JP2022063050A - Cleaning sheet - Google Patents

Abstract

To provide a cleaning sheet made by impregnating a sheet-like base material containing cellulosic fibers with a disinfectant composition, the cleaning sheet being prevented from adsorption of a quaternary ammonium compound contained in the disinfectant composition on the base material without using a monohydric lower alcohol, and being excellent in moisturizing property while suppressing evaporation of the disinfectant composition, which is an impregnating liquid.SOLUTION: Provided is a cleaning sheet made by impregnating a sheet-like base material containing cellulosic fibers with a disinfectant composition. The disinfectant composition comprises: (a) 0.005-1.0 w/v% of a quaternary ammonium compound having a specific structure; and (b) 0.005-5.0 w/v% of a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w/v% of its salts. The composition has a pH of 3.0 to 6.0, and contains no monovalent lower alcohol.SELECTED DRAWING: None

Description

The present invention relates to a quaternary ammonium compound having a specific structure, and a cleaning sheet in which a sheet-like substrate is impregnated with hydroxymonocarboxylic acid and a salt thereof. Specifically, the present invention relates to a cleaning sheet having excellent moisturizing properties when used on the skin by suppressing adsorption of a quaternary ammonium compound on a sheet-like substrate containing cellulosic fibers and evaporation of an impregnating solution.

In recent years, infectious diseases caused by coronavirus have become a social problem, and the importance of hand hygiene is increasing in order to suppress the spread of infectious diseases.
Conventionally, monohydric lower alcohols such as ethanol and isopropanol have been generally used for hand disinfection, and they are characterized by being excellent in quick-drying property, having a good usability, being inexpensive, and having high disinfecting power. On the other hand, alcohol-sensitive patients tend to avoid using it, and monovalent lower alcohol-containing disinfectants have a degreasing effect, which may cause the skin to dry easily and cause rough hands, and quick-drying. Since it is high, the ethanol component of the pharmaceutical product may volatilize and the concentration may decrease.

On the other hand, non-alcohol hand sanitizers that do not contain monovalent lower alcohol are easy to use even in patients with alcohol hypersensitivity, there is less concern about rough hands, and the amount of liquid evaporation tends to be small.
However, if the amount of liquid applied to the fingers is excessive, it takes time for the non-alcoholic disinfectant to evaporate, while if the amount of liquid is small, uneven coating may occur and a sufficient disinfecting effect may not be obtained. .. Therefore, the development of a cleaning sheet in which a non-alcoholic disinfectant is impregnated into a non-woven fabric or the like is being promoted. The cleaning sheet makes it easy to spread an appropriate amount on the fingers and remove foreign substances on the skin surface.

Examples of non-alcoholic disinfectants include hand sanitizers containing a quaternary ammonium compound. The disinfectant is often used by impregnating a sheet-like base material (hydrophilic sheet-like base material) containing cellulosic fibers such as absorbent cotton and gauze, but it contains a quaternary ammonium compound which is a bactericidal component. By impregnating the hydrophilic sheet-like substrate with a disinfectant, there is a problem that the bactericidal component is adsorbed on the sheet-like substrate (Non-Patent Document 1).

In order to solve the above problem, it has been proposed to add ethanol to a chemical solution containing a quaternary ammonium compound to suppress the amount of the quaternary ammonium compound adsorbed on a sheet-like substrate (Patent Document 1). ). However, with a non-alcoholic disinfectant, it is difficult to suppress adsorption, and there is a risk that the bactericidal activity will be significantly reduced.
Therefore, there has been a demand for an ethanol-free cleaning sheet having excellent moisturizing properties while suppressing adsorption of a quaternary ammonium compound on a hydrophilic sheet-like substrate and evaporation of an impregnating solution.

Japanese Unexamined Patent Publication No. 2012-197250

Adsorption of disinfectant to absorbent cotton, etc. Y's Letter Vol. 2 No. 7 (2005) Yoshida Pharmaceutical Co., Ltd.

The subject of the present invention is a cleaning sheet obtained by impregnating a sheet-like substrate containing a cellulosic fiber with a disinfectant composition, and the sheet-like substrate of a quaternary ammonium compound contained in the disinfectant composition. To provide a cleaning sheet having excellent moisturizing properties when used on the skin while suppressing adsorption to the skin without using a monohydric lower alcohol and suppressing evaporation of the disinfectant composition which is an impregnating liquid. be.

As a result of diligent research to solve the above problems, the present inventors have obtained (a) a quaternary ammonium compound having a specific structure, (b) a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and a salt thereof, respectively. By using a disinfectant composition containing a specific amount and having a pH within the specified range and impregnating the sheet-like substrate containing the cellulose-based fiber with the disinfectant composition, the quaternary ammonium compound is adsorbed on the sheet-like substrate. And, it has been found that a cleaning sheet having excellent moisturizing properties can be obtained while suppressing evaporation of the impregnating solution, and the present invention has been completed.
That is, the cleaning sheet of the present invention is as follows.

（式（１）において、Ｒは炭素数８～１８の置換基である。）
［２］前記消毒剤組成物が、さらに、式（２）の構造を有するフェノール系化合物を０．０１～５．０ｗ／ｖ％含有する、上記［１］に記載の清拭シート。

（式（２）において、Ｒ^１は、水素原子、又はエステル骨格を有する炭素数４以下の置換基であり、Ｒ^２は、水素原子、又はヒドロキシ基を有する炭素数４以下の置換基である。） [1] A cleaning sheet obtained by impregnating a sheet-like substrate containing cellulosic fibers with a disinfectant composition, wherein the disinfectant composition has a structure of the formula (a) (1) and is quaternary ammonium. Compound 0.005-1.0 w / v%,
(B) Contains 0.005 to 5.0 w / v% of hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w / v% of a salt thereof.
The pH is 3.0-6.0 and
A cleaning sheet that does not contain monovalent lower alcohol.

(In formula (1), R is a substituent having 8 to 18 carbon atoms.)
[2] The cleaning sheet according to the above [1], wherein the disinfectant composition further contains 0.01 to 5.0 w / v% of a phenolic compound having the structure of the formula (2).

(In the formula (2), R ¹ is a substituent having a hydrogen atom or an ester skeleton and having 4 or less carbon atoms, and R ² is a substituent having a hydrogen atom or a hydroxy group and having 4 or less carbon atoms. .)

According to the present invention, it is a cleaning sheet obtained by impregnating a sheet-like substrate containing a cellulosic fiber with a disinfectant composition, and is a sheet-like substrate of a quaternary ammonium compound contained in the disinfectant composition. It is possible to provide a cleaning sheet having excellent moisturizing properties when used on the skin while suppressing adsorption to the skin without using a monohydric lower alcohol and suppressing evaporation of the disinfectant composition which is an impregnating solution. can.

Hereinafter, the present invention will be described in more detail.
In addition, in this specification, when a preferable numerical range (for example, content) is described step by step, each lower limit value and upper limit value can be combined independently. For example, in the description of "preferably 10 to 100, more preferably 20 to 90", "preferably lower limit value: 10" and "more preferable upper limit value: 90" may be combined to form "10 to 90". can.

（式（１）において、Ｒは、炭素数８～１８の置換基である。）
以下に本発明の詳細を説明する。 The present invention is a cleaning sheet in which a sheet-like substrate containing cellulosic fibers is impregnated with a disinfectant composition, wherein the disinfectant composition is used.
(A) 0.005 to 1.0 w / v% of the quaternary ammonium compound having the structure of the formula (1),
(B) It contains 0.005 to 5.0 w / v% of hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w / v% of a salt thereof, and has a pH of 3.0 to 6. It is a cleaning sheet that is 0 and does not contain monovalent lower alcohol.

(In formula (1), R is a substituent having 8 to 18 carbon atoms.)
The details of the present invention will be described below.

[Bed bath sheet]
The cleaning sheet of the present invention is obtained by impregnating a sheet-like substrate containing cellulosic fibers with a disinfectant composition.

(Disinfectant composition)
The disinfectant composition in the present invention contains 0.005 to 1.0 w / v% of a quaternary ammonium compound having the structure of (a) and (1), and (b) a hydroxymonocarboxylic acid having 2 to 6 carbon atoms. Contains 0.005 to 5.0 w / v% and a salt thereof of 0.005 to 5.0 w / v%, has a pH of 3.0 to 6.0, and does not contain a monovalent lower alcohol.

The disinfectant composition is free of monohydric lower alcohols. By not containing monovalent lower alcohol, the irritation to the skin is reduced, and the disinfectant composition is easy to use for users with alcohol hypersensitivity. Further, by not containing the monohydric lower alcohol, it is possible to suppress the evaporation of the disinfectant composition after impregnating the sheet-like substrate with the disinfectant composition and improve the water retention of the cleaning sheet. ..
Here, the monohydric lower alcohol means a monohydric alcohol having 1 to 3 carbon atoms. The fact that the monohydric lower alcohol is not contained means that the monohydric lower alcohol is not intentionally blended. For example, the monohydric lower alcohol that can be contained as an unavoidable impurity in the disinfectant composition. Is acceptable.

（式（１）において、Ｒは、炭素数８～１８の置換基である） <(A) Quaternary ammonium compound>
The disinfectant composition of the present invention contains a quaternary ammonium compound having the structure of the formula (a) (1) (hereinafter, also referred to as a component (a)).

(In formula (1), R is a substituent having 8 to 18 carbon atoms).

In the formula (1), R ¹ is preferably a hydrocarbon group having 8 to 18 carbon atoms, a group having 8 to 18 carbon atoms having an oxygen atom, or the like, among the substituents having 8 to 18 carbon atoms.

The hydrocarbon group having 8 to 18 carbon atoms is not particularly limited, but an alkyl group having 8 to 18 carbon atoms is preferable. The alkyl group having 8 to 18 carbon atoms may be linear or branched, and may be, for example, an octyl group, a 2-ethylhexyl group, an isooctyl group, a nonyl group, a decyl group, a dodecyl group, a tridecylic group, a tetradecyl group or a pentadecyl group. , Hexadecyl group, heptadecyl group, hexadecyl group, octadecyl group and the like.

Examples of the group having 8 to 18 carbon atoms having an oxygen atom include a hydrocarbon group having an oxygen atom, and among them, the alkylene ether moiety [-(RO) _n- : R is an alkylene having 1 to 3 carbon atoms. It is a group, preferably an ethylene group. n is an integer of 1 to 3, preferably 2], and an aromatic hydrocarbon group having [is preferable.

Specific examples of the quaternary ammonium compound having the structure of the formula (1) include benzalkonium chloride, benzethonium chloride and the like. Among them, benzalkonium chloride is more preferable because it has a wide range of application to the body. The component (a) contained in the disinfectant composition of the present invention may be contained alone or in combination of two or more.
The content of the component (a) in the disinfectant composition of the present invention is 0.005 to 1.0 w / v%. (A) If the content of the component is less than 0.005 w / v%, it may not be possible to exhibit a broad sterilization spectrum. Further, when the content of the component (a) is more than 1.0 w / v%, a large improvement in bactericidal activity cannot be expected, which is not preferable from the viewpoint of cost effectiveness.
From the viewpoint of the bactericidal effect, the content of the component (a) of the present invention is preferably 0.01 w / v% to 0.5 w / v%, and more preferably 0.025 w / v% to 0. It is 25 w / v%, and even more preferably 0.05 w / v% to 0.2 w / v%. The content of the component (a) means the total amount of the component (a) when two or more kinds of the component (a) are contained.

<(B) Hydroxymonocarboxylic acid having 2 to 6 carbon atoms and a salt thereof>
The disinfectant composition of the present invention contains (b) a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and a salt thereof (hereinafter, also referred to as a component (b)). The hydroxymonocarboxylic acid in the present invention refers to a carboxylic acid having 1 or more hydroxy groups and having a valence of 1 (the number of carboxyl groups is 1).
Among the components (b) contained in the disinfectant composition of the present invention, the hydroxymonocarboxylic acid having 2 to 6 carbon atoms is particularly limited as long as it is a compound having 2 to 6 carbon atoms corresponding to the above-mentioned hydroxymonocarboxylic acid. However, specifically, glycolic acid, lactic acid, glyceric acid, 3-hydroxypropionic acid, 1-hydroxybutyric acid, 2-hydroxybutyric acid, gluconic acid, pantoic acid, mevalonic acid, 2,3-dihydroxy-3-methyl. Examples include pentanoic acid. These hydroxymonocarboxylic acids having 2 to 6 carbon atoms may be D-form, L-form, or DL-form.

The hydroxymonocarboxylic acid having 2 to 6 carbon atoms contained in the disinfectant composition of the present invention may contain at least one kind, and contains two or more kinds of hydroxymonocarboxylic acids having 2 to 6 carbon atoms in combination. You may.
The hydroxymonocarboxylic acid having 2 to 6 carbon atoms contained in the disinfectant composition of the present invention is preferably lactic acid or gluconic acid, and more preferably lactic acid, from the viewpoint of bactericidal activity.

Among the components (b) contained in the disinfectant composition of the present invention, the hydroxymonocarboxylic acid salt having 2 to 6 carbon atoms is not particularly limited as long as it is a salt of the hydroxymonocarboxylic acid having 2 to 6 carbon atoms. Examples thereof include sodium salts, potassium salts, calcium salts, magnesium salts and ammonium salts of the above-mentioned hydroxymonocarboxylic acids having 2 to 6 carbon atoms.
The hydroxymonocarboxylate having 2 to 6 carbon atoms contained in the disinfectant composition of the present invention is preferably sodium glycolate, sodium lactate, potassium lactate, sodium gluconate, potassium gluconate, or calcium pantoyate. More preferably, sodium lactate and sodium gluconate are used.

The method of adding the hydroxymonocarboxylate having 2 to 6 carbon atoms contained in the disinfectant composition of the present invention is not limited. For example, sodium lactate may be formed in the disinfectant composition by adding lactic acid and sodium hydroxide without directly adding sodium lactate, and it may be considered that sodium lactate is added.

Among the components (b), the content of the hydroxymonocarboxylic acid having 2 to 6 carbon atoms is 0.005 to 5.0 w / v%. If the content is less than 0.005 w / v%, the adsorption of the quaternary ammonium compound to the sheet-like substrate containing the cellulosic fiber may not be suppressed. Further, when the content is more than 5.0 w / v%, the irritation to the skin may become strong.
Among the components (b) of the present invention, the content of the hydroxymonocarboxylic acid having 2 to 6 carbon atoms is preferable because it suppresses the adsorption of the quaternary ammonium compound on the sheet-like substrate containing the cellulosic fiber. , 0.01 to 2.0 w / v%, more preferably 0.05 to 0.5 w / v%. The content of hydroxymonocarboxylic acid having 2 to 6 carbon atoms means the total amount when two or more kinds are used.

Among the components (b) of the present invention, the content of the hydroxymonocarboxylate having 2 to 6 carbon atoms is 0.005 to 5.0 w / v%. If the content is less than 0.005 w / v% or more than 5.0 w / v%, it can be difficult to control to the target pH.
Among the components (b) of the present invention, the content of the hydroxymonocarboxylate having 2 to 6 carbon atoms is preferably 0.05 to 4.0 w / v% from the viewpoint of easy control to the target pH. Yes, more preferably 0.2 to 3.0 w / v%, still more preferably 1.0 to 2.5 w / v%. The content of the hydroxymonocarboxylate having 2 to 6 carbon atoms means the total amount when two or more kinds are used.

<pH of disinfectant composition>
The pH of the disinfectant composition of the present invention is 3.0 to 6.0. If the pH is lower than 3.0 or higher than 6.0, the skin may be irritated.
The pH of the disinfectant composition of the present invention is preferably 3.5 to 5.5, more preferably 4.0 to 5.0, from the viewpoint of stability and disinfecting power.
The pH shall be measured according to the 17th revised Japanese Pharmacopoeia General Test Method 2.54.

<Phenolic compounds>
In addition to the above components, the disinfectant composition of the present invention may contain a phenolic compound having the structure of the formula (2) (hereinafter, also simply referred to as a phenolic compound). By using the phenolic compound, it is possible to improve the bactericidal activity and the virus-inactivating effect of the disinfectant composition.

式（２）において、Ｒ^１は、水素原子、又はエステル骨格を有する炭素数４以下の置換基であり、Ｒ^２は、水素原子、又はヒドロキシ基を有する炭素数４以下の置換基である。

In the formula (2), R ¹ is a substituent having a hydrogen atom or an ester skeleton and having 4 or less carbon atoms, and R ² is a substituent having a hydrogen atom or a hydroxy group and having 4 or less carbon atoms.

The substituent having an ester skeleton in ^R1 and having 4 or less carbon atoms is preferably a group represented by the following formula (3).
-C (= O) OR ³ (3)
In the formula (3), R ³ is an alkyl group having 1 to 4 carbon atoms, preferably a methyl group.
The substituent having a hydroxy group in ^R2 and having 4 or less carbon atoms is preferably a group represented by the following formula (4).
-R ⁴ -OH (4)
In the formula (4), R ⁴ is an alkylene group having 1 to 4 carbon atoms, preferably an ethylene group.

The phenolic compound represented by the formula (2) is preferably phenoxyethanol or methyl paraoxybenzoate. As the phenolic compound, one kind may be used alone, or two or more kinds may be used in combination.

The content of the phenolic compound in the disinfectant composition of the present invention is preferably 0.01 to 5.0 w / v%. Within this range, the effect on bacteria, fungi and viruses can be particularly enhanced. The phenolic compound is more preferably 0.1 to 1.0 w / v%. The content of the phenolic compound means the total amount when two or more kinds are used.

<MPC copolymer>
The disinfectant composition of the present invention contains, as a moisturizer, a copolymer containing a structural unit based on 2- (meth) acryloyloxyethyl phosphorylcholine (MPC) (hereinafter, may be referred to as "MPC copolymer"). It may be included.
The MPC copolymer includes a constituent unit based on 2- (meth) acryloyloxyethyl phosphorylcholine (MPC) (hereinafter referred to as "a constituent unit based on acrylamide") and a constituent unit based on a hydrophobic monomer. Examples of the structural unit based on the hydrophobic monomer include a coalescence, and examples thereof include a structural unit based on a (meth) acrylic acid alkyl ester, a (meth) acrylamide derivative, and the like.
In addition, in this specification, "(meth) acryloyl" means "acryloyl or methacryloyl". Further, "(meth) acrylic acid" means "acrylic acid or methacrylic acid".

前記式（５）において、Ｒ^６は水素原子又はメチル基を表す。 The structural unit based on the MPC is represented by the following equation (5).

In the formula (5), R ⁶ represents a hydrogen atom or a methyl group.

前記一般式（６）中、Ｒ^７は水素原子又はメチル基であり、Ｒ^８は炭素数１～２４の炭化水素基である。 The structural unit based on the (meth) acrylic acid alkyl ester is represented by the following formula (6).

In the general formula (6), R ⁷ is a hydrogen atom or a methyl group, and R ⁸ is a hydrocarbon group having 1 to 24 carbon atoms.

In the general formula ( ⁶ ), the hydrocarbon group represented by R8 is a linear or branched hydrocarbon group having 1 to 24 carbon atoms, and is a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, or a hexyl group. , Heptyl group, octyl group, decyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, docosyl group and the like.
Therefore, as a structural unit based on the (meth) acrylic acid alkyl ester represented by the formula (6), methyl (meth) acrylate, ethyl (meth) acrylate, propyl (meth) acrylate, and butyl (meth) acrylate. , (Meta) 2-ethylhexyl acrylate, (meth) dodecyl acrylate (lauryl), (meth) tridecyl acrylate, (meth) octadecyl acrylate (stearyl), docosyl (meth) acrylate (behenyl), etc. The unit is mentioned.

Further, as a structural unit based on the (meth) acrylic acid alkyl ester, (meth) acrylic acid diethylaminoethyl, (meth) acrylic acid trifluoroethyl, (meth) acrylic acid heptadecafluorodecyl, etc., in the above formula (6), The ⁽ meth) acrylic acid alkyl ester ⁱⁿ which the alkyl group represented by R8 is substituted with a dialkylamino group or a halogen atom, or the alkyl group represented by R8 is substituted with a hydroxyl group or a quaternary ammonio group. A structural unit based on 2-hydroxy-3- (meth) acryloyloxypropyltrimethylammonium chloride having the above-mentioned structure is also mentioned as a structural unit based on the hydrophobic monomer.

The MPC copolymer may have at least a structural unit based on MPC [constituent unit (5)] and a structural unit based on the hydrophobic monomer [constituent unit (6)], for example, a hydrophilic composition. It may include a unit. Similarly, a plurality of types of hydrophobic constituent units may be contained. The copolymerization ratio of the formula (5) and the formula (6) is 70/30 to 90/10 in molar ratio. The weight average molecular weight (Mw) of the MPC copolymer is 10,000 to 5,000,000.
The weight average molecular weight of the MPC copolymer is measured by gel permeation chromatography (GPC) and is shown by the molecular weight in terms of pullulan.

The polymerization form of the MPC copolymer is not particularly limited, and it may be a random copolymer or a block copolymer, but a random copolymer is preferable.
Further, the MPC copolymer may be a copolymer containing other structural units in addition to the structural unit based on MPC and the structural unit based on the hydrophobic monomer.
The other structural units can be appropriately selected from those that can usually be the structural units of the copolymer as long as they do not affect the effects of the present invention.

Other building blocks include, for example, alkenyl esters of (meth) acrylic acids such as allyl (meth) acrylic acid; cyclic alkyl esters of (meth) acrylic acids such as cyclohexyl (meth) acrylic acid; tetrahydro (meth) acrylic acid. A (meth) acrylic acid ester having an alkyl group substituted with a heterocycle such as furfuryl; a (meth) acrylic acid ester containing an aromatic group such as benzyl (meth) acrylate and phenoxyethyl (meth) acrylate; Esters of (meth) acrylic acid such as isobornyl (meth) acrylic acid and monoterpene alcohol; (meth) glycidyl acrylate; styrene-based monomers such as styrene, methylstyrene, chloromethylstyrene; methylvinyl ether, butylvinyl ether, etc. Vinyl ether-based monomers; Examples thereof include structural units based on vinyl ester-based monomers such as vinyl acetate and vinyl propionate.
These other constituent units may contain one or more, and their content in the MPC copolymer is relative to the total amount of the MPC-based constituent units and the hydrophobic monomer-based constituent units. It is 40 mol% or less, preferably 20 mol% or less.

The MPC copolymer can be produced by a known production method.
For example, in the presence of a radical polymerization initiator, a monomer mixture containing a hydrophobic monomer such as MPC and (meth) acrylic acid alkyl ester and, if necessary, a monomer corresponding to the other structural units described above. , It can be produced by polymerization in an atmosphere of an inert gas such as nitrogen by a known method such as solution polymerization.
The content ratio of each monomer at that time may be a ratio corresponding to the content ratio of each structural unit in the MPC copolymer.

In the liquid composition of the present invention, one type of the above-mentioned MPC copolymer may be selected and contained alone, or two or more types may be selected and contained in combination.
The form of the MPC copolymer contained in the disinfectant composition of the present invention may be solid such as powder or liquid such as a solution or a dispersion.

The content of the MPC copolymer in the disinfectant composition is not particularly limited, but is preferably 0.001 to 1 w / v from the viewpoint of suppressing evaporation of the disinfectant composition and increasing the water retention of the cleaning sheet. %, More preferably 0.01 to 0.5 w / v%.

<Other ingredients>
As long as the effect of the present invention is not impaired, the disinfectant composition of the present invention may contain, as necessary, a moisturizer, an emollient agent, a thickener, a bactericidal agent other than the above-mentioned MPC copolymer, in addition to the above-mentioned components. Other components such as solubilizers, acidic components, or basic components may be contained.

Examples of moisturizers other than MPC copolymers include glycerin, sorbitol, 1,3-butylene glycol, propylene glycol, pyrrolidone carboxylic acid and its salts, hyaluronic acid and its salts, N-cocoyl-L-arginine ethyl ester DL. -Pyrrolidone carboxylate, urea and the like can be mentioned. As a moisturizer, one or more of these can be contained.

Examples of the emollient agent include isopropyl myristate, isopropyl palmitate, isopropyl stearate, isobutyl oleate, isobutyl maleate and the like. As an emollient agent, one or more of these can be contained.

Examples of the thickener include natural polysaccharides and derivatives thereof, specifically, carboxymethyl starch, dialdehyde starch, purulan, mannan, amylopectin, amylopectin, dextran, hydroxyethyldextran, levan, inulin, chitin, chitosan, and xyllo. Examples thereof include glucan, alginic acid, gum arabic, guar gum, tragant gum, heparin, methyl cellulose, carboxymethyl ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, ethyl hydroxyethyl cellulose, hydroxypropyl methyl cellulose and the like. One or more of these can be contained.

Examples of the bactericidal agent include phenolic compounds such as cresol, iodine compounds such as iodine ion, iodine ion and iodine hoa, and pigments such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate and acrinol. Compounds, biguanide compounds such as chlorhexidine gluconate, chlorhexidine hydrochloride, chlorhexidine acetate, polyhexamethylene biguanide, aminocarboxylates such as alkyldiaminoethylglycine hydrochloride, alkylpolyaminoethylglycine hydrochloride, oxidation of oxidol, potassium permanganate and the like. Agents and the like can be mentioned. One or more of these can be contained.

Examples of the solubilizer include polyoxyethylene hydrogenated castor oil, polyethylene glycol monolaurate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene lauryl ether, and polyoxyethylene cetyl ether. can. One or more of these can be contained.

Examples of the acidic component include phosphoric acid, citric acid, sulfuric acid, acetic acid, boric acid, hydrochloric acid and the like. One or more of these can be contained.

Examples of the basic component include hydroxides of alkali metals such as sodium hydroxide and potassium hydroxide, alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, monoisopropanolamine, diisopropanolamine and triisopropanolamine. Examples thereof include alkylamines such as 2-amino-2-methyl-1-propanol and 2-amino-2-methyl-1,3-propanediol, and basic amino acids such as lysine and arginine. One or more of these can be contained.

In the disinfectant composition of the present invention, the above-mentioned component (a), (b) component, and the above-mentioned phenolic compound, MPC copolymer, and other components to be blended as needed are dissolved in water. Is prepared. A cleaning sheet can be obtained by impregnating the sheet-like substrate with the disinfectant composition as described later.

(Sheet-like base material)
The sheet-like base material in the present invention is a sheet-like base material containing cellulosic fibers and is a hydrophilic base material.
The cellulosic fiber is not particularly limited and may be appropriately selected depending on the intended purpose. For example, natural cellulosic fibers such as cotton, pulp and hemp, biscous rayon obtained from pulp, and copper ammonia method rayon ( Cupra), regenerated cellulosic fibers such as rayon spun with a solvent, lyocell, tencel, and the like.
The sheet-like substrate may contain a hydrophobic material such as a hydrophobic fiber as long as it is within the range showing hydrophilicity.

Examples of the sheet-like substrate include paper, wet non-woven fabric, dry non-woven fabric, woven fabric, and knitted fabric.
The sheet-like substrate preferably has a basis weight of 30 g / m ² to 60 g / m ² , and more preferably 35 g / m ² to 55 g / m ² .

(Immersion)
The cleaning sheet of the present invention can be obtained by impregnating a sheet-like substrate with the disinfectant composition. The impregnation method is not particularly limited and may be appropriately selected depending on the intended purpose. For example, a method of impregnating a sheet-like substrate by dropping or spraying a disinfectant composition, a disinfectant composition. Examples thereof include a method of impregnating the sheet-like substrate by immersing it, a method of storing the sheet-like substrate in a packaging tool such as an aluminum pouch, and then filling and sealing the disinfectant composition.
The amount of the disinfectant composition impregnated is preferably 1.5 g to 5.0 g, preferably 2.0 g to 4.0 g, with respect to 1 g of the sheet-shaped substrate in order to sufficiently impregnate the sheet-shaped substrate with the disinfectant composition. Is more preferable.

The cleaning sheet of the present invention is used in a state of being housed in a packaging tool. The packaging tool is not particularly limited, and one usually used for a cleaning sheet can be used.
The cleaning sheet of the present invention is, for example, a deodorant sheet, a face sweating sheet, a body sweating sheet, an antiperspirant sheet, a hand-wiping wet sheet, a foot-wiping sheet, a wipe-off sheet, a nursing-care cleaning sheet, and skin oil. It can be suitably used for a wiping sheet, a drowsiness awakening sheet, a disinfecting sheet and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto. The components used in the examples are as follows.

[Each component of disinfectant composition]
<Component (a)>
Benzalkonium Chloride Benzalkonium Chloride <Component (b)>
Sodium lactate <Phenolic compound>
Phenoxyethanol Methyl paraoxybenzoate

<Other ingredients>
Moisturizer: Common components of MPC copolymer: 1,3-butylene glycol, polyethylene glycol monostearate

(Examples 1 to 7, Comparative Examples 1 to 3)
The disinfectant compositions of Examples 1 to 7 were obtained from the compounding compositions shown in Table 1. Further, the disinfectant compositions of Comparative Examples 1 to 3 were obtained from the compounding compositions shown in Table 2. Each evaluation described later was performed using each of these disinfectant compositions.
“G / 100mL” in each table is equivalent to “w / v%”. The composition of purified water shown in each table is the balance obtained by removing each component other than purified water from the disinfectant composition.

<Residual rate of quaternary ammonium compound in liquid>
As a sheet-like base material containing cellulosic fibers, a sheet base material obtained by molding a rayon / pulp non-woven fabric (weight = 40 g / m ² ) into a rectangle (30 cm × 20 cm) was prepared. The sheet base material was housed in a polyethylene wrapping tool. A cleaning sheet was prepared by filling the sheet substrate with 3.5 g of each of the above disinfectant compositions with respect to 1 g of the non-woven fabric and impregnating the sheet substrate. The disinfectant composition of the cleaning sheet was squeezed out, and the content of the quaternary ammonium compound in the disinfectant composition before and after impregnation of the sheet substrate was quantified by high performance liquid chromatography. The residual ratio of the quaternary ammonium compound was calculated by the following formula and evaluated according to the following criteria.
Residual rate (%) = 100 × [Content of quaternary ammonium in the disinfectant composition squeezed from the cleaning sheet / Content of quaternary ammonium in the disinfectant composition before impregnation]
〔Evaluation criteria〕
⊚: Quaternary ammonium compound residual rate is 90% or more 〇: Quaternary ammonium compound residual rate is less than 90% 80% or more
Δ: Residual rate of quaternary ammonium compound is less than 80%

<Transpiration>
As a sheet-like base material containing cellulosic fibers, a sheet base material obtained by molding a rayon / pulp non-woven fabric (weight = 40 g / m ² ) into a rectangle (30 cm × 20 cm) was prepared. The sheet base material was housed in a polyethylene wrapping tool. A cleaning sheet was prepared by filling the sheet substrate with 3.5 g of each of the above disinfectant compositions with respect to 1 g of the non-woven fabric and impregnating the sheet substrate. After leaving the cleaning sheet at room temperature for 2 hours, the cleaning sheet was used for fingers. Four men and women (25-35 years old) were used as panelists and scored according to the following scoring criteria in the sensory evaluation. The total score of the four evaluation points was calculated and evaluated according to the following evaluation criteria.
[Scoring criteria]
2 points: I feel that the amount of impregnating liquid is sufficient
1 point: I feel that the amount of impregnating liquid is a little sufficient 0 point: I feel that the amount of impregnating liquid is a little insufficient [evaluation criteria]
⊚: Total evaluation points are greater than 6 〇: Total evaluation points are 6 or less and greater than 3 △: Total evaluation points are 3 or less

<Moisturizing property>
The disinfectant composition prepared as described above was applied to four men and women as panelists (25 to 35 years old), the forearms were washed with soap, and then applied 5 times every hour, which was continued for 5 days. The moisturizing feeling of the skin after 5 days was scored according to the following scoring criteria in the sensory evaluation. The total score of the four evaluation points was calculated and evaluated according to the following evaluation criteria.
[Scoring criteria]
2 points: Very moisturizing feeling 1 point: Moisturizing feeling is slightly felt 0 points: Moisturizing feeling is not felt slightly [Evaluation criteria]
⊚: Total evaluation points are greater than 6 〇: Total evaluation points are 6 or less and greater than 3 △: Total evaluation points are 3 or less

As is clear from the results of the examples in Table 1, the cleaning sheet impregnated with the disinfectant composition satisfying the requirements of the present invention has a high residual ratio of the quaternary ammonium compound, and thus is quaternary. It can be seen that the adsorption of the ammonium compound is suppressed. In addition, since the transpiration result was good, the transpiration of the disinfectant composition was suppressed, and the moisturizing property was also good.
On the other hand, as is clear from the results of the comparative examples in Table 2, the quaternary ammonium compound is easily adsorbed on the cleaning sheet impregnated with the disinfectant composition that does not satisfy the requirements of the present invention. Alternatively, even when the adsorption of the quaternary ammonium compound was suppressed, the results of evaporative property and moisturizing property were poor.

Claims (2)

A cleaning sheet obtained by impregnating a sheet-like substrate containing cellulosic fibers with a disinfectant composition, wherein the disinfectant composition is a quaternary ammonium compound having the structure of the formula (a) (1). .005-1.0w / v%,
(B) Contains 0.005 to 5.0 w / v% of hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w / v% of a salt thereof.
The pH is 3.0-6.0 and
A cleaning sheet that does not contain monovalent lower alcohol.

(In formula (1), R is a substituent having 8 to 18 carbon atoms.) The cleaning sheet according to claim 1, wherein the disinfectant composition further contains 0.01 to 5.0 w / v% of a phenolic compound having the structure of the formula (2).

(In the formula (2), R ¹ is a substituent having a hydrogen atom or an ester skeleton and having 4 or less carbon atoms, and R ² is a substituent having a hydrogen atom or a hydroxy group and having 4 or less carbon atoms. .)