JP5289044B2 - 分枝状マルトデキストリンを含む腸のための抗炎症及び/又は鎮痛組成物 - Google Patents
分枝状マルトデキストリンを含む腸のための抗炎症及び/又は鎮痛組成物 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seeds, Soups, And Other Foods (AREA)
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cereal-Derived Products (AREA)
Description
-サリチル化化合物、例えば、スルファサラジン又はその誘導体、5-アミノサリチレート(5-ASA)のようなものに由来する医薬を使用する治療、
-コルチコイド類、例えば、コルチゾン又はプレドニソロンの医薬に基づく治療。
a)分枝状マルトデキストリンを含む上述の第一の組成物
b)腸のための抗炎症剤を含む第二の組成物
を含む、ヒト又は動物の身体の治療的処置のためのキットに関する。
実験ラットを使用して、不溶性繊維(スペントコーングレイン又はセルロース)と共に、本発明の分枝状マルトデキストリン(MDB)又はグルコース(対照)を含む組成物の食餌における効果を、TNBS投与後の結腸粘膜の保護に関して試験した。
実験ラットを使用して、本発明の分枝状デキストロース(実施例1と同一)及びデキストロース(対照)の効果を、オスのWistarラットにおけるTNBS投与により誘導される結腸刺激に対して、及び嫌悪光刺激回避調節試験(aversive light stimulus avoidance conditioning test)におけるそれらの認識能力に対して試験した。
子ブタにおける腸炎に対する、本発明の分枝状マルトデキストロース(実施例1のもの)の保護効果を血液のハプトグロビンをアッセイすることによって試験する。
バッチ1:従来の食餌を与えられた対照動物、
バッチ2:食料の2重量%の割合で本発明に係るMDBを摂取している動物、
バッチ3:試験期間(14日)の間、1000及び400 mg/kgの各々の割合で2種の抗生物質(クロロテトラサイクリン及びスピラマイシン)を含有する食料を摂取して医学的に処置され、次いで残りの試験期間(15から77日)の間、従来の食餌を再び摂取した動物、
バッチ4:試験期間(14日) の間、1000及び400 mg/kgの各々の割合で2種の抗生物質(クロロテトラサイクリン及びスピラマイシン)を含有する食料を摂取して医学的に処置され、次いで残りの試験期間(15から77日)の間、食料の2重量%の割合で本発明に係るMDBを摂取している動物。
本発明の分枝状マルトデキストリン(実施例1のもの)の腸内発酵に対する効果を、実験ラットにおいて試験する。
本発明の分枝状マルトデキストリン(実施例1と同じもの)の酪酸の生産に対する効果を、実験ラットにおいて試験する。
本発明の分枝状マルトデキストリン(実施例1と同じもの)及びデキストロース(対照)の、腸炎に関与する各種の細胞受容体の産生及び鎮痛作用に対する効果を実験マウスにおいて試験する。
-ペルオキシソーム増殖因子活性化受容体(PPARγ)
-μオピオイド受容体(MOR)
について分析する。
-PPARγについて1.72倍の増大
-MORについて4.43倍の増大。
Claims (11)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR0503852A FR2884422B1 (fr) | 2005-04-18 | 2005-04-18 | Composition anti-inflammatoire de l'intestin comprenant des maltodextrines branchees |
FR0503852 | 2005-04-18 | ||
PCT/FR2006/000736 WO2006111624A2 (fr) | 2005-04-18 | 2006-04-04 | Composition anti-inflammatoire et/ou analgesique de l’intestin comprenant des maltodextrines branchees |
Publications (2)
Publication Number | Publication Date |
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JP2008536997A JP2008536997A (ja) | 2008-09-11 |
JP5289044B2 true JP5289044B2 (ja) | 2013-09-11 |
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JP2008507111A Expired - Fee Related JP5289044B2 (ja) | 2005-04-18 | 2006-04-04 | 分枝状マルトデキストリンを含む腸のための抗炎症及び/又は鎮痛組成物 |
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---|---|
US (1) | US7932238B2 (ja) |
EP (1) | EP1871394B1 (ja) |
JP (1) | JP5289044B2 (ja) |
KR (1) | KR101494901B1 (ja) |
CN (1) | CN101163488B (ja) |
AT (1) | ATE488242T1 (ja) |
AU (1) | AU2006237417B2 (ja) |
BR (1) | BRPI0609959A2 (ja) |
CA (1) | CA2604778C (ja) |
DE (1) | DE602006018275D1 (ja) |
ES (1) | ES2356484T3 (ja) |
FR (1) | FR2884422B1 (ja) |
MX (1) | MX2007012915A (ja) |
RU (1) | RU2404780C2 (ja) |
WO (1) | WO2006111624A2 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0525504D0 (en) | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
PL2214679T3 (pl) | 2007-11-13 | 2019-09-30 | Meritage Pharma, Inc. | Kompozycje kortykosteroidów |
FR2933848B1 (fr) | 2008-07-18 | 2019-08-09 | Roquette Freres | Composition de fibres indigestibles solubles et d'organismes eucaryotes dotes d'une paroi polysaccharidique utilisees dans le domaine du bien etre |
ES2425762T3 (es) * | 2008-10-27 | 2013-10-17 | Roquette Freres | Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon |
GB0823265D0 (en) | 2008-12-20 | 2009-01-28 | Convatec Technologies Inc | Antimicrobial Composition |
FR2935228B1 (fr) * | 2009-09-30 | 2013-02-08 | Roquette Freres | Composition de maltodextrines branchees et d'organismes eucaryotes dotes d'une paroi polysaccharidique utilisees dans le domaine du bien etre |
FR2954700B1 (fr) * | 2009-12-24 | 2012-02-03 | Roquette Freres | Utilisation de polysaccharides dans le traitement du stress et de l'anxiete |
EP2386297A1 (en) * | 2010-04-28 | 2011-11-16 | Roquette Frères | Indigestible polymer: starch acetate -based film coatings for colon targeting |
EP2422629A1 (en) * | 2010-08-23 | 2012-02-29 | Abbott Laboratories | Methods for enhancing cognition and/or memory using maltodextrins |
GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
PL2858655T3 (pl) | 2012-06-08 | 2017-01-31 | Finzelberg Gmbh & Co. Kg | Ekstrakty z tymianku i ich zastosowania |
WO2014007606A1 (en) * | 2012-07-05 | 2014-01-09 | N.V. Nutricia | Product for use in the prophylactic or therapeutic treatment of a negative emotion or introvert behaviour |
FR2997819B1 (fr) * | 2012-11-14 | 2015-06-26 | Roquette Freres | Utilisation de polysaccharides dans le bien etre intestinal du nourisson et/ou du jeune enfant |
KR20150099776A (ko) | 2012-12-20 | 2015-09-01 | 컨바텍 테크놀러지스 인크 | 화학적 개질된 셀룰로스 섬유의 처리 |
WO2019099532A1 (en) * | 2017-11-14 | 2019-05-23 | Northwestern University | Treatment of sleep-wake disorders and neurodegenerative disease comprising modified resistant maltodextrin |
FR3075001B1 (fr) * | 2017-12-14 | 2021-09-10 | Tereos Starch & Sweeteners Belgium | Utilisation des maltodextrines pour ameliorer la cognition et/ou stimuler le developpement du cerveau |
FR3077959B1 (fr) | 2018-02-22 | 2021-09-24 | Roquette Freres | Procede de fabrication de dextrine de pois resistante |
WO2020161522A1 (en) * | 2019-02-06 | 2020-08-13 | Thd S.P.A. | Fiber-based composition |
FR3134004A1 (fr) * | 2022-03-30 | 2023-10-06 | Roquette Freres | Dextrines hyperbranchées pour leur utilisation topique pour la prévention ou le traitement d’au moins un symptôme de l’inflammation cutanée. |
FR3133994A1 (fr) * | 2022-03-30 | 2023-10-06 | Roquette Freres | Utilisation non thérapeutique de dextrines hyperbranchées comme agent apaisant. |
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FR2786775B1 (fr) * | 1998-12-04 | 2001-02-16 | Roquette Freres | Maltodextrines branchees et leur procede de preparation |
GB2363713A (en) | 2000-06-21 | 2002-01-09 | Ml Lab Plc | Dextrin compositions |
FR2822647B1 (fr) | 2001-03-30 | 2005-03-04 | Roquette Freres | Boissons enrichies en fibres |
FR2822643B1 (fr) * | 2001-03-30 | 2005-03-04 | Roquette Freres | Procede de preparation d'un aliment hypocalorique |
FR2822645B1 (fr) * | 2001-03-30 | 2005-03-11 | Roquette Freres | Composition pour nutrition enterale comprenant des fibres |
FR2822641B1 (fr) * | 2001-03-30 | 2005-03-04 | Roquette Freres | Procede de fabrication de compositions a base de fruits enrichies en fibres et compositions ainsi obtenues |
JP2002308780A (ja) * | 2001-04-12 | 2002-10-23 | Sanwa Kagaku Kenkyusho Co Ltd | 排便回数改善剤又は排便回数改善食品 |
US20030008844A1 (en) * | 2001-05-17 | 2003-01-09 | Keryx Biopharmaceuticals, Inc. | Use of sulodexide for the treatment of inflammatory bowel disease |
MXPA04011323A (es) * | 2002-05-13 | 2005-02-14 | Pharmacia Corp | Compuestos de celecoxib amorfo estable y su proceso de obtencion. |
FR2842992B1 (fr) | 2002-08-05 | 2006-02-10 | Roquette Freres | Procede de fabrication de snacks alleges en matieres grasses et enrichis en fibres et snacks ainsi obtenus |
US20060177444A1 (en) * | 2003-03-20 | 2006-08-10 | Tatsuo Horizoe | Concomitant drug as therapeutic agent for inflammatory bowel disease |
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- 2006-04-04 MX MX2007012915A patent/MX2007012915A/es active IP Right Grant
- 2006-04-04 WO PCT/FR2006/000736 patent/WO2006111624A2/fr active Application Filing
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- 2006-04-04 ES ES06726178T patent/ES2356484T3/es active Active
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Also Published As
Publication number | Publication date |
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KR20080000655A (ko) | 2008-01-02 |
AU2006237417A1 (en) | 2006-10-26 |
EP1871394B1 (fr) | 2010-11-17 |
WO2006111624A3 (fr) | 2007-03-08 |
CA2604778A1 (fr) | 2006-10-26 |
RU2007142443A (ru) | 2009-05-27 |
CA2604778C (fr) | 2013-09-10 |
KR101494901B1 (ko) | 2015-02-24 |
CN101163488A (zh) | 2008-04-16 |
FR2884422A1 (fr) | 2006-10-20 |
BRPI0609959A2 (pt) | 2010-05-11 |
ATE488242T1 (de) | 2010-12-15 |
WO2006111624A2 (fr) | 2006-10-26 |
RU2404780C2 (ru) | 2010-11-27 |
CN101163488B (zh) | 2011-06-15 |
FR2884422B1 (fr) | 2008-04-11 |
US7932238B2 (en) | 2011-04-26 |
EP1871394A2 (fr) | 2008-01-02 |
DE602006018275D1 (de) | 2010-12-30 |
ES2356484T3 (es) | 2011-04-08 |
US20080182821A1 (en) | 2008-07-31 |
MX2007012915A (es) | 2008-03-14 |
AU2006237417B2 (en) | 2011-10-13 |
JP2008536997A (ja) | 2008-09-11 |
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