JP5456479B2 - グルタミニルシクラーゼの新規阻害剤 - Google Patents
グルタミニルシクラーゼの新規阻害剤 Download PDFInfo
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- JP5456479B2 JP5456479B2 JP2009535729A JP2009535729A JP5456479B2 JP 5456479 B2 JP5456479 B2 JP 5456479B2 JP 2009535729 A JP2009535729 A JP 2009535729A JP 2009535729 A JP2009535729 A JP 2009535729A JP 5456479 B2 JP5456479 B2 JP 5456479B2
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- JP
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- Prior art keywords
- imidazolidin
- benzimidazol
- phenyl
- imidazol
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Applications Claiming Priority (3)
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| US86498806P | 2006-11-09 | 2006-11-09 | |
| US60/864,988 | 2006-11-09 | ||
| PCT/EP2007/062034 WO2008055947A1 (en) | 2006-11-09 | 2007-11-08 | Novel inhibitors of glutaminyl cyclase |
Publications (3)
| Publication Number | Publication Date |
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| JP2010509285A JP2010509285A (ja) | 2010-03-25 |
| JP2010509285A5 JP2010509285A5 (OSRAM) | 2011-02-17 |
| JP5456479B2 true JP5456479B2 (ja) | 2014-03-26 |
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| EP (1) | EP2091945B1 (OSRAM) |
| JP (1) | JP5456479B2 (OSRAM) |
| DK (1) | DK2091945T3 (OSRAM) |
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| WO (1) | WO2008055947A1 (OSRAM) |
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| US8889709B2 (en) | 2006-09-21 | 2014-11-18 | Probiodrug Ag | Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions |
| JP2010504088A (ja) | 2006-09-21 | 2010-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼに関連した新規遺伝子 |
| EP3338795A1 (en) | 2008-07-21 | 2018-06-27 | Probiodrug AG | Diagnostic antibody assay |
| EP2344158B1 (en) * | 2008-09-04 | 2017-12-27 | Probiodrug AG | Use of isoqc inhibitors |
| SG193828A1 (en) | 2008-09-04 | 2013-10-30 | Probiodrug Ag | Novel inhibitors |
| MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
| WO2011076854A1 (en) | 2009-12-22 | 2011-06-30 | Probiodrug Ag | CLEAVAGE OF β-AMYLOID PRECURSOR PROTEIN |
| JP2013519891A (ja) | 2010-02-18 | 2013-05-30 | プロビオドルグ エージー | ピログルタミン酸修飾ｍｃｐ−１を決定することにより炎症性疾患を診断する方法及びグルタミニルシクラーゼの阻害剤のスクリーニング方法 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| US8269019B2 (en) | 2010-03-10 | 2012-09-18 | Probiodrug Ag | Inhibitors |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| US8409837B2 (en) | 2010-08-19 | 2013-04-02 | Probiodrug Ag | Crystal structure of glutaminyl cyclase |
| WO2012110946A1 (en) * | 2011-02-17 | 2012-08-23 | Glenmark Pharmaceuticals Sa | Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate |
| ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
| CN103459421B (zh) | 2011-03-16 | 2017-07-14 | 前体生物药物股份公司 | 诊断性抗体测定 |
| JP6156845B2 (ja) * | 2014-03-04 | 2017-07-05 | 株式会社島津製作所 | マトリックス支援レーザ脱離イオン化質量分析用マトリックス |
| US20170363645A1 (en) | 2014-12-19 | 2017-12-21 | Probiodrug Ag | Novel Method for the Detection of pGlu-Abeta Peptides |
| PL3461819T3 (pl) * | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| CN118019737A (zh) * | 2021-06-24 | 2024-05-10 | 英矽智能科技知识产权有限公司 | 用于治疗疾病的β-内酰胺衍生物 |
| WO2025021012A1 (en) * | 2023-07-21 | 2025-01-30 | Insilico Medicine Ip Limited | Crystalline beta-lactam derivatives and uses thereof |
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| JP4806628B2 (ja) * | 2003-05-05 | 2011-11-02 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤 |
| CA2583342A1 (en) * | 2004-10-13 | 2006-04-27 | Merck And Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease |
| MX2008011216A (es) * | 2006-03-08 | 2008-09-11 | Hoffmann La Roche | 1,5-dihidro-imidazol-2-onas 4-amino-1,5-substituidas. |
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Also Published As
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| WO2008055947A1 (en) | 2008-05-15 |
| EP2091945B1 (en) | 2014-01-15 |
| JP2010509285A (ja) | 2010-03-25 |
| EP2091945A1 (en) | 2009-08-26 |
| DK2091945T3 (da) | 2014-04-22 |
| ES2468546T3 (es) | 2014-06-16 |
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