JP5565765B2 - メラノーマ鑑別指標の導出方法 - Google Patents
メラノーマ鑑別指標の導出方法 Download PDFInfo
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- JP5565765B2 JP5565765B2 JP2009103999A JP2009103999A JP5565765B2 JP 5565765 B2 JP5565765 B2 JP 5565765B2 JP 2009103999 A JP2009103999 A JP 2009103999A JP 2009103999 A JP2009103999 A JP 2009103999A JP 5565765 B2 JP5565765 B2 JP 5565765B2
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- 201000001441 melanoma Diseases 0.000 title claims description 38
- 238000000034 method Methods 0.000 title claims description 31
- 238000009795 derivation Methods 0.000 title claims 2
- 238000001228 spectrum Methods 0.000 claims description 33
- 239000013598 vector Substances 0.000 claims description 28
- 238000004458 analytical method Methods 0.000 description 18
- 230000003211 malignant effect Effects 0.000 description 17
- 230000035945 sensitivity Effects 0.000 description 12
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 10
- 230000004069 differentiation Effects 0.000 description 10
- 230000003287 optical effect Effects 0.000 description 10
- 238000003745 diagnosis Methods 0.000 description 8
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 101700004678 SLIT3 Proteins 0.000 description 6
- 102100027339 Slit homolog 3 protein Human genes 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- 230000003595 spectral effect Effects 0.000 description 6
- 206010039796 Seborrhoeic keratosis Diseases 0.000 description 5
- 210000002752 melanocyte Anatomy 0.000 description 5
- 230000037311 normal skin Effects 0.000 description 5
- 201000003385 seborrheic keratosis Diseases 0.000 description 5
- 238000000985 reflectance spectrum Methods 0.000 description 4
- 238000004611 spectroscopical analysis Methods 0.000 description 4
- 208000007256 Nevus Diseases 0.000 description 3
- 238000000692 Student's t-test Methods 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 238000012353 t test Methods 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000007781 pre-processing Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 238000012800 visualization Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010027145 Melanocytic naevus Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004441 surface measurement Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Description
Claims (2)
- 対象物表面の拡散反射スペクトルを測定し、前記対象物表面の位置情報とその位置における拡散反射スペクトルとを含む複数の画素データを取得する第1のステップと、
前記第1のステップで取得した拡散反射スペクトルを多次元ベクトルとみなし、この多次元ベクトルと基準ベクトルとのなす角度を求める第2のステップと、
前記第2のステップで求めた角度及び画素データの位置情報に基づき、前記対象物表面の分子情報を反映している指標を求める第3のステップと
を備えたことを特徴とするメラノーマ鑑別指標の導出方法。 - 前記分子情報を反映している指標は、擬フラクタル次元、エネルギー指標、エントロピー指標のいずれかであることを特徴とする請求項1記載のメラノーマ鑑別指標の導出方法。
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JP2009103999A JP5565765B2 (ja) | 2009-04-22 | 2009-04-22 | メラノーマ鑑別指標の導出方法 |
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JP2009103999A JP5565765B2 (ja) | 2009-04-22 | 2009-04-22 | メラノーマ鑑別指標の導出方法 |
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JP2010252904A JP2010252904A (ja) | 2010-11-11 |
JP5565765B2 true JP5565765B2 (ja) | 2014-08-06 |
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JP2009103999A Active JP5565765B2 (ja) | 2009-04-22 | 2009-04-22 | メラノーマ鑑別指標の導出方法 |
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JP (1) | JP5565765B2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019208900A (ja) * | 2018-06-05 | 2019-12-12 | 株式会社ニコン | 解析装置、分析装置、分析方法およびプログラム |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5600426B2 (ja) * | 2009-12-24 | 2014-10-01 | 三鷹光器株式会社 | 爪甲色素線条の鑑別装置 |
JP6030002B2 (ja) * | 2013-02-27 | 2016-11-24 | 富士フイルムRiファーマ株式会社 | 画像処理プログラム、画像処理装置、および画像処理方法 |
CN105324068B (zh) * | 2013-06-19 | 2019-05-10 | 莱雅公司 | 用于评估美容产品在皮肤上的美容效果的方法 |
WO2015012028A1 (ja) * | 2013-07-22 | 2015-01-29 | コニカミノルタ株式会社 | メラノーマ診断支援装置、プログラムおよびメラノーマ診断支援方法 |
KR101651659B1 (ko) * | 2015-02-12 | 2016-08-30 | 한국광기술원 | 광 간섭 단층촬영을 이용한 색소 병변의 정량화 시스템 및 방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002028141A (ja) * | 2000-07-13 | 2002-01-29 | Mitsunobu Nagao | 脳血流分布の不均一性評価方法及びその評価装置 |
JP4437202B2 (ja) * | 2004-01-09 | 2010-03-24 | 学校法人慶應義塾 | 色素沈着部位の遠隔診療システム |
EP1719448B1 (en) * | 2004-02-24 | 2012-08-29 | Waseda University | Method of measuring superficial chemical species and apparatus for measuring the same |
KR20080043843A (ko) * | 2005-08-16 | 2008-05-19 | 스킨 캔서 스캐닝 리미티드 | 비침투 피부환부 확인방법 및 피부의 환부를 식별하기위한 디텍터 |
JP4980707B2 (ja) * | 2006-12-22 | 2012-07-18 | 富士フイルムRiファーマ株式会社 | 画像処理装置及び方法 |
EP2238449B1 (en) * | 2008-01-24 | 2018-06-06 | Balter, Inc. | Method for discriminating between malignant and benign tissue lesions |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019208900A (ja) * | 2018-06-05 | 2019-12-12 | 株式会社ニコン | 解析装置、分析装置、分析方法およびプログラム |
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