JP5430944B2 - 炎症および免疫関連用途のためのピリジルフェニル化合物 - Google Patents

炎症および免疫関連用途のためのピリジルフェニル化合物 Download PDF

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JP5430944B2
JP5430944B2 JP2008552512A JP2008552512A JP5430944B2 JP 5430944 B2 JP5430944 B2 JP 5430944B2 JP 2008552512 A JP2008552512 A JP 2008552512A JP 2008552512 A JP2008552512 A JP 2008552512A JP 5430944 B2 JP5430944 B2 JP 5430944B2
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optionally substituted
methyl
pyridin
phenyl
benzamide
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JP2009525285A (ja
JP2009525285A5 (enExample
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ジャン,ジュン
シア,ズー−シャン
チャン,ジュンイ
ボーナート,ゲイリー
チェン,ショウジュン
シェ,ユー
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シンタ ファーマシューティカルズ コーポレーション
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JP2008552512A 2006-01-31 2007-01-31 炎症および免疫関連用途のためのピリジルフェニル化合物 Expired - Fee Related JP5430944B2 (ja)

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US76378206P 2006-01-31 2006-01-31
US60/763,782 2006-01-31
PCT/US2007/002790 WO2007089904A2 (en) 2006-01-31 2007-01-31 Pyridylphenyl compounds for inflammation and immune-related uses

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JP2009525285A JP2009525285A (ja) 2009-07-09
JP2009525285A5 JP2009525285A5 (enExample) 2010-03-18
JP5430944B2 true JP5430944B2 (ja) 2014-03-05

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AU (1) AU2007211276B2 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2922797B2 (ja) 1994-10-07 1999-07-26 大日精化工業株式会社 有色絹糸の製造方法

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI444187B (zh) * 2005-01-25 2014-07-11 Synta Pharmaceuticals Corp 用於炎症及免疫相關用途之噻吩化合物
US8623871B2 (en) * 2006-01-25 2014-01-07 Synta Pharmaceuticals Corp. Substituted biaryl compounds for inflammation and immune-related uses
JP5430943B2 (ja) * 2006-01-25 2014-03-05 シンタ ファーマシューティカルズ コーポレーション 炎症及び免疫関連用途のための置換芳香族化合物
EP1984337B1 (en) * 2006-01-25 2014-04-30 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
US20070254926A1 (en) * 2006-01-31 2007-11-01 Jun Jiang Pyridylphenyl compounds for inflammation and immune-related uses
WO2007109362A2 (en) 2006-03-20 2007-09-27 Synta Pharmaceuticals Corp. Benzoimidazolyl-parazine compounds for inflammation and immune-related uses
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
BRPI0810202A2 (pt) 2007-05-03 2014-10-21 Pfizer Ltd Derivados de piridina
JP5431323B2 (ja) * 2007-08-01 2014-03-05 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途のためのピリジン化合物
US20090099242A1 (en) 2007-08-15 2009-04-16 Cuny Gregory D Heterocyclic inhibitors of necroptosis
CA2699157A1 (en) * 2007-09-10 2009-03-19 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2009076454A2 (en) * 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2321303B1 (en) * 2008-08-27 2019-11-27 Calcimedica, Inc. Compounds that modulate intracellular calcium
US8524763B2 (en) * 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
EP2350006A1 (en) * 2008-10-01 2011-08-03 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
US8143269B2 (en) * 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
EP2477982A4 (en) * 2009-09-16 2013-04-03 Calcimedica Inc COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
PT2563776T (pt) 2010-04-27 2016-09-19 Calcimedica Inc Compostos que modulam o cálcio intracelular
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
CA2797533A1 (en) 2010-04-27 2011-11-10 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN106905311A (zh) 2010-08-27 2017-06-30 钙医学公司 调节细胞内钙的化合物
EP2632906B1 (en) * 2010-10-30 2016-04-06 Lupin Limited Oxazoline and isoxazoline derivatives as crac modulators
JP5985611B2 (ja) * 2011-05-03 2016-09-06 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途のための化合物
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (en) 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
CA2853485A1 (en) * 2011-10-28 2013-05-02 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
IN2014MN02127A (enExample) 2012-05-02 2015-09-11 Lupin Ltd
CA2871270A1 (en) 2012-05-02 2013-11-07 Lupin Limited Substituted pyridine compounds as crac modulators
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2968276A4 (en) 2013-03-15 2017-02-15 President and Fellows of Harvard College Hybrid necroptosis inhibitors
WO2014203217A1 (en) 2013-06-21 2014-12-24 Lupin Limited Substituted heterocyclic compounds as crac modulators
EP3013810A1 (en) 2013-06-24 2016-05-04 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
CA2940237C (en) * 2014-02-21 2023-03-07 Frost Biologic, Inc. Antimitotic amides for the treatment of cancer and proliferative disorders
PL3778595T3 (pl) 2015-02-27 2022-04-19 Calcimedica, Inc. Leczenie zapalenia trzustki
JP6738575B2 (ja) 2015-08-07 2020-08-12 カルシメディカ,インク. 脳卒中および外傷性脳損傷の処置のためのcracチャネル阻害剤の使用
KR20200051646A (ko) * 2017-08-17 2020-05-13 이케나 온콜로지, 인코포레이티드 Ahr 억제제 및 이의 용도
KR20210062023A (ko) 2018-09-14 2021-05-28 리젠 파마슈티컬스 아게 Crac 억제제 및 코르티코스테로이드를 포함하는 조성물 및 그의 사용 방법
CN115209952B (zh) 2020-01-13 2025-05-30 维基分析有限公司 经取代的吡唑并嘧啶及其用途
CN118084860A (zh) * 2024-02-06 2024-05-28 中国药科大学 芳酰胺类化合物及其药物组合物和应用
KR20250144817A (ko) * 2024-03-27 2025-10-13 동국대학교 산학협력단 신규 옥사다이아졸 유도체 및 이를 포함하는 암 예방 또는 치료용 조성물

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6274171B1 (en) 1996-03-25 2001-08-14 American Home Products Corporation Extended release formulation of venlafaxine hydrochloride
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
BR9908539A (pt) * 1998-01-28 2000-12-05 Shionogi & Co Ltda Compostos tricìclicos
GB9825652D0 (en) * 1998-11-23 1999-01-13 Celltech Therapeutics Ltd Chemical compounds
US6552188B2 (en) * 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
ATE485275T1 (de) * 2002-02-12 2010-11-15 Glaxosmithkline Llc Nicotinamide und deren verwendung als p38 inhibitoren
US20040063761A1 (en) * 2002-08-06 2004-04-01 Kuduk Scott D. 2-(biarylalkyl)amino-3-(fluoroalkanoylamino)pyridine derivatives
AU2003299797A1 (en) * 2002-12-19 2004-07-14 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
PT1651232E (pt) * 2003-07-23 2011-02-16 Synta Pharmaceuticals Corp Compostos para inflamação e utilizações imunorelacionadas
GB0402137D0 (en) 2004-01-30 2004-03-03 Smithkline Beecham Corp Novel compounds
GB0404574D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Amino acids
MX2007003342A (es) * 2004-09-21 2007-06-05 Synta Pharmaceutical Corp Compuestos para inflamacion y usos relacionados con trastornos inmunitarios.
US7165455B2 (en) 2004-12-18 2007-01-23 Honeywell International Inc. Surface acoustic wave sensor methods and systems
TWI441819B (zh) * 2005-01-07 2014-06-21 Synta Pharmaceuticals Corp 用於炎症及免疫相關用途之化合物
JP5430943B2 (ja) * 2006-01-25 2014-03-05 シンタ ファーマシューティカルズ コーポレーション 炎症及び免疫関連用途のための置換芳香族化合物
US8623871B2 (en) * 2006-01-25 2014-01-07 Synta Pharmaceuticals Corp. Substituted biaryl compounds for inflammation and immune-related uses
US20070254926A1 (en) 2006-01-31 2007-11-01 Jun Jiang Pyridylphenyl compounds for inflammation and immune-related uses

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2922797B2 (ja) 1994-10-07 1999-07-26 大日精化工業株式会社 有色絹糸の製造方法

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CA2640049A1 (en) 2007-08-09
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