CA2479037C - 2-amino-9[(2-hydroxymethyl)cyclopropylidenemethyl]purines as antiviral agents - Google Patents

2-amino-9[(2-hydroxymethyl)cyclopropylidenemethyl]purines as antiviral agents Download PDF

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Publication number
CA2479037C
CA2479037C CA2479037A CA2479037A CA2479037C CA 2479037 C CA2479037 C CA 2479037C CA 2479037 A CA2479037 A CA 2479037A CA 2479037 A CA2479037 A CA 2479037A CA 2479037 C CA2479037 C CA 2479037C
Authority
CA
Canada
Prior art keywords
group
amino
cycloalkyl
cycloalkynyl
cycloalkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2479037A
Other languages
English (en)
French (fr)
Other versions
CA2479037A1 (en
Inventor
Jiri Zemlicka
John C. Drach
Xinchao Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wayne State University
University of Michigan System
Original Assignee
Wayne State University
University of Michigan System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wayne State University, University of Michigan System filed Critical Wayne State University
Publication of CA2479037A1 publication Critical patent/CA2479037A1/en
Application granted granted Critical
Publication of CA2479037C publication Critical patent/CA2479037C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CA2479037A 2002-03-15 2003-03-13 2-amino-9[(2-hydroxymethyl)cyclopropylidenemethyl]purines as antiviral agents Expired - Fee Related CA2479037C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36449502P 2002-03-15 2002-03-15
US60/364,495 2002-03-15
PCT/US2003/007909 WO2004006867A2 (en) 2002-03-15 2003-03-13 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents

Publications (2)

Publication Number Publication Date
CA2479037A1 CA2479037A1 (en) 2004-01-22
CA2479037C true CA2479037C (en) 2010-11-09

Family

ID=30115469

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2479037A Expired - Fee Related CA2479037C (en) 2002-03-15 2003-03-13 2-amino-9[(2-hydroxymethyl)cyclopropylidenemethyl]purines as antiviral agents

Country Status (8)

Country Link
US (2) US7183268B2 (OSRAM)
EP (1) EP1490015B1 (OSRAM)
JP (2) JP5420135B2 (OSRAM)
AT (1) ATE443507T1 (OSRAM)
AU (1) AU2003276824B8 (OSRAM)
CA (1) CA2479037C (OSRAM)
DE (1) DE60329375D1 (OSRAM)
WO (1) WO2004006867A2 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
AU2003267947B2 (en) * 2002-03-15 2008-11-13 The Regents Of The University Of Michigan 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents
JP3991223B2 (ja) * 2003-02-13 2007-10-17 信越化学工業株式会社 新規スルホニルジアゾメタン化合物、光酸発生剤、並びにそれを用いたレジスト材料及びパターン形成方法
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
CA2552279C (en) * 2003-12-02 2014-07-15 The Ohio State University Research Foundation Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors
JP2007532526A (ja) 2004-04-07 2007-11-15 ファイザー・インク ピラゾロ［４，３−ｄ］ピリミジン類
WO2009048752A2 (en) 2007-10-09 2009-04-16 Dow Agrosciences Llc Insecticidal substituted azinyl derivatives
JP5437254B2 (ja) 2007-10-09 2014-03-12 ダウ アグロサイエンシィズ エルエルシー 殺虫性（１，３，５）−トリアジニルフェニルヒドラゾン
US8058279B2 (en) 2007-10-09 2011-11-15 Dow Agrosciences Llc Insecticidal pyrimidinyl aryl hyrdrazones
SG11201901633WA (en) * 2016-08-29 2019-03-28 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
WO1998030563A1 (en) * 1997-01-08 1998-07-16 The Regents Of The University Of Michigan 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents
AU2003267947B2 (en) * 2002-03-15 2008-11-13 The Regents Of The University Of Michigan 2,2-bis(hydroxymethyl)cyclopropylidenemethyl - purines and -pyrimidines as antiviral agents

Also Published As

Publication number Publication date
US20070225302A1 (en) 2007-09-27
DE60329375D1 (en) 2009-11-05
JP2005524720A (ja) 2005-08-18
EP1490015A2 (en) 2004-12-29
EP1490015B1 (en) 2009-09-23
AU2003276824A2 (en) 2004-02-02
JP5420135B2 (ja) 2014-02-19
AU2003276824B2 (en) 2009-01-08
ATE443507T1 (de) 2009-10-15
US7183268B2 (en) 2007-02-27
US9174990B2 (en) 2015-11-03
CA2479037A1 (en) 2004-01-22
US20050124582A1 (en) 2005-06-09
WO2004006867A3 (en) 2004-10-21
EP1490015A4 (en) 2005-12-28
WO2004006867A2 (en) 2004-01-22
AU2003276824B8 (en) 2009-01-22
JP2012180361A (ja) 2012-09-20
AU2003276824A1 (en) 2004-02-02

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Effective date: 20150313