CN101438155B - 一种预测使用酪氨酸激酶抑制剂的处理的心脏毒性的方法 - Google Patents

一种预测使用酪氨酸激酶抑制剂的处理的心脏毒性的方法 Download PDF

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CN101438155B
CN101438155B CN2007800136974A CN200780013697A CN101438155B CN 101438155 B CN101438155 B CN 101438155B CN 2007800136974 A CN2007800136974 A CN 2007800136974A CN 200780013697 A CN200780013697 A CN 200780013697A CN 101438155 B CN101438155 B CN 101438155B
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fatty acid
cell
acid oxidation
tyrosine kinase
kinase inhibitor
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CN101438155A (zh
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S·S·巴克斯
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Targeted Molecular Diagnostics LLC
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    • A61P3/02—Nutrients, e.g. vitamins, minerals
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061—Muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • G01—MEASURING; TESTING
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G01N2333/4706—Regulators; Modulating activity stimulating, promoting or activating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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CN2007800136974A 2006-02-27 2007-02-27 一种预测使用酪氨酸激酶抑制剂的处理的心脏毒性的方法 Expired - Fee Related CN101438155B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US77709606P 2006-02-27 2006-02-27
US60/777,096 2006-02-27
US82123006P 2006-08-02 2006-08-02
US60/821,230 2006-08-02
US82737206P 2006-09-28 2006-09-28
US60/827,372 2006-09-28
US82834506P 2006-10-05 2006-10-05
US60/828,345 2006-10-05
US86773606P 2006-11-29 2006-11-29
US60/867,736 2006-11-29
PCT/US2007/062871 WO2007101191A2 (en) 2006-02-27 2007-02-27 Compositions and methods for reducing cellular fat and for predicting cardiac toxicity and upon treatment with tyrosine kinase inhibitors

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CN2013101368247A Division CN103217520A (zh) 2006-02-27 2007-02-27 用于减少细胞脂肪和预测用酪氨酸激酶抑制剂治疗后的心脏毒性的组合物和方法

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CN101438155A CN101438155A (zh) 2009-05-20
CN101438155B true CN101438155B (zh) 2013-04-24

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CN2013101368247A Pending CN103217520A (zh) 2006-02-27 2007-02-27 用于减少细胞脂肪和预测用酪氨酸激酶抑制剂治疗后的心脏毒性的组合物和方法

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US (2) US8709738B2 (cg-RX-API-DMAC7.html)
EP (1) EP1996939B1 (cg-RX-API-DMAC7.html)
JP (2) JP5539653B2 (cg-RX-API-DMAC7.html)
KR (1) KR101390625B1 (cg-RX-API-DMAC7.html)
CN (2) CN101438155B (cg-RX-API-DMAC7.html)
AU (1) AU2007220094B2 (cg-RX-API-DMAC7.html)
CA (1) CA2643846A1 (cg-RX-API-DMAC7.html)
ES (1) ES2475162T3 (cg-RX-API-DMAC7.html)
IL (1) IL193715A (cg-RX-API-DMAC7.html)
NZ (2) NZ594178A (cg-RX-API-DMAC7.html)
WO (1) WO2007101191A2 (cg-RX-API-DMAC7.html)

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WO2010036910A1 (en) * 2008-09-26 2010-04-01 Yoshikazu Ohta Heart protection by administering an amp-activated protein kinase activator
WO2015027171A1 (en) * 2013-08-23 2015-02-26 Quintiles Transnational Corporation Methods for predicting toxicity in response to treatment with a drug by assessing activation of the sterol regulatory binding protein (srebp) pathway
WO2015148832A1 (en) 2014-03-27 2015-10-01 Salk Institute For Biological Studies Compositions and methods for treating type 1 and type 2 diabetes and related disorders
CA2977520A1 (en) * 2015-02-27 2016-09-01 Salk Institute For Biological Studies Reprogramming progenitor compositions and methods of use therefore
WO2017205511A1 (en) 2016-05-25 2017-11-30 Salk Institute For Biological Studies Compositions and methods for organoid generation and disease modeling
JP7032723B2 (ja) * 2017-07-21 2022-03-09 公立大学法人福島県立医科大学 薬剤の心毒性評価方法及びそのための試薬又はキット
WO2019084395A1 (en) 2017-10-27 2019-05-02 University Of Virginia Patent Foundation COMPOUNDS AND METHODS FOR REGULATING, LIMITING OR INHIBITING AVIL EXPRESSION
TWI711458B (zh) * 2019-07-08 2020-12-01 大江生醫股份有限公司 植物發酵物及其製備方法與用於胃臟保健的用途
KR102493664B1 (ko) 2020-01-29 2023-02-01 한국화학연구원 심장 독성 예측 모델링 시스템 및 모델링 방법

Citations (1)

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CN1436174A (zh) * 2000-06-15 2003-08-13 布里斯托尔-迈尔斯斯奎布公司 HMG－CoA还原酶抑制剂及其作为治疗与胆固醇相关疾病的药物的应用

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GB9618420D0 (en) * 1996-09-04 1996-10-16 Scotia Holdings Plc Fatty acid treatment
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
DE60233743D1 (de) * 2001-09-24 2009-10-29 Lipomics Technologies Inc Verfahren zur verwendung von quantitativen lipidmetabolondaten
SG152922A1 (en) 2002-11-04 2009-06-29 Univ California Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
DE602004015626D1 (de) * 2003-08-28 2008-09-18 Ipsogen Bei brustkrebs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1436174A (zh) * 2000-06-15 2003-08-13 布里斯托尔-迈尔斯斯奎布公司 HMG－CoA还原酶抑制剂及其作为治疗与胆固醇相关疾病的药物的应用

Non-Patent Citations (1)

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Tokarska-schlattner et al..Acute toxicity of doxorubicin on isolated perfused heart: response of kinases regulating energy supply..《Am. J. Physiol. Heart Circ. Physiol.》.2005,第289卷H37-H47. *

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US8709738B2 (en) 2014-04-29
IL193715A0 (en) 2009-05-04
EP1996939A2 (en) 2008-12-03
EP1996939B1 (en) 2014-03-26
US20090186910A1 (en) 2009-07-23
IL193715A (en) 2014-06-30
JP2013063090A (ja) 2013-04-11
CN103217520A (zh) 2013-07-24
CN101438155A (zh) 2009-05-20
ES2475162T3 (es) 2014-07-10
KR101390625B1 (ko) 2014-04-29
NZ571465A (en) 2011-09-30
AU2007220094A1 (en) 2007-09-07
US20130288285A1 (en) 2013-10-31
AU2007220094B2 (en) 2013-12-05
CA2643846A1 (en) 2007-09-07
WO2007101191A3 (en) 2007-12-13
WO2007101191A2 (en) 2007-09-07
JP2009533017A (ja) 2009-09-17
EP1996939A4 (en) 2009-07-15
KR20090008194A (ko) 2009-01-21
NZ594178A (en) 2013-02-22
JP5539653B2 (ja) 2014-07-02

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