JP5537033B2 - 無痛覚 - Google Patents

無痛覚 Download PDF

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Publication number
JP5537033B2
JP5537033B2 JP2008546592A JP2008546592A JP5537033B2 JP 5537033 B2 JP5537033 B2 JP 5537033B2 JP 2008546592 A JP2008546592 A JP 2008546592A JP 2008546592 A JP2008546592 A JP 2008546592A JP 5537033 B2 JP5537033 B2 JP 5537033B2
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JP
Japan
Prior art keywords
glycine
receptor
effect
compounds
compound
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Expired - Fee Related
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JP2008546592A
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English (en)
Japanese (ja)
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JP2009520010A (ja
JP2009520010A5 (enExample
Inventor
マルティン ロイヴァー
ゲルトルート ヘゼラー
ジェレミー ランバート
デリア ベレリ
Original Assignee
ザ ユニヴァーシティー オブ リヴァプール
ザ ユニヴァーシティー オブ ダンディー
メディツィニシェ ホッホシューレ ハノーヴァー
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Publication of JP2009520010A publication Critical patent/JP2009520010A/ja
Publication of JP2009520010A5 publication Critical patent/JP2009520010A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • A61K31/055Phenols the aromatic ring being substituted by halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2008546592A 2005-12-19 2006-12-19 無痛覚 Expired - Fee Related JP5537033B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75155905P 2005-12-19 2005-12-19
US60/751,559 2005-12-19
US79627006P 2006-04-27 2006-04-27
US60/796,270 2006-04-27
PCT/GB2006/004762 WO2007071967A2 (en) 2005-12-19 2006-12-19 Substituted phenol derivatives as analgesics

Publications (3)

Publication Number Publication Date
JP2009520010A JP2009520010A (ja) 2009-05-21
JP2009520010A5 JP2009520010A5 (enExample) 2010-02-12
JP5537033B2 true JP5537033B2 (ja) 2014-07-02

Family

ID=37909696

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008546592A Expired - Fee Related JP5537033B2 (ja) 2005-12-19 2006-12-19 無痛覚

Country Status (6)

Country Link
US (2) US20070142477A1 (enExample)
EP (1) EP1965780B1 (enExample)
JP (1) JP5537033B2 (enExample)
AU (1) AU2006328198B2 (enExample)
CA (1) CA2632561C (enExample)
WO (1) WO2007071967A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5537033B2 (ja) * 2005-12-19 2014-07-02 ザ ユニヴァーシティー オブ リヴァプール 無痛覚
EP2810927A1 (en) * 2007-05-09 2014-12-10 Sowood Healthcare LLC Therapeutic compounds
KR20100017435A (ko) * 2007-05-09 2010-02-16 파마코포어, 인크. 치료 화합물
GB0822486D0 (en) * 2008-12-10 2009-01-14 Univ Liverpool Compounds for use in the treatment of pain
WO2011019747A1 (en) * 2009-08-11 2011-02-17 The Trustees Of Columbia University In The City Of New York Compositions and methods of treating chronic pain by administering propofol derivatives
CN103896743B (zh) * 2012-12-28 2017-04-05 四川海思科制药有限公司 一种2,6‑二异丙基‑4‑氟苯酚的制备方法
GB201322905D0 (en) 2013-12-23 2014-02-12 Univ Liverpool Pharmacologically active compounds
US10449198B2 (en) 2016-07-01 2019-10-22 The University Of Liverpool Method for treating pain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2087019B1 (es) * 1994-02-08 1997-03-16 Bobel246 S L Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
US6518315B1 (en) * 1997-10-21 2003-02-11 The University Of Sydney Medicinal uses of phenylaikanols and derivatives
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
EP1124416A1 (en) * 1999-03-15 2001-08-22 John Claude Krusz Treatment of acute headaches and chronic pain using rapidly-cleared anesthetic drug at sub-anesthetic dosages
IL155999A0 (en) * 2000-12-04 2003-12-23 Hoffmann La Roche Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
EP1383445A4 (en) * 2001-03-20 2005-04-13 Cydex Inc FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN
US20040038874A1 (en) * 2002-08-22 2004-02-26 Osemwota Omoigui Method of treatment of persistent pain
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US7261882B2 (en) * 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US20070043121A1 (en) * 2003-09-29 2007-02-22 Brown Milton L Discovery of novel soluble crystalline anesthetics
DE102005033496A1 (de) * 2005-07-19 2007-01-25 Bayer Healthcare Ag Desinfektionsmittel
JP5537033B2 (ja) * 2005-12-19 2014-07-02 ザ ユニヴァーシティー オブ リヴァプール 無痛覚

Also Published As

Publication number Publication date
CA2632561C (en) 2015-01-27
JP2009520010A (ja) 2009-05-21
US20070142477A1 (en) 2007-06-21
AU2006328198A1 (en) 2007-06-28
US20160095823A1 (en) 2016-04-07
CA2632561A1 (en) 2007-06-28
WO2007071967A2 (en) 2007-06-28
EP1965780B1 (en) 2017-03-08
EP1965780A2 (en) 2008-09-10
AU2006328198B2 (en) 2013-07-18
WO2007071967A3 (en) 2007-10-11

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