JP5539653B2 - 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 - Google Patents
細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 Download PDFInfo
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Classifications
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5061—Muscle cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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| US82123006P | 2006-08-02 | 2006-08-02 | |
| US60/821,230 | 2006-08-02 | ||
| US82737206P | 2006-09-28 | 2006-09-28 | |
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| US82834506P | 2006-10-05 | 2006-10-05 | |
| US60/828,345 | 2006-10-05 | ||
| US86773606P | 2006-11-29 | 2006-11-29 | |
| US60/867,736 | 2006-11-29 | ||
| PCT/US2007/062871 WO2007101191A2 (en) | 2006-02-27 | 2007-02-27 | Compositions and methods for reducing cellular fat and for predicting cardiac toxicity and upon treatment with tyrosine kinase inhibitors |
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| JP2012282502A Division JP2013063090A (ja) | 2006-02-27 | 2012-12-26 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
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| JP2009533017A JP2009533017A (ja) | 2009-09-17 |
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| JP2008556587A Expired - Fee Related JP5539653B2 (ja) | 2006-02-27 | 2007-02-27 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
| JP2012282502A Pending JP2013063090A (ja) | 2006-02-27 | 2012-12-26 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
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| US (2) | US8709738B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1996939B1 (cg-RX-API-DMAC7.html) |
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| WO2010036910A1 (en) * | 2008-09-26 | 2010-04-01 | Yoshikazu Ohta | Heart protection by administering an amp-activated protein kinase activator |
| WO2015027171A1 (en) * | 2013-08-23 | 2015-02-26 | Quintiles Transnational Corporation | Methods for predicting toxicity in response to treatment with a drug by assessing activation of the sterol regulatory binding protein (srebp) pathway |
| CA2944181C (en) | 2014-03-27 | 2019-09-17 | Salk Institute For Biological Studies | Compositions and methods for treating type 1 and type 2 diabetes and related disorders |
| EP3262157A4 (en) * | 2015-02-27 | 2018-12-05 | Salk Institute for Biological Studies | Reprogramming progenitor compositions and methods of use therefore |
| EP3485001A4 (en) | 2016-05-25 | 2020-08-12 | Salk Institute for Biological Studies | COMPOSITIONS AND PROCESSES FOR THE PRODUCTION OF ORGANOIDS AND THE MODELING OF DISEASES |
| JP7032723B2 (ja) * | 2017-07-21 | 2022-03-09 | 公立大学法人福島県立医科大学 | 薬剤の心毒性評価方法及びそのための試薬又はキット |
| US11369608B2 (en) | 2017-10-27 | 2022-06-28 | University Of Virginia Patent Foundation | Compounds and methods for regulating, limiting, or inhibiting AVIL expression |
| TWI711458B (zh) * | 2019-07-08 | 2020-12-01 | 大江生醫股份有限公司 | 植物發酵物及其製備方法與用於胃臟保健的用途 |
| KR102493664B1 (ko) | 2020-01-29 | 2023-02-01 | 한국화학연구원 | 심장 독성 예측 모델링 시스템 및 모델링 방법 |
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| GB9618420D0 (en) * | 1996-09-04 | 1996-10-16 | Scotia Holdings Plc | Fatty acid treatment |
| DE19932555A1 (de) * | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
| US20020028826A1 (en) * | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| DK1438420T3 (da) | 2001-09-24 | 2010-01-18 | Lipomics Technologies Inc | Fremgangsmåder til anvendelse af kvantitative lipid-metablom-data |
| SG152922A1 (en) * | 2002-11-04 | 2009-06-29 | Univ California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| PL1668152T3 (pl) * | 2003-08-28 | 2009-06-30 | Ipsogen | Identyfikacja sygnatury ekspresji genów ERBB2 w rakach sutka |
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2007
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2008
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2012
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2013
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| US20090186910A1 (en) | 2009-07-23 |
| CN101438155B (zh) | 2013-04-24 |
| WO2007101191A2 (en) | 2007-09-07 |
| IL193715A0 (en) | 2009-05-04 |
| EP1996939A4 (en) | 2009-07-15 |
| IL193715A (en) | 2014-06-30 |
| JP2013063090A (ja) | 2013-04-11 |
| AU2007220094A1 (en) | 2007-09-07 |
| EP1996939B1 (en) | 2014-03-26 |
| US8709738B2 (en) | 2014-04-29 |
| US20130288285A1 (en) | 2013-10-31 |
| JP2009533017A (ja) | 2009-09-17 |
| AU2007220094B2 (en) | 2013-12-05 |
| EP1996939A2 (en) | 2008-12-03 |
| CA2643846A1 (en) | 2007-09-07 |
| CN101438155A (zh) | 2009-05-20 |
| ES2475162T3 (es) | 2014-07-10 |
| CN103217520A (zh) | 2013-07-24 |
| NZ571465A (en) | 2011-09-30 |
| NZ594178A (en) | 2013-02-22 |
| KR20090008194A (ko) | 2009-01-21 |
| WO2007101191A3 (en) | 2007-12-13 |
| KR101390625B1 (ko) | 2014-04-29 |
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