JP5537755B2 - 直接圧縮可能なα型マンニトールの製造方法 - Google Patents

直接圧縮可能なα型マンニトールの製造方法 Download PDF

Info

Publication number
JP5537755B2
JP5537755B2 JP2003556370A JP2003556370A JP5537755B2 JP 5537755 B2 JP5537755 B2 JP 5537755B2 JP 2003556370 A JP2003556370 A JP 2003556370A JP 2003556370 A JP2003556370 A JP 2003556370A JP 5537755 B2 JP5537755 B2 JP 5537755B2
Authority
JP
Japan
Prior art keywords
mannitol
spray
powder
powdered
fluidized bed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2003556370A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005513151A5 (enExample
JP2005513151A (ja
Inventor
エルドマン，マルティン
ハム，ウォルター
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7709161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5537755(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2005513151A publication Critical patent/JP2005513151A/ja
Publication of JP2005513151A5 publication Critical patent/JP2005513151A5/ja
Application granted granted Critical
Publication of JP5537755B2 publication Critical patent/JP5537755B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Glanulating (AREA)
JP2003556370A 2001-12-13 2002-12-13 直接圧縮可能なα型マンニトールの製造方法 Expired - Lifetime JP5537755B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10161402.0 2001-12-13
DE10161402A DE10161402A1 (de) 2001-12-13 2001-12-13 Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
PCT/EP2002/014202 WO2003055834A2 (de) 2001-12-13 2002-12-13 VERFAHREN ZUR HERSTELLUNG VON DIREKT TABLETTIERBAREM α-MANNIT

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013026628A Division JP2013139455A (ja) 2001-12-13 2013-02-14 直接圧縮可能なα−マンニトールの製造方法

Publications (3)

Publication Number Publication Date
JP2005513151A JP2005513151A (ja) 2005-05-12
JP2005513151A5 JP2005513151A5 (enExample) 2006-02-09
JP5537755B2 true JP5537755B2 (ja) 2014-07-02

Family

ID=7709161

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003556370A Expired - Lifetime JP5537755B2 (ja) 2001-12-13 2002-12-13 直接圧縮可能なα型マンニトールの製造方法
JP2002362318A Pending JP2004002290A (ja) 2001-12-13 2002-12-13 直接圧縮用β−マンニトールの製造方法
JP2013026628A Pending JP2013139455A (ja) 2001-12-13 2013-02-14 直接圧縮可能なα−マンニトールの製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002362318A Pending JP2004002290A (ja) 2001-12-13 2002-12-13 直接圧縮用β−マンニトールの製造方法
JP2013026628A Pending JP2013139455A (ja) 2001-12-13 2013-02-14 直接圧縮可能なα−マンニトールの製造方法

Country Status (7)

Country Link
US (2) US6998481B2 (enExample)
EP (2) EP1319644B2 (enExample)
JP (3) JP5537755B2 (enExample)
AT (1) ATE296791T1 (enExample)
AU (2) AU2002360958A1 (enExample)
DE (3) DE10161402A1 (enExample)
WO (2) WO2003053896A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10161402A1 (de) † 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7118765B2 (en) 2001-12-17 2006-10-10 Spi Pharma, Inc. Co-processed carbohydrate system as a quick-dissolve matrix for solid dosage forms
DE10240778A1 (de) * 2002-08-30 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem a-Mannit
US8186265B2 (en) * 2005-08-08 2012-05-29 Ron's Enterprises, Inc. Device to efficiently cook food
NZ572106A (en) * 2006-03-31 2010-12-24 Rubicon Res Private Ltd Directly compressible composite for orally disintegrating tablets
US20100092564A1 (en) * 2006-12-21 2010-04-15 Jae Han Park Composition of and Method for Preparing Orally Disintegrating Tablets
WO2009016133A1 (en) * 2007-07-27 2009-02-05 Cargill, Incorporated Micronization of polyols
JP5756749B2 (ja) 2008-06-20 2015-07-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 直接圧縮性および迅速崩壊性錠剤マトリックス
FR2933299B1 (fr) 2008-07-04 2012-02-03 Roquette Freres Mannitol orodispersible
EP2327424A4 (en) 2008-08-18 2014-10-01 Mitsubishi Shoji Foodtech Co Ltd NEW AUXILIARY FOR MANNITOL TABLETTING
FR2944971B1 (fr) * 2009-04-30 2012-09-07 Roquette Freres Coagglomerats de mannitol et d'amidon granulaire comprimables et a ecoulement libre
EP2451446B1 (de) 2009-07-10 2014-03-05 Merck Patent GmbH Zusammensetzung für die tablettenherstellung und verfahren zu deren herstellung
ES2655719T3 (es) 2009-07-10 2018-02-21 Merck Patent Gmbh Sustancia auxiliar con bajo contenido de agua para formación de comprimidos y procedimiento para su fabricación
AU2010305833A1 (en) * 2009-10-12 2012-04-19 Basf Se Method for producing a powder containing one or more complexing agent salts
HUE054747T2 (hu) * 2010-12-17 2021-09-28 Merck Patent Gmbh Eljárás közvetlenül tablettázható delta-mannit elõállítására
AR086505A1 (es) 2012-05-21 2013-12-18 Consejo Nac Invest Cient Tec Un excipiente co-procesado, obtenido mediante secado por atomizacion, utilizable como excipiente farmaceutico o aditivo alimenticio
JP6480866B2 (ja) * 2013-09-30 2019-03-13 第一三共株式会社 スプレードライ法を用いたＤ−マンニトールα型結晶の選択的製造方法
FR3038836B1 (fr) * 2015-07-17 2017-07-14 Roquette Freres Granules de mannitol pour compression directe
CN110172012A (zh) * 2019-07-06 2019-08-27 浙江华康药业股份有限公司 直接压片甘露醇的制备方法
CN110787722A (zh) * 2019-12-01 2020-02-14 浙江华康药业股份有限公司 一种结晶甘露醇干法造粒装置及工艺
MX2024009496A (es) 2022-02-08 2024-08-19 Roquette Freres Granulos de manitol directamente compresibles.
FR3132522B1 (fr) 2022-02-08 2025-04-04 Roquette Freres Granules de mannitol directement comprimable
CN115671053A (zh) * 2022-11-09 2023-02-03 江西中医药大学 一种含有多孔甘露醇的载药粉末的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145146A (en) * 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
FR2571046B1 (fr) * 1984-10-03 1987-10-16 Roquette Freres Procede de preparation de mannitol granulaire directement compressible
FR2571045B1 (fr) * 1984-10-03 1987-12-11 Roquette Freres Mannitol granulaire directement compressible et son procede de fabrication
JPS6185330A (ja) * 1984-10-04 1986-04-30 Fuji Kagaku Kogyo Kk 直打用賦形薬の製造法
DK160809C (da) * 1989-01-09 1995-10-02 Niro Holding As Fremgangsmåde og forstøvningstørringsapparat til fremstilling af stabile partikelagglomerater
DE69022861T2 (de) * 1989-01-24 1996-04-04 Spi Polyols Inc Kryoschützende kristalline Sorbitolkügelchen.
FR2710637B1 (fr) * 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
JP3126683B2 (ja) * 1996-04-16 2001-01-22 武田薬品工業株式会社 Ｄ−マンニトールおよびその製造法
BR9708672A (pt) * 1996-04-16 1999-08-03 Bayer Ag D-manitol e sua preparação
DE19615418A1 (de) † 1996-04-22 1997-10-23 Merck Patent Gmbh Polyol-Zusammensetzung
DE19927537A1 (de) † 1999-06-16 2000-12-21 Merck Patent Gmbh Sprühtrocknungsanlage und Verfahren zu ihrer Verwendung
DE10161402A1 (de) * 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit

Also Published As

Publication number Publication date
DE10161402A1 (de) 2003-06-18
DE50203302D1 (de) 2005-07-07
ATE296791T1 (de) 2005-06-15
US20030114717A1 (en) 2003-06-19
EP1319644A1 (de) 2003-06-18
EP1453781B1 (de) 2005-06-01
AU2002360958A1 (en) 2003-07-09
WO2003055834A2 (de) 2003-07-10
EP1319644B2 (de) 2009-04-01
DE50205571D1 (de) 2006-04-06
AU2002360972A1 (en) 2003-07-15
US6998481B2 (en) 2006-02-14
EP1319644B1 (de) 2006-01-11
WO2003053896A1 (de) 2003-07-03
JP2004002290A (ja) 2004-01-08
EP1453781B2 (de) 2014-03-05
JP2005513151A (ja) 2005-05-12
US6998482B2 (en) 2006-02-14
US20050008693A1 (en) 2005-01-13
EP1453781A2 (de) 2004-09-08
WO2003055834A3 (de) 2003-10-16
JP2013139455A (ja) 2013-07-18

Similar Documents

Publication Publication Date Title
JP5537755B2 (ja) 直接圧縮可能なα型マンニトールの製造方法
US9119788B2 (en) Method for production of particles of pharmaceutical substances and the use thereof
JP4459326B2 (ja) 混合肥料造粒方法
EP2834217B1 (en) Nicotinamide powder and process and device for its production
JP2003501252A (ja) 噴霧乾燥プラント、およびその使用方法
EP1638678B1 (de) Enzym-granulat-herstellungsverfahren und erhältliche enzym-granulate
US6362157B1 (en) Method for producing tenside granulates with a higher bulk density
JP6419759B2 (ja) 直接圧縮可能なδ−マンニトールの調製方法
TW201718407A (zh) 硫酸銨之造粒
JP7683192B2 (ja) 粒状硫安組成物の製造方法
DE102004008020A1 (de) Enzym-Granulats-Herstellungsverfahren
WO2004020648A1 (de) Verfahren zur herstellung von direkt tablettierbarem alpha-mannit
DE102004004202A1 (de) Herstellungsverfahren für Enzym-Granulate und erhältliche Enzym-Granulate
HK1095110B (en) Method for production of enzyme granules and enzyme granules produced thus

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051213

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051213

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090106

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090406

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090507

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090608

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090529

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090622

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090706

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100420

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100820

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20101008

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20101210

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120208

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120213

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120308

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120313

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120409

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120412

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121114

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121119

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20121214

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20121219

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130115

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130118

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130214

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130814

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130820

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131015

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20131022

R150 Certificate of patent or registration of utility model

Ref document number: 5537755

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140428

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term