JP5486768B2 - 細胞内ミトコンドリアの分極モニタリング - Google Patents
細胞内ミトコンドリアの分極モニタリング Download PDFInfo
- Publication number
- JP5486768B2 JP5486768B2 JP2007550225A JP2007550225A JP5486768B2 JP 5486768 B2 JP5486768 B2 JP 5486768B2 JP 2007550225 A JP2007550225 A JP 2007550225A JP 2007550225 A JP2007550225 A JP 2007550225A JP 5486768 B2 JP5486768 B2 JP 5486768B2
- Authority
- JP
- Japan
- Prior art keywords
- change
- cells
- cell
- mitochondrial
- rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007550225A JP5486768B2 (ja) | 2005-12-14 | 2006-12-14 | 細胞内ミトコンドリアの分極モニタリング |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005360458 | 2005-12-14 | ||
| JP2005360458 | 2005-12-14 | ||
| PCT/JP2006/324960 WO2007069692A1 (ja) | 2005-12-14 | 2006-12-14 | 細胞内ミトコンドリアの分極モニタリング |
| JP2007550225A JP5486768B2 (ja) | 2005-12-14 | 2006-12-14 | 細胞内ミトコンドリアの分極モニタリング |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012006779A Division JP5514233B2 (ja) | 2005-12-14 | 2012-01-17 | 細胞内ミトコンドリアの分極モニタリング |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2007069692A1 JPWO2007069692A1 (ja) | 2009-05-28 |
| JP5486768B2 true JP5486768B2 (ja) | 2014-05-07 |
Family
ID=38162994
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550225A Expired - Fee Related JP5486768B2 (ja) | 2005-12-14 | 2006-12-14 | 細胞内ミトコンドリアの分極モニタリング |
| JP2012006779A Expired - Fee Related JP5514233B2 (ja) | 2005-12-14 | 2012-01-17 | 細胞内ミトコンドリアの分極モニタリング |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012006779A Expired - Fee Related JP5514233B2 (ja) | 2005-12-14 | 2012-01-17 | 細胞内ミトコンドリアの分極モニタリング |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110003321A1 (enExample) |
| EP (1) | EP1961824A4 (enExample) |
| JP (2) | JP5486768B2 (enExample) |
| CN (1) | CN101336297B (enExample) |
| WO (1) | WO2007069692A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009122016A (ja) * | 2007-11-16 | 2009-06-04 | Kyushu Univ | 判定装置、選定装置、判定方法、細胞生産方法、プログラム及び記録媒体 |
| JP5808772B2 (ja) * | 2013-05-13 | 2015-11-10 | 株式会社エヌ・エル・エー | 肝細胞内のミトコンドリアの活性化方法 |
| CN112881355B (zh) * | 2021-01-17 | 2022-03-18 | 复旦大学 | 用于细胞内pH和氧气浓度同时测量的双参数荧光纳米传感器及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004042079A1 (en) * | 2002-11-07 | 2004-05-21 | Unisearch Limited | Induction of the mitochondrial permeability transition |
| JP2005017081A (ja) * | 2003-06-25 | 2005-01-20 | Japan Science & Technology Agency | 抗がん作用物質のスクリーニング方法及び装置 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3795312B2 (ja) * | 2000-09-06 | 2006-07-12 | 独立行政法人科学技術振興機構 | 細胞活性の評価方法 |
-
2006
- 2006-12-14 WO PCT/JP2006/324960 patent/WO2007069692A1/ja not_active Ceased
- 2006-12-14 CN CN2006800520438A patent/CN101336297B/zh not_active Expired - Fee Related
- 2006-12-14 JP JP2007550225A patent/JP5486768B2/ja not_active Expired - Fee Related
- 2006-12-14 EP EP06834714A patent/EP1961824A4/en not_active Withdrawn
- 2006-12-14 US US12/086,394 patent/US20110003321A1/en not_active Abandoned
-
2012
- 2012-01-17 JP JP2012006779A patent/JP5514233B2/ja not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004042079A1 (en) * | 2002-11-07 | 2004-05-21 | Unisearch Limited | Induction of the mitochondrial permeability transition |
| JP2005017081A (ja) * | 2003-06-25 | 2005-01-20 | Japan Science & Technology Agency | 抗がん作用物質のスクリーニング方法及び装置 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6011025968; Int. J. Cancer., 2002, Vol. 98, No. 5, p. 761-769. * |
| JPN6012024610; Analytical Biochemistry 2002;302:28-37 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110003321A1 (en) | 2011-01-06 |
| EP1961824A1 (en) | 2008-08-27 |
| CN101336297A (zh) | 2008-12-31 |
| JPWO2007069692A1 (ja) | 2009-05-28 |
| EP1961824A4 (en) | 2009-04-08 |
| CN101336297B (zh) | 2011-09-07 |
| JP5514233B2 (ja) | 2014-06-04 |
| JP2012093369A (ja) | 2012-05-17 |
| WO2007069692A1 (ja) | 2007-06-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6348635B2 (ja) | 生細胞干渉法を介した急速超並列単細胞薬物反応測定法 | |
| Palmer et al. | Autofluorescence Spectroscopy of Normal and Malignant Human Breast Cell Lines¶ | |
| Zhao et al. | A red emitting mitochondria-targeted AIE probe as an indicator for membrane potential and mouse sperm activity | |
| Smith et al. | Raman spectroscopy: an evolving technique for live cell studies | |
| Vo-Dinh et al. | Fiber-optic nanosensors for single-cell monitoring | |
| JP2011514963A (ja) | 細胞応答のデュアル検出システム及び方法 | |
| Day et al. | A simple approach for measuring FRET in fluorescent biosensors using two-photon microscopy | |
| Ajito et al. | Detection of glutamate in optically trapped single nerve terminals by Raman spectroscopy | |
| JP5514233B2 (ja) | 細胞内ミトコンドリアの分極モニタリング | |
| Shlush et al. | Quantitative digital in situ senescence-associated β-galactosidase assay | |
| Gensch et al. | Determination of intracellular chloride concentrations by fluorescence lifetime imaging | |
| Sun et al. | Graphene-based confocal refractive index microscopy for label-free differentiation of living epithelial and mesenchymal cells | |
| Hao et al. | Long-chain fluorescent probe for straightforward and nondestructive staining mitochondria in fixed cells and tissues | |
| Liao et al. | Multifocal Raman spectrophotometer for examining drug-induced and chemical-induced cellular changes in 3D cell spheroids | |
| Ci et al. | An in situ fluorescent copolymer dots-based kit for the specific detection of monoamine oxidase-A in cell/tissue/human prostate cancer | |
| Chen et al. | Probing oxidant effects on superoxide dismutase 1 oligomeric states in live cells using single-molecule fluorescence anisotropy | |
| Trapani et al. | Intracellular magnesium detection by fluorescent indicators | |
| Nishijima et al. | Development of signaling echo method for cell-based quantitative efficacy evaluation of anti-cancer drugs in apoptosis without drug presence using high-precision surface plasmon resonance sensing | |
| WO2005001472A1 (ja) | 抗がん作用物質のスクリーニング方法及び装置 | |
| Zhang et al. | Penetration-then-growth enables label-free surface-enhanced Raman spectroscopic discrimination of fibrotic cells and kidney tissues | |
| Li et al. | Ag nanoparticles for the direct detection of Oxaprozin in the blood using surface-enhanced Raman spectroscopy | |
| CN105378456B (zh) | 用于评价化学心脏毒性的免标记方法 | |
| Nakabayashi et al. | Liquid–Liquid Phase Separation from the Viewpoint of Molecular Crowding Environment: A Raman Imaging Study | |
| Bajar et al. | FRET imaging of rho GTPase activity with red fluorescent protein-based FRET pairs | |
| Rong et al. | Real‐time detection of single‐living pancreatic β‐cell by laser tweezers Raman spectroscopy: High glucose stimulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20091111 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20110330 |
|
| A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20110509 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110523 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110722 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20110725 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110725 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20111018 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120117 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120209 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20120302 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20120309 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20120518 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140123 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140128 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140224 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5486768 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |