JP5294635B2 - コポリマー1と組み合わせた、神経発生の誘発及び幹細胞治療 - Google Patents
コポリマー1と組み合わせた、神経発生の誘発及び幹細胞治療 Download PDFInfo
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- JP5294635B2 JP5294635B2 JP2007542516A JP2007542516A JP5294635B2 JP 5294635 B2 JP5294635 B2 JP 5294635B2 JP 2007542516 A JP2007542516 A JP 2007542516A JP 2007542516 A JP2007542516 A JP 2007542516A JP 5294635 B2 JP5294635 B2 JP 5294635B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/32—Alcohol-abuse
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63116304P | 2004-11-29 | 2004-11-29 | |
| US60/631,163 | 2004-11-29 | ||
| US69049805P | 2005-06-15 | 2005-06-15 | |
| US60/690,498 | 2005-06-15 | ||
| PCT/IL2005/001275 WO2006057003A2 (en) | 2004-11-29 | 2005-11-29 | Induction of neurogenesis and stem cell therapy in combination with copolymer 1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248619A Division JP2013040204A (ja) | 2004-11-29 | 2012-11-12 | コポリマー1と組み合わせた、神経発生の誘発及び幹細胞治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521796A JP2008521796A (ja) | 2008-06-26 |
| JP2008521796A5 JP2008521796A5 (enExample) | 2009-01-22 |
| JP5294635B2 true JP5294635B2 (ja) | 2013-09-18 |
Family
ID=36498362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542516A Expired - Fee Related JP5294635B2 (ja) | 2004-11-29 | 2005-11-29 | コポリマー1と組み合わせた、神経発生の誘発及び幹細胞治療 |
| JP2012248619A Abandoned JP2013040204A (ja) | 2004-11-29 | 2012-11-12 | コポリマー1と組み合わせた、神経発生の誘発及び幹細胞治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012248619A Abandoned JP2013040204A (ja) | 2004-11-29 | 2012-11-12 | コポリマー1と組み合わせた、神経発生の誘発及び幹細胞治療 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20090191173A1 (enExample) |
| EP (1) | EP1827108B1 (enExample) |
| JP (2) | JP5294635B2 (enExample) |
| AU (1) | AU2005308396B2 (enExample) |
| CA (1) | CA2588908C (enExample) |
| ES (1) | ES2541780T3 (enExample) |
| WO (1) | WO2006057003A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| WO2009040814A1 (en) * | 2007-09-24 | 2009-04-02 | Hadasit Medical Research Services & Development Ltd | Use of copolymer 1 for treatment of muscular dystrophy |
| WO2010071862A1 (en) * | 2008-12-19 | 2010-06-24 | Ethicon, Incorporated | Umbilical cord tissue derived cells for treating neuropathic pain and spasticity |
| PL2411504T3 (pl) | 2009-03-26 | 2017-10-31 | Depuy Synthes Products Inc | Komórki ludzkiej tkanki pępowinowej jako terapia choroby Alzheimera |
| AU2010289419A1 (en) * | 2009-09-02 | 2012-03-29 | The University Of Chicago | Methods and systems for inducible ablation of neural cells |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| ES2601892T3 (es) | 2011-04-21 | 2017-02-16 | Mapi Pharma Limited | Pentapolímero aleatorio para el tratamiento de enfermedades autoinmunes |
| GB201300684D0 (en) | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
| EP3478300B1 (en) | 2016-06-30 | 2022-08-24 | Stem Cell Medicine Ltd. | Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells |
| CN107703292B (zh) * | 2016-08-09 | 2019-07-12 | 杨琴 | BrdU标记免疫荧光检测细胞增殖的改良方法 |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| AU2017319728B2 (en) | 2016-08-31 | 2024-09-05 | Mapi Pharma Ltd | Depot systems comprising glatiramer acetate |
| IL316573A (en) | 2017-03-26 | 2024-12-01 | Mapi Pharma Ltd | Storage systems containing glatiramer acetate for the treatment of multiple sclerosis |
| IL269893B2 (en) | 2017-05-15 | 2023-10-01 | Stem Cell Medicine Ltd | Treatment of multiple sclerosis with adipose-derived stem cells |
| EP3624815A4 (en) * | 2017-05-15 | 2021-01-20 | Stem Cell Medicine Ltd. | TREATMENT OF MULTIPLE SCLEROSIS WITH LONG-ACTING GLATIRAMER AND ADAPTIVE STEM CELLS |
| EP3765034A1 (en) | 2018-03-12 | 2021-01-20 | Yeda Research and Development Co. Ltd | Treatment of a heart disease |
| KR101994640B1 (ko) * | 2018-03-16 | 2019-07-02 | (주)메디노 | 신경줄기세포의 고효율 분리배양 방법 |
| WO2020245832A1 (en) * | 2019-06-07 | 2020-12-10 | Ramot At Tel-Aviv University Ltd. | Compositions and methods of using same for tissue regeneration |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980885A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | Growth factor-induced proliferation of neural precursor cells in vivo |
| US6497872B1 (en) * | 1991-07-08 | 2002-12-24 | Neurospheres Holdings Ltd. | Neural transplantation using proliferated multipotent neural stem cells and their progeny |
| US6294346B1 (en) * | 1991-07-08 | 2001-09-25 | Neurospheres Holdings, Ltd. | Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents |
| US6071889A (en) * | 1991-07-08 | 2000-06-06 | Neurospheres Holdings Ltd. | In vivo genetic modification of growth factor-responsive neural precursor cells |
| IL113812A (en) * | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| IL112834A (en) * | 1995-03-01 | 2000-12-06 | Yeda Res & Dev | Pharmaceutical compositions for controlled release of soluble receptors |
| US6214791B1 (en) * | 1997-01-10 | 2001-04-10 | Yeda Research And Development Co. Ltd. | Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 |
| JP2002503658A (ja) * | 1998-02-13 | 2002-02-05 | オートイミューン インク | COP−1及びTh−2促進性サイトカインを使用した、多発性硬化症の治療 |
| SE9802264D0 (sv) * | 1998-06-25 | 1998-06-25 | Neuronova Ab | A method of isolating cells |
| ES2527760T3 (es) * | 1998-07-23 | 2015-01-29 | Yeda Research And Development Co., Ltd. | Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos |
| US6800287B2 (en) * | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| US6531130B1 (en) * | 1999-07-06 | 2003-03-11 | The Board Of Trustees Of The Leland Stanford University | Treatment of demyelinating autoimmune disease with ordered peptides |
| HK1054507B (zh) * | 2000-01-20 | 2008-10-31 | 耶达研究及发展有限公司 | 共聚物1和相关肽和多肽及其处理过的t细胞在神经保护性治疗中的用途 |
| US7037493B2 (en) * | 2000-05-01 | 2006-05-02 | Cornell Research Foundation, Inc. | Method of inducing neuronal production in the brain and spinal cord |
| US20020077278A1 (en) * | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
| DE60116467T2 (de) * | 2000-06-07 | 2006-11-02 | Yeda Research And Development Co., Ltd. | Verwendung des Copolymer-1 Peptids sowie von damit verwandten Peptiden und Polypeptiden und von damit behandelten T-Zellen zur Neuroprotektion gegen die Toxizität von Glutamat |
| US6835711B2 (en) * | 2001-06-28 | 2004-12-28 | Yeda Research And Development Co. Ltd. | Use of poly-Glu,Tyr for neuroprotective therapy |
| US7399740B2 (en) * | 2001-06-28 | 2008-07-15 | Yeda Research And Development Co. Ltd. | Poly-Glu,Tyr for neuroprotective therapy |
| EP1459065B1 (en) * | 2001-12-04 | 2010-07-28 | Teva Pharmaceutical Industries, Ltd. | Processes for the measurement of the potency of glatiramer acetate |
| JP4374469B2 (ja) * | 2002-01-09 | 2009-12-02 | 独立行政法人科学技術振興機構 | 記憶障害治療剤 |
| US7576065B2 (en) * | 2002-02-15 | 2009-08-18 | Cornell Research Foundation, Inc. | Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein |
| WO2005032482A2 (en) * | 2003-10-03 | 2005-04-14 | Bayhill Therapeutics, Inc. | Treatment of demyelinating autoimmune disease with modified ordered peptides |
-
2005
- 2005-11-29 ES ES05810540.4T patent/ES2541780T3/es not_active Expired - Lifetime
- 2005-11-29 JP JP2007542516A patent/JP5294635B2/ja not_active Expired - Fee Related
- 2005-11-29 AU AU2005308396A patent/AU2005308396B2/en not_active Ceased
- 2005-11-29 CA CA2588908A patent/CA2588908C/en not_active Expired - Lifetime
- 2005-11-29 EP EP05810540.4A patent/EP1827108B1/en not_active Expired - Lifetime
- 2005-11-29 US US11/791,681 patent/US20090191173A1/en not_active Abandoned
- 2005-11-29 WO PCT/IL2005/001275 patent/WO2006057003A2/en not_active Ceased
-
2011
- 2011-10-26 US US13/281,908 patent/US20120135016A1/en not_active Abandoned
-
2012
- 2012-11-12 JP JP2012248619A patent/JP2013040204A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2541780T3 (es) | 2015-07-24 |
| AU2005308396B2 (en) | 2011-06-09 |
| JP2008521796A (ja) | 2008-06-26 |
| EP1827108B1 (en) | 2015-04-08 |
| CA2588908C (en) | 2014-09-23 |
| US20120135016A1 (en) | 2012-05-31 |
| US20090191173A1 (en) | 2009-07-30 |
| CA2588908A1 (en) | 2006-06-01 |
| JP2013040204A (ja) | 2013-02-28 |
| WO2006057003A3 (en) | 2007-03-01 |
| WO2006057003A2 (en) | 2006-06-01 |
| AU2005308396A1 (en) | 2006-06-01 |
| EP1827108A4 (en) | 2009-10-28 |
| EP1827108A2 (en) | 2007-09-05 |
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