JP5441928B2 - 一酸化窒素供与化合物 - Google Patents
一酸化窒素供与化合物 Download PDFInfo
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- JP5441928B2 JP5441928B2 JP2010545422A JP2010545422A JP5441928B2 JP 5441928 B2 JP5441928 B2 JP 5441928B2 JP 2010545422 A JP2010545422 A JP 2010545422A JP 2010545422 A JP2010545422 A JP 2010545422A JP 5441928 B2 JP5441928 B2 JP 5441928B2
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- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
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- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 1
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- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 1
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- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 230000015843 photosynthesis, light reaction Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- UBDXVNAAGCHEIC-UHFFFAOYSA-N piperidin-4-yl nitrate;hydrochloride Chemical compound Cl.[O-][N+](=O)OC1CCNCC1 UBDXVNAAGCHEIC-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- VVWRJUBEIPHGQF-UHFFFAOYSA-N propan-2-yl n-propan-2-yloxycarbonyliminocarbamate Chemical compound CC(C)OC(=O)N=NC(=O)OC(C)C VVWRJUBEIPHGQF-UHFFFAOYSA-N 0.000 description 1
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- 239000003586 protic polar solvent Substances 0.000 description 1
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- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- PWQLFIKTGRINFF-UHFFFAOYSA-N tert-butyl 4-hydroxypiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(O)CC1 PWQLFIKTGRINFF-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US694608P | 2008-02-07 | 2008-02-07 | |
| US61/006,946 | 2008-02-07 | ||
| PCT/EP2009/050416 WO2009098113A1 (en) | 2008-02-07 | 2009-01-15 | Nitric oxide donor compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511022A JP2011511022A (ja) | 2011-04-07 |
| JP2011511022A5 JP2011511022A5 (https=) | 2012-03-01 |
| JP5441928B2 true JP5441928B2 (ja) | 2014-03-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2010545422A Expired - Fee Related JP5441928B2 (ja) | 2008-02-07 | 2009-01-15 | 一酸化窒素供与化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8003811B2 (https=) |
| EP (1) | EP2238143B1 (https=) |
| JP (1) | JP5441928B2 (https=) |
| CA (1) | CA2706082C (https=) |
| ES (1) | ES2393049T3 (https=) |
| WO (1) | WO2009098113A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2731298T3 (es) | 2005-05-27 | 2019-11-14 | Univ North Carolina Chapel Hill | Partículas de liberación de óxido nítrico para agentes terapéuticos de óxido nítrico y aplicaciones biomédicas |
| WO2011022652A1 (en) | 2009-08-21 | 2011-02-24 | Novan, Inc. | Topical gels |
| CA2771389C (en) | 2009-08-21 | 2019-04-09 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| KR101794363B1 (ko) | 2009-12-11 | 2017-11-06 | 디에스엠 아이피 어셋츠 비.브이. | 반추동물에서의 메탄 방출을 감소시키고/감소시키거나 반추동물 수익성을 개선시키기 위한 사료중의 니트로옥시 알칸산 및 이의 유도체 |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
| US10154981B2 (en) | 2011-05-26 | 2018-12-18 | Dsm Ip Assets B.V. | Use of a feed composition for reducing methane emission in ruminants, and/or to improve ruminant performance |
| CN105026402A (zh) * | 2013-03-05 | 2015-11-04 | 阿彻丹尼尔斯米德兰德公司 | 异己糖醇单三氟甲磺酸酯及其合成方法 |
| EP2986288B1 (en) * | 2013-04-18 | 2017-04-12 | Nicox Science Ireland | Quinone based nitric oxide donating compounds for ophthalmic use |
| WO2016022944A1 (en) * | 2014-08-08 | 2016-02-11 | Central Michigan University | Flame retardants from renewable resources |
| US10610509B2 (en) | 2014-11-19 | 2020-04-07 | Nicox S.A. | Combinations of prostaglandins and nitric oxide donors |
| EP3088388A1 (en) | 2015-04-30 | 2016-11-02 | NicOx S.A. | Nitric oxide donating derivatives of prostaglandins |
| WO2018224419A1 (en) | 2017-06-06 | 2018-12-13 | Nicox S.A. | Nitric oxide donating isomannide derivatives |
| JP7596257B2 (ja) | 2018-08-06 | 2024-12-09 | ニコックス エス．エー． | 一酸化窒素放出性ホスホジエステラーゼ５型阻害薬 |
| US11779560B2 (en) * | 2020-03-28 | 2023-10-10 | Coeurative, Inc. | Methods of using nitric oxide donor compounds for treatment of COVID-19 and other infectious diseases |
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| JPS60149521A (ja) * | 1984-01-18 | 1985-08-07 | Eisai Co Ltd | 高眼圧・緑内障治療・予防用点眼剤 |
| DE3831949A1 (de) | 1988-09-20 | 1990-03-22 | Mack Chem Pharm | Arzneimittel |
| ES2142773B1 (es) * | 1998-10-07 | 2001-01-01 | Lacer Sa | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
| IE20070934A1 (en) * | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Efficient aspirin prodrugs |
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2009
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- 2009-01-15 EP EP09708682A patent/EP2238143B1/en not_active Not-in-force
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Also Published As
| Publication number | Publication date |
|---|---|
| US8003811B2 (en) | 2011-08-23 |
| ES2393049T3 (es) | 2012-12-18 |
| US20100249189A1 (en) | 2010-09-30 |
| CA2706082C (en) | 2017-10-03 |
| EP2238143B1 (en) | 2012-08-15 |
| EP2238143A1 (en) | 2010-10-13 |
| CA2706082A1 (en) | 2009-08-13 |
| WO2009098113A1 (en) | 2009-08-13 |
| JP2011511022A (ja) | 2011-04-07 |
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