KR960002395B1 - Antiseptic compositions - Google Patents

Abstract

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Description

Disinfectant Composition

The present invention relates to an antiseptic composition having a fast and effective antimicrobial and antiviral activity, and more particularly, the present invention is directed to a method for treating an antiseptic composition with one or more agents having a residual antimicrobial and / or antiviral action. It relates to a composition containing an iodine carrier that acts.

The composition of the present invention is a disinfectant skin cleanser, a disinfectant solution used before treatment with a plaster bandage, for example, a disinfection lotion for skin disinfection prior to surgery or first aid, pre-surgical skin cleaning and showering agents and shampoos, and shavings. It can be used in medical fields such as disinfectant lotion, antiseptic drug, rinse liquid of hospital laundry, diaper disinfectant and surface sprays, and in the fields of agriculture and veterinary medicine, treatment of foot rot and It is used in medicaments, such as prophylactic and animal Samfuje.

And surprisingly, it was found that there is a synergy between the iodine carrier and the residual antibacterial and antiviral drugs.

Traditionally, surgeons and other medical practitioners have only used soap and water to wash their hands, but recently they have continued to search for more practical hand cleaning methods that provide effective skin cleaning, prevent immediate re-infection, and even sterilize. Iodine is well known as an effective hand and skin cleanser that effectively cleans the skin, prevents rapid sterilization and prevents future reinfection. Since it has excellent bactericidal properties, it has been used for a long time as a bactericidal component of skin cleaners. Came.

As illustrated in U.S. Patent No. 3777022, it is superior to conventional iodine preparations containing iodine in dissolved form by forming 3-iodide with alkali or hydrogen iodide, such as iodine or Lugol solution. It is well known for the benefits of iodine, which can be used as a bactericidal active ingredient by forming a complex in combination with an iodide carrier.

Iodine, especially in combination with polyvinylpyrrolidone, known as povidone-iodine, is a complex known as povidone-iodine. It has been used as an antiseptic skin cleaner.

However, this iodine has the disadvantage that the skin does not have any residual effect from re-infection even after it is used on the skin even though there is a great advantage of the disinfectant cleanser, which is more effective than other drugs that do not contain iodine.

Therefore, quaternary ammonium compounds, which do not act as fast as iodine carriers, do not have a wide range of germicidal areas, and do not act strongly against several strains of gram-positive and gram-negative microorganisms, have a sustained antibacterial effect on the skin after use. Other bactericidal components, such as chlorohexidine salts, have been widely used in various disinfecting agents.

In addition, bacteriostatic agents form the third group of fungicides that are widely used as cleansers for the skin and hands, which have a high affinity for the skin and have a sustained antimicrobial effect and are completely reinfected even with continued use. In addition to providing residual antimicrobial properties, these agents minimize the bacterial layer that remains on the skin without being removed by any of these antimicrobial agents.

From this fact, it is necessary to combine sterilizing ingredients such as iodine complexes, which have a rapid effect and a wide range of application, and drugs which have a persistent disinfecting effect, although they do not give a continuous action after use.

That is, in all cases where a rapid disinfection effect is required, it is clear that continuous protection against re-infection is necessary, even for a limited time, especially in the hands and skin of disinfecting cleansers of iodine complexes and residues. It is very important to combine bacteriostatic agents to form a bactericidal protective film with immediate skin disinfection, so that there is no possibility of future reinfection.

Therefore, the preparation of a disinfectant composition having both a long-term antimicrobial effect and a wide and rapid sterilization effect against all germs will result in remarkable developments in general hand and skin hygiene and sterilization techniques.

In the past, for example, attempts have been made to combine iodine and bacteriostatic components in bactericidal solutions as in US Pat. No. 37,77022 and Canadian Pat. The reactions in the liver have resulted in substantial losses of significant amounts of iodine, and most have not been successful.

Accordingly, it is an object of the present invention to prepare disinfectant compositions containing at least one or more iodine complexes and at least one residual fungicide, together with a pharmacologically, veterinary or agriculturally acceptable carrier or diluent.

The iodine complex referred to in the present invention is a complex of iodine, known as povidone-iodine, with polyvinylpyrrolidone, or a complex of a nonionic surface active agent and iodine having the following general formula.

R (CH ₂ CH ₂ O) ₂ H

In addition, a polycondensate of ethylene oxide and propylene oxide having a molecular weight of 1000 or more, preferably 2500 to 4000, wherein R represents an alkylphenol, a fat alcohol or a fatty acid residue, and x represents 6 To 100, preferably 7 to 15.

Such complexes have a fast sterilization effect and a wide range of sterilization areas, so that you can use them for disinfectant skin cleansers for preoperative disinfection, disinfectants for general hospitals and homes, disinfectant cleaners for veterinary use and food, and related industries. It has been a useful bactericidal component for use, and such complexes also include iodine complexes containing amphoteric surfactants and quaternary ammonium compounds.

Preferred complexes of iodine with polyvinylpyrrolidone have a 10% iodine and a K-value of 30, and nonylphenoxy- (ethyleneoxy) -iodine, polyethyleneoxypoly as well as other commercially available components. It may also contain propyleneoxy-iodine and undecoylinium-chlorine-iodine.

Suitable bacteriostatic agents that can be used as components of the present invention are also hydrogenated hydroxydiphenyl derivatives, hydrogenated salicylanilides and carbanilides.

For example, the bacteriostatic agent may be represented by the following structural formula.

Wherein R ₁ to R ₉ are each hydrogen, halogen, lower alkyl, lower haloalkyl, lower alkoxy, allyl, cyano, amino or acetyl and O-acyl derivatives thereof, and at least one of R ₁ to R ₉ is halogen :

Wherein X ₈ to X ₁₀ in formula (II) are each hydrogen, halogen, haloalkyl, nitro or alkoxy, at least one of which is halogen:

In formula (III), Y ₁ to Y ₉ are each hydrogen or halogen, at least two of which are halogen:

In formula (IV), Z ₁ to Z ₈ are each hydrogen or halogen, and each phenyl ring is substituted with at least two halogen atoms.

Such compounds are already disclosed in Australian patents 200868, 209986, 236460, 273941, 278661 and 283648, and US Pat. Nos. 2250840, 2967885, 3254121, 3057920 and 3064048.

Further, examples of the more preferable bacteriostatic agent include 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan): 2,2'-dihydroxy-3,3'-5,5 ' -6,6'-hexachlorodiphenylmethane (hexachlorophene): 3,5,4'-tribromosalicylate (tribromsalan) and 3,4,4'-trichloro- or 3-trifluoromethyl- 4,4'-dichloro-carbylides (triclocarban and cloflucorban).

In particular, triclozan is a preferred bacteriostatic agent for use in the present invention.

Since the composition of the present invention preferably contains more available iodine than the bacteriostatic agent, the iodine complex in the components of the composition according to the present invention is 0.01 to 5.0% (W / V), in particular 0.35 to 2.0% (W / V) is included to provide usable iodine, while bacteriostatic support is included in the composition at a rate of 0.01-3.0% (W / V), in particular 0.5-2.0% (W / V). . Furthermore, if one or more surfactants are additionally contained in the composition, at least one of them should be a nonionic surfactant.

The disinfectant composition of this patent is stable for a significant time of two years if there is no light at a temperature below 25 ° C.

The bactericidal effect exhibited as a combination of available iodine and bacteriostatic agents would be greater than would be expected from the values of bactericidal power obtained by the addition of iodine and bacteriostatic agents, respectively. The cumulative effect of is also shown in the following table obtained by in vitro minimun inhibitory tests as a series of dilutions using Difco AOAC solution.

Solution containing 1.0% (W / V) triclozan in clear liquid

A solution containing 0.75% povidone-iodine available in the same cleaning liquid

Solution containing 0.5% povidone-iodine and 1.0% (W / V) triclozan useful iodine in the same cleaning solution

In addition, when surfactants are used to provide cleanliness, such as compositions requiring cleanliness, such surfactants must be stable as well as saturated in a solution of pH 6 or less in order to remain long without being separated from the solution. The hand cleaner according to the present invention exhibits the property of forming a sufficient foam at a composition pH of 6 or less, although the pH of the composition may range from 2 to 6 for practical reasons, but the skin cleaner and disinfectant are selected from 4 It is preferable to select a pH of about 2 for the cleaning agent for wound surface sterilization.

Suitable surfactants are also nonionics such as nonylphenolpolyethoxy condensates, alkali ammonium and treethanol amine salts of phenoxy or alkyloxypolyoxy-ethylene sulfonates, or polycondensates of propylene oxide of ethylene oxide, and they are solely It may be used as a mixture or mixed with the above.

Furthermore, along with the surface active agent, foaming agents such as alkyldimethylamine oxide such as laurylmethylamine oxide or lauryl diethanol amide or fatty acid dimethanol amide may be used.

In the present invention, the bacteriostatic agent may be used by appropriately dissolving in a general solvent such as ethanol, isopropanol or propylene glycol, or may be used directly if the composition has sufficient solubility to contain the bacteriostatic agent in solution. .

Due to the different compositions and their different actions, many ingredients must be added to give the composition the desired properties, and care must be taken in the selection of ingredients to ensure that those ingredients are suitable without affecting the stability of the iodine complex.

And if they do not affect the iodine complex and the bacteriostatic agent used in the composition, may be used in combination with glycerin or other softening agents widely used in hand and skin cleansing agents as needed.

Hereinafter, the present invention will be described in detail with reference to Examples, and the present invention is not limited to the Examples. It is noted that each component is combined by a standard cooling mixing process.

Disinfectant Skin and Cleanser

Iodine Complex * 4.0g

Nonionic Surfactant ** 5.0g

Sodium lauryl ethoxysulfate *** 20.0 g

Laurylmethylamineoxide **** 5.0g

Glycerol 1.0 g

trichlocarban 2.0g

5.0 ml of propanol

Phosphoric Acid (to adjust to pH 4.5)

Water (to make 100.0 ml)

* (Antarox VRO 20 from GAF, USA)

** (Antarox CO 730 from GAF, USA)

*** (Albright & Wilson's Empigen 5Q 25)

**** (Embrite & Wilson's Empigen OB)

Example 2

Sanitary freshener

7.5 g of povidone-iodine with 10.0% (W / V) of useful iodine

Sodium salt of sulfonated alkylphenoxy poly (ethyleneoxy) ethanol * 20.0 g

Lauryl diethanol Ahmad 2.0g

Glycerol 1.0 g

0.5 g of triclosan

10.0 ml isopropanol

Phosphoric Acid (to adjust to pH 4.5)

Water (to make 100 ml)

* (FenopanCO., GAF, USA)

The bacteriostatic agent used is dissolved in isopropanol before mixing with other ingredients.

Example 3

Disinfection Solution

10.0 g of povidone-iodine with 10.0% (W / V) of useful iodine

40.0 ml of 2: 1 mixture of ethanol and isopropanol

tribromsalan 0.25 g

Nonionic Surfactant ** 0.50 g

Phosphate-citrate buffer (to adjust pH 4.5)

Water (to make volume 100.00 ml)

Triclozan is dissolved in alcohol before the other ingredients are mixed.

Example 4

Disinfectant Link

5.0 g of povidone-iodine with 10.0% (W / V) of useful iodine

Lanogel 61 * 0.25g

Ethanol 70.00ml

Triclozan 0.25g

Phosphate-citrate buffer (to adjust pH 4.5)

Water (to make volume 100.0 ml)

* Nonionic Lanolin Derivative Surfactant (Amerchol, USA)

Example 5

Skin cleanser for preoperative disinfection

10.0 g of povidone-iodine containing 10.0% (W / V) of useful iodine

5.0 g nonionic surfactant

Sodium lauryl ethoxysulfate * 30.0 g

2.0 g of coconut diethylolamide

10.0 ml of propylene glycol

Triclozan 1.0g

Phosphate (to adjust pH 4.5)

Water (to make volume 100.0 ml)

* (Useful Empigen 5Q 25 from Albright and Wilson)

PVP-I, sodium lauryl and coconitdieethanolamide were dissolved in water and slowly added with triclozan dissolved in propylene glycol. The pH was adjusted to 4.5 and the final volume of the composition was adjusted to 100.0 ml with water.

Example 6

Disinfectant lotion after shaving

0.5 g of povidone-iodine containing 10.0% (W / V) useful iodine

Glucan E 10 * 4.0g

Glucan P 20 * 3.0g

Ethanol 45.0ml

10.0 ml of propylene glycol

Triclozan 0.01g

triclocarban 0.01g

Glycerin 2.5g

Phosphate-citrate buffer (to adjust to pH 5.5)

Spices, dyes q.s

Water (to adjust volume to 100.0 ml)

* (Nonionic propoxylated glucose derivative of Amerchol, USA)

Example 7

Ringworm Treatment

10.0 g of povidone-iodine containing 10.0% (W / V) of useful iodine

Polyethylene Glycol 400 60.0 g

Polyethylene Glycol 4000 25.0 g

Triclozan 0.5g

4.0 g of water

The mixed solution of polyethylene glycol was heated to 45 ° C., and then slowly stirred to dissolve triclozan and dissolved with PVP-I. An ointment-like product was obtained by allowing to cool slowly until the clear solution became a continuous cream color.

Example 8

Teat DIP for mastitis prevention

Iodine Complex * 2.5g

Glycerin 4.0g

Propylene Glycol 3.0ml

Triclozan 0.5g

Phosphate-citrate buffer (to adjust to pH 4.0)

Water (to adjust volume to 100.0 ml)

* (Antarox VRO 20 from GAF, USA)

Example 9

Animal Shampoo

Iodine Complex * 10.0g

5.0 g nonionic surfactant

Sodium Lauryl Ethoxy Sulfate 20.0g

2.0 g of coconut diethanolamide

5.0 g of propylene glycol

0.5 g of hexachlorophene

Phosphoric Acid (to match pH 4.0)

Water (to make volume 100.0 ml)

* (Antarox VRO 20 from GAF, USA)

Example 10

Bath preparations before surgery or during skin diseases

Iodine Complex * 10.0g

Nonionic Surfactant 10.0g

Triclozan 1.75g

Sodium laurylethoxy sulde 40.0 g

Cononutane Ethanolamide 5.0g

Citric acid (to adjust pH 4.5)

Water (to adjust volume to 100.0 ml)

* (Antarox VRO 20 from GAF, USA)

Comparative Example 1

Aqueous wash solutions containing 7.5% povidone-iodine (containing 0.94% W / V of useful iodine) were divided into two, and triclozan was added to 2.0% in only one solution. The two solutions were then left to stand at room temperature for two years and then observed to find that the two solutions had the same small amount of useful iodine loss.

Therefore, this experiment shows that no reaction occurs between the bacterial growth inhibitor and iodine.

Claims (8)

A disinfectant composition wherein at least one iodine complex is formed with a pharmacological veterinary or agriculturally acceptable carrier or diluent, wherein the composition further comprises at least one residual antimicrobial agent. The composition of claim 1, wherein the antimicrobial agent, i.e., bacterial growth inhibitor, is made using a halogenated hydroxydiphenyl derivative, a halogenated salicylate, or a halogenated carbanide. 5. The bacteriostatic agent of claim 4, wherein the bacteriostatic agent is 2,4,4'-trichloro-2'-hydroxyziphenyl ether 2,2'-dihydroxy-3,3'-5,5'-6, 6'-hexachlorodiphenylmethane 3,5,4'-tribromosalicylanilide or 3,4,4'-trichlorocarbanilide or 3-trifluoromethyl-4,4'-dichlorocarbanilide Using the composition. The disinfectant composition of claim 1 wherein the composition further comprises a saturated surfactant that is stable in a solution of pH 6 or below. 8. The composition of claim 7, wherein the surface active agent is a nonylphenol polyethoxy condensate, a polycondensate of phenoxy- or alkyloxypolyoxy ethylene oxide and propylene oxide, or a mixture of two or more thereof. 8. The disinfectant composition according to claim 7, further comprising a foaming agent in a surface active agent. The composition according to claim 9, wherein the foaming agent is made using fatty acid diethanolamide. The composition according to claim 1, wherein the disinfectant composition has a value of pH 7 or less.