JP5321260B2 - 光学的測定装置、並びにフローサイトメーター及び光学的測定方法 - Google Patents

光学的測定装置、並びにフローサイトメーター及び光学的測定方法 Download PDF

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JP5321260B2
JP5321260B2 JP2009140043A JP2009140043A JP5321260B2 JP 5321260 B2 JP5321260 B2 JP 5321260B2 JP 2009140043 A JP2009140043 A JP 2009140043A JP 2009140043 A JP2009140043 A JP 2009140043A JP 5321260 B2 JP5321260 B2 JP 5321260B2
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light
sample
light irradiation
electrical signal
conversion
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JP2010286341A5 (enExample
JP2010286341A (ja
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洋介 村木
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Sony Corp
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Sony Corp
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Priority to JP2009140043A priority Critical patent/JP5321260B2/ja
Priority to US12/792,271 priority patent/US8350231B2/en
Priority to CN2010101982220A priority patent/CN101923046B/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1438—Using two lasers in succession
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2009140043A 2009-06-11 2009-06-11 光学的測定装置、並びにフローサイトメーター及び光学的測定方法 Expired - Fee Related JP5321260B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009140043A JP5321260B2 (ja) 2009-06-11 2009-06-11 光学的測定装置、並びにフローサイトメーター及び光学的測定方法
US12/792,271 US8350231B2 (en) 2009-06-11 2010-06-02 Optical measurement apparatus, flow site meter and optical measurement method
CN2010101982220A CN101923046B (zh) 2009-06-11 2010-06-04 光学测量装置、流量现场测量计及光学测量方法

Applications Claiming Priority (1)

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JP2009140043A JP5321260B2 (ja) 2009-06-11 2009-06-11 光学的測定装置、並びにフローサイトメーター及び光学的測定方法

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JP2010286341A JP2010286341A (ja) 2010-12-24
JP2010286341A5 JP2010286341A5 (enExample) 2012-03-22
JP5321260B2 true JP5321260B2 (ja) 2013-10-23

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US (1) US8350231B2 (enExample)
JP (1) JP5321260B2 (enExample)
CN (1) CN101923046B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833341C (en) 2011-04-29 2021-03-02 Becton, Dickinson And Company Cell sorter system and method
JP2013040782A (ja) * 2011-08-11 2013-02-28 Sony Corp 光学的測定装置及びチップ寿命判定方法
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
WO2013145905A1 (ja) 2012-03-30 2013-10-03 ソニー株式会社 微小粒子分取装置及び該装置における流体ストリーム最適化方法
EP3511694A1 (en) 2012-03-30 2019-07-17 Sony Corporation Microparticle sorting device and method for controlling position in microparticle sorting device
JP6304034B2 (ja) 2013-01-28 2018-04-04 ソニー株式会社 微小粒子分取装置、微小粒子分取方法及びプログラム
US9597229B2 (en) 2013-03-15 2017-03-21 Abbott Medical Optics Inc. Phacoemulsification flow rate detection system and method
US9857284B1 (en) * 2013-07-15 2018-01-02 Stratedigm, Inc. Method and apparatus for detection and measurement of particles with a wide dynamic range of measurement
EP3035030B1 (en) 2013-10-16 2019-07-10 Sony Corporation Particle fractionation device, particle fractionation method, and program
JP2015094737A (ja) * 2013-11-14 2015-05-18 ソニー株式会社 光照射装置、粒子分析装置および光照射方法
US10309892B2 (en) 2014-02-13 2019-06-04 Sony Corporation Particle sorting device, particle sorting method, program, and particle sorting system
US20170227447A1 (en) * 2014-08-06 2017-08-10 Beckman Coulter, Inc. Evaluation of multi-peak events using a flow cytometer
CN104198002A (zh) * 2014-08-28 2014-12-10 内蒙古大学 一种基于红外光幕的非接触原奶流量计
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
JP2016095221A (ja) * 2014-11-14 2016-05-26 ソニー株式会社 粒子分析装置、粒子分析方法
WO2017062319A1 (en) 2015-10-05 2017-04-13 Becton, Dickinson And Company Automated drop delay calculation
JP6729597B2 (ja) 2015-10-19 2020-07-22 ソニー株式会社 画像処理装置、微小粒子分取装置及び画像処理方法
JP6932132B2 (ja) 2015-12-18 2021-09-08 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 粒子検出方法及びそれを実施するためのシステム
JP6654059B2 (ja) * 2016-02-18 2020-02-26 アズビル株式会社 粒子検出システム及び粒子の検出方法
JP2020051936A (ja) 2018-09-27 2020-04-02 ソニー株式会社 微小粒子測定装置及び微小粒子測定方法
JP2023541613A (ja) * 2020-09-10 2023-10-03 ベクトン・ディキンソン・アンド・カンパニー フローストリーム中の試料を照射するためのレーザ光伝搬システム、及びそれを使用するための方法
JP2023549475A (ja) * 2020-10-20 2023-11-27 ベクトン・ディキンソン・アンド・カンパニー 傾斜ビーム成形光学部品を含むフローサイトメータ、及びフローサイトメータを使用する方法
CN113476739B (zh) * 2021-06-07 2022-11-08 浙江迪远医疗器械有限公司 具有检测装置的血液泵

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
JPH0785054B2 (ja) * 1990-07-04 1995-09-13 リオン株式会社 微粒子計
JP3102935B2 (ja) * 1991-11-20 2000-10-23 シスメックス株式会社 イメージングフローサイトメータ
JPH0792077A (ja) * 1993-09-24 1995-04-07 Canon Inc 粒子解析装置
US5827660A (en) * 1996-08-09 1998-10-27 University Of Massachusetts Caged fluorochrome-labeled probes and subtraction of autoflourescence background
JP2003139696A (ja) * 2001-10-30 2003-05-14 Toshiba Corp 油劣化診断装置
GB2383127B (en) * 2001-12-12 2004-10-20 Proimmune Ltd Device and method for investigating analytes in liquid suspension or solution
US6897954B2 (en) * 2002-12-20 2005-05-24 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
JP2005001866A (ja) 2003-06-13 2005-01-06 Canon Electronics Inc シート排出装置及びプリンタ装置
CA2799683C (en) * 2003-07-02 2014-03-25 Terumo Bct, Inc. Monitoring and control system for blood processing
US7692773B2 (en) * 2003-08-05 2010-04-06 Luminex Corporation Light emitting diode based measurement systems
JP3931875B2 (ja) * 2003-10-29 2007-06-20 財団法人雑賀技術研究所 分光光度計
JP2007518991A (ja) * 2004-01-14 2007-07-12 ルミネックス・コーポレーション ダイナミックレンジを拡大する方法及びシステム
US20060219873A1 (en) * 2005-04-01 2006-10-05 Martin Steven M Detection system for a flow cytometer
JP4758723B2 (ja) * 2005-10-03 2011-08-31 シスメックス株式会社 粒子分析装置及び粒子分析方法
CN1959373A (zh) * 2006-11-03 2007-05-09 刘文清 光学流速颗粒物浓度测量方法及装置
WO2008118353A1 (en) * 2007-03-23 2008-10-02 Beckman Coulter, Inc. Multi-gain adaptive linear processing and gated digital system for use in flow cytometry
CN101082559B (zh) * 2007-06-27 2010-11-03 上海理工大学 透过率相关频谱法颗粒测量方法及其装置
JP4509154B2 (ja) * 2007-09-04 2010-07-21 ソニー株式会社 光照射装置、微粒子解析装置及び光照射方法
CN101965508B (zh) * 2007-09-17 2013-11-27 卢米尼克斯股份有限公司 识别流中的微粒的系统和方法

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CN101923046B (zh) 2012-09-19
US20100314555A1 (en) 2010-12-16
US8350231B2 (en) 2013-01-08
JP2010286341A (ja) 2010-12-24
CN101923046A (zh) 2010-12-22

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