KR20180088463A - An alcoholic composition having a predetermined content of octenidine dihydrochloride - Google Patents

Abstract

The present invention relates to a composition comprising a) at least 20% by weight of ethanol, b) at least 1% by weight of n-propanol, and c) at least 0.02% by weight of octenidine dihydrochloride. The compositions are particularly used for hygienic hand sanitization and surgical hand sanitization.

Description

An alcoholic composition having a predetermined content of octenidine dihydrochloride

The present invention relates to a special alcoholic composition having a certain amount of octenidine dihydrochloride. The compositions are particularly used for hygienic hand sanitization and surgical hand sanitization. Moreover, the present invention relates to the use of octenidine dihydrochloride to improve the effectiveness of alcoholic agents for skin antisepsis, hygienic and surgical hand washing, and hygienic and surgical hand disinfection will be.

The effectiveness of alcoholic compositions for skin disinfection, mucous membrane disinfection, wound disinfection, hygienic hand disinfection, hygienic hand washing, surgical hand disinfection and surgical hand washing is known. Considering the effectiveness against many bacteria, fungi and viruses, aliphatic alcohols such as ethanol, n-propanol (1-propanol) and isopropanol (2-propanol) are used for this purpose. Their effectiveness begins shortly after a short period of time, especially if the designated alcohol is present at a relatively high concentration. In contrast, a composition with a lower content of aliphatic alcohol is more dermatologically compatible, consequently beneficial for hand disinfection or hand washing.

The combination of active ingredients and aliphatic alcohols, proven to be remanence effects, in principle provides benefits for skin disinfection, hand disinfection and hand washing. Thus, these formulations may be advantageous, for example, because a smaller amount of alcohol is required, and thus effective, but fewer degreasing agents are available. However, it has been found that active ingredients with residual effect can not be directly formulated in providing aliphatic alcohol-based disinfectants. For example, the active ingredient chlorhexidine is not stable enough in ethanol (see, in particular, US 5,800,827 B).

Octenidine dihydrochloride is the active ingredient with proven residual effect. For example, the product octeniderm ^® (Schuelke & Mayr GmbH, Nordrhein-Tätt, Germany) contains 0.1% by weight of octenidine dihydrochloride as a medically effective ingredient, 30.0% by weight of 1-propanol and 45.0% Of 2-propanol. The product octeniman ^® contains 0.1 wt% of octenidine dihydrochloride, 40.0 wt% of 1-propanol and 30.0 wt% of 2-propanol. Taking into account the relatively high content of aliphatic alcohols, they are only suitable for a limited extent as cleaning agents. They are also only viral to a limited extent. In contrast, a formulation is also advantageous for hygienic hand disinfection if it has an excellent effect on non-coat retention viruses such as norovirus, adenovirus and poliovirus. This will be especially in the form of a formulation with a high ethanol content.

DE 10 2010 054 155 A1 discloses the use of aliphatic alcohols in the production of disinfectants to prevent contamination of disinfectants due to bacterial spores. Disinfectants for typical germs of transient and superficial skin flora (e.g., including fungi and bacteria, including Staphylococcus aureus ), which are particularly important for hygienic and surgical hand disinfection And the effect on the virus are not discussed in DE 10 2010 054 155 A1.

DE 10 2011 077 432 A1 discloses the use of bispyridinium alkanes. The compositions are used on inanimate surfaces, for example on surfaces or instrument disinfection, or on biological surfaces, such as human skin.

It was an object of the present invention to provide a composition for sanitary hand disinfection and surgical hand disinfection, which naturally does not have a high content of aliphatic alcohols (but, if necessary, a high content of aliphatic alcohols Lt; / RTI > Therefore, the composition will also be suitable as a cleaning agent and will have better flesh virus effectiveness.

This object is achieved according to the invention by a composition comprising a) at least 20% by weight of ethanol, b) at least 1% by weight of n-propanol, and c) at least 0.02% by weight of octenidine dihydrochloride.

Surprisingly, in the case of a combination of an aliphatic alcohol and octenidine dihydrochloride, a mixture of ethanol and 1-propanol [mixture (i)] proved to be more antimicrobially more effective than mixture of ethanol and isopropanol (mixture (ii) .

Moreover, the beneficial results of the quantitative suspension experiments could be confirmed in experiments simulating the conditions in practice for sanitary hand disinfection according to EN 1500.

The combination of an aliphatic alcohol and octenidine dihydrochloride provides a broad spectrum of antimicrobial efficacy and residual efficacy due to the choice of taking advantage of its virulence characteristics and the content of octenidine dihydrochloride, particularly when ethanol is used at relatively high concentrations Lt; RTI ID = 0.0 > viral < / RTI >

Moreover, the surprising findings of improved efficacy, especially due to the content of 1-propanol, are also interesting with respect to cleaning and disinfecting agents.

Accordingly, in a first aspect, the present invention relates to a composition comprising:

a) at least 20% by weight of ethanol,

b) at least 1% by weight of n-propanol, and

c) at least 0.02% by weight of octenidine dihydrochloride.

In the description of the present invention, the stated ethanol content relates to pure materials (and does not include, for example, industrial or medicinal purity ethanol or water-in-water denaturants).

According to a particular embodiment, the composition as defined above comprises up to 95% by weight of ethanol.

a) The preferred amount of ethanol is from 23 to 95% by weight, preferably from 25 to 85% by weight, especially from 30 to 80% by weight, for example from 34 to 75% by weight.

In a further preferred embodiment, the composition comprises less than 78% by weight of ethanol, such as up to 75% by weight of ethanol.

According to another particular embodiment, the composition as defined above comprises up to 30% by weight of n-propanol.

b) A preferred amount of n-propanol is at least 1.5% by weight, preferably at least 1.8% by weight, especially at least 2.0% by weight, such as from 2.0 to 30% by weight or from 2.2 to 30% by weight, for example from 2.5 to 25% - propanol. An amount of 2.5 to 20% by weight of n-propanol, such as 2.5 to 15% by weight of n-propanol, is particularly preferred.

According to a particular embodiment, the composition as defined above comprises up to 0.25% by weight of octenidine dihydrochloride.

In a preferred embodiment, the amount of c) octenidine dihydrochloride is from 0.025 to 0.25% by weight, preferably from 0.03 to 0.2% by weight, in particular from 0.035 to 0.18% by weight, such as from 0.04 to 0.16% by weight, About 0.15% by weight of octenidine dihydrochloride.

According to a more detailed aspect, the composition as defined above comprises

a) from 25 to 85% by weight of ethanol,

b) from 2% to 30% by weight of n-propanol, and

c) from 0.03 to 0.2% by weight of octenidine dihydrochloride; Especially more,

a) from 30 to 80% by weight of ethanol,

b) 2.5% to 25% by weight of n-propanol, and

c) 0.05 to 0.15% by weight of octenidine dihydrochloride.

In addition to the essentially defined components a) ethanol, b) n-propanol and c) octenidine dihydrochloride, the compositions according to the invention optionally comprise,

d) at least one surfactant, preferably an amphoteric or nonionic surfactant.

As nonionic surfactants , all suitable nonionic surfactants can be used, including (i) (fatty) alcohol ethoxylates, (ii) sorbitan esters, (iii) alkyl glycosides (especially alkyl polyglycosides) (iv) amine oxides and (v) ethylene oxide / propylene oxide block copolymers.

(i) Alcohol Polyalkoxylates include fatty alcohol alkoxylates, such as isodecyl ethoxylate, isotridecyl ethoxylate, stearyl, lauryl and cetyl and oleyl alcohols having various fractions of ethylene oxide Polyethylene glycol ether. In the present specification, the alcohol may be alkoxylated with any desired mixture of ethylene oxide, propylene oxide or ethylene oxide and propylene oxide. Alcohol polyalkoxylates are especially known under the trade names Lutensol ^® , Marlipal ^® , Marlox ^® , Brij ^® and Plurafac ^® . As non-ionic surfactants, lauryl alcohol ethoxylate is particularly preferred.

Further, the nonionic surfactant (ii) used is a sorbitan ester, which is referred to as the oleate, mostly present as stearate, laurate and palmitate, and polysorbate (e.g., Tween ^®).

Furthermore, the non-ionic surfactant (iii) an alkyl glycoside, such as an alkyl glucoside (i.e., an alkyl glycoside of glucose), more preferably C ₈ -C ₂₀ - alkyl poly-glucose, in particular fatty alcohol C ₈ -C ₁₆ -Alkylpolyglucose, and lauryl polyglucose, decylpolyglucose or a mixture thereof is preferable. The carbon atom length is 8 to 16 atoms in the case of cocoylpolyglucose, 12 to 16 carbon atoms in the case of lauryl polyglucose and 8 to 16 carbon atoms in the case of decylpolyglucose.

Typical amounts of alkyl glycosides are 0.03 to 10% by weight, preferably 0.06 to 5% by weight, especially 0.1 to 2% by weight.

According to the present invention, in principle all suitable amine oxides can be used as (iv) amine oxides. Amine oxides of N-oxides of tertiary amines include aliphatic amine oxides, cyclic amine oxides (e.g., N-alkyl morpholine oxides) and aromatic amine oxides (e.g., pyridine N-oxides). In a preferred embodiment, the amine oxide has the general formula:

R ¹ R ² R ³ NO

Wherein R ¹ is methyl, ethyl or 2-hydroxyethyl, R ² is methyl, ethyl or 2-hydroxyethyl, R ¹ and R ² together can be morpholine, and R ³ is 8 to 18 R ⁴ CONH (CH ₂ ) _n wherein R ⁴ is alkyl having 8 to 18 carbon atoms and n is an integer from 1 to 10, preferably 1 to 5, more preferably 2 To 4, in particular 3, and 2-hydroxyethyl can be condensed with 1 to 2000 ethylene oxide, ethylene oxide / propylene oxide or propylene oxide units.

Examples of amine oxides are cocamidopropyl amine oxide, N-cocomorpholine oxide, decyl dimethyl amine oxide, dimethyl cetyl amine oxide, dimethyl cocamine oxide, dimethyl hydrogenated tallow amine oxide, Dimethylmyristylamine oxide, (2-hydroxyethyl) cocamine oxide and oleamine oxide. See also International Cosmetic Ingredient Dictionary and Handbook, 10th edition 2004, volume 3, pages 2268-2275 (Surfactants - Cleansing Agents).

In a preferred embodiment, the amine oxide is cocamidopropylamine oxide, i.e., R ⁴ CO is an acyl radical derived from the fatty acid of coconut oil, n = 3, and R ¹ and R ² are methyl. This product is sold as Rewominox B 204 by Goldschmidt of the Federal Republic of Germany.

Typical amounts of amine oxides are 0.03 to 10 wt%, preferably 0.06 to 5 wt%, especially 0.1 to 2 wt%.

Also suitable as surfactants are amphoteric surfactants such as betaine. Suitable betaines are described in EP 560 114 A2. Cocamidopropyl betaine is particularly preferred. Typical amounts of betaine are 0.03 to 10% by weight, preferably 0.06 to 5% by weight, especially 0.1 to 2% by weight.

Moreover, cationic surfactants such as quaternary ammonium salts are suitable as surfactants. In principle, all suitable quaternary ammonium compounds can be used according to the invention. Preferably, the quaternary ammonium compound is a dialkyldimethylammonium salt.

The quaternary ammonium salt used according to the present invention is given by the formula [R ¹ R ² R ³ (CH ₃ ) N] ⁺ [X] ^- , wherein R ¹ to R ³ , which may be the same or different, R ¹ to R ³ are selected from C ₁ - to C ₃₀ -alkyl, -aralkyl, -alkenyl and mixtures which may have one or more atoms selected from S, N and P, for example C ₈ - C ₁₈ -alkyl, benzyl or methyl, preferably C ₉ - to C ₁₈ -alkyl, benzyl or methyl, such as C ₁₆ -alkyl, benzyl or methyl. X is an anion (of an inorganic or organic acid). In the present specification, both the anion and the cation of the quaternary ammonium salt may be polyvalent ions, which cause stoichiometry [A ^{(n +)} ] _m [K ^{(m +)} ] _n .

According to the present invention, suitable quaternary ammonium salts are all quaternary ammonium salts of the above-mentioned formula, known in the art, as disclosed, for example, in WO 00/63337, herein incorporated by reference. However, dialkyldimethylammonium salts, such as dialkyldimethylammonium to use the chloride would be preferred, its alkyl chains are independently selected from C ₈ to each other - to C ₁₈ - alkyl, preferably C ₉ - to C ₁₈ - alkyl, , Such as _C16 -alkyl. In the dialkyldimethylammonium salts, one of the methyl groups may be an alkoxylated, e.g. ethoxylated, hydroxymethyl group.

The quaternary ammonium salts preferably used according to the invention of the formula _{^{[R 1 N (CH 3)}} 3] + [X] -, [R 1 R 2 N (CH 3) 2] + [X] - and [R the compound, wherein R ¹ to R ³ are independently from each other C ₈ ^{- - 1 R 2 R 3 (} CH 3) n] + [X] to C ₁₈ - alkyl and ^{_{- (CH 2 -CHR 4 O)}} n - R ⁵ , wherein n is a number from 1 to 20, preferably from 1 to 5, and R ⁴ and R ^5, which may be the same or different, are selected from H and / or C ₁ - to C ₄ -alkyl, Lt; / RTI >

Examples of anion and anion classes of quaternary ammonium salts used in accordance with the present invention include, but are not limited to, hydroxides, sulfates, hydrogen sulfates, methosulfates, ethosulfates, lauryl sulfates, lauryl ether sulfates, cellulose sulfates, sulfamates, halides (Rhodanide), carboxylate, carboxylate, phosphate, phosphate, phosphite, thiocyanate (rhodanide), nitrate, nitrate, For example, benzoates, lactates, acetates, propionates, citrates, succinates, glutarates, adipates, toluenesulfonates (tosylates) and salicylates. Particularly preferred anions are chloride and propionate.

Particularly preferably, a quaternary ammonium salt, meseturonium ethyl sulfate (hexadecyl (ethyl) dimethylammonium ethylsulfate) and benzalkonium chloride are used.

In addition to the essentially defined components a) ethanol, b) n-propanol and c) octenidine dihydrochloride, and optional component d), the compositions according to the invention optionally comprise,

e) - further comprises at least one solvent.

Preferred solvents are glycol and water, and mixtures thereof. A preferred solvent is water.

In addition to the essentially defined components a) ethanol, b) n-propanol and c) octenidine dihydrochloride, and optional components d) and or e)

f) further comprises at least one active ingredient and / or adjuvant.

Examples of active ingredients and / or adjuvants which may optionally be present in the composition according to the invention are skin protection additives, refatting agents, perfumes, fragrances, thickeners, pH adjusting agents, softeners, wetting agents and dyes. These are in particular:

- polyols which function as skin protection additives, fat supplements and wetting agents such as glycerol, erythritol, 1,2,6-hexanetriol, inositol, lactitol, maltitol, mannitol, methylpropanediol, Sorbitol and xylitol; Of these, glycerol is particularly preferred,

- glycerol esters, preferably coconut fatty acid glycerol monoesters, fatty alcohol esters such as cetearyl octanoate (cetearyl octanoate) myristic acid isopropyl ester (isopropyl myristate), which serve as fat supplements, Palmitic acid isopropyl ester (isopropyl palmitate), fatty acid glyceryl triester,

Allantoin acting as a skin protection additive, and / or

- Sodium gluconate acting as a buffer.

For example, the composition according to the invention preferably comprises one or more fat supplements.

Fat supplement

The compositions according to the invention preferably comprise d) fatty acid esters of one or more monovalent C ₁ - to C ₆ -alkyl alcohols.

Preferably, the alkyl alcohol of the fatty acid ester is selected from methanol, ethanol, n- and isopropanol. Particularly preferably, the alkyl alcohol of the fatty acid ester is specifically isopropanol.

It is also preferred that the fatty acid of the fatty acid ester is selected from C ₁₀ - to C ₁₈ -fatty acids, preferably C ₁₂ - to C ₁₆ -fatty acids, and the fatty acid is preferably myristic acid.

Consequently, in all embodiments of the present invention, the fat replenishment component is preferably isopropyl myristate.

The component, preferably myristic acid isopropyl ester, is preferably present in an amount of from 0.02 to 5% by weight, preferably from 0.1 to 4% by weight, more preferably from 0.2 to 3% by weight, especially from 0.3 to 2.0% Is present in the composition according to the invention in an amount of from 0.5 to 1.8% by weight, for example from 0.6 to 1.6% by weight, for example from about 0.75 to about 1.4% by weight.

Furthermore, it is preferred that the composition according to the invention does not have an aromatic alcohol content (as defined essentially in accordance with DE 10 2011 077 432 A1 in the presence of aliphatic alcohols).

According to a further preferred embodiment, the content of isopropanol in the composition is limited, for example less than 25 wt%, preferably less than 20 wt%, especially less than 15 wt%, such as less than 10 wt% % ≪ / RTI > isopropanol.

Moreover, the content of chlorhexidine derivatives is preferably limited, less than 0.3% by weight, for example less than 0.2% by weight, and the composition according to the invention is particularly preferably free of chlorhexidine derivatives. Preferably, the presence is limited according to the invention, and particularly preferably the chlorhexidine derivative in which the presence is excluded is preferably chlorhexidine digluconate.

Moreover, in a further embodiment, the invention relates to a composition for use in a method for skin disinfection, sanitary hand disinfection, sanitary hand washing, surgical hand disinfection or surgical hand cleansing.

Accordingly, the present invention also relates to the use of compositions for skin disinfection, sanitary hand sanitization, sanitary hand washing, surgical hand disinfection or surgical hand cleansing.

Thus, according to the present invention there is also provided a method for skin disinfection, sanitary hand sanitization, sanitary hand washing, surgical hand disinfection or surgical hand washing, wherein the composition is allowed to act on the area or hand of the subject's skin.

Application of the composition according to the invention is possible in particular for the following methods:

i) skin disinfection,

ii) sanitary hand disinfection (according to EN 1500, ASTM 1174),

iii) Hygienic handwashing (according to EN 1499),

iv) Surgical hand disinfection, or

v) Surgical hand washing (according to EN 12791, ASTM 1115).

Thus, in one embodiment, the invention relates to the application during sanitary hand disinfection according to EN 1500, preferably according to EN 1500: 2013. In a further embodiment, the invention relates to the application of a composition for sanitary hand disinfection according to ASTM 1174, preferably according to ASTM 1174-13.

In a further embodiment, the invention relates to the application of the composition during sanitary hand washing according to EN 1499, preferably according to EN 1499: 2013.

In a further embodiment, the invention relates to the application of a composition according to EN 12791, preferably during a surgical hand wash according to EN 12791: 2013. Furthermore, the present invention relates to the application of the composition according to ASTM 1115, preferably during surgical hand washing according to ASTM 1115-11.

Furthermore, the present invention relates to the use of octenidine dihydrochloride to improve the residual effect of the composition comprising:

a) at least 20% by weight of ethanol, and

b) at least 1% by weight of n-propanol.

The compositions according to the invention are used to control transient pathogens, particularly in sanitary hand disinfection. For example, the composition according to the present invention is effective against human pathogenic bacteria such as Escherichia coli or yeast-like fungi such as Candida albicans . Furthermore, the composition according to the invention is effective against enveloped viruses such as HIV, HBV or HCV and their surrogate viruses (BVDV or vaccinia virus), and in a preferred embodiment also enveloped viruses such as Norovirus, Adeno It is also effective against viruses and polioviruses. The compositions according to the present invention are also used to reduce superficial skin fungi during surgical hand disinfection. These are preferably bacterial gram-positive microorganisms, such as Staphylococcus spp. Or Corynebacterium spp., Characterized by the inability to form any endogenous spores.

The advantages of the invention are particularly evident from the following examples. The percentages referred to are by weight unless otherwise stated.

Example

Experiment 1 : Efficacy of various combinations of aliphatic alcohol and octenidine dihydrochloride (quantitative suspension experiments as follows: German Society for Hygiene and Microbiology (DGHM) 2001, Dirty Condition, Test Organism; Candida albicans)

50 g of denatured ethanol in 100 g of solution corresponds to about 46.5% by weight of ethanol.

40 g of denatured ethanol in 100 g of solution corresponds to about 37.2 wt% of ethanol.

** MEK: methyl ethyl ketone.

The results of the effectiveness for contact times of 15, 30 and 60 seconds are graphically shown in Figure 1 (CT = contact time; Oct = octenidine dihydrochloride; EtOH = ethanol; 1-propOH = 1-propanol; 2-propOH = 2-propanol). This includes data within the kinetic effectiveness range, where there is still no saturation of effect, and for that reason different efficacies become evident:

Experiment A shows the effectiveness of 46.5 wt% ethanol.

Experiment G shows the effectiveness of 0.05 wt% of octenidine dihydrochloride.

Experiment B (46.5% by weight of ethanol and 0.05% by weight of octenidine dihydrochloride) demonstrates that octenidine dihydrochloride in ethanol suppresses efficacy at, for example, 30 seconds.

Experiment C shows the efficacy of 37.2 wt% ethanol combined with 10 wt% isopropanol.

Experiment D shows that inhibition by octenidine dihydrochloride also occurs in the case of these alcohol mixtures.

Experiment E shows the efficacy of 37.2 wt% ethanol combined with 10 wt% n-propanol.

Experiment F demonstrates that in this case no inhibition occurs upon addition of octenidine dihydrochloride.

Experiment 2

Furthermore, the following formulations were tested according to EN 1500: 1997 (30 sec, 3 ml). The reference alcohol used in each case was the standard (2 x 3 ml, 60% (v / v) 2-propanol, 60 sec) provided in EN 1500: 1997. For 12 to 15 healthy subjects, the tests were performed and statistically evaluated in each case as envisioned in EN 1500: 1997.

79.00 g of denatured ethanol in 100 g of solution corresponds to 73.45 wt% of ethanol.

- < / RTI > ethanol and n-propanol is effective. Upon addition of 0.1% by weight octenidine dihydrochloride (Formulation II), efficacy is maintained.

- Formulation III with a content of ethanol and isopropanol is effective. This efficacy is not retained upon addition of 0.1 wt.% Of octenidine dihydrochloride (Form IV), and specifically also when the addition amount of octenidine dihydrochloride is reduced to 0.05 wt.% (Form V) It does not.

Claims (20)

a) at least 20% by weight of ethanol,
b) at least 1% by weight of n-propanol and
c) at least 0.02% by weight of octenidine dihydrochloride. The composition of claim 1 comprising up to 95% by weight of ethanol. According to claim 1 or 2, wherein the amount of the ethanol composition, characterized in that 25 to 85% by weight. The method of claim 3 wherein the amount of the ethanol composition, characterized in that 30 to 80% by weight. According to claim 1 or 2, wherein the composition comprises a n- propanol, up to 30% by weight. Any one of claims 1 to 5 according to any one of claims, wherein the composition, characterized in that the amount of n- propanol, 2% to 30% by weight. The method of claim 6, wherein the composition, characterized in that the amount of n- propanol 2.5% by weight to 25% by weight. The method of claim 7, wherein the composition, characterized in that the amount of n- propanol 2.5% by weight to 15% by weight. The method according to any one of claims 1, 2, and 5, The composition comprising the c) octanoic'll Dean dihydrochloride of up to 0.25% by weight. 10. The method according to any one of claims 1 to 9, The amount of octanoic'll Dean dihydrochloride composition, characterized in that 0.03 to 0.2% by weight. 11. The method of claim 10, The amount of octanoic'll Dean dihydrochloride composition, characterized in that 0.05 to 0.15% by weight. 12. The method according to any one of claims 1 to 11,
d) at least one surfactant selected from lauryl alcohol ethoxylate, lauryl polyglucose, decyl polyglucose, or mixtures thereof, cocamidopropylamine oxide and cocamidopropyl betaine
The composition characterized in that it further comprises. 13. The method according to any one of claims 1 to 12,
e) at least one solvent, preferably water
A composition characterized in that it further comprises a. 14. The method according to any one of claims 1 to 13,
f) -glycerol, erythritol, 1,2,6-hexanetriol, inositol, lactitol, maltitol, mannitol, methylpropanediol, At least one active ingredient selected from isopropyl myristate, cetearyl octanoate, palmitoyl isopropyl ester, and fatty acid glyceryl triester, allantoin, and sodium gluconate, and /
The composition characterized in that it further comprises. 15. The method of claim 14,
f) 0.02 to 5% by weight of isopropyl myristate
The composition characterized in that it further comprises. 16. The composition according to any one of claims 1 to 15, wherein the composition has no aromatic alcohol content. 17. A composition according to any one of the preceding claims, characterized in that it contains less than 25% by weight of isopropanol, preferably less than 20% by weight, in particular less than 15% by weight, such as less than 10% the composition comprises a. Claim 1 to claim 17 according to any one of claims, comprising less than 0.3% by weight of chlorhexidine derivative, such as less than 0.2% by weight of chlorhexidine derivative, most preferably a composition wherein the chlorhexidine derivative members. A method according to any one of claims 1 to 18 for use in a method for skin antisepsis, hygienic hand disinfection, hygienic hand washing, surgical hand disinfection or surgical hand washing. Composition. Use of octenidine dihydrochloride to improve the remanence effect of a composition comprising:
a) at least 20% by weight of ethanol, and
b) at least 1% by weight of n-propanol.

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