JP5339227B2 - アクロレイン、インターロイキン−６及びｃｒｐの含有量、ポリアミンオキシダーゼ活性又はポリアミンオキシダーゼの蛋白質量、並びに、被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法 - Google Patents

アクロレイン、インターロイキン−６及びｃｒｐの含有量、ポリアミンオキシダーゼ活性又はポリアミンオキシダーゼの蛋白質量、並びに、被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法 Download PDF

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JP5339227B2
JP5339227B2 JP2007132239A JP2007132239A JP5339227B2 JP 5339227 B2 JP5339227 B2 JP 5339227B2 JP 2007132239 A JP2007132239 A JP 2007132239A JP 2007132239 A JP2007132239 A JP 2007132239A JP 5339227 B2 JP5339227 B2 JP 5339227B2
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polyamine oxidase
acrolein
interleukin
cerebral infarction
content
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JP2008286651A (ja
JP2008286651A5 (enExample
Inventor
一衛 五十嵐
信重郎 並木
円 吉田
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国立大学法人 千葉大学
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Priority to JP2007132239A priority Critical patent/JP5339227B2/ja
Priority to US12/598,125 priority patent/US20100167322A1/en
Priority to PCT/JP2008/052701 priority patent/WO2008142888A1/ja
Priority to EP08711525A priority patent/EP2163645B1/en
Publication of JP2008286651A publication Critical patent/JP2008286651A/ja
Publication of JP2008286651A5 publication Critical patent/JP2008286651A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5412—IL-6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2007132239A 2007-05-18 2007-05-18 アクロレイン、インターロイキン−６及びｃｒｐの含有量、ポリアミンオキシダーゼ活性又はポリアミンオキシダーゼの蛋白質量、並びに、被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法 Expired - Fee Related JP5339227B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2007132239A JP5339227B2 (ja) 2007-05-18 2007-05-18 アクロレイン、インターロイキン−６及びｃｒｐの含有量、ポリアミンオキシダーゼ活性又はポリアミンオキシダーゼの蛋白質量、並びに、被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法
US12/598,125 US20100167322A1 (en) 2007-05-18 2008-02-19 Method of detecting cerebral stroke or asymptomatic cerebral infarction using acrolein, interleukin-6 and crp contents, polyamine oxidase activity or polyamine oxidase protein content and subject's age as indicators
PCT/JP2008/052701 WO2008142888A1 (ja) 2007-05-18 2008-02-19 アクロレイン、インターロイキン－６及びcrpの含有量、ポリアミンオキシダーゼ活性又はポリアミンオキシダーゼの蛋白質量、並びに、被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法
EP08711525A EP2163645B1 (en) 2007-05-18 2008-02-19 Method of detecting cerebral stroke or asymptomatic cerebral infarction using acrolein, interleukin-6 and crp contents, polyamine oxidase activity or polyamine oxidase protein content and subject's age as indications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007132239A JP5339227B2 (ja) 2007-05-18 2007-05-18 アクロレイン、インターロイキン−６及びｃｒｐの含有量、ポリアミンオキシダーゼ活性又はポリアミンオキシダーゼの蛋白質量、並びに、被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法

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JP2008286651A JP2008286651A (ja) 2008-11-27
JP2008286651A5 JP2008286651A5 (enExample) 2010-07-01
JP5339227B2 true JP5339227B2 (ja) 2013-11-13

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JP2007132239A Expired - Fee Related JP5339227B2 (ja) 2007-05-18 2007-05-18 アクロレイン、インターロイキン−６及びｃｒｐの含有量、ポリアミンオキシダーゼ活性又はポリアミンオキシダーゼの蛋白質量、並びに、被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法

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Country Link
US (1) US20100167322A1 (enExample)
EP (1) EP2163645B1 (enExample)
JP (1) JP5339227B2 (enExample)
WO (1) WO2008142888A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012067150A1 (ja) * 2010-11-16 2014-05-12 三菱化学株式会社 Ｉｎｔｅｒｌｅｕｋｉｎ−６ｒｅｃｅｐｔｏｒｓｕｂｕｎｉｔｂｅｔａ蛋白質による脳梗塞の検査方法
JP6499342B2 (ja) * 2018-03-19 2019-04-10 隆樹 日和佐 脳梗塞の診断マーカー

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3081043B2 (ja) * 1991-12-27 2000-08-28 シスメックス株式会社 脳梗塞の診断方法
JP3609014B2 (ja) 2000-09-22 2005-01-12 善行 澤田 気体溶解装置
WO2003016910A1 (en) 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
JP4426929B2 (ja) * 2004-03-25 2010-03-03 株式会社アミンファーマ研究所 脳卒中・無症候性脳梗塞のスクリーニング方法

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Publication number Publication date
JP2008286651A (ja) 2008-11-27
WO2008142888A1 (ja) 2008-11-27
EP2163645A4 (en) 2010-07-21
EP2163645A1 (en) 2010-03-17
US20100167322A1 (en) 2010-07-01
EP2163645B1 (en) 2012-09-26

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