JP5437267B2 - 炎症モジュレーターとしてのフェニル酢酸誘導体 - Google Patents

炎症モジュレーターとしてのフェニル酢酸誘導体 Download PDF

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JP5437267B2
JP5437267B2 JP2010539482A JP2010539482A JP5437267B2 JP 5437267 B2 JP5437267 B2 JP 5437267B2 JP 2010539482 A JP2010539482 A JP 2010539482A JP 2010539482 A JP2010539482 A JP 2010539482A JP 5437267 B2 JP5437267 B2 JP 5437267B2
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Japan
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compound
formula
alkyl
acid
chloro
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JP2010539482A
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Japanese (ja)
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JP2011507847A5 (OSRAM
JP2011507847A (ja
Inventor
グリロ，マーク
リー，アン−ロン
リウ，ジウエン
メデイナ，ジユリオ・シー
スウ，ヨンリー
ワン，インツアイ
ジヨナ，ジヤナン
アルガイヤー，アラン
ミルン，ジヤクリーン
マリー，ジエリー
パヤツク，ジヨゼフ・エフ
シユトルツ，トーマス
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2010539482A 2007-12-19 2008-12-18 炎症モジュレーターとしてのフェニル酢酸誘導体 Expired - Fee Related JP5437267B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US843307P 2007-12-19 2007-12-19
US61/008,433 2007-12-19
PCT/US2008/013833 WO2009085177A1 (en) 2007-12-19 2008-12-18 Phenyl acetic acid derivatives as inflammation modulators

Publications (3)

Publication Number Publication Date
JP2011507847A JP2011507847A (ja) 2011-03-10
JP2011507847A5 JP2011507847A5 (OSRAM) 2011-12-22
JP5437267B2 true JP5437267B2 (ja) 2014-03-12

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Family Applications (1)

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JP2010539482A Expired - Fee Related JP5437267B2 (ja) 2007-12-19 2008-12-18 炎症モジュレーターとしてのフェニル酢酸誘導体

Country Status (20)

Country Link
US (1) US8183293B2 (OSRAM)
EP (1) EP2231595B1 (OSRAM)
JP (1) JP5437267B2 (OSRAM)
KR (1) KR20100102668A (OSRAM)
CN (1) CN101903338A (OSRAM)
AR (1) AR071279A1 (OSRAM)
AU (1) AU2008343924B2 (OSRAM)
BR (1) BRPI0821197A2 (OSRAM)
CA (1) CA2707789A1 (OSRAM)
CL (1) CL2008003832A1 (OSRAM)
CO (1) CO6321234A2 (OSRAM)
CR (1) CR11572A (OSRAM)
EA (1) EA201001029A1 (OSRAM)
ES (1) ES2471919T3 (OSRAM)
IL (1) IL206069A0 (OSRAM)
MA (1) MA32013B1 (OSRAM)
PE (1) PE20091526A1 (OSRAM)
TN (1) TN2010000223A1 (OSRAM)
TW (1) TW200940051A (OSRAM)
WO (1) WO2009085177A1 (OSRAM)

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EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
MX2014007239A (es) 2011-12-16 2014-08-08 Atopix Therapeutics Ltd Combinacion de un antagonista crth2 y un inhibidor de bomba de proton para el tratamiento de esofagitis eosinofilica.
US9974759B2 (en) * 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
JP6770522B2 (ja) * 2015-02-13 2020-10-14 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト
MY195948A (en) 2016-03-22 2023-02-27 Merck Sharp & Dohme Allosteric Modulators of Nicotinic Acetylcholine Receptors
EP3424927B1 (en) 2017-07-04 2019-04-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid

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IL110159A0 (en) 1993-06-30 1994-10-07 Wellcome Found Diaryl compounds, their preparation and pharmaceutical compositions containing them
US5545669A (en) 1994-06-02 1996-08-13 Adams; Jerry L. Anti-inflammatory compounds
PT799206E (pt) 1994-12-20 2003-01-31 Hoffmann La Roche Derivados de aril- e heteroaril-sulfonamida processo para a sua preparacao e sua utilizacao como antagonistas da endotelina
US6008234A (en) 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
CN1234798A (zh) 1996-09-12 1999-11-10 舍林股份公司 环状氨基酸和环状羟基羧酸衍生物取代的苄脒衍生物和它们用作抗凝剂的用途
TW523506B (en) 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
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AR023659A1 (es) 1998-09-18 2002-09-04 Vertex Pharma Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
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Also Published As

Publication number Publication date
BRPI0821197A2 (pt) 2015-06-16
CR11572A (es) 2010-08-13
JP2011507847A (ja) 2011-03-10
TN2010000223A1 (en) 2011-11-11
MA32013B1 (fr) 2011-01-03
AU2008343924A1 (en) 2009-07-09
US8183293B2 (en) 2012-05-22
AU2008343924A2 (en) 2011-02-17
AU2008343924B2 (en) 2013-01-17
EP2231595B1 (en) 2014-04-23
WO2009085177A1 (en) 2009-07-09
KR20100102668A (ko) 2010-09-24
EA201001029A1 (ru) 2011-06-30
EP2231595A1 (en) 2010-09-29
TW200940051A (en) 2009-10-01
US20090275659A1 (en) 2009-11-05
CN101903338A (zh) 2010-12-01
IL206069A0 (en) 2010-11-30
CA2707789A1 (en) 2009-07-09
PE20091526A1 (es) 2009-11-01
AR071279A1 (es) 2010-06-09
CL2008003832A1 (es) 2010-03-26
CO6321234A2 (es) 2011-09-20
ES2471919T3 (es) 2014-06-27

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