ES2080079T3 - 13-alquil-11-beta-fenil-gonanos. - Google Patents
13-alquil-11-beta-fenil-gonanos.Info
- Publication number
- ES2080079T3 ES2080079T3 ES89730155T ES89730155T ES2080079T3 ES 2080079 T3 ES2080079 T3 ES 2080079T3 ES 89730155 T ES89730155 T ES 89730155T ES 89730155 T ES89730155 T ES 89730155T ES 2080079 T3 ES2080079 T3 ES 2080079T3
- Authority
- ES
- Spain
- Prior art keywords
- radicals
- beta
- gonanos
- alquil
- fenil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Lubricants (AREA)
- Hydrogenated Pyridines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
SE DESCRIBEN 13- ALQUIL -11 BETA- FENIL -GONANOS DE LA FORMULA GENERAL I, DONDE: Z, R1, R2, R3 Y R4 TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, PRODECIMIENTO PARA SU FABRICACION, PREPARADOS FARMACEUTICOS QUE CONTIENEN COMBINACIONES ASI COMO SU UTILIZACION PARA FABRICACION DE MEDICAMENTOS. LAS NUEVAS COMBINACIONES DE LA FORMULA GENERAL I TIENEN EXCELENTE EFECTIVIDAD ANTIGESTAGENA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3822770A DE3822770A1 (de) | 1988-07-01 | 1988-07-01 | 13-alkyl-11ss-phenylgonane |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2080079T3 true ES2080079T3 (es) | 1996-02-01 |
Family
ID=6358021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89730155T Expired - Lifetime ES2080079T3 (es) | 1988-07-01 | 1989-07-03 | 13-alquil-11-beta-fenil-gonanos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US5273971A (es) |
EP (1) | EP0349481B1 (es) |
JP (1) | JP2956776B2 (es) |
AT (1) | ATE129717T1 (es) |
AU (1) | AU644060B2 (es) |
CA (1) | CA1334668C (es) |
DD (2) | DD287511A5 (es) |
DE (2) | DE3822770A1 (es) |
ES (1) | ES2080079T3 (es) |
GR (1) | GR3018069T3 (es) |
HU (1) | HU208021B (es) |
IE (1) | IE70664B1 (es) |
IL (1) | IL90826A (es) |
NO (1) | NO180451C (es) |
PT (1) | PT91031B (es) |
WO (1) | WO1990000174A1 (es) |
ZA (1) | ZA895058B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3822770A1 (de) * | 1988-07-01 | 1990-01-04 | Schering Ag | 13-alkyl-11ss-phenylgonane |
US5707982A (en) * | 1989-02-24 | 1998-01-13 | Roussel Uclaf | 19-nor-steroids |
US6790971B1 (en) * | 1989-02-24 | 2004-09-14 | Aventis Pharma S.A. | 19-Nor-steroids |
DE4018168A1 (de) * | 1990-06-01 | 1991-12-05 | Schering Ag | Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen |
DE4042004A1 (de) * | 1990-12-22 | 1992-06-25 | Schering Ag | 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene |
EP0683172B1 (en) * | 1994-05-19 | 1997-08-13 | Akzo Nobel N.V. | 11,21-Bisphenyl-19-norpregnane derivatives |
DE4434488A1 (de) * | 1994-09-14 | 1996-03-21 | Schering Ag | Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
US5929262A (en) * | 1995-03-30 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method for preparing 17α-acetoxy-11β-(4-N, N-dimethylaminophyl)-19-Norpregna-4,9-diene-3, 20-dione, intermediates useful in the method, and methods for the preparation of such intermediates |
US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
ES2152671T3 (es) * | 1996-05-01 | 2001-02-01 | Us Gov Health & Human Serv | Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales. |
US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US5962444A (en) * | 1998-05-29 | 1999-10-05 | Research Triangle Institute | 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
US6262042B1 (en) | 1998-05-29 | 2001-07-17 | Research Triangle Institute | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
WO2002010188A1 (en) * | 2000-07-28 | 2002-02-07 | Akzo Nobel N.V. | 16alpha-methyl or ethyl substituted estrogens |
US20060111577A1 (en) * | 2003-02-28 | 2006-05-25 | Kim Hyun K | Method for preparing 17 alpha-acetoxy-11beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates |
TW200531977A (en) | 2004-03-25 | 2005-10-01 | Akzo Nobel Nv | Progesterone receptor modulators |
US20060196449A1 (en) * | 2004-09-17 | 2006-09-07 | Mockry Eldon F | Fluid heating system and method |
US20100160275A1 (en) * | 2006-09-26 | 2010-06-24 | Lee Eva Y H P | Methods and compositions for cancer prevention and treatment |
US9517240B2 (en) | 2006-09-26 | 2016-12-13 | The Regents Of The University Of California | Methods and compositions for cancer prevention and treatment |
CA2673128C (en) | 2006-10-24 | 2018-07-03 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
US7784843B2 (en) * | 2008-01-08 | 2010-08-31 | Toyota Motor Engineering & Manufacturing North America, Inc. | Vehicle console with sliding panel |
US8172293B2 (en) * | 2008-01-09 | 2012-05-08 | Toyota Motor Engineering & Manufacturing North America, Inc. | Vehicle electronic device support systems |
TWI539953B (zh) | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
CN102906103A (zh) | 2010-03-22 | 2013-01-30 | 利普生物药剂公司 | 用于抗孕酮的非毒性递送的组合物和方法 |
MX2015012142A (es) | 2013-03-12 | 2016-01-15 | Arno Therapeutics | Formas polimorfas de onapristona y metodos de uso. |
US9096641B2 (en) * | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
MX2017005163A (es) | 2014-11-17 | 2018-01-18 | Arno Therapeutics Inc | Composiciones de liberación prolongada de onapristona y métodos. |
BR112018005999A2 (pt) | 2015-09-25 | 2019-01-08 | Context Biopharma Inc | métodos para a produção de intermediários de onapristona |
CN108883067B (zh) | 2015-12-15 | 2021-03-09 | 康特斯生物制药公司 | 非晶奥那司酮组合物及其制备方法 |
US20180148471A1 (en) | 2016-11-30 | 2018-05-31 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3971772A (en) * | 1975-01-06 | 1976-07-27 | E. R. Squibb & Sons, Inc. | Steroidal[16α,17-b]1,4-dioxanes and Steroidal[16α,17-b]1,4-dioxins |
ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
ES533260A0 (es) * | 1983-06-15 | 1985-02-01 | Schering Ag | Procedimiento para la preparacion de 13a-alquilgonanos |
US4780461A (en) * | 1983-06-15 | 1988-10-25 | Schering Aktiengesellschaft | 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same |
FR2576025B1 (fr) * | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
AU580843B2 (en) * | 1985-02-07 | 1989-02-02 | Schering Aktiengesellschaft | 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them |
DE3625315A1 (de) * | 1986-07-25 | 1988-01-28 | Schering Ag | 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3822770A1 (de) * | 1988-07-01 | 1990-01-04 | Schering Ag | 13-alkyl-11ss-phenylgonane |
DE3832303A1 (de) * | 1988-09-20 | 1990-04-12 | Schering Ag | 11ss-phenyl-14ssh-steroide |
-
1988
- 1988-07-01 DE DE3822770A patent/DE3822770A1/de not_active Withdrawn
-
1989
- 1989-06-30 CA CA000604596A patent/CA1334668C/en not_active Expired - Fee Related
- 1989-06-30 PT PT91031A patent/PT91031B/pt not_active IP Right Cessation
- 1989-06-30 IL IL9082689A patent/IL90826A/en not_active IP Right Cessation
- 1989-07-03 AU AU38568/89A patent/AU644060B2/en not_active Ceased
- 1989-07-03 IE IE214189A patent/IE70664B1/en not_active IP Right Cessation
- 1989-07-03 ZA ZA895058A patent/ZA895058B/xx unknown
- 1989-07-03 DE DE58909476T patent/DE58909476D1/de not_active Expired - Fee Related
- 1989-07-03 EP EP89730155A patent/EP0349481B1/de not_active Expired - Lifetime
- 1989-07-03 JP JP1507188A patent/JP2956776B2/ja not_active Expired - Fee Related
- 1989-07-03 US US07/374,809 patent/US5273971A/en not_active Expired - Fee Related
- 1989-07-03 DD DD89330342A patent/DD287511A5/de not_active IP Right Cessation
- 1989-07-03 AT AT89730155T patent/ATE129717T1/de not_active IP Right Cessation
- 1989-07-03 WO PCT/DE1989/000443 patent/WO1990000174A1/de active Application Filing
- 1989-07-03 ES ES89730155T patent/ES2080079T3/es not_active Expired - Lifetime
- 1989-07-03 HU HU894130A patent/HU208021B/hu not_active IP Right Cessation
- 1989-07-03 DD DD89341722A patent/DD295638A5/de not_active IP Right Cessation
-
1990
- 1990-12-27 NO NO905609A patent/NO180451C/no unknown
-
1993
- 1993-11-02 US US08/144,474 patent/US5446036A/en not_active Expired - Fee Related
-
1995
- 1995-11-10 GR GR950403170T patent/GR3018069T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE129717T1 (de) | 1995-11-15 |
CA1334668C (en) | 1995-03-07 |
HU894130D0 (en) | 1991-06-28 |
DD287511A5 (de) | 1991-02-28 |
DE3822770A1 (de) | 1990-01-04 |
ZA895058B (en) | 1990-04-25 |
NO905609L (no) | 1991-02-28 |
NO180451B (no) | 1997-01-13 |
EP0349481B1 (de) | 1995-11-02 |
NO905609D0 (no) | 1990-12-27 |
DD295638A5 (de) | 1991-11-07 |
EP0349481A1 (de) | 1990-01-03 |
US5446036A (en) | 1995-08-29 |
JPH03505727A (ja) | 1991-12-12 |
GR3018069T3 (en) | 1996-02-29 |
IE70664B1 (en) | 1996-12-11 |
PT91031B (pt) | 1994-12-30 |
PT91031A (pt) | 1990-02-08 |
AU644060B2 (en) | 1993-12-02 |
HUT56114A (en) | 1991-07-29 |
AU3856889A (en) | 1990-01-23 |
JP2956776B2 (ja) | 1999-10-04 |
IE892141L (en) | 1990-01-01 |
WO1990000174A1 (de) | 1990-01-11 |
NO180451C (no) | 1997-04-23 |
DE58909476D1 (de) | 1995-12-14 |
US5273971A (en) | 1993-12-28 |
IL90826A0 (en) | 1990-01-18 |
IL90826A (en) | 1994-06-24 |
HU208021B (en) | 1993-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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