) are further preferably used.

In the present invention, the plant-derived proteoglycan preferably used as a proteoglycan is obtained as a purified product obtained by removing mainly arabinogalactan and glycoprotein from gum arabic obtained from a plant such as gum arabic described above.
For the purposes of the present invention, plant proteoglycans have a weight average molecular weight of 900,000 to 3,500,000 as measured by size exclusion chromatography with an online connection of a multi-angle light scattering detector and a differential index detector. Some are preferably used, and those with a value of 1,000,000 to 3,000,000 are more preferably used.
Further, it is measured by an aldehyde quantification kit such as Amplite ™ aldehyde quantification kit (colorimetric) (Colorimetric Aldehyde Quantation Kit) (product number: 10015) (manufactured by AAT Bioquest). Those having a total aldehyde content of 0.005 μmol equivalent / g to 2 μmol equivalent / g are preferably used.
In the present invention, the vegetable proteoglycan may be used in any of a liquid form such as an aqueous solution and a dispersion, and a solid form such as a powder.
Further, the plant proteoglycan is preferably purified by subjecting an aqueous Arabic rubber solution prepared in an amount of 0.5% by mass to 40% by mass to a porous type I strong basic anion exchange resin and a strong acid cation exchange resin. Although it can be produced, in the present invention, as a plant proteoglycan, a product commercially available as an aqueous solution having an effective content of about 1% by mass can also be used.

In the present invention, as the proteoglycan, any of the above-mentioned plant-derived proteoglycan and animal-derived proteoglycan can be used, and one type may be used alone or two or more types may be used in combination.
However, considering the production cost and the tendency of recent preference for plant-based raw materials, it is preferable to use plant-based proteoglycan.

The content of proteoglycan in the disinfectant composition of the present invention is 0.001% by mass to 10% by mass, and the smoothness of attachment / detachment when attaching the protective device after use on the skin (hereinafter referred to as the present specification). From the viewpoint of "smoothness of attachment / detachment"), it is preferably 0.005% by mass to 5% by mass.
If the content of proteoglycan is less than 0.001% by mass, it is not possible to impart sufficient smoothness of attachment / detachment to the disinfectant composition, and even if the content of proteoglycan exceeds 10% by mass, the effect commensurate with the content. May not be obtained.

The lower alcohol contained in the disinfectant composition of the present invention is usually an alcohol having 5 or less carbon atoms, can dissolve proteoglycans and anionic polymer surfactants, and can be used for the skin. Any alcohol can be used without particular limitation, but a monohydric alcohol having 3 or less carbon atoms is preferable, and a monohydric alcohol having 2 or 3 carbon atoms is more preferable.
Examples of the lower alcohol preferably used in the present invention include ethanol, propanol, isopropanol and the like, and ethanol and isopropanol are more preferably used.
In the present invention, one type of lower alcohol may be used alone, or two or more types may be used in combination.
As the lower alcohol, products commercially available from various companies for pharmaceuticals, cosmetics, etc. can be used.

When the disinfectant composition of the present invention contains a lower alcohol, the interfacial tension of the disinfectant composition decreases, and the composition easily spreads to the uneven portion of the skin, so that the uniformity during film formation is improved. , It becomes easy to apply evenly to the skin and medical equipment, and the smoothness of putting on and taking off becomes good.
The content of the lower alcohol in the disinfectant composition of the present invention is 40% by mass to 90% by mass, preferably 50% by mass to 80% by mass, and more preferably 60% by mass to 80% by mass.
If the content of the lower alcohol is less than 40% by mass, the uniformity of the formed film may be lowered, and the smoothness of attachment / detachment may be inferior. On the other hand, even if the lower alcohol is contained in an amount of more than 90% by mass, the effect commensurate with the content may not be obtained, and the solubility of proteoglycan may be lowered.

Examples of the anionic polymer surfactant contained in the disinfectant composition of the present invention include polyacrylic acid, sodium polyacrylic acid, acrylic acid / acryloyldimethyltaurate copolymer, and acrylic acid / alkyl methacrylate copolymer. Acrylic acid-based polymer surfactants such as; Polymethacrylic acid, Methacrylic acid-based polymer surfactants such as polysodium methacrylate; Maleic acid-based polymer surfactants such as methylvinyl ether / maleic acid copolymer; Anhydrous Maleic anhydride homopolymer, acrylic acid / maleic anhydride copolymer, ethylene / maleic anhydride copolymer, styrene / maleic anhydride copolymer, methyl vinyl ether / maleic anhydride copolymer, etc. Examples include polymer surfactants.
In the disinfecting composition of the present invention, one type of anionic polymer surfactant may be selected and used alone, or two or more types may be used in combination.

For the purposes of the present invention, a maleic anhydride-based polymer surfactant is preferably used.
The maleic anhydride-based polymer surfactant may be a homopolymer of maleic anhydride or a copolymer, but both ethylene / maleic anhydride copolymer and methyl vinyl ether / maleic anhydride. A polymer such as a polymer is preferable, and a methyl vinyl ether / maleic anhydride copolymer is particularly preferable in terms of availability and the like.
Further, a free acid type in which the maleic anhydride group of the maleic anhydride copolymer is ring-opened with water or alcohol, or a copolymer in which a monoalkyl ester is used may be used.
As the methyl vinyl ether / maleic anhydride copolymer, for example, a copolymer sold by AISP (ISP) under the trade name of GANTREZ AN series can be used, and the composition of the copolymer can be used. A copolymer in which the ratio (molar ratio) of the unit methyl vinyl ether to maleic anhydride is approximately 1: 1 is preferable.

The weight average molecular weight of the anionic polymer surfactant is not particularly limited, but is usually 10,000 to 3,000,000, preferably 100,000 to 2,000,000.
The weight average molecular weight of the anionic polymer surfactant is measured by size exclusion chromatography connected online with a differential refractometer detector and is expressed in terms of sodium polystyrene sulfonate equivalent molecular weight. In the chromatography, as the eluent, for example, a 5 mM phosphate buffer solution (pH = 8.0) to which acetonitrile is added can be used.

In the present invention, the anionic polymer surfactant may be produced and used by appropriately polymerizing a monomer as a constituent unit, but is commercially available from various companies such as the above-mentioned GANTREZ AN series. The product can be used.
The content of the anionic polymer surfactant in the disinfectant composition of the present invention is usually 0.0001% by mass to 1% by mass, preferably 0.005% by mass to 1% by mass.
If the content of the anionic polymer surfactant is less than 0.0001% by mass, the smoothness of attachment / detachment may be inferior, and if it exceeds 1% by mass, stickiness or sliminess may increase when rubbing against fingers. be.

In the present invention, anionic polymer surfactants such as acrylic acid-based polymer surfactants, methacrylic acid-based polymer surfactants, maleic acid-based polymer surfactants, and maleic anhydride-based polymer surfactants. When used in combination with a neutralizing agent, the agent is preferable because the carboxylate ion increases and the repulsion between the negative ions increases, so that the viscosity can be increased.
Examples of the neutralizing agent include inorganic bases such as sodium hydroxide, potassium hydroxide and ammonium hydroxide salt, and water-soluble substances such as triethanolamine, aminomethylpropanol and 2-amino-2-hydroxymethyl-1,3-propanediol. Examples thereof include sex amines. In the disinfectant composition of the present invention, the neutralizing agent is used so that the pH of the solution of the anionic polymer surfactant is about 4 to 10 depending on the content of the anionic polymer surfactant. Is preferable.

Further, the disinfecting composition of the present invention may contain a disinfectant, if necessary, from the viewpoint of disinfecting effect.
In the disinfectant composition of the present invention, the bactericidal agent is an agent capable of killing or suppressing the growth of pathogenic microorganisms, which can be used for disinfecting the skin, and is a proteoglycan and an anionic polymer. As long as the surfactant does not impair the above-mentioned effect on the smoothness of attachment / detachment, it can be used without particular limitation.
Such disinfectants include cationic surfactants such as benzalkonium chloride, benzethonium chloride and cetylpyridinium chloride; amphoteric surfactants such as alkyldiaminoethylglycine hydrochloride; biguanide compounds such as chlorhexidine gluconate and chlorhexidine hydrochloride; iodine. Halogen (iodine) compounds such as ions, iodoform and povidone iodine; silver-based inorganic compounds such as silver ions; phenol-based compounds such as cresol and isopropylmethylphenol can be mentioned.
From the viewpoint of bactericidal activity and low irritation to the skin, benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate and the like are preferably used.
In the disinfectant composition of the present invention, one type of disinfectant may be used alone, or two or more types may be selected and used in combination.

In the present invention, as the bactericide, products commercially available from various companies for pharmaceuticals, cosmetics, etc. can be used.
The content of the disinfectant in the disinfectant composition of the present invention can be appropriately set depending on the type of the disinfectant and the like, but is preferably 0.01% by mass to 5% by mass, and more preferably 0.01% by mass or more. It is 0.05% by mass.

Further, the disinfectant composition of the present invention is a copolymer containing a structural unit based on 2- (meth) acryloyloxyethyl phosphorylcholine (MPC) (hereinafter, "MPC copolymer") as long as the effect of the present invention is not impaired. May be described as).
Examples of the MPC copolymer that can be contained in the disinfectant composition of the present invention include a copolymer containing a structural unit based on acrylamide and a structural unit based on a hydrophobic monomer, and are based on the hydrophobic monomer. Examples of the structural unit include a structural unit based on a (meth) acrylic acid alkyl ester, a (meth) acrylamide derivative, and the like.

The structural unit based on MPC is represented by the following formula (1). In addition, in this specification, "(meth) acryloyl" means "acryloyl or methacryloyl".

(In the formula, R ¹ represents a hydrogen atom or a methyl group.)

The structural unit based on the (meth) acrylic acid alkyl ester is represented by the following formula (2). Here, "(meth) acrylic acid" means "acrylic acid or methacrylic acid".

(In the formula, R ² represents a hydrogen atom or a methyl group, and R ³ represents an alkyl group having 1 to 24 carbon atoms.)

In the formula ( ² ), the alkyl group represented by R3 is a linear or branched alkyl group having 1 to 24 carbon atoms, and is methyl, ethyl, propyl, butyl, pentyl, hexyl, octyl, 2-ethylhexyl, decyl. , Dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl and the like are exemplified.

Therefore, the structural unit based on the (meth) acrylic acid alkyl ester represented by the formula (2) includes methyl (meth) acrylate, ethyl (meth) acrylate, propyl (meth) acrylate, and (meth) acrylic acid. Examples thereof include structural units based on butyl, 2-ethylhexyl (meth) acrylate, dodecyl (meth) acrylate, tridecyl (meth) acrylate, octadecyl (meth) acrylate, docosyl (meth) acrylate and the like.
Further, as a structural unit based on the (meth) acrylic acid alkyl ester, (meth) acrylic acid diethylaminoethyl, (meth) acrylic acid trifluoroethyl, (meth) acrylic acid heptadecafluorodecyl, etc., in the above formula (2), The (meth) acrylic acid alkyl ester in which the alkyl group represented by R ³ is substituted with a dialkylamino group, a halogen atom, or the like, or the alkyl group represented by R ³ is substituted with a hydroxyl group and a quaternary ammonio group. A structural unit based on 2-hydroxy-3- (meth) acryloyloxypropyltrimethylammonium chloride having a structure is also exemplified as a structural unit based on a hydrophobic monomer.

The structural unit based on the (meth) acrylamide derivative is represented by the following formula (3). Here, "(meth) acrylamide" means "acrylamide or methacrylamide".

(In the formula, R ⁴ represents a hydrogen atom or a methyl group, R ⁵ and R ⁶ each independently represent a methyl group or an ethyl group, and m represents an integer of 1 to 3.)

For the object of the present invention, a copolymer containing N, N-dimethylaminoethylacrylamide or a structural unit based on N, N-dimethylaminopropylacrylamide is preferable as the structural unit based on the (meth) acrylamide derivative.

In the present invention, as the MPC copolymer, a copolymer containing one or more structural units based on MPC and the above-mentioned hydrophobic monomer can be used.
An object of the present invention is to use a structural unit based on a (meth) acrylic acid alkyl ester, a structural unit based on 2-hydroxy-3- (meth) acryloyloxypropyltrimethylammonium chloride, as a structural unit based on a hydrophobic monomer. And a copolymer containing one or more selected from the group consisting of structural units based on (meth) acrylamide derivatives is preferably used.

The ratio of the content of each of the constituent units based on MPC and the constituent unit based on the hydrophobic monomer in the MPC copolymer ([Constituent unit based on MPC]: [Constituent unit based on hydrophobic monomer]] ) (N ₁ : n ₂ ) have a molar ratio of 9: 1 to 2: 1, preferably 8: 1 to 7: 3, and more preferably 6: 1 to 3: 1.

The weight average molecular weight of the MPC copolymer contained in the disinfectant composition of the present invention is 10,000 to 5,000,000, preferably 20,000 to 1,000,000.
If the weight average molecular weight of the MPC copolymer is less than 10,000, the film property may be deteriorated and the effect of improving the smoothness of attachment / detachment may not be expected. The viscosity may increase sharply, making it difficult to prepare a disinfectant composition.
The weight average molecular weight of the MPC copolymer is measured by gel permeation chromatography (GPC) and is shown by the molecular weight in terms of pullulan.

The polymerization form of the MPC copolymer is not particularly limited, and it may be a random copolymer or a block copolymer, but a random copolymer is preferable.
Further, the MPC copolymer may be a copolymer containing other structural units in addition to the structural unit based on MPC and the structural unit based on the hydrophobic monomer.
The other structural units can be appropriately selected from those that can usually be the structural units of the copolymer as long as they do not affect the effects of the present invention.
Other building blocks include, for example, alkenyl esters of (meth) acrylic acids such as allyl (meth) acrylic acid; cyclic alkyl esters of (meth) acrylic acids such as cyclohexyl (meth) acrylic acid; tetrahydro (meth) acrylic acid. A (meth) acrylic acid ester having an alkyl group substituted with a heterocycle such as furfuryl; a (meth) acrylic acid ester containing an aromatic group such as benzyl (meth) acrylate and phenoxyethyl (meth) acrylate; Esters of (meth) acrylic acid such as isobornyl (meth) acrylic acid and monoterpene alcohol; (meth) glycidyl acrylate; styrene-based monomers such as styrene, methylstyrene and chloromethylstyrene; methylvinyl ether, butylvinyl ether and the like. Vinyl ether-based monomer; A structural unit based on a vinyl ester-based monomer such as vinyl acetate and vinyl propionate can be mentioned.
These other constituent units may contain one or more, and their content in the MPC copolymer is relative to the total amount of the MPC-based constituent units and the hydrophobic monomer-based constituent units. It is 40 mol% or less, preferably 20 mol% or less.

The MPC copolymer can be produced by a known production method.
For example, in the presence of a radical polymerization initiator, a monomer mixture containing a hydrophobic monomer such as MPC and (meth) acrylic acid alkyl ester and, if necessary, a monomer corresponding to the other structural units described above. , It can be produced by polymerization in an atmosphere of an inert gas such as nitrogen by a known method such as solution polymerization.
The content ratio of each monomer at that time may be a ratio corresponding to the content ratio of each structural unit in the MPC copolymer.
The MPC copolymer can be produced and used by the above-mentioned polymerization method, but a commercially available product as a solution or dispersion of water or a polyhydric alcohol can also be used.

In the disinfectant composition of the present invention, one type of the above-mentioned MPC copolymer may be selected and used alone, or two or more types may be selected and used in combination.
The form of the MPC copolymer contained in the disinfectant composition of the present invention may be solid such as powder or liquid such as a solution or a dispersion.

The content of the MPC copolymer in the disinfectant composition of the present invention can be appropriately selected in the range of 0.001% by mass to 10% by mass, and from the viewpoint of smooth attachment / detachment, 0.005% by mass or more. It is preferable to select in the range of 5% by mass.
If the content of the MPC copolymer is less than 0.001% by mass, the disinfectant composition may not be smoothly attached and detached, and if the content of the MPC copolymer exceeds 10% by mass, the reverse is true. In some cases, the smoothness of attachment and detachment may be impaired.

The disinfectant composition of the present invention usually contains water.
In preparing the disinfectant composition of the present invention, it is preferable to use the above-mentioned lower alcohol as a mixed solvent with water because the adhesion of the proteoglycan and the anionic polymer surfactant to the skin can be improved. .. This is because the hydrophobic groups of the proteoglycan and the anionic polymer surfactant can be effectively oriented on the skin surface because the evaporation rates of the lower alcohol and the water are different when the composition is dried.
As the water contained in the disinfectant composition of the present invention, water generally used for cosmetics or pharmaceuticals can be used, and ion-exchanged water, purified water, water for injection and the like are preferably used.
The content of water in the disinfectant composition of the present invention is preferably 3% by mass to 59% by mass, and more preferably 5% by mass to 50% by mass.
If the water content is less than 3% by weight, or more than 59% by weight, the adhesion of proteoglycan to the skin may decrease.

In addition, the disinfectant composition of the present invention may contain a wetting agent as long as the effects of the present invention are not impaired.
Examples of the wetting agent include ethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, pentylene glycol, hexylene glycol, isoprene glycol, 2-ethyl-1,3-. Dihydric alcohols such as hexanediol and isopentyldiol; glycerin; glycerin condensates such as diglycerin and polyglycerin; polyol-based compounds such as sugar alcohols such as sorbitol, xylitol, martitol, mannitol and erythritol. The seeds can be used alone or as a mixture of two or more.
Among these wetting agents, propylene glycol, dipropylene glycol, 1,3-butylene glycol and glycerin are more preferably used because of their good compatibility with the skin.
The content of the wetting agent in the disinfectant composition of the present invention is selected within a range that does not impair the effect of the present invention, and is preferably 0.01% by mass to 10% by mass.

The disinfectant composition of the present invention can further contain additives generally used for external preparations such as disinfectant compositions, as long as the effects of the present invention are not impaired.
Examples of such additives include nonionic surfactants, thickeners, foaming agents, propellants, organic acids, antioxidants, stabilizers, preservatives, sequestrants, fragrances, pigments, coloring materials and the like. Can be mentioned. These additives may be used alone or in combination of two or more depending on the purpose.

The disinfectant composition of the present invention comprises the above-mentioned proteoglycan, lower alcohol, anionic polymer surfactant and the like, as required, a bactericide, an MPC copolymer, water, a wetting agent and other general additives. Can be added and mixed as appropriate to produce a uniform product.

The disinfectant composition of the present invention may be provided in a liquid form, a semi-solid form such as a paste, or the like.
From the viewpoint of convenience and safety during use, the disinfectant composition of the present invention is in a liquid form, and is a liquid discharge type filled in a container with a dispenser pump, a spray type filled in a container with a spray pump, and a former. It is preferable to use a product such as a foam discharge type filled in a container with a pump or an aerosol container, or an impregnated type impregnated with a cleaning wipe.
When the disinfectant composition of the present invention is used, for example, for disinfecting fingers, it is possible to take an appropriate amount (about 1 mL to 3 mL) of the disinfectant composition in the hand, rub it on the fingers to apply it, and then dry it before use. can.
When the disinfecting composition of the present invention is impregnated into a wiping wipe, 100 parts by mass of the wiping wipe is impregnated with about 10 parts by mass to 400 parts by mass of the disinfecting composition of the present invention, and the wipe is impregnated. It can be used by wiping the skin and medical equipment.

The disinfectant composition of the present invention is excellent in the glossiness of the skin after use and is excellent in the smoothness of putting on and taking off. Therefore, when the disinfectant composition of the present invention is used on the skin of fingers or the like, it is possible to give the skin a good glossy appearance and prevent rough hands, and further, after using the composition on the skin of fingers or the like. When wearing protective equipment such as gloves, the protective equipment can be smoothly attached and detached.

Hereinafter, the present invention will be described in more detail with reference to examples.

[Examples 1 to 7, Comparative Examples 1 to 4]
The disinfecting compositions of Examples 1 to 7 and Comparative Examples 1 to 4 were prepared as follows according to the formulations shown in Table 1.
An anionic polymer surfactant was added to 10 g of purified water, and the mixture was stirred at 80 ° C. to completely dissolve the mixture, and then cooled to room temperature. Further, an aqueous sodium hydroxide solution (1 mol / L) was added to the solution, and the mixture was stirred and mixed to make it uniform. Then, vegetable proteoglycan, MPC copolymer and benzalkonium chloride were added, stirred and mixed to make them uniform. Ethanol was added to the aqueous solution, and the mixture was sufficiently stirred and mixed to make it uniform. Purified water was added so that the total amount was 100 g, and a disinfectant composition was prepared.

As the anionic polymer surfactant, a methylvinyl ether / maleic anhydride copolymer (“Gantrez AN-119”, manufactured by ASP Japan Co., Ltd., weight average molecular weight = 216,000) is used. As the vegetable proteoglycan, one having a weight average molecular weight of about 1,200,000 and a total aldehyde content of 1.8 μmol equivalent / g was used, and as the MPC copolymer, MPC / butyl methacrylate copolymer weight was used. A coalescence (copolymerization composition ratio of MPC and butyl methacrylate [MPC / butyl methacrylate] (molar ratio) = 80/20, weight average molecular weight = 600,000) was used.
As ethanol and benzalkonium chloride, general raw materials commercially available for external use were used.

For each of the disinfecting compositions of the above Examples and Comparative Examples, the smoothness of attachment / detachment when the protective device was attached after use on the skin and the glossiness of the skin after use were evaluated as follows.

(1) Evaluation of smoothness of attachment / detachment (“smoothness of attachment / detachment”) when attaching protective equipment after use on the skin For each disinfectant composition of Examples and Comparative Examples, the smoothness of attachment / detachment is 25 years old. It was evaluated by sensory evaluation by 20 male and female panelists aged up to 55 years.
That is, in an environment of room temperature = 25 ° C. and relative humidity = 60%, each panelist was asked to pick up 2 mL of each of the disinfectant compositions, rub them into the fingers 10 times, and then rubber gloves (“FT latex”, “FT latex”. Tokyo Glass Instruments Co., Ltd. (TGK) was attached and detached, and the smoothness of attachment and detachment was evaluated according to the following evaluation criteria. The total score of the evaluation points of the 20 panelists was calculated, and the smoothness of attachment / detachment was judged according to the following criteria.
<Evaluation criteria>
Protective equipment can be attached / detached smoothly; 2 points Protective equipment can be attached / detached slightly smoothly; 1 point Protective equipment cannot be attached / detached smoothly; 0 points <Judgment criteria>
31 points to 40 points: ◎; Disinfectant composition with excellent attachment / detachment smoothness 21 points to 30 points: ○; Disinfection composition with slightly excellent attachment / detachment smoothness 20 points or less: ×; Smooth attachment / detachment It is a disinfectant composition that lacks

(2) Evaluation of skin gloss after use The skin gloss after using each disinfectant composition of Examples and Comparative Examples on the skin is sensory evaluated by 20 male and female panelists aged 25 to 55 years. Evaluated by.
That is, in an environment of room temperature = 25 ° C. and relative humidity = 60%, each panelist was asked to pick up 2 mL of each of the disinfectant compositions, rub them into the fingers 10 times, and then visually check the glossiness of the fingers. It was evaluated according to the following evaluation criteria. The total score of the evaluation points of 20 panelists was calculated, and the glossiness of the skin after use was judged according to the following criteria.
<Evaluation criteria>
Glossy: 2 points Slightly glossy: 1 point No gloss: 0 points <Judgment criteria>
31 points to 40 points: ◎; Disinfectant composition with glossy skin after use 21 to 30 points: ○; Disinfectant composition with slightly glossy skin after use 20 points or less : ×; A disinfectant composition that does not give a glossy feeling to the skin after use.

Table 1 also shows the evaluation results of the smoothness of attachment and detachment and the glossiness of the skin after use.

As shown in Table 1, each of the disinfecting compositions of Examples 1 to 7 of the present invention was evaluated to be excellent or slightly excellent in smoothness of attachment and detachment, and the skin after use was evaluated as having good or slightly good gloss. It was evaluated to have a feeling. In particular, the disinfectant compositions of Examples 1, 2 and 6 containing the MPC copolymer in addition to 0.01% by mass of the vegetable proteoglycan and 0.01% by mass of the anionic polymer surfactant are removable. It was found that both the smoothness of the skin and the glossiness of the skin after use were excellent.
On the other hand, in the disinfectant composition of Comparative Example 1, which contained an anionic polymer surfactant and an MPC copolymer but did not contain vegetable proteoglycan, a glossy feeling of the skin after use was observed. It was evaluated that the smoothness of attachment and detachment was insufficient. Further, Comparative Example 2, which contains an anionic polymer surfactant but does not contain a vegetable proteoglycan and an MPC copolymer, and a vegetable proteoglycan containing a vegetable proteoglycan but does not contain an anionic polymer surfactant and an MPC copolymer. In each of the disinfecting compositions of Comparative Example 3 which does not contain the MPC copolymer but does not contain both the vegetable proteoglycan and the anionic polymer surfactant, the smoothness of attachment / detachment and the post-use Both of the glossiness of the skin were evaluated to be insufficient.

From the above evaluation results for each disinfectant composition of Examples and Comparative Examples, the disinfectant composition of the present invention disinfects Comparative Examples which does not contain either or both of a vegetable proteoglycan and an anionic polymer surfactant. It was clarified that it is superior in both smoothness of attachment and detachment and glossiness of the skin after use as compared with the composition for use.

As described in detail above, according to the present invention, it is possible to provide a disinfectant composition which is excellent in the glossiness of the skin after use and is excellent in the smoothness of attachment and detachment when the protective device is attached to the skin after use. can.
When the disinfectant composition of the present invention is used on the skin of fingers or the like, it can give a good appearance with a glossy feeling to the skin and prevent rough hands, and further, after using it on the skin of fingers or the like, gloves or the like. When the protective equipment is attached, the protective equipment can be smoothly attached and detached.

This application is based on Japanese Patent Application No. 2020-172756 filed in Japan, the contents of which are all included in the present specification.

Claims

A disinfectant composition containing 0.001% by mass to 10% by mass of proteoglycan, 40% by mass to 90% by mass of lower alcohol, and 0.001% by mass to 1% by mass of an anionic polymer surfactant.
The disinfectant composition according to claim 1, wherein the proteoglycan is a plant-derived proteoglycan.
The disinfectant composition according to claim 1 or 2, wherein the lower alcohol is at least one selected from the group consisting of ethanol and isopropanol.
One of claims 1 to 3, wherein the anionic polymer surfactant is at least one selected from the group consisting of an ethylene / maleic anhydride copolymer and a methyl vinyl ether / maleic anhydride copolymer. Disinfectant composition according to.
The disinfectant composition according to any one of claims 1 to 4, further containing a bactericidal agent.
The disinfectant composition according to any one of claims 1 to 5, further comprising a copolymer containing a structural unit based on 2- (meth) acryloyloxyethyl phosphorylcholine.