CN101903338A - 用作炎症调节剂的苯基乙酸衍生物 - Google Patents

用作炎症调节剂的苯基乙酸衍生物 Download PDF

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Publication number
CN101903338A
CN101903338A CN2008801215268A CN200880121526A CN101903338A CN 101903338 A CN101903338 A CN 101903338A CN 2008801215268 A CN2008801215268 A CN 2008801215268A CN 200880121526 A CN200880121526 A CN 200880121526A CN 101903338 A CN101903338 A CN 101903338A
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CN
China
Prior art keywords
compound
formula
alkyl
acid
transition
Prior art date
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Pending
Application number
CN2008801215268A
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English (en)
Chinese (zh)
Inventor
M·格里洛
李安蓉
刘纪文
J·C·梅迪娜
苏泳丽
王英才
J·乔纳
A·阿尔盖尔
J·米尔恩
J·默里
J·F·帕亚克
T·斯托尔茨
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Amgen Inc
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Amgen Inc
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CN101903338A publication Critical patent/CN101903338A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2008801215268A 2007-12-19 2008-12-18 用作炎症调节剂的苯基乙酸衍生物 Pending CN101903338A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US843307P 2007-12-19 2007-12-19
US61/008433 2007-12-19
PCT/US2008/013833 WO2009085177A1 (en) 2007-12-19 2008-12-18 Phenyl acetic acid derivatives as inflammation modulators

Publications (1)

Publication Number Publication Date
CN101903338A true CN101903338A (zh) 2010-12-01

Family

ID=40564868

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801215268A Pending CN101903338A (zh) 2007-12-19 2008-12-18 用作炎症调节剂的苯基乙酸衍生物

Country Status (20)

Country Link
US (1) US8183293B2 (enExample)
EP (1) EP2231595B1 (enExample)
JP (1) JP5437267B2 (enExample)
KR (1) KR20100102668A (enExample)
CN (1) CN101903338A (enExample)
AR (1) AR071279A1 (enExample)
AU (1) AU2008343924B2 (enExample)
BR (1) BRPI0821197A2 (enExample)
CA (1) CA2707789A1 (enExample)
CL (1) CL2008003832A1 (enExample)
CO (1) CO6321234A2 (enExample)
CR (1) CR11572A (enExample)
EA (1) EA201001029A1 (enExample)
ES (1) ES2471919T3 (enExample)
IL (1) IL206069A0 (enExample)
MA (1) MA32013B1 (enExample)
PE (1) PE20091526A1 (enExample)
TN (1) TN2010000223A1 (enExample)
TW (1) TW200940051A (enExample)
WO (1) WO2009085177A1 (enExample)

Cited By (1)

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CN110831944A (zh) * 2017-07-04 2020-02-21 意大利合成制造有限公司 通过极有效制备中间体2,4,5-三氟苯乙酸来制备西他列汀的有效方法

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US9974759B2 (en) * 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
WO2016128565A1 (en) * 2015-02-13 2016-08-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
GEP20207149B (en) 2016-03-22 2020-09-10 Merck Sharp & Dohme Allosteric modulators of nicotinic acetylcholine receptors

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110831944A (zh) * 2017-07-04 2020-02-21 意大利合成制造有限公司 通过极有效制备中间体2,4,5-三氟苯乙酸来制备西他列汀的有效方法
CN110831944B (zh) * 2017-07-04 2022-05-27 意大利合成制造有限公司 通过制备中间体2,4,5-三氟苯乙酸来制备西他列汀的方法

Also Published As

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CL2008003832A1 (es) 2010-03-26
CR11572A (es) 2010-08-13
US20090275659A1 (en) 2009-11-05
MA32013B1 (fr) 2011-01-03
BRPI0821197A2 (pt) 2015-06-16
JP5437267B2 (ja) 2014-03-12
EP2231595B1 (en) 2014-04-23
KR20100102668A (ko) 2010-09-24
EA201001029A1 (ru) 2011-06-30
EP2231595A1 (en) 2010-09-29
AR071279A1 (es) 2010-06-09
CA2707789A1 (en) 2009-07-09
IL206069A0 (en) 2010-11-30
TN2010000223A1 (en) 2011-11-11
US8183293B2 (en) 2012-05-22
AU2008343924A1 (en) 2009-07-09
AU2008343924B2 (en) 2013-01-17
JP2011507847A (ja) 2011-03-10
PE20091526A1 (es) 2009-11-01
WO2009085177A1 (en) 2009-07-09
CO6321234A2 (es) 2011-09-20
TW200940051A (en) 2009-10-01
AU2008343924A2 (en) 2011-02-17
ES2471919T3 (es) 2014-06-27

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Application publication date: 20101201