JP5356174B2 - S−ラクトイルグルタチオン及び/又はその塩を含有することを特徴とする医薬組成物 - Google Patents
S−ラクトイルグルタチオン及び/又はその塩を含有することを特徴とする医薬組成物 Download PDFInfo
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- JP5356174B2 JP5356174B2 JP2009230208A JP2009230208A JP5356174B2 JP 5356174 B2 JP5356174 B2 JP 5356174B2 JP 2009230208 A JP2009230208 A JP 2009230208A JP 2009230208 A JP2009230208 A JP 2009230208A JP 5356174 B2 JP5356174 B2 JP 5356174B2
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- salt
- lactoylglutathione
- glutathione
- thrombosis
- blood
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- 108700035050 S-lactoylglutathione Proteins 0.000 title claims description 32
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Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
処方 配合量(g)
1.S−ラクトイルグルタチオン 0.1
2.クエン酸 0.7
3.果糖ブドウ糖液糖 60.0
4.香料 0.1
5.精製水 39.1
全量 100.0
[製造方法]成分5に成分1〜4を加え、攪拌溶解してろ過し、加熱殺菌後、50mlガラス瓶に充填する。当該飲料を1日1本摂取することで、S−ラクトイルグルタチオン及び/又はその塩を50mg/日摂取できる。
処方例1において、S−ラクトイルグルタチオンを精製水に置き換えたものを従来の飲料とした。
処方 配合量(g)
1.S−ラクトイルグルタチオンナトリウム 5.0
2.トウモロコシデンプン 10.0
3.精製白糖 20.0
4.カルボキシメチルセルロースカルシウム 10.0
5.微結晶セルロース 40.0
6.ポリビニルピロリドン 5.0
7.タルク 10.0
全量 100.0
[製造方法]成分1〜5を混合し、次いで成分6の水溶液を結合剤として加え、常法により顆粒化する。これに滑沢剤として成分7を加えて配合した後、1錠100mgの錠剤に打錠する。当該錠剤を1日12錠摂取することで、S−ラクトイルグルタチオン及び/又はその塩を60mg/日摂取できる。
処方 配合量(g)
1.S−ラクトイルグルタチオンカルシウム 5.0
2.微結晶セルロース 60.0
3.トウモロコシデンプン 15.0
4.乳糖 18.0
5.ポリビニルピロリドン 2.0
全量 100.0
[製造方法]成分1〜5を混合して顆粒化した後、2号硬カプセルに250mg充填してカプセル剤を得る。当該カプセル剤を1日6個摂取することで、S−ラクトイルグルタチオン及び/又はその塩を75mg/日摂取できる。
処方 配合量(g)
1.S−ラクトイルグルタチオン 5.0
2.微結晶セルロース 40.0
3.トウモロコシデンプン 55.0
全量 100.0
[製造方法]成分1〜3を混合し、常法により散剤を得る。当該顆粒を1日1g摂取することで、S−ラクトイルグルタチオン及び/又はその塩を50mg/日摂取できる。
処方 配合量(g)
1.S−ラクトイルグルタチオンカルシウム 1.0
2.乾燥コーンスターチ 50.0
3.エリスリトール 40.0
4.クエン酸 5.0
5.ショ糖脂肪酸エステル 3.0
6.香料 1.0
全量 100.0
[製造方法]成分1〜4に精製水を適量加えて練和し、押出し造粒した後、乾燥して顆粒を得る。顆粒に成分5及び6を加えて打錠し、1個1gの錠菓を得る。当該錠菓を1日6個摂取することで、S−ラクトイルグルタチオン及び/又はその塩を60mg/日摂取できる。
HMVECを60mm dishに2ラ105個播種した。そこに、10μMの5−bromo−2−deoxyuridine(BrdU)を添加して4日間培養することにより、老化誘導した。同時に、10μMのS−ラクトイルグルタチオン、比較対象として10μMのグルタチオン及び10μMのS−(1,2−ジカルボキシエチル)グルタチオン(いずれもWako)を添加した。培養後、総RNAの抽出を行った。細胞からの総RNAの抽出はTRIZOL Reagent(Invitrogen)を用いて行い、総RNA量は分光光度計(NanoDrop)を用いて260nmにおける吸光度により求めた。mRNA発現量の測定は、細胞から抽出した総RNAを基にしてリアルタイムRT−PCR法により行った。リアルタイムRT−PCR法には、SuperScriptIII Platinum Two−Step qRT−PCR Kit with SYBR Green(Invitrogen)を用いた。すなわち、500ngの総RNAを逆転写反応後、PCR反応(95℃:15秒間、60℃:30秒間、40cycles)を行った。使用したプライマーを以下に示す。その他の操作は定められた方法に従い、mRNAの発現量を内部標準であるGAPDHmRNAの発現量に対する割合として求めた。尚、各遺伝子の発現量の測定に使用したプライマーは次の通りである。
CGTGGTTTTCTCACCCTATGG(配列番号1)
CTGGGTTTCTCCTCCTGTTGTC(配列番号2)
GAPDH用のプライマーセット
TGAACGGGAAGCTCACTGG(配列番号3)
TCCACCACCCTGTTGCTGTA(配列番号4)
処方例1及び比較例1の飲料を用いて、男性被験者6名ずつの合計12名(25−60歳)を対象に、1日50mlを任意の時間に摂取させ、2ヶ月間の使用試験を行った。飲用前及び2ヶ月後に血液を採取し、動脈硬化の診断基準として使用されるLDLコレステロール及び中性脂肪の測定を行った(動脈硬化性疾患予防ガイドライン、2007年度版)。又、血管年齢(アルテットC、U−Medica Inc.)も同時に測定した。血管年齢とは、指先に伝播する心拍の波形から動脈硬化の進展を推測し、血管老化度を年齢として算出したものである。
Claims (3)
- 化学式(1)で表されるS−ラクトイルグルタチオン及び/又はその塩を含有することを特徴とする抗血栓症薬。
- 血栓症によって引き起こされる動脈硬化、敗血症、心筋梗塞、肝疾患、悪性腫瘍、重症感染症、DICから選ばれる1種又は2種以上の疾患を予防、改善、治療するための、請求項1に記載の抗血栓症薬。
- S−ラクトイルグルタチオン及び/又はその塩を含有することを特徴とするPAI−1(plasminogen activator inhibitor−1)産生抑制剤。
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JP2522940B2 (ja) * | 1987-04-23 | 1996-08-07 | 有限会社 野々川商事 | S−ラクトイルグルタチオンおよび/またはその塩を有効成分とする医薬 |
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