JP5466351B2 - 移動式生理学的モニタリングからのデータを処理する方法及びシステム - Google Patents
移動式生理学的モニタリングからのデータを処理する方法及びシステム Download PDFInfo
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Description
と同様の式、又は実質的に、
QTLC=Qt+0.154(1−RR)
と同様の式を使用して推定されることを含む。
本発明の好ましい及び/又は例示的な実施形態が説明される。しかし、本発明の原理は、これらの好ましい及び/又は例示的な実施形態に限定されない。これらの原理は、当業者には明白なように、より広範囲に適用することができ、及び/又は将来の技術開発に適合させることができる。本発明は、そのような付加的な実施形態を含むものと理解されるべきである。
本発明の好ましい実施形態は、被験者の瞬間毎の心肺機能、活動レベル、及び付随の又は他の生理学的システム又は過程をモニタする。特定的な実施形態は、より少ない生理学的システム又は過程をモニタすることができる一方で、他の実施形態は、移動式の非侵襲的センサの使用可能性次第で特別な生理学的システムをモニタすることができる。
例示的システムは、説明の目的でモニタリング・サブシステムに観念的に分割することができ、このサブシステムは、処理のための信号を収集するセンサと本発明の処理方法を実施するためのプラットフォームを提供する処理のサブシステムとを含む。
サイズセンサを実施するための例示的な(非制限的)技術は、誘導性プレチスモグラフィ(IP)であり、以下にIP技術を要約する。IPセンサは、関連の平面内の被験者の周りに形成された導電ループの自己インダクタンスを測定することによってサイズの印しを判断する。導電ループは、例えば、弾性バンドに組み込まれて着用可能に構成され、取り囲まれた身体部分のサイズ変化をループの自己インダクタンスの変化に対応させて厳密に追随し、次に自己インダクタンスがループを共振回路に組み込んで、例えば、既知の時間間隔で振動する電流パルスを計数して共振周波数の変化を測定することによって測定される。
好ましい実施形態では、本発明の個々の処理方法のいくつかは、基本的に心臓−呼吸モニタリングに関するモニタリング・サブシステムからのMPM信号を処理する統合システムに連結される。統合された構成が最初に説明され、次にその構成段階の詳細が説明される。
図2は、心臓−呼吸の移動式MPMモニタリングのために有用な好ましい処理の構成を示している。この図では、処理の段階がボックスによって示され、データの流れが線で示され、削除又はバイパスすることができる段階が波線の輪郭線で示されている。移動式モニタリング・サブシステム43は、モニタされた被験者41から基本的な(及び例示的な)組の心臓−呼吸モニタリング信号(MPM)を収集する。収集された呼吸信号は、好ましくは、被験者のRC及びAB(図2で「呼吸」と名付けられた)からの2つのサイズセンサ信号を含み、収集された心臓信号は、心臓成分(「胸郭」と名付けられた)を有する中間胸腔からの信号を含み、活動レベル信号は、運動アーチファクト(「運動」と名付けられた)のための基準として部分的に使用される1から3軸加速度信号を含み、単一のEEGに感度の良いリード線(「EEG」と名付けられた)からのEEG信号を含む。
個々の処理段階53、55、57、59、61、及び63(図2)とそれらの機能性の例がここで詳細に説明される。
図3A−Bは、被験者の運動に感応する基準信号と共に呼吸信号を適応処理することにより呼吸信号を運動アーチファクトから分離することを示している。これらの図は、RC信号処理、例えば、AB又はVt信号のような別の呼吸信号の処理を示すが厳密には同様である。
zk=pk−yk (2)
pkとzkのいずれか又は両方が次に更に処理される。N個のフィルタ係数の設定は、第1の時間サンプルで通常ゼロに初期化され、ここで、NはFIRフィルタの長さであり、通常ゼロに初期化される。
w(0)i=0 (3)
次の時間サンプルにおいて、全てのフィルタ係数は、以下のように更新される。
w(k+1)i=w(k)i+2μzkpk-i (4)
ここで、μは、収束パラメータであり、収束の速度とLMS法の安定性を制御する。
運動アーチファクトは、呼吸信号からの運動アーチファクトの除去に関して上述した技術と実質的に同様の技術を使用して、他の信号、特に段階55の胸郭信号と段階57のEEG信号から除去される。
胸郭信号「THORAXイン」は、好ましくは、中間胸腔サイズセンサからの信号であり、振幅が望ましくない呼吸成分の振幅の1%から5%よりも大きくない望ましい心臓拍動成分を有する場合が多い。この比較的小さな心臓成分の信頼することができる抽出には、2つの基準信号、すなわち、呼吸基準信号とECG基準信号を考慮する必要があることが見出されている。呼吸基準信号は、胸郭サイズセンサからの信号が「THORAXイン」内の望ましくない呼吸成分と最も密接に相関することになっているので「RCイン」である。ECG信号は、R波信号を抽出するために処理される。
被験者の睡眠の研究は、移動式多重パラメータ生理学的モニタリングシステムの1つの応用である。眠っている被験者は、活発に歩いているなどという意味では「移動性」ではなく、制限のない通常の睡眠中のモニタリングは、睡眠活動のより現実的な記録を提供することができる。従って、移動式MPMシステムは、睡眠のモニタリングにさえも使用することができる。
心拍変動(HRV)は、多くの場合にRR間隔の変化から測定される心拍数の変更を意味する。HRVには多くの生理学的な用途があり、心臓血管疾患の評価に更に有用である。一般的に、心拍数は、自律神経系(ANS)により、特にANSの交感神経性と副交感神経性(迷走神経性)ブランチの間で変動する均衡によって影響される。化学受容体処理、体温調節、及び凝乳酵素アンギオテンシン系は、約0.04Hz未満の非常に低い周波数のHRVの原因になると考えられている。0.04Hzと0.15Hzの間の低周波数(LF)成分は、ANSの交感神経性と副交感神経性ブランチの均衡に影響すると考えられている。最後に、洞房結節の直接の迷走神経性(副交感神経性)変調は、約0.15から約0.4Hz又はそれより高い高周波数帯域(HF)HRVの原因になる。迷走神経性活動は、一般的に呼吸によって強く影響され、大部分が呼吸周波数において見出される得られるHF変調は、呼吸洞性不整脈(RSA)として公知である。
図11に転ずると、それは、ECG心臓サイクルの概略であり、ECG内のQT間隔は、Q波(QRSコンプレックスの第1の成分)と直後のT波の間の時間間隔(通常ミリ秒で規定される)である。電気生理学的には、QRSコンプレックスは、心室の心臓収縮脱分極を表し、T波は、心室の再分極を表し、QT間隔は、心室脱分極のほぼ安定期間を表している。この間隔は、非常に重要であり、それが長引くことは、悪性の心室不整脈と心筋梗塞症後の患者の突然の心臓死に関する増大する危険性と関連付けられ、新しい薬剤の評価は、今ではQT長に対する薬剤の効果の評価を含まなければならない。
QTLC=Qt+0.154(1−RR) (7)
ここで、QTLCは線形補正されたQT間隔、RRは、測定されたRR間隔である。例えば、Sagie他、1992年、「心拍数のQT間隔を調節するための改良された方法(フラミンガムの心臓研究)」、「Am J Cardiol」、70:797−801ページを参照されたい。これらの技術の限界は、心拍数が高い時のQT間隔の過度の補正、又は移動条件の検証がなく、予測力が限られていることを含む(線形回帰モデルは、QT間隔分散の僅か約46%、r=0.68のみを説明する)。
21 ローカルユニット
Claims (5)
- モニタ被験者の複数の生理学的システムまたはプロセスに敏感なセンサから発生し、被験者からモニタされた第1センサ信号を処理する方法であって、
アーチファクト成分に対して第1センサ信号の生理学的成分を適応的に強化する段階であって、前記生理学的成分の適応的な強化が、前記第1センサ信号とアーチファクト基準信号との差である第1のエラー信号を減らすように調節される調節可能な第1特性を有する第1フィルタによって前記第1センサ信号をフィルタリングする第1の段階、及び
適応的に強化された第1センサ信号において、望まない別の生理学的システムまたはプロセスに敏感な成分に対して、望ましい生理学的システムまたはプロセスに敏感な成分を適応的に強化する第2の段階
を含み、
前記望ましい生理学的システムまたはプロセスに敏感な前記成分を適応的に強化する第2の段階は、前記適応的に強化された第1センサ信号と参照信号との差である第2のエラー信号を減らすように調節された、調節可能な第2特性を有する第2フィルタによって、適応的に強化された前記第1センサシグナルをフィルタリングする段階、
を含むことを特徴とし、
ここで、前記参照信号は望まない別の生理学的システムまたはプロセスに敏感な成分を含み、前記参照信号はアーチファクト成分に対して前記望まない別の生理学的システムまたはプロセスに敏感な成分を適応的に強化することによって得られるものであり、前記望まない別の生理学的システムまたはプロセスに敏感な成分の適応的な強化は、第2センサ信号とアーチファクト基準信号との差である第3のエラー信号を減らすように調節される調節可能な第3特性を有する第3フィルタによって前記第2センサ信号をフィルタリングするものである、
方法。 - 前記望ましい生理学的システムまたはプロセスが、心臓の機械的段階および脳波段階の1つを含み、前記望まない別の生理学的システムまたはプロセスが呼吸段階を含む、請求項1に記載の方法。
- 生理学的センサ信号を処理するためのシステムであって、
複数の生理学的プロセス及びアーチファクトの双方から発生する成分を含む第1センサ信号を生成するセンサを含む着用可能な構成と、
アーチファクト成分に対して第1センサ信号の生理学的成分を適応的に強化する段階であって、前記生理学的成分の適応的な強化が、前記第1センサ信号とアーチファクト基準信号との差である第1のエラー信号を減らすように調節される調節可能な第1特性を有する第1フィルタによって前記第1センサ信号をフィルタリングする第1の段階、
前記適応的に強化された第1センサ信号における他の望ましくない生理学的システム又は過程に感応する成分に対して、望ましい生理学的システム又は過程に感応する成分を適応的に強化する段階であって、前記適応的に強化された第1センサ信号と参照信号との差である第2のエラー信号を減らすように調節される調節可能な第2の特性を有する第2フィルタを用いて前記適応的に強化された第1センサ信号をフィルタリングすることによって、前記望ましい生理学的システム又は過程に感応する前記成分を適応的に強化する第2の段階、及び
前記第2の適応的に強化された第1センサ信号を出力する第3の段階、
を実行するコンピュータ命令を含むコンピュータメモリとを含むことを特徴とするシステムであって、
ここで、前記参照信号は望まない別の生理学的システムまたはプロセスに敏感な成分を含み、前記参照信号はアーチファクト成分に対して前記望まない別の生理学的システムまたはプロセスに敏感な成分を適応的に強化する段階を実行する前記コンピュータ命令を含むコンピュータメモリによって得られるものであり、前記望まない別の生理学的システムまたはプロセスに敏感な成分を適応的に強化する段階は、第2センサ信号とアーチファクト基準信号との差である第3のエラー信号を減らすように調節される調節可能な第3特性を有する第3フィルタによって前記第2センサ信号をフィルタリングするものである、
システム。 - 前記第1センサ信号が、心臓の収縮と拡張から発生する前胸部の拍動を含み、前記適応的に強化された第1センサ信号を前記第2フィルタでフィルタリングすることによって得られた、前記望ましい生理学的システム又は過程に感応する前記成分が適応的に強化された信号が、呼吸プロセス及びアーチファクトから発生する成分に対して強化された前記心拍動成分を含むことを特徴とする請求項3に記載のシステム。
- 前記第1センサ信号が、脳波(EEG)プロセスから発生する成分を含み、前記適応的に強化された第1センサ信号を前記第2フィルタでフィルタリングすることによって得られた、前記望ましい生理学的システム又は過程に感応する前記成分が適応的に強化された信号が、呼吸プロセス及びアーチファクトから発生する成分に対して強化された前記EEG成分を含むことを特徴とする請求項3に記載のシステム。
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EP1765165A2 (en) | 2004-05-24 | 2007-03-28 | Equusys, Incorporated | Animal instrumentation |
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US20120184826A1 (en) | 2012-07-19 |
US8137270B2 (en) | 2012-03-20 |
JP5529796B2 (ja) | 2014-06-25 |
US9277871B2 (en) | 2016-03-08 |
JP2011156376A (ja) | 2011-08-18 |
EP2508124A3 (en) | 2014-01-01 |
WO2005048824A2 (en) | 2005-06-02 |
CA2842420A1 (en) | 2005-06-02 |
EP2508123B1 (en) | 2015-05-20 |
AU2004290588A1 (en) | 2005-06-02 |
CA2545881A1 (en) | 2005-06-02 |
JP2007521852A (ja) | 2007-08-09 |
EP2508123A1 (en) | 2012-10-10 |
EP1684626B1 (en) | 2016-09-14 |
EP2508124A2 (en) | 2012-10-10 |
WO2005048824A3 (en) | 2007-06-28 |
CA2842420C (en) | 2016-10-11 |
EP1684626A4 (en) | 2008-02-27 |
US20050240087A1 (en) | 2005-10-27 |
EP1684626A2 (en) | 2006-08-02 |
US20160183881A1 (en) | 2016-06-30 |
CA2545881C (en) | 2014-04-08 |
WO2005048824A8 (en) | 2006-10-12 |
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