ATE443507T1 - Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel - Google Patents

Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel

Info

Publication number
ATE443507T1
ATE443507T1 AT03764294T AT03764294T ATE443507T1 AT E443507 T1 ATE443507 T1 AT E443507T1 AT 03764294 T AT03764294 T AT 03764294T AT 03764294 T AT03764294 T AT 03764294T AT E443507 T1 ATE443507 T1 AT E443507T1
Authority
AT
Austria
Prior art keywords
amino
cycloalkyl
group
cyclopropylidenmethyl
purines
Prior art date
Application number
AT03764294T
Other languages
English (en)
Inventor
Jiri Zemlicka
John Drach
Xinchao Chen
Original Assignee
Univ Wayne State
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wayne State, Univ Michigan filed Critical Univ Wayne State
Application granted granted Critical
Publication of ATE443507T1 publication Critical patent/ATE443507T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
AT03764294T 2002-03-15 2003-03-13 Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel ATE443507T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36449502P 2002-03-15 2002-03-15
PCT/US2003/007909 WO2004006867A2 (en) 2002-03-15 2003-03-13 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents

Publications (1)

Publication Number Publication Date
ATE443507T1 true ATE443507T1 (de) 2009-10-15

Family

ID=30115469

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03764294T ATE443507T1 (de) 2002-03-15 2003-03-13 Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel

Country Status (8)

Country Link
US (2) US7183268B2 (de)
EP (1) EP1490015B1 (de)
JP (2) JP5420135B2 (de)
AT (1) ATE443507T1 (de)
AU (1) AU2003276824B8 (de)
CA (1) CA2479037C (de)
DE (1) DE60329375D1 (de)
WO (1) WO2004006867A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
CA2479039C (en) * 2002-03-15 2011-06-28 Jiri Zemlicka 2,2-bis(hydroxymethyl)cyclopropylidenemethyl -purines and -pyrimidines as antiviral agents
JP3991223B2 (ja) * 2003-02-13 2007-10-17 信越化学工業株式会社 新規スルホニルジアゾメタン化合物、光酸発生剤、並びにそれを用いたレジスト材料及びパターン形成方法
WO2004096810A1 (en) 2003-04-29 2004-11-11 Pfizer Limited 5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
ES2562778T3 (es) * 2003-12-02 2016-03-08 The Ohio State University Research Foundation Ácidos grasos de cadena corta unidos a motivos quelantes de Zn2+ como una clase novedosa de inhibidores de histona deacetilasa
WO2005097799A1 (en) 2004-04-07 2005-10-20 Pfizer Limited Pyrazolo`4,3-d! pyrimidines
EP2197853B1 (de) 2007-10-09 2011-11-09 Dow AgroSciences LLC Insektizide pyrimidinyl-aryl-hydrazone
EP2195302B1 (de) 2007-10-09 2015-02-18 Dow AgroSciences LLC Substituierte azinylderivate als insektizide
EP2197857B1 (de) 2007-10-09 2013-03-06 Dow AgroSciences LLC (1,3,5)-triazinylphenylhydrazone als insektizid
PT3504210T (pt) * 2016-08-29 2021-04-19 H Hoffnabb La Roche Ag Compostos de sulfonimidoílpurinona 7-substituídos para o tratamento e profilaxia de infeção por vírus

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents
WO1998030563A1 (en) * 1997-01-08 1998-07-16 The Regents Of The University Of Michigan 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents
CA2479039C (en) * 2002-03-15 2011-06-28 Jiri Zemlicka 2,2-bis(hydroxymethyl)cyclopropylidenemethyl -purines and -pyrimidines as antiviral agents

Also Published As

Publication number Publication date
JP2012180361A (ja) 2012-09-20
WO2004006867A2 (en) 2004-01-22
EP1490015A4 (de) 2005-12-28
EP1490015B1 (de) 2009-09-23
US20070225302A1 (en) 2007-09-27
WO2004006867A3 (en) 2004-10-21
US7183268B2 (en) 2007-02-27
AU2003276824B2 (en) 2009-01-08
CA2479037C (en) 2010-11-09
EP1490015A2 (de) 2004-12-29
DE60329375D1 (en) 2009-11-05
US9174990B2 (en) 2015-11-03
US20050124582A1 (en) 2005-06-09
JP5420135B2 (ja) 2014-02-19
CA2479037A1 (en) 2004-01-22
AU2003276824A1 (en) 2004-02-02
JP2005524720A (ja) 2005-08-18
AU2003276824A2 (en) 2004-02-02
AU2003276824B8 (en) 2009-01-22

Similar Documents

Publication Publication Date Title
ATE443507T1 (de) Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel
MX2007004738A (es) Inhibidores de mif.
DE69429922T2 (de) Viskose tensidzusammensetzungen als emulsion
ATE225341T1 (de) In 6-position durch thio substituierte paclitaxele
ATE464299T1 (de) Neues phenylalaninderivat
GT200600262A (es) Uso de la sangliferina en el hcv (virus de la hepatitis "c")
ATE413217T1 (de) Flugeinrichtung
DK0526543T3 (da) Derivater og analoger af 2-deoxy-2,3-didehydro-N-acetylneuraminsyre og deres anvendelse som antivirale midler
TR200100438T2 (tr) Hepatit C inhibitörü peptitler
NO20071579L (no) 4-Heteroarylmetylsubstituerte ftalazinonderivater
ATE384773T1 (de) Schutz von verbrennungsmotoren aus magnesium oder magnesiumlegierungen vor korrosion unter verwendung von gefrierschutzmittelkonzentraten auf basis von amiden.
ATE375347T1 (de) Pyrazolopyrimidinonderivate mit pde7-hemmender wirkung
NO905609D0 (no) 13-alkyl-1beta-fenylgonaner.
DK1280813T3 (da) Antivirale pyrimidin-nukleosidanaloger
DK0758231T3 (da) Farmaceutiske præparater på basis af derivater tilhørende taxanklassen
CO4750713A1 (es) Macrolidos
AR020538A1 (es) Derivados de mononitrato de isosorbida y su empleo como agentes de vasodilatadores con tolerancia disminuida.
BR0115080A (pt) Derivados de acila e sulfonila de 2-(trans-1,4-diaminocicloexil)-purinas 6,9-dissubstituìdas e o uso destes como agentes antiproliferativos
DK0925789T4 (da) Anvendelse af azithromycin ved topisk behandling af öjeninfektioner
BR0111729A (pt) 1-aril-4-oxo-1,4-dihidro-3-quinolinacarboxamidas como agentes antivirais
ATE375978T1 (de) Benzoylsulfonamide als antitumor-mittel
DK1485625T3 (da) Radioisotopgenerator omfattende én eller flere elementstøtter
DK1082962T3 (da) Anvendelse af 2-hydroxy-4-trifluormethylbenzoesyrederivater som inhibitorer af aktiveringen af de nukleare transskriptionsfaktorer NF-(K)B
DE69319262T2 (de) 4H-Naphtho(1,2b-b)Pyranderivate als antiproliferative Mittel
DE60134702D1 (de) Mischungen von Isoflavonen und Flavonen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties