JP5437267B2 - 炎症モジュレーターとしてのフェニル酢酸誘導体 - Google Patents

炎症モジュレーターとしてのフェニル酢酸誘導体 Download PDF

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Publication number
JP5437267B2
JP5437267B2 JP2010539482A JP2010539482A JP5437267B2 JP 5437267 B2 JP5437267 B2 JP 5437267B2 JP 2010539482 A JP2010539482 A JP 2010539482A JP 2010539482 A JP2010539482 A JP 2010539482A JP 5437267 B2 JP5437267 B2 JP 5437267B2
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compound
formula
alkyl
acid
chloro
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JP2011507847A (ja
JP2011507847A5 (enExample
Inventor
グリロ，マーク
リー，アン−ロン
リウ，ジウエン
メデイナ，ジユリオ・シー
スウ，ヨンリー
ワン，インツアイ
ジヨナ，ジヤナン
アルガイヤー，アラン
ミルン，ジヤクリーン
マリー，ジエリー
パヤツク，ジヨゼフ・エフ
シユトルツ，トーマス
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2010539482A 2007-12-19 2008-12-18 炎症モジュレーターとしてのフェニル酢酸誘導体 Expired - Fee Related JP5437267B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US843307P 2007-12-19 2007-12-19
US61/008,433 2007-12-19
PCT/US2008/013833 WO2009085177A1 (en) 2007-12-19 2008-12-18 Phenyl acetic acid derivatives as inflammation modulators

Publications (3)

Publication Number Publication Date
JP2011507847A JP2011507847A (ja) 2011-03-10
JP2011507847A5 JP2011507847A5 (enExample) 2011-12-22
JP5437267B2 true JP5437267B2 (ja) 2014-03-12

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JP2010539482A Expired - Fee Related JP5437267B2 (ja) 2007-12-19 2008-12-18 炎症モジュレーターとしてのフェニル酢酸誘導体

Country Status (20)

Country Link
US (1) US8183293B2 (enExample)
EP (1) EP2231595B1 (enExample)
JP (1) JP5437267B2 (enExample)
KR (1) KR20100102668A (enExample)
CN (1) CN101903338A (enExample)
AR (1) AR071279A1 (enExample)
AU (1) AU2008343924B2 (enExample)
BR (1) BRPI0821197A2 (enExample)
CA (1) CA2707789A1 (enExample)
CL (1) CL2008003832A1 (enExample)
CO (1) CO6321234A2 (enExample)
CR (1) CR11572A (enExample)
EA (1) EA201001029A1 (enExample)
ES (1) ES2471919T3 (enExample)
IL (1) IL206069A0 (enExample)
MA (1) MA32013B1 (enExample)
PE (1) PE20091526A1 (enExample)
TN (1) TN2010000223A1 (enExample)
TW (1) TW200940051A (enExample)
WO (1) WO2009085177A1 (enExample)

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EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2790696A1 (en) 2011-12-16 2014-10-22 Atopix Therapeutics Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
US9974759B2 (en) * 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
EP4420734A3 (en) 2015-02-13 2024-11-06 Institut National de la Santé et de la Recherche Médicale Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
SI3433234T1 (sl) 2016-03-22 2022-01-31 Merck Sharp & Dohme Corp. Alosterični modulatorji nikotinskih acetilholinskih receptorjev
ES2733477T3 (es) * 2017-07-04 2019-11-29 Fis Fabbrica Italiana Sintetici Spa Procedimiento eficaz para la preparación de sitagliptina a través de una preparación muy eficaz del intermedio ácido 2,4,5-trifluorofenilacético

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ATE223899T1 (de) * 1994-12-20 2002-09-15 Hoffmann La Roche Aryl-und hetaryl-sulfonamid derivate, deren herstellung und deren verwendung als endothelin- antagonisten
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
WO1998011094A1 (en) 1996-09-12 1998-03-19 Schering Aktiengesellschaft Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants
TW523506B (en) 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
JPH11202458A (ja) 1998-01-16 1999-07-30 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US5929250A (en) 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
EP1076641A1 (en) 1998-04-29 2001-02-21 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
AR023659A1 (es) 1998-09-18 2002-09-04 Vertex Pharma Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
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TR200102561T2 (tr) 1999-03-01 2002-02-21 Pfizer Products Inc. Tiroid alıcı ligantları olarak oksamik asitler ve türevleri
JP3828364B2 (ja) 1999-03-10 2006-10-04 塩野義製薬株式会社 ［２．２．１］および［３．１．１］ビシクロ骨格を有するｐｇｄ２／ｔｘａ２両受容体拮抗性医薬組成物
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Also Published As

Publication number Publication date
CL2008003832A1 (es) 2010-03-26
AU2008343924A1 (en) 2009-07-09
KR20100102668A (ko) 2010-09-24
AU2008343924B2 (en) 2013-01-17
CN101903338A (zh) 2010-12-01
TN2010000223A1 (en) 2011-11-11
CA2707789A1 (en) 2009-07-09
WO2009085177A1 (en) 2009-07-09
MA32013B1 (fr) 2011-01-03
CR11572A (es) 2010-08-13
JP2011507847A (ja) 2011-03-10
EP2231595B1 (en) 2014-04-23
US8183293B2 (en) 2012-05-22
BRPI0821197A2 (pt) 2015-06-16
AR071279A1 (es) 2010-06-09
EA201001029A1 (ru) 2011-06-30
EP2231595A1 (en) 2010-09-29
PE20091526A1 (es) 2009-11-01
CO6321234A2 (es) 2011-09-20
TW200940051A (en) 2009-10-01
US20090275659A1 (en) 2009-11-05
ES2471919T3 (es) 2014-06-27
AU2008343924A2 (en) 2011-02-17
IL206069A0 (en) 2010-11-30

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