CN108495552A - The alcohol composition of Octenidine dihydrochloride with certain content - Google Patents

The alcohol composition of Octenidine dihydrochloride with certain content Download PDF

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Publication number
CN108495552A
CN108495552A CN201680079870.XA CN201680079870A CN108495552A CN 108495552 A CN108495552 A CN 108495552A CN 201680079870 A CN201680079870 A CN 201680079870A CN 108495552 A CN108495552 A CN 108495552A
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weight
composition
composition according
alcohol
amount
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Inventor
安吉洛·达席尔瓦诺拉斯科
安雅·大卫
卡特琳·施泰因豪尔
莫娜·哈恩
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Chico Maier Ltd
Schuelke and Mayr GmbH
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Chico Maier Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances

Abstract

The present invention relates to a kind of composition, the composition includes a) by weight at least 20% ethyl alcohol, b) by weight at least 1% normal propyl alcohol and c) by weight at least 0.02% Octenidine dihydrochloride.Particularly, these compositions are used for hygienic hand-wrist bones and surgery hand-wrist bones.

Description

The alcohol composition of Octenidine dihydrochloride with certain content
The present invention relates to the specific alcohol compositions of the Octenidine dihydrochloride with certain content.Particularly, by these Composition is used for hygienic hand-wrist bones and surgery hand-wrist bones.In addition, the present invention relates to Octenidine dihydrochlorides for improving alcohol examination Purposes of the agent for antibacterial skin, health and surgical hand and health and the validity of surgery hand-wrist bones.
Alcohol composition is for antibacterial skin, mucous membrane antibacterial, wound disinfection, hygienic hand-wrist bones, sanitary washing, surgery hand-wrist bones Validity with surgical hand is known.Since it resists the validity of a large amount of bacteriums, fungi and virus, use for this purpose Fatty alcohol, such as ethyl alcohol, normal propyl alcohol (1- propyl alcohol) and isopropanol (2- propyl alcohol).Its validity starts after the only short time, special It is not if specific alcohol exists with quite high concentration.In contrast, the composition of the fatty alcohol with lower content is more Skin-compatible and therefore hand-wrist bones or wash one's hands are advantageous.
Fatty alcohol in the combination principle of the active constituent with the magnetic after effect confirmed antibacterial skin, hand-wrist bones and to wash Hand provides advantage.For example, these combinations can be advantageous because then need less amount of alcohol and therefore effectively but compared with Few degreasing preparation is obtainable.However, it has been found that the active constituent with magnetic after effect cannot directly be prepared to generate Disinfectant based on fatty alcohol.For example, active constituent Chlorhexidine be not in ethanol it is substantially stabilized (referring particularly to US 5, 800,827 B)。
Octenidine dihydrochloride is the active constituent with the magnetic after effect confirmed.For example, product (cities Nuo Desitaite of the Federal Republic of Germany Shu Mei companies (Sch ü lke＆Mayr GmbH, Norderstedt, Federal Republic of Germany)) include by weight 0.1% Octenidine as medically active ingredient Dihydrochloride, by weight 30.0% 1- propyl alcohol and by weight 45.0% 2- propyl alcohol.ProductIncluding By weight 0.1% Octenidine dihydrochloride, by weight 40.0% 1- propyl alcohol and by weight 30.0% 2- third Alcohol.Due to the fatty alcohol of high relative contents, they are only suitable as detergent compositions on limited extent.They are also only in limited journey It kills the virus on degree.In contrast, if preparation, which also has, resists nonenveloped virus (e.g., norovirus, adenovirus and ridge Marrow poliovirus) good validity, hygienic hand-wrist bones are advantageous.This will be particularly present in high ethano content In preparation.
10 2,010 054 155 A1 of DE disclose fatty alcohol in the production of disinfectant for preventing disinfectant by bacterium The purposes of spore contamination.Without discussing that disinfectant is directed to tabernacle and Chang Ju skin floras in 10 2,010 054 155 A1 of DE The effect of the typical bacteria of (such as fungi and bacterium, including staphylococcus aureus) and for virus effect, these effect It is especially important for health and surgery hand-wrist bones.
10 2,011 077 432 A1 of DE disclose the use of double pyridinium alkanes.These compositions are in abiotic table It (such as surface or instrument disinfection) or is used in lived surface (such as application on human skin) on face.
The object of the present invention is to provide compositions, in particular for hygienic hand-wrist bones and surgery hand-wrist bones, these compositions Automatically with high-content fatty alcohol (still, if it is desired to, can be prepared with the fatty alcohol of high-content).These combinations Therefore object should be also adaptable as detergent compositions, also, have good validity of killing the virus in addition.
Realize that this purpose, the composition include a) by weight at least 20% second by a kind of composition according to the present invention Alcohol, b) by weight at least 1% normal propyl alcohol and c) by weight at least 0.02% Octenidine dihydrochloride.
Unexpectedly, for the combination of fatty alcohol and Octenidine dihydrochloride, the mixture of ethyl alcohol and 1- propyl alcohol is [mixed Close object (i)] have proven to more antimicrobial than the mixture [mixture (ii)] of ethyl alcohol and isopropanol more effective.In addition, The favourable outcome of quantitative suspension test can obtain in being simulated about the experiment of the physical condition of hygienic hand-wrist bones according to EN 1500 To confirmation.
The combination of fatty alcohol and Octenidine dihydrochloride especially provides utilization when with rather high concentration using ethyl alcohol It kills the virus and characteristic and has wide anti-microbial effectiveness and magnetic after effect since the content of Octenidine dihydrochloride obtains The selection of virucidal compositions.Further, since this of the improved validity of the content of especially 1- propyl alcohol has now surprisingly been found that It is also to attract people's attention about washing and antibiotic preparation.
Therefore, in a first aspect, the present invention relates to a kind of composition, the composition includes：
A) ethyl alcohol-by weight at least 20%,
B) normal propyl alcohol-by weight at least 1% and
C) Octenidine dihydrochloride-by weight at least 0.02%.
In the description of the present invention, the ethyl alcohol of the content refer to pure material (and include for example industry or medicine Denaturant present in the ethyl alcohol of purity or water).
According to a specific aspect, such as composition as defined above includes the ethyl alcohol for being up to 95% by weight.
A) the preferred amount of ethyl alcohol be by weight 23% to 95%, preferably by weight 25% to 85%, particularly by Weight meter 30% to 80%, the such as ethyl alcohol of by weight 34% to by weight 75%.
In another preferred embodiment, the composition includes the ethyl alcohol, such as by weight for being less than 78% by weight Most 75% ethyl alcohol.
According to another specific aspect, such as composition as defined above includes be up to 30% by weight positive third Alcohol.
B) the preferred amount of normal propyl alcohol be by weight at least 1.5%, preferably by weight at least 1.8%, particularly by Weight meter at least 2.0%, such as by weight 2.0% to 30% or by weight 2.2% to 30%, such as by weight 2.5% To 25% normal propyl alcohol.Give it is particularly preferred be by weight 2.5% to 20% normal propyl alcohol, such as by weight 2.5% to The amount of 15% normal propyl alcohol.
According to a specific aspect, such as composition as defined above includes to be up to 0.25% Austria by weight for Buddhist nun Pyridine dihydrochloride.
In a preferred embodiment, c) amount of Octenidine dihydrochloride is by weight 0.025% to 0.25%, preferably By weight 0.03% to 0.2%, particularly by weight 0.035% to 0.18%, such as by weight 0.04% to 0.16%, Such as the Octenidine dihydrochloride of by weight about 0.05% to about 0.15%.
Include according to more specifically aspect, such as a composition as defined above：
A)-by weight from 25% to 85% ethyl alcohol,
B)-by weight from 2% to 30% normal propyl alcohol and
C)-by weight from 0.03% to 0.2% Octenidine dihydrochloride；And also more particularly：
A)-by weight from 30% to 80% ethyl alcohol,
B)-by weight from 2.5% to 25% normal propyl alcohol and
C)-by weight from 0.05% to 0.15% Octenidine dihydrochloride；
It is according to the present invention in addition to the component a) ethyl alcohol of mandatory provision, b) normal propyl alcohol and c) other than Octenidine dihydrochloride Composition optionally further includes：
D)-one or more surfactants, preferably both sexes or nonionic surfactant.
AsNonionic surfactant, all suitable nonionic surfactants can be used, wherein it is preferred that (i) (fat) alcohol ethoxylate, (ii) sorbitan ester, (iii) alkyl glycosides (especially alkyl poly glucoside), (iv) amine oxide and (v) ethylene oxide/propylene oxide block copolymer.
(i) alcohol poly-alkoxyl compound includes fatty alcohol alkoxy compound, such as the ethylene oxide with various scores is different Decyl ethoxylate, isotridecyl ethoxylate, the polyglycol ether of stearyl alcohol, laruyl alcohol and cetanol and oleyl alcohol. Here, alcohol can be by any desired mixture alcoxyl of ethylene oxide, propylene oxide or ethylene oxide and propylene oxide Base.Alcohol poly-alkoxyl compound is especially with titleWithIt is known.As nonionic surfactant, particularly preferably bay alcohol ethoxylate is given.
In addition, used nonionic surfactant (ii) is sorbitan ester, most of with oleate, hard Resin acid ester, laurate and palmitate exist and be referred to as polysorbate (for example,)。
In addition, nonionic surfactant can be (iii) alkyl glycosides, if alkyl-glucoside is (that is, the alkane of glucose Base glucosides), more preferable C8-C20The C of alkyl polydextrose, particularly fatty alcohol8-C16Alkyl polydextrose, wherein it is preferred that the moon Or mixtures thereof osmanthus base polydextrose, decyl polyglucose.Carbon chain lengths in the case of cocoyl polydextrose be 8 to 16 atoms are 12 to 16 carbon atoms in the case of lauryl polydextrose, and in the case of decyl polyglucose Equally it is 8 to 16 carbon atoms.
The typical amount of alkyl glycosides is by weight 0.03% to 10%, preferably by weight 0.06% to 5%, especially It is by weight 0.1% to 2%.
According to the present invention, all suitable amine oxides may be used as (iv) amine oxide in principle.N- as tertiary amine is aoxidized The amine oxide of object includes aliphatic amine oxide, cyclic annular amine oxide (such as N- alkyl morpholines oxide) and aromatic series amine oxide (such as pyrrole Pyridine N- oxides).In a preferred embodiment, amine oxide has following general formula
R1R2R3N-O,
Wherein, R1It is methyl, ethyl or 2- ethoxys, R2It is methyl, ethyl or 2- ethoxys, R1And R2Can be together Morpholine, R3It is alkyl or R with 8 to 18 carbon atoms4CONH(CH2)n, wherein R4It is the alkyl with 8 to 18 carbon atoms And n be from 1 to 10, preferably 1 to 5, it is more preferable 2 to 4 in the range of and especially 3, and 2- ethoxys can be with 1 It is condensed to 2000 ethylene oxide, ethylene oxide/propylene oxide or propylene oxide units.
The example of amine oxide is cocamidopropyl propyl amide amine oxide, N- cocomorpholines oxide, decyldimethyl amine oxygen Compound, dimethyl cetyl amine oxide, dimethylcocoamine oxide, dimethyl hydrogenated tallow base amine oxide, dimethyl Lauryl amine oxide, dimethyl myristyl amine oxide, (2- ethoxys) cocoamine oxide and oleyl amine oxide.Also join See " International Cosmetic Ingredient Dictionary and Handbook [International Cosmetic Ingredient words Allusion quotation and handbook] ", the 10th edition, volume 2004,3, the 2268-2275 pages (surfactant-detergent).
In a preferred embodiment, amine oxide is cocamidopropyl propyl amide amine oxide, i.e. R4CO is derived from coconut oil The acyl group of aliphatic acid, n=3, and R1 and R2 are methyl.This product is as Rewominox B 204 by the republicanism of federation of Germany The Gao De Schmitts company (Goldschmidt) of state sells.
Amine oxide it is typical amount be by weight 0.03% to 10%, preferably by weight 0.06% to 5%, particularly By weight 0.1% to 2%.
Be also suitable as surfactant isAmphoteric surfactant, such as glycine betaine.Suitable glycine betaine description In 560 114 A2 of EP.Give particularly preferably Cocoamidopropyl betaine.The typical amount of glycine betaine is by weight Meter 0.03% to 10%, preferably by weight 0.06% to 5%, particularly by weight 0.1% to 2%.
In addition, be suitable as surfactant isCationic surfactant, such asQuaternary ammonium salt.In principle, all suitable Quaternary ammonium compound can be used according to the invention.Preferably, quaternary ammonium compound is dialkyl dimethyl ammonium salt.
Quaternary ammonium salt used according to the invention is by formula [R1R2R3(CH3)N]+[X]-It provides, wherein R1To R3Can be it is identical or It is different and be selected from C1To C30Alkyl ,-aralkyl ,-alkenyl and can have one or more selected from O, S, N and P The mixed group of atom, wherein R1To R3It is such as C8To C18Alkyl, benzyl or methyl, preferably C9To C18Alkyl, benzyl or Methyl, such as C16Alkyl, benzyl or methyl.X is (inorganic or organic acid) anion.Here, the anion of quaternary ammonium salt and sun from Both sub can be multivalent ion, this obtains stoichiometry [A(n+)]m[K(m+)]n。
According to the present invention, suitable quaternary ammonium salt is all quaternary ammonium salts known in the prior art with previously described formula, such as Such as disclosed in WO 00/63337, it is referred at this.It is however preferred to use dialkyl dimethyl ammonium salt, such as Dialkyl dimethyl ammonium chloride, alkyl chain are independently from each other C8To C18Alkyl, preferably C9To C18Alkyl, such as C16- Alkyl.In dialkyl dimethyl ammonium salt, one of these methyl can be alkoxylated (such as ethoxylation) methylol.
Quaternary ammonium salt preferably used according to the invention is with formula [R1N(CH3)3]+[X]-、[R1R2N(CH3)2]+[X]-With [R1R2R3(CH3)N]+[X]-Compound, wherein R1To R3It is independently from each other C8To C18Alkyl and-(CH2-CHR4O)n- R5, wherein n is the number from 1 to 20, preferably 1 to 5, and R4And R5Can be identical or different, it is H and/or C1To C4Alkyl, it is excellent Select H.
The example of the anion of quaternary ammonium salt used according to the invention and the type of anion are hydroxyl, sulfate radical, sulphur Sour hydrogen radical, methyl-sulfuric acid root, etherosulfuric acid root, lauryl sulfate root, laureth sulfate root, cellulose sulfate root, sulfamic acid root, Halogen (fluorine ion, chlorion, bromide ion, iodide ion), nitrite anions, nitrate anion, carbonate, bicarbonate radical, phosphate radical, alkyl Phosphate radical, metaphosphoric acid radical, multi-phosphate, thiocyanate radical (thiocyanate, rhodanide), carboxylate radical such as benzoate anion, breast Acid group, acetate, propionate, citrate, amber acid radical, glutarate, adipic acid root, tosylate (toluenesulphonate, tosylate) and salicylate.Particularly preferred anion is chlorion and propionate.
It is particularly preferred that using quaternary ammonium salt Mecetronium Etilsulfate (cetyl (ethyl) dimethyl ammonium ethylsulfate) and Benzalkonium chloride.
In addition to the component a) ethyl alcohol of mandatory provision, b) normal propyl alcohol and c) Octenidine dihydrochloride and optional component D) outside, composition according to the present invention optionally further includes：
E)-one or more solvents.
Preferred solvent is two alcohol and waters and its mixture.Preferred solvent is water.
In addition to the component a) ethyl alcohol of mandatory provision, b) normal propyl alcohol and c) Octenidine dihydrochloride and optional component D) and/or e) outside, composition according to the present invention optionally further includes：
F)-one or more active constituents and/or auxiliary agent.
The example that active constituent and/or auxiliary agent in composition according to the present invention can be optionally present in is skin nursing Additive, fatting agent (refatting agent), fragrance, aromatic, thickener, pH adjusting agent, emollient, wetting agent and dye Material.These are especially：
Polyalcohol serves as skin nursing additive, fatting agent and wetting agent, as glycerine, erythrose alcohol, 1,2,6- oneself Triol, inositol, lactitol, maltitol, mannitol, methyl propanediol, phytantriol, polyglycereol, D-sorbite and xylose Alcohol, wherein particularly preferred glycerine,
Glyceride, preferably coconut oil fat monoglyceride, aliphatic alcohol ester, such as cetearyl stearyl (cetearyl Stearyl ester) isopropyl myristate (isopropyl myristate), isopropyl myristate (isopropyl palmitate) and aliphatic acid Triglycerides serves as fatting agent,
Allantoin serves as skin nursing additive, and/or
Sodium gluconate serves as buffer.
For example, composition according to the present invention preferably comprises one or more fatting agents.
Fatting agent
Composition according to the present invention preferably comprises d) monohydroxy C1To C6One or more aliphatic esters of alkylol.
Preferably, the alkylol of the aliphatic ester is selected from methanol, ethyl alcohol, normal propyl alcohol and isopropanol.It is particularly preferred that the fat The alkylol of fat acid esters especially isopropanol.
It is also preferred that the aliphatic acid of the aliphatic ester is selected from C10To C18Aliphatic acid, preferably C12To C16Fat Acid, the wherein aliphatic acid are preferably myristic acid.
Therefore, it is preferably in all embodiments of the invention, which is isopropyl myristate.
Component, preferably isopropyl myristate are preferably with the weight based on the composition from 0.02% To 5%, preferably by weight 0.1% to 4%, more preferably by weight 0.2% to 3%, particularly by weight 0.3% To 2.0%, such as by weight 0.5% to 1.8%, such as by weight 0.6% to 1.6%, such as by weight about 0.75% or About 1.4% amount is present in composition according to the present invention.
Moreover it is preferred that composition according to the present invention does not have the content of aromatic alcohol (such as according to DE 10 2011 077 432 A1 mandatory provisions, if fatty alcohol presence).
According to another preferred embodiment, the content of the isopropanol in these compositions be it is limited and be, for example, by Weight meter is less than 25%, is preferably less than 20% by weight, is particularly less than 15% by weight, is such as less than by weight 10%, for example it is less than 5% isopropanol by weight.
In addition, the content of Chlorhexidine derivative is preferably limited and is by weight less than 0.3%, such as by weight Less than 0.2%, wherein composition according to the present invention is particularly preferably free of Chlorhexidine derivative.Chlorhexidine derivative is preferably chlorine Oneself determines digluconate, the presence of the Chlorhexidine derivative be preferably according to the present invention it is limited and particularly preferably exclude it In the presence of.
In addition, in another embodiment, the present invention relates to the compositions for antibacterial skin, hygienic hand-wrist bones, health It washes one's hands, in the method for surgery hand-wrist bones or surgical hand.
The present invention therefore further relate to the composition for antibacterial skin, hygienic hand-wrist bones, sanitary washing, surgery hand-wrist bones or The purposes of surgical hand.
Thus according to the present invention it is also for antibacterial skin, hygienic hand-wrist bones, sanitary washing, surgery hand-wrist bones or surgery The method washed one's hands, wherein the composition is made to work on the region of the skin or hand that are discussed.
The application of composition according to the present invention is particularly happened in the method for following item：
I) antibacterial skin,
Ii) hygienic hand-wrist bones (according to EN 1500, ASTM 1174),
Iii) sanitary washing (according to EN 1499),
Iv) surgery hand-wrist bones, or
V) surgical hand (according to EN 12791, ASTM 1115).
In one embodiment, present invention is accordingly directed to according to EN 1500, preferably according to EN 1500:2013 in hygienic hand It is applied during disinfection.In another embodiment, the present invention relates to applied according to ASTM 1174, preferably according to ASTM 1174-13 It is used for hygienic hand-wrist bones with these compositions.
In another embodiment, the present invention relates to according to EN 1499, preferably according to EN 1499:2013 in sanitary washing Period applies these compositions.
In another embodiment, the present invention relates to according to EN 12791, preferably according to EN 12791:2013 wash in surgery These compositions are applied during hand.In addition, the present invention relates to according to ASTM 1115, preferably according to ASTM 1115-11 in surgery These compositions are applied during washing one's hands.
In addition, the present invention relates to Octenidine dihydrochlorides to be used to improve the magnetic after effect of the composition comprising following item Purposes
A) by weight at least 20% ethyl alcohol and
B) by weight at least 1% normal propyl alcohol.
Composition according to the present invention is particularly used for controlling tabernacle pathogen when hygienic hand-wrist bones.For example, according to this The composition of invention is reasonably resistant to people pathogenic bacteria such as Escherichia coli or yeast-like fungi such as Candida albicans.In addition, according to this The composition of invention is reasonably resistant to envelope virus (such as HIV, HBV or HCV) and it is substituted viral (BVDV or vaccinia virus) And nonenveloped virus such as norovirus, adenovirus and poliovirus are also resisted in a preferred embodiment.According to this The composition of invention, which is additionally operable to reduce during surgery hand-wrist bones, often occupies skin flora.It is micro- that these are preferably bacterial Gram positive Biology, which is characterized in that any endospore cannot be formed, such as staphylococcus or corynebacterium.
Advantages of the present invention is apparent from following instance in particular.Unless otherwise stated, the percentage otherwise stated Refer to weight.
Example
Experiment 1：The validity of the various combinations of fatty alcohol and Octenidine dihydrochloride is (according to German health and microorganism Association (DGHM) 2001, dirty condition, test organism：The quantitative suspension test of Candida albicans)
* in 100g solution the denatured ethyl alcohol of 50g be equivalent to by weight about 46.5% ethyl alcohol.In 100g solution The denatured ethyl alcohol of 40g is equivalent to by weight about 37.2% ethyl alcohol.
**MEK：Methyl ethyl ketone.
The result of the validity of the time of contact of 15s, 30s and 60s is graphically illustrated in Fig. 1 (when CT=is contacted Between；Oct=Octenidine dihydrochlorides；EtOH=ethyl alcohol；1-propOH=1- propyl alcohol；2-propOH=2- propyl alcohol).This includes Data within the scope of dynamics validity, wherein the saturation acted on is still not present, different validity becomes for this reason It obtains clear：
Experiment A shows the validity of by weight 46.5% ethyl alcohol.
Experiment G shows the validity of by weight 0.05% Octenidine dihydrochloride.
Experiment B (by weight 46.5% ethyl alcohol and by weight 0.05% Octenidine dihydrochloride) is demonstrated Octenidine dihydrochloride in ethanol for example inhibits validity in 30s.
Experiment C shows the validity for by weight 37.2% ethyl alcohol that the isopropanol with by weight 10% combines.
Experiment D shows that the mixture for this alcohol has also appeared the inhibition due to Octenidine dihydrochloride.
Experiment E shows the validity for by weight 37.2% ethyl alcohol that the normal propyl alcohol with by weight 10% combines.
Then experiment F is demonstrated does not inhibit after Octenidine dihydrochloride is added.
Experiment 2
In addition, following preparation is according to EN 1500:1997 (30 seconds, 3ml) are tested.It uses in each case Reference alcohol is in EN 1500:The reference substance provided in 1997 (2 × 3ml, 60% (v/v) 2- propyl alcohol, 60 seconds).Such as in EN 1500:That imagines in 1997 is tested in each case, is had 12-15 health volunteer and is statistically carried out Assessment.
* in 100g solution the denatured ethyl alcohol of 79.00g be equivalent to by weight 73.45% ethyl alcohol.
The preparation I of content with ethyl alcohol and normal propyl alcohol is effective.Buddhist nun is replaced in the Austria for being added by weight 0.1% After pyridine dihydrochloride (preparation II), validity is retained.
The preparation III of content with ethyl alcohol and isopropanol is effective.It is replaced in the Austria for being added by weight 0.1% When Buddhist nun's pyridine dihydrochloride (preparation IV), this validity does not retain, and especially if adding Octenidine dihydrochloride Dosage is reduced to 0.05% (preparation V) validity by weight and does not also retain.

Claims (20)

1. a kind of composition, the composition include
A) by weight at least 20% ethyl alcohol,
B) by weight at least 1% normal propyl alcohol and
C) by weight at least 0.02% Octenidine dihydrochloride.
2. composition according to claim 1, which is characterized in that the composition includes the second for being up to 95% by weight Alcohol.
3. composition according to claim 1 or 2, which is characterized in that the amount of ethyl alcohol is by weight 25% to 85%.
4. composition according to claim 3, which is characterized in that the amount of ethyl alcohol is by weight 30% to 80%.
5. composition according to claim 1 or 2, which is characterized in that the composition includes to be up to 30% by weight Normal propyl alcohol.
6. composition according to any one of claim 1 to 5, which is characterized in that the amount of normal propyl alcohol is by weight 2% To 30%.
7. composition according to claim 6, which is characterized in that the amount of normal propyl alcohol is by weight 2.5% to 25%.
8. composition according to claim 7, which is characterized in that the amount of normal propyl alcohol is by weight 2.5% to 15%.
9. according to the composition described in any one of claim 1,2 or 5, which is characterized in that the composition includes by weight Up to 0.25% c) Octenidine dihydrochloride.
10. composition according to any one of claim 1 to 9, which is characterized in that the amount of Octenidine dihydrochloride is By weight 0.03% to 0.2%.
11. composition according to claim 10, which is characterized in that the amount of Octenidine dihydrochloride is by weight 0.05% to 0.15%.
12. composition according to any one of claim 1 to 11, which is characterized in that the composition further includes：
D)-one or more surfactants, selected from bay alcohol ethoxylate, lauryl polydextrose, the poly- grape of decyl Sugar, or mixtures thereof, cocamidopropyl propyl amide amine oxide and Cocoamidopropyl betaine.
13. composition according to any one of claim 1 to 12, which is characterized in that the composition further includes：
E)-one or more solvents, preferably water.
14. composition according to any one of claim 1 to 13, which is characterized in that the composition further includes：
F)-one or more active constituents and/or auxiliary agent, selected from glycerine, antierythrite, 1,2,6- hexanetriols, inositol, lactose Alcohol, maltitol, mannitol, methyl propanediol, phytantriol, D-sorbite and xylitol, preferably glycerine, coconut oil fat Monoglyceride, isopropyl myristate, cetearyl stearyl, isopropyl palmitate and fatty acid triglycercide, allantois Element and sodium gluconate.
15. composition according to claim 14, which is characterized in that the composition further includes：
F) by weight 0.02% to 5% isopropyl myristate.
16. the composition according to one of preceding claims, which is characterized in that the composition does not have containing for aromatic alcohol Amount.
17. the composition according to one of preceding claims, which is characterized in that the composition includes to be less than by weight 25% isopropanol, preferably by weight be less than 20%, particularly by weight be less than 15%, such as by weight be less than 10%, Such as the isopropanol by weight less than 5%.
18. the composition according to one of preceding claims, which is characterized in that the composition includes to be less than by weight 0.3% Chlorhexidine derivative, the Chlorhexidine derivative for being such as less than 0.2% by weight, wherein the composition are particularly preferably not Derivative containing Chlorhexidine.
19. the composition according to one of preceding claims, it to be used for antibacterial skin, hygienic hand-wrist bones, sanitary washing, outer In the method for section's hand-wrist bones or surgical hand.
20. Octenidine dihydrochloride is used to improve the purposes of the magnetic after effect of the composition comprising following item
A) ethyl alcohol-by weight at least 20% and
B) normal propyl alcohol-by weight at least 1%.
CN201680079870.XA 2015-12-18 2016-12-14 The alcohol composition of Octenidine dihydrochloride with certain content Withdrawn CN108495552A (en)

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AU2016372336B2 (en) 2019-10-31
KR20180088463A (en) 2018-08-03
WO2017102850A1 (en) 2017-06-22

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