ATE443507T1 - Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel - Google Patents
Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittelInfo
- Publication number
- ATE443507T1 ATE443507T1 AT03764294T AT03764294T ATE443507T1 AT E443507 T1 ATE443507 T1 AT E443507T1 AT 03764294 T AT03764294 T AT 03764294T AT 03764294 T AT03764294 T AT 03764294T AT E443507 T1 ATE443507 T1 AT E443507T1
- Authority
- AT
- Austria
- Prior art keywords
- amino
- cycloalkyl
- group
- cyclopropylidenmethyl
- purines
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- -1 2-aminopurine-9-yl Chemical group 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 101150009274 nhr-1 gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36449502P | 2002-03-15 | 2002-03-15 | |
| PCT/US2003/007909 WO2004006867A2 (en) | 2002-03-15 | 2003-03-13 | 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443507T1 true ATE443507T1 (de) | 2009-10-15 |
Family
ID=30115469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03764294T ATE443507T1 (de) | 2002-03-15 | 2003-03-13 | Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7183268B2 (OSRAM) |
| EP (1) | EP1490015B1 (OSRAM) |
| JP (2) | JP5420135B2 (OSRAM) |
| AT (1) | ATE443507T1 (OSRAM) |
| AU (1) | AU2003276824B8 (OSRAM) |
| CA (1) | CA2479037C (OSRAM) |
| DE (1) | DE60329375D1 (OSRAM) |
| WO (1) | WO2004006867A2 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY141789A (en) * | 2001-01-19 | 2010-06-30 | Lg Chem Investment Ltd | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same. |
| AU2003267947B2 (en) * | 2002-03-15 | 2008-11-13 | The Regents Of The University Of Michigan | 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents |
| JP3991223B2 (ja) * | 2003-02-13 | 2007-10-17 | 信越化学工業株式会社 | 新規スルホニルジアゾメタン化合物、光酸発生剤、並びにそれを用いたレジスト材料及びパターン形成方法 |
| EA008596B1 (ru) | 2003-04-29 | 2007-06-29 | Пфайзер Инк. | 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ |
| US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| CA2552279C (en) * | 2003-12-02 | 2014-07-15 | The Ohio State University Research Foundation | Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors |
| JP2007532526A (ja) | 2004-04-07 | 2007-11-15 | ファイザー・インク | ピラゾロ［４，３−ｄ］ピリミジン類 |
| WO2009048752A2 (en) | 2007-10-09 | 2009-04-16 | Dow Agrosciences Llc | Insecticidal substituted azinyl derivatives |
| JP5437254B2 (ja) | 2007-10-09 | 2014-03-12 | ダウ アグロサイエンシィズ エルエルシー | 殺虫性（１，３，５）−トリアジニルフェニルヒドラゾン |
| US8058279B2 (en) | 2007-10-09 | 2011-11-15 | Dow Agrosciences Llc | Insecticidal pyrimidinyl aryl hyrdrazones |
| SG11201901633WA (en) * | 2016-08-29 | 2019-03-28 | Hoffmann La Roche | 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| PT95516A (pt) * | 1989-10-06 | 1991-08-14 | Wellcome Found | Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos |
| WO1998030563A1 (en) * | 1997-01-08 | 1998-07-16 | The Regents Of The University Of Michigan | 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents |
| US6352991B1 (en) * | 1997-01-08 | 2002-03-05 | Wayne State University | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents |
| AU2003267947B2 (en) * | 2002-03-15 | 2008-11-13 | The Regents Of The University Of Michigan | 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents |
-
2003
- 2003-03-13 DE DE60329375T patent/DE60329375D1/de not_active Expired - Lifetime
- 2003-03-13 CA CA2479037A patent/CA2479037C/en not_active Expired - Fee Related
- 2003-03-13 WO PCT/US2003/007909 patent/WO2004006867A2/en not_active Ceased
- 2003-03-13 AT AT03764294T patent/ATE443507T1/de not_active IP Right Cessation
- 2003-03-13 AU AU2003276824A patent/AU2003276824B8/en not_active Ceased
- 2003-03-13 EP EP03764294A patent/EP1490015B1/en not_active Expired - Lifetime
- 2003-03-13 JP JP2004521423A patent/JP5420135B2/ja not_active Expired - Fee Related
-
2004
- 2004-09-15 US US10/942,314 patent/US7183268B2/en not_active Expired - Fee Related
-
2007
- 2007-02-15 US US11/707,248 patent/US9174990B2/en not_active Expired - Fee Related
-
2012
- 2012-05-01 JP JP2012104611A patent/JP2012180361A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20070225302A1 (en) | 2007-09-27 |
| DE60329375D1 (en) | 2009-11-05 |
| JP2005524720A (ja) | 2005-08-18 |
| EP1490015A2 (en) | 2004-12-29 |
| EP1490015B1 (en) | 2009-09-23 |
| AU2003276824A2 (en) | 2004-02-02 |
| JP5420135B2 (ja) | 2014-02-19 |
| AU2003276824B2 (en) | 2009-01-08 |
| US7183268B2 (en) | 2007-02-27 |
| US9174990B2 (en) | 2015-11-03 |
| CA2479037A1 (en) | 2004-01-22 |
| US20050124582A1 (en) | 2005-06-09 |
| WO2004006867A3 (en) | 2004-10-21 |
| EP1490015A4 (en) | 2005-12-28 |
| CA2479037C (en) | 2010-11-09 |
| WO2004006867A2 (en) | 2004-01-22 |
| AU2003276824B8 (en) | 2009-01-22 |
| JP2012180361A (ja) | 2012-09-20 |
| AU2003276824A1 (en) | 2004-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |