JP5301464B2 - キメラうま味受容体、それをコードする核酸およびその利用 - Google Patents

キメラうま味受容体、それをコードする核酸およびその利用 Download PDF

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Publication number
JP5301464B2
JP5301464B2 JP2009545787A JP2009545787A JP5301464B2 JP 5301464 B2 JP5301464 B2 JP 5301464B2 JP 2009545787 A JP2009545787 A JP 2009545787A JP 2009545787 A JP2009545787 A JP 2009545787A JP 5301464 B2 JP5301464 B2 JP 5301464B2
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Prior art keywords
csr
protein
chimeric protein
cells
chimeric
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JP2009545787A
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English (en)
Japanese (ja)
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JP2010516232A5 (enExample
JP2010516232A (ja
Inventor
スラック，ジェイ，パトリック
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ジボダン エス エー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C07K14/43—Sweetening agents, e.g. thaumatin, monellin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2009545787A 2007-01-18 2007-12-14 キメラうま味受容体、それをコードする核酸およびその利用 Active JP5301464B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88098107P 2007-01-18 2007-01-18
US60/880,981 2007-01-18
PCT/CH2007/000636 WO2008086634A2 (en) 2007-01-18 2007-12-14 Chimeric umami taste receptor, nucleic acid encoding it and use thereof

Publications (3)

Publication Number Publication Date
JP2010516232A JP2010516232A (ja) 2010-05-20
JP2010516232A5 JP2010516232A5 (enExample) 2012-12-27
JP5301464B2 true JP5301464B2 (ja) 2013-09-25

Family

ID=39521493

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009545787A Active JP5301464B2 (ja) 2007-01-18 2007-12-14 キメラうま味受容体、それをコードする核酸およびその利用

Country Status (5)

Country Link
US (1) US8039233B2 (enExample)
EP (1) EP2121748B1 (enExample)
JP (1) JP5301464B2 (enExample)
KR (1) KR101511394B1 (enExample)
WO (1) WO2008086634A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1198836C (zh) * 1998-07-28 2005-04-27 加利福尼亚大学董事会 编码与感觉转导有关的g－蛋白偶联受体的核酸
CN102369275A (zh) * 2009-02-02 2012-03-07 卓莫赛尔公司 新型细胞系和方法
WO2013072332A1 (en) 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5825980B2 (ja) * 1976-02-12 1983-05-31 ヤマサ醤油株式会社 サイクリックヌクレオチドの定量法
WO1990005745A1 (en) * 1988-11-18 1990-05-31 The General Hospital Corporation A cAMP-RESPONSIVE TRANSCRIPTIONAL ENHANCER BINDING PROTEIN
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
WO2001018050A2 (en) 1999-09-10 2001-03-15 The Regents Of The University Of California T2r taste receptor family
TW201022287A (en) * 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7368285B2 (en) * 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
JP5001512B2 (ja) * 2001-06-26 2012-08-15 セノミックス インコーポレイテッド Ｔ１ｒヘテロオリゴマー味覚受容体及び前記受容体を発現する細胞系並びに味覚化合物の特定のためのその使用
AU2002320294B2 (en) 2001-07-03 2009-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mammalian sweet and amino acid heterodimeric taste receptors
WO2004055048A2 (en) 2002-12-18 2004-07-01 Givaudan Sa Chimeric alpha q-gustducin g-proteins
NZ619746A (en) * 2003-08-06 2014-05-30 Senomyx Inc Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
US20060045953A1 (en) * 2004-08-06 2006-03-02 Catherine Tachdjian Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers
WO2007147275A1 (en) * 2006-06-19 2007-12-27 Givaudan Sa Nucleic acid, polypeptide and its use

Also Published As

Publication number Publication date
WO2008086634A2 (en) 2008-07-24
KR20090112704A (ko) 2009-10-28
US8039233B2 (en) 2011-10-18
EP2121748B1 (en) 2018-03-21
KR101511394B1 (ko) 2015-04-10
WO2008086634A3 (en) 2008-09-04
JP2010516232A (ja) 2010-05-20
EP2121748A2 (en) 2009-11-25
US20100015640A1 (en) 2010-01-21

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