JP5420135B2 - 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン - Google Patents

抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン Download PDF

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JP5420135B2
JP5420135B2 JP2004521423A JP2004521423A JP5420135B2 JP 5420135 B2 JP5420135 B2 JP 5420135B2 JP 2004521423 A JP2004521423 A JP 2004521423A JP 2004521423 A JP2004521423 A JP 2004521423A JP 5420135 B2 JP5420135 B2 JP 5420135B2
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amino
group
compound
cycloalkyl
cyclopropylidenemethyl
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JP2005524720A (ja
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ゼムリカ，ジリ
ドラシユ，ジヨン・シー
チェン シンチャオ
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ウエイン・ステイト・ユニバーシテイ
ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・ミシガン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2004521423A 2002-03-15 2003-03-13 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン Expired - Fee Related JP5420135B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36449502P 2002-03-15 2002-03-15
US60/364,495 2002-03-15
PCT/US2003/007909 WO2004006867A2 (en) 2002-03-15 2003-03-13 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents

Related Child Applications (1)

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JP2012104611A Division JP2012180361A (ja) 2002-03-15 2012-05-01 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン

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JP2005524720A JP2005524720A (ja) 2005-08-18
JP5420135B2 true JP5420135B2 (ja) 2014-02-19

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JP2004521423A Expired - Fee Related JP5420135B2 (ja) 2002-03-15 2003-03-13 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン
JP2012104611A Ceased JP2012180361A (ja) 2002-03-15 2012-05-01 抗ウイルス薬としての新規２−アミノ−９−［（２−ヒドロキシメチル）シクロプロピリデンメチル］プリン

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US (2) US7183268B2 (OSRAM)
EP (1) EP1490015B1 (OSRAM)
JP (2) JP5420135B2 (OSRAM)
AT (1) ATE443507T1 (OSRAM)
AU (1) AU2003276824B8 (OSRAM)
CA (1) CA2479037C (OSRAM)
DE (1) DE60329375D1 (OSRAM)
WO (1) WO2004006867A2 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
AU2003267947B2 (en) * 2002-03-15 2008-11-13 The Regents Of The University Of Michigan 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents
JP3991223B2 (ja) * 2003-02-13 2007-10-17 信越化学工業株式会社 新規スルホニルジアゾメタン化合物、光酸発生剤、並びにそれを用いたレジスト材料及びパターン形成方法
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
CA2552279C (en) * 2003-12-02 2014-07-15 The Ohio State University Research Foundation Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors
JP2007532526A (ja) 2004-04-07 2007-11-15 ファイザー・インク ピラゾロ［４，３−ｄ］ピリミジン類
WO2009048752A2 (en) 2007-10-09 2009-04-16 Dow Agrosciences Llc Insecticidal substituted azinyl derivatives
JP5437254B2 (ja) 2007-10-09 2014-03-12 ダウ アグロサイエンシィズ エルエルシー 殺虫性（１，３，５）−トリアジニルフェニルヒドラゾン
US8058279B2 (en) 2007-10-09 2011-11-15 Dow Agrosciences Llc Insecticidal pyrimidinyl aryl hyrdrazones
SG11201901633WA (en) * 2016-08-29 2019-03-28 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
WO1998030563A1 (en) * 1997-01-08 1998-07-16 The Regents Of The University Of Michigan 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents
AU2003267947B2 (en) * 2002-03-15 2008-11-13 The Regents Of The University Of Michigan 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents

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Publication number Publication date
US20070225302A1 (en) 2007-09-27
DE60329375D1 (en) 2009-11-05
JP2005524720A (ja) 2005-08-18
EP1490015A2 (en) 2004-12-29
EP1490015B1 (en) 2009-09-23
AU2003276824A2 (en) 2004-02-02
AU2003276824B2 (en) 2009-01-08
ATE443507T1 (de) 2009-10-15
US7183268B2 (en) 2007-02-27
US9174990B2 (en) 2015-11-03
CA2479037A1 (en) 2004-01-22
US20050124582A1 (en) 2005-06-09
WO2004006867A3 (en) 2004-10-21
EP1490015A4 (en) 2005-12-28
CA2479037C (en) 2010-11-09
WO2004006867A2 (en) 2004-01-22
AU2003276824B8 (en) 2009-01-22
JP2012180361A (ja) 2012-09-20
AU2003276824A1 (en) 2004-02-02

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