JP5508053B2 - Fungicide - Google Patents

Description

  The present invention relates to a bactericide. The present invention mainly relates to a disinfectant used for disinfecting human fingers and medical instruments, and a fabric containing the disinfectant.

In hospitals, so-called nosocomial infections, in which medical workers such as doctors and nurses, as well as hospitalized or outpatients, suffer from various infectious diseases, have become a problem. Pathogens are brought into hospitals through various routes and can cause nosocomial infections. Moreover, the same infection may be caused not only in the hospital but also in home medical care sites and nursing homes. Such nosocomial infections can be prevented to some extent by enforcing hand washing by medical staff and patients. However, pathogenic bacteria cannot be completely removed by hand washing alone. Therefore, sterilization of fingers using a disinfectant has been conventionally performed. Recently, a quick-drying ethanol preparation mainly composed of disinfecting ethanol is used.
In other words, a formulation containing a suitable disinfectant for hand disinfection is deployed at hospital nurse stations, ward entrances, ICUs, hospital entrances, etc., and hand disinfection with this product before and after patient treatment and care It is carried out. In particular, ethanol preparations are often used because they receive a suitable amount of antiseptic solution in the palm of the hand and can be rubbed to easily disinfect the fingers and are quick-drying.

Disinfectants are used not only for medical workers such as doctors and nurses, in-hospital or hospital patients, but also for food processing workers including restaurants and restaurants, for general use such as nursing homes and nursing facilities, It is used everywhere, such as disinfection of fingers in the home such as home medical care, disinfection for public health.
In general, many bactericidal components in the bactericidal agent have skin irritation and cause rough hands by repeated use of the bactericidal agent. In particular, ethanol for sterilization (76.9-81.4 v / v% ethanol aqueous solution) is generally used as an alcohol preparation for sterilization. If used frequently during the day, sebum components, intercellular lipid components or NMF (natural moisturizing factor) components are eluted by the penetration of ethanol into the skin, and the water content and water retention capacity in the stratum corneum associated with this. Induces rough hands (skin disorder) due to lowering. In addition, the hands in rough hands are more likely to adhere to the bacteria and easily cause secondary infection.

  Therefore, ethanol preparations containing water-soluble moisturizing agents or oil-soluble emollients for protecting the skin are already on the market as means for suppressing hand roughening due to ethanol for pharmacopoeia. Such an ethanol preparation suppresses rough hands by leaving a water-soluble moisturizing agent or oil-soluble emollient on the skin surface, but after disinfecting hands with an ethanol preparation, it is necessary to engage in various operations. The water-soluble humectant or emollient must be adjusted and added so as not to interfere with the work due to stickiness of the fingers. In addition, when engaging in various operations, there are physical loads such as washing with water such as hand washing, use of medical instruments, and friction caused by contact with clothing. Therefore, even from the viewpoint of suppressing hand roughness, the moisturizing effect is maintained, it is excellent in water resistance and friction resistance even after being used for fingers, and it is necessary to protect the fingers from excessive drying.

However, just adding a water-soluble humectant provides good friction resistance but not good water resistance. Moreover, water resistance is good only by adding an oil-soluble emollient, but the friction resistance is not good. As a countermeasure, when a large amount of an emollient is blended in order to improve the friction resistance, the fingers become sticky and the work is hindered. As described above, when both the water-soluble humectant and the emollient are added alone, the effect of suppressing the rough hand is insufficient, and an ethanol preparation having a sufficient effect of suppressing the rough hand has not been found.
From such a background, in Patent Document 1, in order to obtain a disinfecting composition free of rough hand and stickiness, a composition containing a lower alcohol, a cationic disinfectant, and a wetting agent is added to a predetermined polar oil and Although it has been proposed that a cyclic or chain silicone is blended, even with this composition, it has not been possible to sufficiently suppress the rough hand prevention in frequent rubbing use.

JP-A-7-165571

As described above, there is no bactericidal agent that can be used satisfactorily by medical workers who must frequently use bactericides without worrying about rough hands.
The problem to be solved by the present invention is to provide a disinfectant and a fabric containing the disinfectant that can be used with confidence without causing rough hands even after repeated use.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have confirmed that a disinfectant containing a bactericidal component and a specific compound and a fabric containing the bactericidal agent do not cause rough hands even after repeated use. As a result, the present invention has been completed.
That is, the present invention is as follows.
[1] A bactericide containing a compound represented by the following general formula (1) in addition to the bactericidal component.

(In the general formula (1), R ¹ represents a hydrocarbon group having 2 to 20 carbon atoms, and R ² represents hydrogen, carbon atoms having 1 to 3 carbon atoms which may have a carboxylic acid group or a sulfonic acid group. Represents a hydrogen group, Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a salt thereof; Z represents —NR ′ — (R ′ represents hydrogen or a hydrocarbon group having 1 to 10 carbon atoms; ), -O-, or -S-, j and k are either 0, 1 or 2, and j and k are not 0 at the same time, and n is an integer of 2 to 20. X is (This represents a hydrocarbon chain having a molecular weight of 1 million or less, which may have a substituent.)

[2] The fungicide according to the above [1], wherein X in the general formula (1) has 1 to 40 carbon atoms.
[3] A bactericide containing a compound represented by the following general formula (2) in addition to the bactericidal component.

(In the general formula (2), R ¹ represents a hydrocarbon group having 1 to 23 carbon atoms, and R ² represents hydrogen, carbon atoms having 1 to 3 carbon atoms which may have a carboxylic acid group or a sulfonic acid group. Represents a hydrogen group, Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a salt thereof; Z represents —NR ′ — (R ′ represents hydrogen or a hydrocarbon group having 1 to 10 carbon atoms; ), —O—, or —S—, wherein X ′ is a carboxyl group or a salt thereof, —NHR ′ group (R ′ is hydrogen or a hydrocarbon group having 1 to 10 carbon atoms), —OH group, — A hydrocarbon chain having 1 to 20 carbon atoms and having at least one of SH groups, j and k are either 0, 1 or 2 and j and k are not 0 at the same time.)

[4] The bactericidal agent according to any one of the above [1] to [3], wherein the bactericidal component is an alcohol having 1 to 4 carbon atoms.
[5] In any one of the above [1] to [4], the compound represented by the general formula (1) or (2) is contained in an amount of 0.001 mass ppm to 500,000 mass ppm with respect to the total amount of the bactericide. The disinfectant described.
[6] A fabric containing the bactericide according to any one of [1] to [5].
[7] The fabric according to [6], including 0.5 to 5 parts by mass of a disinfectant with respect to 1 part by mass of the fabric.
[8] The fabric according to the above [6] or [7], which contains 2% by mass to 100% by mass of fibers having an official moisture content of 1% or more.

  ADVANTAGE OF THE INVENTION According to this invention, the cloth containing the disinfectant and disinfectant which can be used in peace without causing rough hand by repeated use can be provided.

Hereinafter, the present invention will be described in detail.
The bactericide of the present invention is a bactericide containing a bactericidal component and a compound represented by a specific general formula (1) or (2).
Specific examples of the bactericidal component used in the present invention include the following.
Examples of the organic acid, or a salt thereof or a derivative thereof include benzoic acid, sodium benzoate, undelenic acid, salicylic acid, sorbic acid, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, and paraoxybenzoic acid ester.

  Phenols include isopropylmethylphenol, chlorhexidine gluconate, cresol, chlorothymol, chlorophenesin, chlorocresol, dichloroxylenol, dichlorobenzyl alcohol, thiobischlorophenol, thymol, trichlorocarbanilide, trichlorohydroxydiphenyl ether, sodium phenoxide , Parachlorophenol, halocarban, phenylethyl alcohol, phenylphenol, sodium phenylphenol, phenoxyethanol, phenol, fexachlorophene and benzyl alcohol.

  The quaternary ammonium salts include stearyl dimethyl benzyl alcohol chloride, stearyl trimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, cetyl trimethyl ammonium chloride, benzalkonium chloride, octyl dimethyl benzyl ammonium chloride, lauryl dimethyl benzyl ammonium chloride, myristyl dimethyl benzyl chloride. Ammonium, cetyldimethylbenzylammonium chloride, cetylpyridinium chloride, benzethonium chloride, methylbenzethonium chloride, lauryltrimethylammonium chloride, laurylpyridinium chloride, lauroylcolaminoformylmethylpyridinium chloride, alkylisoquinolinium bromide, cetyltrimethylammonium bromide , Domifene bromide, lauryltrimethylammoni bromide Arm and cetyltrimethylammonium saccharin, and the like.

Examples of the photosensitive element include platonin, pionine, luminescence, and photosensitive element NK143.
Examples of plant extracts having antibacterial activity include tea extract, hinokitiol, apple extract and polylysine.
Antibacterial agents include glutaral, chloramine T, chlorhexidine, dipromopropamidine diisethionate, zinc pyrithione, triclosan, pyrithione Na, furfural and chloramine T.
These bactericidal components can be used alone or in combination of two or more.
Among these, benzalkonium chloride having 8 to 18 carbon atoms and alkyldimethylbenzylammonium chloride having 8 to 18 carbon atoms are particularly preferable because of less skin irritation.

Moreover, when using alcohol as a bactericidal component, a C1-C4 thing is preferable since the effect which can prevent a rough hand is seen even if it uses repeatedly.
Specific examples of the alcohol having 1 to 4 carbon atoms include the following.
Examples of monools include methanol, ethanol, propanol, isopropyl alcohol, 2-methoxyethanol, 2-ethoxyethanol, 2-methoxypropanol, and 2-methoxyisopropanol.
Diols include ethylene glycol, propylene glycol, 1,3-propanediol, 2,3-butanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2-methyl-1 , 2-propanediol, diethylene glycol, 1,4-butynediol and the like.
Examples of polyols include glycerin, 1,2,4-butanetriol, erythritol and the like.
Among these, particularly preferred alcohols having 1 to 4 carbon atoms include ethanol, propanol, isopropanol, ethylene glycol, propylene glycol, 1,3-butanediol, diethylene glycol, glycerin and the like. More preferred are ethanol and isopropanol, and still more preferred is ethanol.
Next, the compound represented by the following general formula (1) will be described.

In the general formula (1), R ¹ is a hydrocarbon group having 1 to 23 carbon atoms. Preferably, it is a hydrocarbon group having 7 to 17 carbon atoms.
In general formula (1), R ² is hydrogen or a hydrocarbon group having 1 to 3 carbon atoms which may have a carboxyl group or sulfonic acid group. Specific examples of the hydrocarbon group include a methyl group, an ethyl group, a propyl group, an isopropyl group, a hydroxymethyl group, a hydroxyethyl group, a hydroxy (iso) propyl group, a dihydroxy (iso) propyl group, a carboxymethyl group, and a carboxyethyl group. , Carboxypropyl group, sulfoethyl group and the like. Preferably, it is hydrogen.
In the general formula (1), Y is a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a salt thereof. Preferably, it is a carboxyl group or a salt thereof.

Y can form salts with various basic substances. Specific examples of metals that can form salts are given below.
Examples of the alkali metal include sodium, potassium, and lithium.
Examples of the alkaline earth metal include calcium and magnesium.
Examples of metals other than those described above include salts of aluminum, zinc, iron, cobalt, titanium, zirconium, silver, and the like.
Moreover, although it does not specifically limit as a basic substance containing the above-mentioned metal, The following are mentioned.
Examples of the organic amine salt include salts of ammonia, monoethanolamine, diethanolamine, triethanolamine, triisopropanolamine, and the like.
Examples of basic amino acid salts include arginine and lysine salts.
Other examples include ammonium salts and polyvalent metal salts.
Moreover, in General formula (1), Y may contain the 1 type, or 2 or more types of salt arbitrarily chosen from the above-mentioned salt.
In General formula (1), Z is -NR'- (R 'is hydrogen or a C1-C10 hydrocarbon group), -O-, or -S-.

Next, X in the general formula (1) will be described.
X is a hydrocarbon chain having a molecular weight of 1 million or less which may have a substituent. X may be a straight chain, a branched chain, a cyclic chain, or an aromatic hydrocarbon chain. X may have a substituent, and particularly preferably has a carboxyl group. The number of carbon atoms in X is preferably 1 to 40, and the molecular weight is preferably 28 to 2000.
In addition, when X contains a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group, or the like, salts may be formed with various basic substances. Examples of the metal capable of forming a salt and the basic substance containing the metal include those described above.
Moreover, there are n parts in parentheses in the general formula (1), which may be the same or different.
The compound represented by the following general formula (2) is an example in the case of n = 2 in the compound represented by the general formula (1). A bactericidal agent using the compound is particularly preferable because it hardly causes rough hands even after repeated use.

In the general formula (2), X ′ is a carboxyl group or a salt thereof, —NHR ′ group (R ′ is hydrogen or a hydrocarbon group having 1 to 10 carbon atoms), —OH group, or —SH group. A C1-C20 hydrocarbon chain which has at least any one is shown. R ¹ , R ² , Y, Z, j, and k are the same as those in the general formula (1).
As a method for producing the compound represented by the general formula (1), an N-acyl acidic amino acid anhydride represented by the following general formula (3) and m functional groups selected from a hydroxyl group, an amino group, and a thiol group ( m can be obtained by reacting a compound having a molecular weight of 1 million or less (hereinafter referred to as m-valent compound).

  The N-acyl acidic amino acid anhydride represented by the general formula (3) is an anhydride in which an acidic amino acid is N-acylated. The N-acyl acidic amino acid anhydride may be any of D-form, L-form, and racemate which are optical isomers. In particular, an L-acidic amino acid which is an L-form is preferable because of its excellent biodegradability.

Acidic amino acids are those having more carboxyl groups than amino groups in the molecule. For example, monoaminodicarboxylic acid having 2 and 1 carboxyl groups and amino groups, respectively, can be mentioned. The hydrogen of the amino group may be substituted with a hydrocarbon group having 1 to 3 carbon atoms. Specific examples of the acidic amino acid include glutamic acid and aspartic acid.
The m-valent compound is a compound having a molecular weight of 1,000,000 or less having m functional groups selected from a hydroxyl group, an amino group, and a thiol group (m ≧ n and an integer of 2 to 20). Here, the m-valent compound can form a bond derived from m functional groups. That is, a hydroxyl group can create an ester bond, an amino group can create an acid amide bond, and a thiol group can create a thioester bond. Further, this compound may have a substituent other than the above-described functional group.

Specific examples of such m-valent compounds include the following.
Specific examples of the compound having two or more hydroxyl groups in the molecule include the following.
Examples of the divalent hydroxyl compound include ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, pentanediol, , 6-hexanediol, cyclohexanediol, dimethylolcyclohexane, neopentyl glycol, 1,8-octanediol, 2,2,4-trimethyl-1,3-pentanediol, isoprene glycol, 3-methyl-1,5- Pentanediol, sorbite, catechol, resorcin, hydroquinone, bisphenol A, bisphenol F, hydrogenated bisphenol A, hydrogenated bisphenol F, dimer diol, dimethylolpropionic acid, dimethylolbutanoic acid, tartaric acid, dihydroxytartaric acid, mevalon , 3,4-dihydroxy cinnamic acid, 3,4-dihydroxy-hydro cinnamic acid, hydroxy benzoic acid, dihydroxy stearic acid, dihydroxyphenylalanine and the like.

Examples of the trivalent hydroxyl compound include glycerin, trioxyisobutane, 1,2,3-butanetriol, 1,2,3-pentanetriol, 2-methyl-1,2,3-propanetriol, and 2-methyl-2. , 3,4-butanetriol, 2-ethyl-1,2,3-butanetriol, 2,3,4-pentanetriol, 2,3,4-hexanetriol, 4-propyl-3,4,5-heptane Triol, 2,4-dimethyl-2,3,4-pentanetriol, 1,2,4-butanetriol, 1,2,4-pentanetriol, trimethylolethane, trimethylolpropane, diethanolamine, triethanolamine and triol Examples thereof include hydroxystearic acid.
Examples of tetravalent hydroxyl compounds include pentaerythritol, erythritol, 1,2,3,4-pentanetetrol, 2,3,4,5-hexanetetrol, 1,2,4,5-pentanetetrol, , 3,4,5-hexanetetrol, diglycerin, sorbitan and the like.

Examples of pentavalent hydroxyl compounds include adonitol, arabitol, xylitol, and triglycerin.
Examples of the hexavalent hydroxyl compound include dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, and allose.
Or the dehydration condensate of above-mentioned 2-6 valent hydroxyl compounds, polyglycerol, etc. are mentioned.

Examples of the m-valent polyhydroxyl compound include saccharides. Specific examples are given below.
Examples of tetrose include erythrose, sreose and erythrulose.
Examples of pentose include ribose, arabinose, xylose, lyxose, xylulose and ribulose.
Examples of monosaccharides include hexose such as allose, altrose, glucose, mannose, guylose, idose, galactose, talose, fructose, sorbose, psicose and tagatose.
Examples of oligosaccharides include maltose, isomaltose, cellobiose, gentiobiose, melibiose, lactose, tulanose, trehalose, saccharose, mannitolose, cellotriose, gentianose, raffinose, meletitose, cellotetorose, and stachyose.
Other sugars include residues such as heptose, deoxy sugar, amino sugar, thio sugar, seleno sugar, aldone sugar, uronic acid, sugar acid, ketoaldonic acid, anhydro sugar, unsaturated sugar, sugar ester, sugar ether and glycoside. Alternatively, polysaccharides such as starch, glycogen, cellulose, chitin, and chitosan, or those obtained by hydrolyzing the above saccharides may be used.

Specific examples of the compound having two or more amino groups in the molecule include the following.
Aliphatic diamines include N, N′-dimethylhydrazine, ethylenediamine, N, N′-dimethylethylenediamine, diaminopropane, diaminobutane, diaminopentane, diaminohexane, diaminoheptane, diaminooctane, diaminononane, diaminodecane, diaminododecane , Diaminoadipic acid, diaminopropanoic acid, diaminobutanoic acid and the like.
Aliphatic triamines include diethylenetriamine, triaminohexane, triaminododecane, 1,8-diamino-4-aminomethyl-octane, 2,6-diaminocapric acid-2-aminoethyl ester, 1,3,6- Examples include triaminohexane, 1,6,11-triaminoundecane, and di (aminoethyl) amine.
Examples of the alicyclic polyamines include diaminocyclobutane, diaminocyclohexane, 3-aminomethyl-3,5,5-trimethylcyclohexylamine, and triaminocyclohexane.

Examples of aromatic polyamines include diaminobenzene, diaminotoluene, diaminobenzoic acid, diaminoanthraquinone, diaminobenzenesulfonic acid, diaminobenzoic acid and the like.
Examples of the araliphatic polyamines include diaminoxylene, di (aminomethyl) benzene, di (aminomethyl) pyridine, and di (aminomethyl) naphthalene.
Examples thereof include polyamines in which hydroxyl groups are substituted on the above-described amine derivatives, such as m-diaminohydroxypropane having a polyvalent poly ≧ n and an integer of 2 to 20).
Examples of amino acids include serine, threonine, cysteine, cystine, cystine disulfoxide, cystathionine, methionine, arginine, lysine, tyrosine, histidine, tryptophan, and oxyproline. These amino acids may be proteins, peptides, etc., or hydrolyzed ones thereof.

Specific examples of the compound having two or more thiol groups in the molecule include dithiol compounds such as dithioethylene glycol, dithioerythritol and dithiothreitol.
Here, the m-valent compound may have two or more functional groups selected from a hydroxyl group, an amino group, and a thiol group. Examples are given below.
Examples of the compound having an amino group and a hydroxyl group in the molecule include aminoethanol, aminopropanol, aminobutanol, aminopentanol, aminohexanol, aminopropanediol, aminoethylethanolamine, aminoethylaminoethanol, aminocresol, aminonaphthol, Examples include aminonaphtholsulfonic acid, aminohydroxybenzoic acid, aminohydroxybutanoic acid, aminophenol, aminophenethyl alcohol, and glucosamine.
Examples of the compound having a thiol group and a hydroxyl group in the molecule include mercaptoethanol, mercaptophenol, mercaptopropanediol, and glucothiose.
Examples of the compound having a thiol group and an amino group in the molecule include aminothiophenol and aminotriazole thiol.

The m-valent compound may be any of the optical isomers D-form, L-form, and racemate, and may be each isomer.
Further, among m-valent compounds, those having 1 to 40 carbon atoms are preferable, and those having 1 to 20 carbon atoms are more preferable. In addition, since naturally occurring compounds are superior in biodegradability, amino acids, peptides, saccharides and the like are preferable.
When reacting the N-acyl acidic amino acid anhydride and the m-valent compound, a solvent may be used. Examples of the solvent used in the reaction include water, a mixed solvent of water and an organic solvent, or an inert solvent such as tetrahydrofuran, benzene, toluene, xylene, carbon tetrachloride, chloroform, and acetone. The reaction temperature is preferably −5 ° C. to 200 ° C. and mixed and reacted at a temperature equal to or higher than the melting point of the above compound.

As another method for producing the compound represented by the general formula (1), not an N-acyl acidic amino acid anhydride but an N-acyl acidic amino acid mono-lower ester (for example, methyl ester, ethyl ester) and the above m-valent It can also be obtained by reacting with a compound.
An N-acyl acidic amino acid mono-lower ester and an m-valent compound are dissolved in a suitable solvent such as dimethylformamide, a catalyst such as potassium carbonate is added, and the mixture is heated at -5 ° C to 250 ° C under reduced pressure. Thereafter, it is obtained by removing the reaction solvent. Or it can also obtain by carrying out heat-melting without a solvent without using a solvent, adding a catalyst, such as sodium hydroxide, and carrying out transesterification at room temperature-250 degreeC.

Next, the disinfectant of the present invention will be described.
The fungicide of the present invention preferably contains 0.00001 to 90% by mass of the bactericidal component, and contains 0.001 mass ppm to 500,000 mass ppm of the compound represented by the general formula (1) or (2). Is preferred. The content of the compound represented by the general formula (1) or (2) is more preferably 0.001 ppm or more and 300,000 mass ppm or less, and further preferably 0.001 ppm or more and 100,000 mass ppm or less.
The content of the sterilizing component is preferably in the above range from the viewpoints of sterilization / sterilizing power, safety, stickiness, and the like. Moreover, the roughening prevention effect becomes favorable by making content of the compound shown by General formula (1) or (2) into the said range.
In particular, when benzalkonium chloride and lauryldimethylbenzylammonium chloride are used as the bactericidal component, the content of the bactericidal component is preferably 0.00001 to 1% by mass. In that case, the compound represented by the general formula (1) or (2) is preferably contained in an amount of 0.001 to 1000 mass ppm, more preferably 0.001 to 100 mass ppm, and still more preferably 0.001 to 1 mass. It contains ppm.

Moreover, when using C1-C4 alcohol as a bactericidal component, it is preferable that content of a bactericidal component is 1-90 mass%. In that case, the compound represented by the general formula (1) or (2) is preferably contained in an amount of 0.001 to 100,000 ppm by mass, more preferably 0.001 to 50,000 ppm by mass, and still more preferably 0.001 to 0.001. It is to contain 10,000 mass ppm. In addition, the content of other components other than alcohol having 1 to 4 carbon atoms and water in the bactericide is preferably 10% by mass or less from the viewpoint of reducing the sticky feeling. Furthermore, if the content of other components is 0.0001 to 7% by mass, the antibacterial persistence on the surface coated with the fabric containing the disinfectant of the present invention and the surface sprayed with the disinfectant can also be obtained. preferable.
Moreover, it is preferable that the disinfectant of the present invention is an aqueous solution containing the disinfecting component and the compound represented by the general formula (1) or (2) in the above amounts.

The disinfectant of the present invention can be produced by mixing the disinfecting component and the compound represented by the general formula (1) or (2). The mixing method is not particularly limited. A solvent may be added in the mixing, and as specific examples of the solvent to be added, purified water, alcohols such as ethyl alcohol, isopropyl alcohol, propylene glycol, and glycerin can be used. The mixing temperature is not particularly limited as long as the disinfectant is uniformly mixed, but it may be from the freezing point to the boiling point of the raw material used.
The disinfectant of the present invention may contain additives such as a surfactant, a pH adjuster, a chelating agent, a thickener, and a fragrance as long as the effects of the present invention are not impaired. Specific examples thereof are given below.
Although it does not specifically limit as surfactant, For example, a nonionic surfactant, an amphoteric surfactant, a cationic surfactant, an anionic surfactant etc. are mentioned.

Specific examples of the nonionic surfactant include the following.
Lecithin, polymer emulsifier, glycerin fatty acid ester, glycerin fatty acid ester such as lipophilic glyceryl monostearate, polyglyceryl fatty acid ester such as polyglyceryl monooleate, polyglyceryl pentaoleate, polyglyceryl dekaoleate, polyoxymonostearate Polyoxyethylene glycerol fatty acid esters such as ethylene glycerin, sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monooleate, sorbitan trioleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan trioleate, etc. Oxyethylene sorbitan fatty acid esters, monolauric acid polyoxyethylene sorbitol, tetraoleic acid polyoxyethylene sorbitol Polyoxyethylene sorbite fatty acid esters such as polyoxyethylene lanolin, polyoxyethylene lanolin, lanolin alcohol and beeswax derivatives such as polyoxyethylene sorbit beeswax, polyoxyethylene castor oil, polyoxyethylene such as polyoxyethylene castor oil and polyoxyethylene hydrogenated castor oil Castor oil / hardened castor oil, polyoxyethylene sterols / hydrogenated sterols such as polyoxyethylene cholestanol ether, polyethylene glycol fatty acid esters such as ethylene glycol monostearate and polyethylene glycol monooleate, polyoxyethylene lauryl ether , Polyoxyethylene alkyl ethers such as polyoxyethylene cetyl ether and polyoxyethylene behenyl ether, polyoxyethylene Polyoxyethylene polyoxypropylene alkyl ethers such as reoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene alkylphenyl ethers such as polyoxyethylene nonylphenyl ether, polyoxyethylene stearamide And polyoxyethylene alkylamine / fatty acid amides, sucrose fatty acid esters, alkyl glucosides and the like.

  Among these, particularly preferred nonionic surfactants include glycerin fatty acid esters such as lecithin, glycerin fatty acid ester, lipophilic glyceryl monostearate, polyglyceryl fatty acid such as polyglyceryl monooleate, polyglyceryl pentaoleate, and polyglyceryl dekaoleate. Sorbitan fatty acid esters such as esters, sorbitan monolaurate, sorbitan monooleate, sorbitan trioleate, sucrose fatty acid esters, alkyl glucosides, and polyoxyethylene alkyl ethers are less likely to affect the bactericidal activity of bactericidal components Is preferable.

Specific examples of the amphoteric surfactant include the following.
Glycine-type amphoteric surfactants such as sodium lauryldiaminoethylglycine, alkyldiaminoethylglycine chloride, coconut oil fatty acid acyl-N-carboxyethoxyethyl-N-carboxyethylethylenediamine disodium, coconut oil fatty acid acyl-N-hydroxyethylethylenediamine sodium Aminopropionic acid-type amphoteric surfactants such as laurylaminopropionate such as alkyldimethylaminoacetic acid betaine, sodium alkyldimethylbetaine, coconut oil fatty acid amidepropylbetaine lauric acidamidopropylacetic acid betaine And sulfobetaine-type amphoteric surfactants such as lauryl hydroxysulfobetaine.

  Among these, particularly preferred amphoteric surfactants are glycine-type amphoteric surfactants such as sodium lauryldiaminoethylglycine, alkyldiaminoethylglycine chloride, and palm oil fatty acid acyl-N-carboxyethoxyethyl-N-carboxyethylethylenediamine disodium. Aminopropionic acid type amphoteric surfactants such as lauryl aminopropionate such as coconut oil fatty acid acyl-N-hydroxyethylethylenediamine sodium, alkyldimethylaminoacetic acid betaine, sodium alkyldimethylbetaine, coconut oil fatty acid amidopropyl betaine amide propyl laurate Examples thereof include aminoacetic acid betaine type amphoteric surfactants such as betaine acetate.

Specific examples of the cationic surfactant include the following.
Aliphatic amine salts such as stearic acid diethylaminoethylamide, alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, alkyltrimethylammonium saccharin, alkyl quaternary ammonium such as dipolyoxyethylene alkylmethylammonium chloride, alkyldimethylbenzylammonium chloride, chloride Examples thereof include cyclic quaternary ammonium salts such as lauryl pyridinium and alkyldimethyl (ethylbenzyl) ammonium chloride.
Among these, particularly preferred cationic surfactants include alkyl quaternary ammonium such as alkyl trimethyl ammonium chloride, alkyl trimethyl ammonium bromide, alkyl trimethyl ammonium saccharin, dipolyoxyethylene alkyl methyl ammonium chloride, alkyl dimethyl benzyl ammonium chloride, chloride Examples thereof include cyclic quaternary ammonium salts such as lauryl pyridinium and alkyldimethyl (ethylbenzyl) ammonium chloride.

The following are mentioned as an anionic surfactant.
N-acyl organic acid salt type anions such as polyoxyethylene alkyl ether acetic acid and alkyl ether carboxylic acid type anionic surfactants such as salts thereof, N-acyl sarcosine salts, N-acyl glutamates, N-acyl alkyl taurates Surfactants, sulfonate anionic surfactants such as α-olefin sulfonates and alkylsulfosuccinates, sulfate anionic surfactants such as alkyl sulfates, polyoxyethylene alkyl ether phosphates Examples thereof include phosphate type anionic surfactants such as salts, and polyoxyethylene alkyl ether sulfates such as sodium polyoxyethylene lauryl ether sulfate.
Among these, particularly preferred anionic surfactants include alkyl ether carboxylic acid type anionic surfactants such as polyoxyethylene alkyl ether acetic acid and salts thereof, N such as N-acyl glutamate and N-acyl alkyl taurine salts. -Acyl organic acid salt type anionic surfactants, polyoxyethylene alkyl ether sulfates such as sodium polyoxyethylene lauryl ether sulfate, and the like.

Although it does not specifically limit as a pH adjuster, Citric acid, malic acid, adipic acid, glutamic acid, arginine, aspartic acid, sodium citrate, sodium hydroxide, hydrochloric acid, sulfuric acid, sodium thiosulfate, etc. can be mentioned. .
The chelating agent is not particularly limited as long as it has a metal-capturing action, but includes the following.
Complexane, alanine, ethylenediaminehydroxyethyl triacetate trisodium, edetic acid, edetate disodium, edetate disodium calcium, edetate trisodium, edetate tetrasodium, sodium citrate, citric acid, gluconic acid, tartaric acid, phytin Acid, sodium polyphosphate, sodium metaphosphate, etc. are raised.
Among these, particularly preferable chelating agents include alanine, disodium edetate, disodium calcium edetate, sodium citrate, citric acid, gluconic acid, tartaric acid, sodium polyphosphate, sodium metaphosphate, and the like.
Although it will not specifically limit as a thickener as long as it is a component which shows a viscosity, A xanthan gum, a carboxyl vinyl polymer, and an acrylic acid type polymer can be mentioned.
Although it will not specifically limit as a fragrance | flavor if it is a component which shows an odor, A natural fragrance | flavor, a synthetic fragrance | flavor, a blended fragrance | flavor, etc. can be mentioned.

Examples of other additives include the following.
Nonionic polymers include natural rubbers such as gum arabic and tragacanth, glucosides such as saponin, cellulose derivatives such as methylcellulose, carboxycellulose and hydroxymethylcellulose, natural polymers such as lignin sulfonate and shellac, polyacrylic acid Salt, salt of styrene-acrylic acid copolymer, salt of vinyl naphthalene-maleic acid copolymer, sodium salt of β-naphthalene sulfonic acid formalin condensate and phosphate, polyvinyl alcohol, polyvinyl Examples include pyrrolidone, polyethylene glycol, polyoxyethylene fatty acid ester methyl glycoside and the like.
Examples of the polymeric surfactant include sodium alginate, starch derivatives and tragacanth rubber.

Examples of natural surfactants include lecithin, lanolin, cholesterol and saponin.
As fats and oils, avocado oil, almond oil, olive oil, cacao oil, sesame oil, safflower oil, soybean oil, camellia oil, persic oil, castor oil, mink oil, cottonseed oil, owl, coconut oil, egg yolk oil, palm oil, palm kernel Oil, synthetic triglyceride, jojoba oil and the like.
Examples of the hydrocarbon include liquid paraffin, petrolatum, ceresin, microcrystalline wax and isoparaffin.
Examples of the waxes include beeswax, whale wax, lanolin, carnauba wax, candelilla wax and derivatives thereof.
Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, behenic acid, undecylenic acid, lanolin fatty acid, hard lanolin fatty acid, and soft lanolin fatty acid.

Examples of the higher alcohol include lauryl alcohol, cetanol, cetostearyl alcohol, stearyl alcohol, oleyl alcohol, behenyl alcohol, lanolin alcohol, hydrogenated lanolin alcohol, hexyl decanol and octyldodecanol.
Examples of ester oils include isopropyl myristate and butyl stearate.
Volatile and non-volatile oils include metal soap, dimethylpolysiloxane, polyether-modified silicone, alcohol-modified silicone, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone And silicones such as volatile silicones.
Examples of the humectant include trimethyl glycine, sorbitol, raffinose, pyrrolidone carboxylates, lactates, hyaluronates and ceramides.

  Examples of water-soluble and oil-soluble polymers include hydroxyethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose hydroxypropyl trimethyl ammonium chloride ether, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, soluble starch, carboxymethyl starch, methyl starch, propylene alginate Glycol ester, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methyl ether, carboxyvinyl polymer, polyacrylate, guar gum, locust bin gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, dextran, succino glucan , Card run, hi Ruronic acid, gelatin, casein, albumin, collagen, methoxyethylene maleic anhydride copolymer, amphoteric methacrylate copolymer, polydimethylmethylenepiperidinium chloride, polyacrylate copolymer, polyvinyl acetate, nitrocellulose And silicone resin.

Examples of the sequestering agent include ethylenediaminetetraacetic acid and its salts, hydroxyethylenediaminetriacetic acid and its salts, phosphoric acid, ascorbic acid, succinic acid, gluconic acid, polyphosphates, metaphosphates and hinokitiles.
Examples of the ultraviolet absorber include benzophenone derivatives, paraaminobenzoic acid derivatives, paramethoxycinnamic acid derivatives and salicylic acid derivatives.
Examples of the whitening agent include arbutin, kojic acid, ascorbic acid, hinokitile and derivatives thereof.
Examples of the blood circulation promoter include assembly extract, cephalanthin, vitamin E and derivatives thereof, gamma oryzanol, capsicum tincture, ginger tincture, cantharis tincture, nicotinic acid benzyl ester and the like.
Examples of anti-inflammatory agents include glycyrrhetinic acid, glycyrrhizic acid derivatives, allantoin, azulene, aminocaproic acid, and hydrocortisone.

Examples of the astringent include zinc oxide, zinc sulfate, allantoin hydroxyaluminum, aluminum chloride, zinc sulfocolate and tannic acid.
Examples of the antioxidant include tocopherols, BHA, BHT, gallic acid and NDGA.
Examples include refreshing agents such as menthol and camphor, antihistamines, silicone materials such as polymeric silicones and cyclic silicones, sebum inhibitors such as estradiol, estrone and ethinylestradiol, and exfoliating and dissolving agents such as sulfur, salicylic acid and resorcin. .

In addition, oyster extract, N-methyl-L-serine, whey, nicotinamide, diisopropylamine dichloroacetate, mevalonic acid, γ-aminobutyric acid (including γ-amino-β-hydroxybutyric acid), altea extract, aloe Extract, apricot kernel extract, turmeric extract, oolong tea extract, seawater dried product, hydrolyzed wheat powder, hydrolyzed silk, carrot extract, cucumber extract, gentian extract, yeast extract, rice germ oil, comfrey extract, bonito extract, siberian extract , Sicon extract, birch extract, Atlantic mint extract, assembly extract, bisabolol, propolis, loofah extract, bodaiju extract, hop extract, maronier extract, muroji extract, melissa extract, eucalyptus extract, yukinoshita extract, rosemary ex Can be included Romakamitsureekisu, royal jelly extract, seaweed, rice bran, licorice, citrus unshiu peel, angelica, pulverized Momonoha, sphingolipids, the guaiazulene and vitamin C, etc. as additives.
In the present invention, the above-mentioned additives can be used alone or in combination of two or more.

It is preferable to use the disinfectant of the present invention in a fabric.
The cloth is not particularly limited as long as it is a fiber, but natural fibers such as absorbent cotton, paper, cotton, hemp, wood pulp, silk, linen, cotton linter, viscose rayon, copper ammonia rayon, solvent spinning rayon, etc. Recycled fiber, nylon (polyamide fiber), polyester (polyester fiber), acrylic (polyacrylonitrile fiber), vinylon (polyvinyl alcohol fiber), polypropylene (polypropylene fiber), vinylidene (polyvinylidene chloride fiber), polyurethane (Polyurethane fiber), synthetic fibers such as polyethylene can be used alone or as a mixture.
Among these, a fabric containing 2% or more and 100% or less of hydrophilic fibers having an official moisture content of 1% or more is particularly desirable. By using it, the fabric can be sufficiently impregnated with the disinfectant of the present invention, so that the effect of the disinfectant can be sufficiently obtained. The hydrophilic fiber here is a fiber having an official moisture content of 1% or more, and examples thereof include absorbent cotton, rayon, wood pulp, and cotton.
Examples of the form of the fabric using these fibers include paper, non-woven fabric, and cloth. The production method is not particularly limited as long as it is a known method for producing paper, non-woven fabric, and cloth, but the non-woven fabric is particularly preferable in consideration of simplicity and cost.
Basis weight of the fiber sheet is preferably used in 10~120g / ^{m 2} for difficult to use or too thick or too thin, furthermore, it is preferably used in 15 to 80 g / ^{m 2.}

The fabric containing the disinfectant of the present invention preferably contains 0.5 to 5 parts by mass of the disinfectant with respect to 1 part by mass of the fabric. If it is the said range, since a bactericidal effect is exhibited and there is little wiping residue, it is preferable. More preferably, it is preferable to impregnate 1-5 mass parts of a disinfectant.
The method of using the bactericide of the present invention is not particularly limited as long as it is a method of sterilizing in contact with an object, and includes a method of spraying in a trigger type container or a mist type container. In the case of sterilization of fingers, a method of spraying a sterilizing agent directly on the hand and a method of sterilizing by immersing the hand in a sterilizing agent placed in a container such as a basin can be exemplified.
Items to be sterilized include food conveyor belt conveyors and work tables, working tools such as stainless steel buds and bowls, refrigerators and tools used for making dishes, toys, toilet seats, window glasses, vehicle window glasses, and washstands. It is suitably used for cleaning the human body, sterilizing and disinfecting.
The fabric containing the disinfectant of the present invention is used for making various surfaces such as cleaning, disinfecting, antibacterial, for example, belt conveyors and work tables in food factories, working tools such as stainless steel pads and bowls, refrigerators and dishes. It is suitably used for tools, toys, toilet seats, window glass, vehicle window glass, wash basins, human body cleaning, sterilization and disinfection.

Hereinafter, the present embodiment will be described more specifically with reference to examples and comparative examples. However, the present embodiment is not limited to only these examples.
The compound represented by the general formula (1) was produced by the method described below.
[Production Example 1]
9.1 g (0.05 mol) of L-lysine hydrochloride was mixed with 57 g of water. This liquid was stirred while adjusting the pH range to 10 to 11 with a 25% aqueous sodium hydroxide solution and maintaining the reaction temperature at 5 ° C. Under stirring, 31.1 g (0.1 mol) of N-lauroyl-L-glutamic anhydride was added over 2 hours to carry out the reaction. Thereafter, stirring was continued for another 30 minutes, and tertiary butanol was added to a concentration of 20% by mass in the liquid, 75% sulfuric acid was added dropwise to adjust the pH value of the liquid to 2, and the liquid temperature was adjusted to 65. Adjusted to ° C.
After completion of the sulfuric acid addition, stirring was stopped, and the mixture was allowed to stand at 65 ° C. for 20 minutes to separate into an organic layer and an aqueous layer, and the organic layer was separated therefrom. Tertiary butanol and water were added to the separated organic layer, the temperature was raised to 65 ° C., and the mixture was stirred for 20 minutes. After the stirring was stopped, the mixture was allowed to stand to separate into an organic layer and an aqueous layer. After repeating the same water washing operation described above for the obtained organic layer, the solvent was removed from the obtained organic layer, and the resulting solution was made into an aqueous solution having a solid content of 30% by mass and pH 6.5 (25 ° C.) with sodium hydroxide. After neutralization and preparation, this was dried to obtain a compound represented by the following formula (4).
In the reaction of N-lauroyl-L-glutamic anhydride and L-lysine hydrochloride, four types of compounds are produced as shown by the following formula (4) depending on the way of binding.

(In Formula 4, R is a hydrocarbon group having 11 carbon atoms, and M is each independently H or Na)

[Production Example 2]
The same procedure as in Production Example 1 was performed except that 31.1 g of N-lauroyl-L-glutamic acid anhydride was changed to 31.1 g of N-cocoyl-L-glutamic acid anhydride in Production Example 1.
[Production Example 3]
In the manufacture example 1, it implemented on the same conditions as the method of the manufacture example 1 except having implemented the neutralization process with potassium hydroxide.
The performance evaluation test methods performed in the examples and comparative examples are as follows.

<Evaluation method for rough skin scaling>
A skin rough scaling confirmation test was performed by the following method. For the forearm flexion side of 8 male and female subjects (26 to 52 years old), disinfectant (inventive products 1 to 6, comparative products 1 and 2) with predetermined parts (5 cm ² , 10 wards) 1 person was applied to each of the preparations, and the operation was repeated 10 times per day for 5 consecutive days.
Ten days after the application end date, the application part was observed with a microscope (Keyence, VH-6200, × 10 magnification) to determine the state of scaling. The criteria were as follows.
Judgment criteria:
Evaluation of scaling 3: A considerable amount of peeling of the epidermis and stratum corneum is observed.
2: Many peelings of the epidermis and stratum corneum are observed.
1: Some peeling of epidermis and stratum corneum is observed.
0: No change in the state of the epidermis and stratum corneum compared to the untreated part.
Table 1 shows the evaluation results of the bactericides. In addition, a display numerical value is an average value of 8 persons.

<Skin irritation>
Spray 3ml of germicide on the fingers of 8 male and female subjects (26 to 52 years old) by spraying, and rub them together until dry. This operation was repeated 10 times every 30 minutes. The stimulation to the skin after the operation was performed by sensory evaluation in subjects. The obtained results were judged according to the following criteria.
Evaluation of skin irritation 3: I felt the irritation very much.
2: I felt irritation.
1: I felt that there was little irritation.
The total score of 8 people is 20 points or more: ×
15-19 points: △
10-14 points: ○
9 points or less: ◎
Table 1 shows the evaluation results of the bactericides. In addition, a display numerical value is an average value of 8 persons.

<Sterilization performance>
After dispensing 10 ml of a bactericidal agent into a sterilized test tube, 0.1 ml of an E. coli solution prepared to 1 × 10 ⁵ cfu / mL (Colony Forming Unit) was inoculated and treated at room temperature for 1 minute. Immediately after the treatment, 1 ml of the solution was added to 9 ml of peptone saline buffer to stop the reaction. 0.1 ml of the stopped solution was smeared on a SCD agar plate medium (soybean agar medium), cultured at 35 ° C. for 48 hours, and the number of bacteria that appeared on the medium was measured. For comparison, the same operation was performed using sterilized purified water instead of the bactericidal agent.
Evaluation of bactericidal performance More than 10% of the bacteria appearing compared to the comparison target: ×
10 to 1%: △
1 to 0.01%: ○
Less than 0.01%: ◎

<Evaluation of skin irritation of fabric containing disinfectant>
The wiping operation using a fabric containing a disinfectant was repeated 10 times every 10 minutes for 8 men and women (26 to 52 years old). The stimulation to the skin after the operation was performed by sensory evaluation in subjects. The obtained results were judged according to the following criteria.
Evaluation of skin irritation 3: I felt irritation very much.
2: I felt irritation.
1: I felt that there was little irritation.
The total score of 8 people is 20 points or more: ×
15-19 points: △
10-14 points: ○
9 points or less: ◎
The fabric names used in the examples and comparative examples are as follows.
Wood pulp / polyester = 54/46 (trade name: Sontara 8838 manufactured by DuPont): Hereinafter, it is abbreviated as Sontara 8838. Polyester is a hydrophobic fiber having an official moisture content of 0.4%.
Rayon / PP, PE composite fiber (trade name: AS40 (spun lace) manufactured by Daiwa Spinning Co., Ltd., 80% hydrophilic fiber): hereinafter, abbreviated as AS40.
Polyester non-woven fabric (manufactured by Vilene)

[Example 1]
All the components in Table 1 (benzalkonium chloride, compound 1 and purified water) were uniformly mixed at room temperature so as to have the contents shown in Table 1 to obtain a fungicide. The evaluation results are shown in Table 1.

[Examples 2-6, Comparative Examples 1-2]
A fungicide was obtained in the same manner as in Example 1 except that the composition described in Table 1 was used. The evaluation results are shown in Table 1.

From the results of Table 1, the bactericides of Examples 1 to 6 have a high bactericidal power and have the effect of not causing skin irritation and rough hands even after repeated use.
On the other hand, Comparative Examples 1 and 2, which do not contain the compound represented by the general formula (4), are excellent in bactericidal power, but are not sufficient bactericides in that they do not cause skin irritation or rough hands.

[Example 7]
25 g of the disinfectant obtained in Example 1 was impregnated uniformly into 10 g of the fabric “Sontara 8838” (impregnation rate: 250%), and a disinfectant-containing fabric was obtained and evaluated.

[Examples 8 to 10 and Comparative Example 3]
A disinfectant-containing fabric was obtained in the same manner as in Example 7 except that the disinfectant and the fabric were changed to the composition and fabric described in Table 2, respectively. The evaluation results are shown in Table 2.

From the results of Table 2, the disinfectant-containing fabrics of Examples 7 to 10 have the effect that they do not cause skin irritation even after repeated use.
On the other hand, the disinfectant-containing fabric of Comparative Example 3 that does not contain the compound represented by the general formula (4) is not a sufficient disinfectant-containing fabric in that it causes skin irritation.
Further, in the disinfectant-containing fabric of Example 10 using a non-woven fabric that does not contain hydrophilic fibers, the disinfectant is unevenly distributed in the impregnation state of the impregnating liquid (disinfectant), and the disinfectant is sufficiently sterilized. It is not an agent-containing fabric.

  The disinfectant and disinfectant-containing fabric of the present invention have high disinfectant power, and can be used with confidence without causing rough hands even after repeated use. For example, food factory belt conveyors and work tables, working tools such as stainless steel pads and bowls, refrigerators and tools used when making dishes, toys, toilet seats, window glass, vehicle window glass, washstands, human body cleanliness, It can be suitably used for sterilization and the like.

Claims (8)

In addition to the bactericidal component, a bactericidal agent containing a compound represented by the following general formula (1).

(In the general formula (1), R ¹ represents a hydrocarbon group having 1 to 23 carbon atoms, and R ² is hydrogen, or a carbon atom having 1 to 3 carbon atoms which may have a carboxylic acid group or a sulfonic acid group. Represents a hydrogen group, Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a salt thereof; Z represents —NR ′ — (R ′ represents hydrogen or a hydrocarbon group having 1 to 10 carbon atoms; ), -O-, or -S-, j and k are either 0, 1 or 2, and j and k are not 0 at the same time, and n is an integer of 2 to 20. X is (This represents a hydrocarbon chain having a molecular weight of 1 million or less, which may have a substituent.)   The fungicide according to claim 1 or 2, wherein X in the general formula (1) has 1 to 40 carbon atoms. In addition to the bactericidal component, a bactericide containing a compound represented by the following general formula (2).

(In the general formula (2), R ¹ represents a hydrocarbon group having 1 to 23 carbon atoms, and R ² represents hydrogen, carbon atoms having 1 to 3 carbon atoms which may have a carboxylic acid group or a sulfonic acid group. Represents a hydrogen group, Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group or a salt thereof; Z represents —NR ′ — (R ′ represents hydrogen or a hydrocarbon group having 1 to 10 carbon atoms; ), —O—, or —S—, wherein X ′ is a carboxyl group or a salt thereof, —NHR ′ group (R ′ is hydrogen or a hydrocarbon group having 1 to 10 carbon atoms), —OH group, — A hydrocarbon chain having 1 to 20 carbon atoms and having at least one of SH groups, j and k are either 0, 1 or 2 and j and k are not 0 at the same time.)   The bactericidal agent according to any one of claims 1 to 3, wherein the bactericidal component is an alcohol having 1 to 4 carbon atoms.   The disinfectant according to any one of claims 1 to 4, wherein the compound represented by the general formula (1) or (2) is contained in an amount of 0.001 to 500,000 ppm by mass with respect to the total amount of the disinfectant.   A fabric comprising the bactericide according to any one of claims 1 to 5.   The fabric according to claim 6, comprising 0.5 to 5 parts by mass of a disinfectant with respect to 1 part by mass of the fabric.   The fabric according to claim 6 or 7, comprising 2% by mass or more and 100% by mass or less of fibers having an official moisture content of 1% or more.