CA2632561C - Substituted propofol derivatives as analgesics - Google Patents

Substituted propofol derivatives as analgesics Download PDF

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Publication number
CA2632561C
CA2632561C CA2632561A CA2632561A CA2632561C CA 2632561 C CA2632561 C CA 2632561C CA 2632561 A CA2632561 A CA 2632561A CA 2632561 A CA2632561 A CA 2632561A CA 2632561 C CA2632561 C CA 2632561C
Authority
CA
Canada
Prior art keywords
glycine
receptors
compounds
compound
chloropropofol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2632561A
Other languages
English (en)
French (fr)
Other versions
CA2632561A1 (en
Inventor
Martin Leuwer
Gertrud Haeseler
Jeremy Lambert
Delia Belelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hannover Medical School
University of Liverpool
University of Dundee
Original Assignee
Hannover Medical School
University of Liverpool
University of Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hannover Medical School, University of Liverpool, University of Dundee filed Critical Hannover Medical School
Publication of CA2632561A1 publication Critical patent/CA2632561A1/en
Application granted granted Critical
Publication of CA2632561C publication Critical patent/CA2632561C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2632561A 2005-12-19 2006-12-19 Substituted propofol derivatives as analgesics Expired - Fee Related CA2632561C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75155905P 2005-12-19 2005-12-19
US60/751,559 2005-12-19
US79627006P 2006-04-27 2006-04-27
US60/796,270 2006-04-27
PCT/GB2006/004762 WO2007071967A2 (en) 2005-12-19 2006-12-19 Substituted phenol derivatives as analgesics

Publications (2)

Publication Number Publication Date
CA2632561A1 CA2632561A1 (en) 2007-06-28
CA2632561C true CA2632561C (en) 2015-01-27

Family

ID=37909696

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2632561A Expired - Fee Related CA2632561C (en) 2005-12-19 2006-12-19 Substituted propofol derivatives as analgesics

Country Status (6)

Country Link
US (2) US20070142477A1 (enExample)
EP (1) EP1965780B1 (enExample)
JP (1) JP5537033B2 (enExample)
AU (1) AU2006328198B2 (enExample)
CA (1) CA2632561C (enExample)
WO (1) WO2007071967A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5537033B2 (ja) * 2005-12-19 2014-07-02 ザ ユニヴァーシティー オブ リヴァプール 無痛覚
WO2008141097A2 (en) * 2007-05-09 2008-11-20 Pharmacofore, Inc. Stereoisomers propofol therapeutic compounds
RU2470907C2 (ru) * 2007-05-09 2012-12-27 Сигничер Терапьютикс, Инк. Терапевтические соединения
GB0822486D0 (en) 2008-12-10 2009-01-14 Univ Liverpool Compounds for use in the treatment of pain
US20130005718A1 (en) * 2009-08-11 2013-01-03 Tibbs Gareth R Compositions and methods of treating chronic pain by administering propofol derivatives
CN103896743B (zh) * 2012-12-28 2017-04-05 四川海思科制药有限公司 一种2，6‑二异丙基‑4‑氟苯酚的制备方法
GB201322905D0 (en) 2013-12-23 2014-02-12 Univ Liverpool Pharmacologically active compounds
US10449198B2 (en) 2016-07-01 2019-10-22 The University Of Liverpool Method for treating pain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2087019B1 (es) * 1994-02-08 1997-03-16 Bobel246 S L Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
US6518315B1 (en) * 1997-10-21 2003-02-11 The University Of Sydney Medicinal uses of phenylaikanols and derivatives
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
WO2000054588A1 (en) * 1999-03-15 2000-09-21 John Claude Krusz Treatment of acute headaches and chronic pain using rapidly-cleared anesthetic drug at sub-anesthetic dosages
NZ525917A (en) * 2000-12-04 2005-11-25 F Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists and their use in treating mGLuR5 receptor mediated disorders
EP1383445A4 (en) * 2001-03-20 2005-04-13 Cydex Inc FORMULATIONS WITH PROPOFOL AND A SULFOALKYL ETHER CYCLODEXTRIN
US20040038874A1 (en) * 2002-08-22 2004-02-26 Osemwota Omoigui Method of treatment of persistent pain
US20040147581A1 (en) * 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
US7261882B2 (en) * 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US20070043121A1 (en) * 2003-09-29 2007-02-22 Brown Milton L Discovery of novel soluble crystalline anesthetics
DE102005033496A1 (de) * 2005-07-19 2007-01-25 Bayer Healthcare Ag Desinfektionsmittel
JP5537033B2 (ja) * 2005-12-19 2014-07-02 ザ ユニヴァーシティー オブ リヴァプール 無痛覚

Also Published As

Publication number Publication date
EP1965780B1 (en) 2017-03-08
AU2006328198B2 (en) 2013-07-18
WO2007071967A3 (en) 2007-10-11
US20070142477A1 (en) 2007-06-21
US20160095823A1 (en) 2016-04-07
JP2009520010A (ja) 2009-05-21
AU2006328198A1 (en) 2007-06-28
CA2632561A1 (en) 2007-06-28
EP1965780A2 (en) 2008-09-10
WO2007071967A2 (en) 2007-06-28
JP5537033B2 (ja) 2014-07-02

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Effective date: 20201221