JP5438028B2 - アザビシクロオクタンの誘導体、その製造方法及びそのジペプチジルペプチダーゼｉｖの阻害剤としての用途 - Google Patents

アザビシクロオクタンの誘導体、その製造方法及びそのジペプチジルペプチダーゼｉｖの阻害剤としての用途 Download PDF

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JP5438028B2
JP5438028B2 JP2010543359A JP2010543359A JP5438028B2 JP 5438028 B2 JP5438028 B2 JP 5438028B2 JP 2010543359 A JP2010543359 A JP 2010543359A JP 2010543359 A JP2010543359 A JP 2010543359A JP 5438028 B2 JP5438028 B2 JP 5438028B2
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Japan
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compound
group
cyclopenta
carboxylic acid
hexahydro
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Expired - Fee Related
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JP2010543359A
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English (en)
Japanese (ja)
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JP2011510026A5 (https=
JP2011510026A (ja
Inventor
タン・ペンチョ
リン・ツィアン
リュー・ヘジン
シャオ・フーチン
リー・リー
ヤン・ファンロン
フー・チャンホン
ワン・リン
シェン・コワンユワン
コワン・トンレアン
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Shanghai Hengrui Pharmaceutical Co Ltd
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Shanghai Hengrui Pharmaceutical Co Ltd
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Priority claimed from CN 200810004727 external-priority patent/CN101230059B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010543359A 2008-01-23 2008-05-20 アザビシクロオクタンの誘導体、その製造方法及びそのジペプチジルペプチダーゼｉｖの阻害剤としての用途 Expired - Fee Related JP5438028B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN 200810004727 CN101230059B (zh) 2007-01-23 2008-01-23 双环氮杂烷类衍生物、其制备方法及其在医药上的用途
CN200810004727.1 2008-01-23
PCT/CN2008/071014 WO2009094866A1 (en) 2008-01-23 2008-05-20 Dicycloazaalkane derivates, preparation processes and medical uses thereof

Publications (3)

Publication Number Publication Date
JP2011510026A JP2011510026A (ja) 2011-03-31
JP2011510026A5 JP2011510026A5 (https=) 2011-06-30
JP5438028B2 true JP5438028B2 (ja) 2014-03-12

Family

ID=40921930

Family Applications (1)

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JP2010543359A Expired - Fee Related JP5438028B2 (ja) 2008-01-23 2008-05-20 アザビシクロオクタンの誘導体、その製造方法及びそのジペプチジルペプチダーゼｉｖの阻害剤としての用途

Country Status (9)

Country Link
US (2) US8304411B2 (https=)
EP (1) EP2246347B1 (https=)
JP (1) JP5438028B2 (https=)
KR (1) KR101469306B1 (https=)
BR (1) BRPI0822143A2 (https=)
CA (1) CA2712352C (https=)
MX (1) MX2010008049A (https=)
RU (1) RU2487866C2 (https=)
WO (1) WO2009094866A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102174007B (zh) * 2011-03-11 2013-06-12 成都博天化工有限责任公司 [2-(2-氰基-吡咯烷-1-基)-2-氧代-乙基]-氨基甲酸叔丁基酯的工业化制备方法
KR102032934B1 (ko) 2011-12-21 2019-10-16 지앙수 헨그루이 메디슨 컴퍼니 리미티드 피롤 6원 헤테로아릴 고리 유도체, 그의 제조 방법, 및 그의 의약 용도
US9567300B2 (en) 2012-06-25 2017-02-14 Sunshine Lake Pharma Co., Ltd. Hexahydropentaleno derivatives, preparation method and use in medicine thereof
CN104030967B (zh) * 2013-03-05 2018-01-02 连云港恒运药业有限公司 一种dpp‑iv抑制剂的中间体、其制备方法和通过其制备dpp‑iv抑制剂的方法
WO2015048507A1 (en) 2013-09-26 2015-04-02 Mnemosyne Pharmaceuticals, Inc. Selective octahydro-cyclopenta[c] pyrrole negative modulators of nr2b
JO3579B1 (ar) 2014-09-26 2020-07-05 Luc Therapeutics Inc مُعدِلات تفاغرية سالبة لمستقبل nr2b من المركب n-ألكيل أريل-5-أوكسي أريل-ثامن هيدرو-خماسي الحلقة [c] بيرول
US20170301620A1 (en) * 2016-04-15 2017-10-19 International Business Machines Corporation Structure and process for metal cap integration

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US5280028A (en) * 1992-06-24 1994-01-18 G. D. Searle & Co. Benzimidazole compounds
DE69511086T2 (de) * 1994-05-18 2000-01-05 Nisshin Flour Milling Co., Ltd. Pyrimidinderivate
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
US6110949A (en) 1999-06-24 2000-08-29 Novartis Ag N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
DE60221983T2 (de) 2001-06-27 2008-05-15 Smithkline Beecham Corp. Fluorpyrrolidine als dipeptidyl-peptidase inhibitoren
US6861440B2 (en) * 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
HUP0200849A2 (hu) * 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
TW200401635A (en) * 2002-07-23 2004-02-01 Yamanouchi Pharma Co Ltd 2-Cyano-4-fluoropyrrolidine derivative or salt thereof
WO2004087142A1 (en) * 2003-04-04 2004-10-14 Novartis Ag Quinoline-2-one-derivatives for the treatment of airways diseases
GB0307856D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
CA2557275C (en) * 2004-02-27 2012-06-05 Kyorin Pharmaceutical Co., Ltd. Bicyclo derivative
FR2870538B1 (fr) * 2004-05-19 2006-07-14 Servier Lab Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20070270417A1 (en) * 2004-07-22 2007-11-22 Glaxo Group Limited Antibacterial Agents
ATE507832T1 (de) * 2004-09-03 2011-05-15 Athersys Inc Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren
US20080300251A1 (en) * 2005-09-05 2008-12-04 Sattigeri Jitendra A Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors
CN101050194B (zh) * 2006-04-05 2013-08-21 上海恒瑞医药有限公司 双环辛烷类衍生物、其制备方法及其在医药上的用途
CN101230059B (zh) 2007-01-23 2011-08-17 上海恒瑞医药有限公司 双环氮杂烷类衍生物、其制备方法及其在医药上的用途
CN101230058A (zh) * 2007-01-23 2008-07-30 上海恒瑞医药有限公司 双环氮杂烷类衍生物、其制备方法及其在医药上的用途

Also Published As

Publication number Publication date
BRPI0822143A2 (pt) 2019-09-24
AU2008349110A1 (en) 2009-08-06
US20100311747A1 (en) 2010-12-09
US20130012705A1 (en) 2013-01-10
MX2010008049A (es) 2010-11-12
CA2712352A1 (en) 2009-08-06
EP2246347A1 (en) 2010-11-03
KR20100103881A (ko) 2010-09-28
JP2011510026A (ja) 2011-03-31
CA2712352C (en) 2016-05-10
RU2487866C2 (ru) 2013-07-20
US8304411B2 (en) 2012-11-06
KR101469306B1 (ko) 2014-12-04
WO2009094866A1 (en) 2009-08-06
US8415349B2 (en) 2013-04-09
RU2010128972A (ru) 2012-02-27
EP2246347B1 (en) 2016-09-28
EP2246347A4 (en) 2012-01-11

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