JP5284779B2 - コンジュゲート化された向精神薬の新規な塩およびその調製方法 - Google Patents

コンジュゲート化された向精神薬の新規な塩およびその調製方法 Download PDF

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Publication number
JP5284779B2
JP5284779B2 JP2008515378A JP2008515378A JP5284779B2 JP 5284779 B2 JP5284779 B2 JP 5284779B2 JP 2008515378 A JP2008515378 A JP 2008515378A JP 2008515378 A JP2008515378 A JP 2008515378A JP 5284779 B2 JP5284779 B2 JP 5284779B2
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acid
chemical
residue
conjugate
addition salt
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Japanese (ja)
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JP2008545777A5 (enExample
JP2008545777A (ja
Inventor
アブラハム ヌデルマン，
アダ レファエリ，
イリット ギル−アド，
アブラハム ウェイズマン，
スロミット ハラチミ，
エラン， ジェイ． ベンジャミン，
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Ramot at Tel Aviv University Ltd
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Ramot at Tel Aviv University Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2008515378A 2005-06-07 2006-06-07 コンジュゲート化された向精神薬の新規な塩およびその調製方法 Expired - Fee Related JP5284779B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68785105P 2005-06-07 2005-06-07
US60/687,851 2005-06-07
US79450106P 2006-04-25 2006-04-25
US60/794,501 2006-04-25
PCT/IL2006/000666 WO2006131923A2 (en) 2005-06-07 2006-06-07 Novel salts of conjugated psychotropic drugs and processes of preparing same

Publications (3)

Publication Number Publication Date
JP2008545777A JP2008545777A (ja) 2008-12-18
JP2008545777A5 JP2008545777A5 (enExample) 2009-07-16
JP5284779B2 true JP5284779B2 (ja) 2013-09-11

Family

ID=37033348

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008515378A Expired - Fee Related JP5284779B2 (ja) 2005-06-07 2006-06-07 コンジュゲート化された向精神薬の新規な塩およびその調製方法

Country Status (8)

Country Link
US (1) US20090298814A1 (enExample)
EP (1) EP1888120B1 (enExample)
JP (1) JP5284779B2 (enExample)
AU (1) AU2006256369B2 (enExample)
CA (1) CA2610838A1 (enExample)
ES (1) ES2400772T3 (enExample)
MX (1) MX2007015511A (enExample)
WO (1) WO2006131923A2 (enExample)

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US9278947B2 (en) 2006-06-22 2016-03-08 Ramot At Tel-Aviv University Ltd. Serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity
CN101511388B (zh) * 2006-07-17 2012-10-24 特拉维夫大学拉莫特有限公司 含有精神药物或gaba激动剂和有机酸的缀合物以及它们在治疗疼痛和其它cns疾病中的用途
EP2252578B1 (en) 2008-02-11 2012-08-01 Ramot at Tel Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
AU2010329440A1 (en) * 2009-12-09 2012-08-09 Bar-Ilan University Methods of improving cognitive functions
CA2789654A1 (en) * 2010-02-24 2011-09-01 Ramot At Tel-Aviv University Ltd. Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same
US8916610B2 (en) 2010-09-22 2014-12-23 Ramot At Tel-Aviv University Ltd. Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
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US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
AU2020258086A1 (en) 2019-04-17 2021-11-11 Compass Pathfinder Limited Methods of treating neurocognitive disorders, chronic pain and reducing inflammation

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Also Published As

Publication number Publication date
ES2400772T3 (es) 2013-04-12
EP1888120A2 (en) 2008-02-20
AU2006256369B2 (en) 2012-08-02
AU2006256369A8 (en) 2006-12-14
MX2007015511A (es) 2008-03-06
EP1888120B1 (en) 2012-12-05
JP2008545777A (ja) 2008-12-18
WO2006131923A2 (en) 2006-12-14
US20090298814A1 (en) 2009-12-03
CA2610838A1 (en) 2006-12-14
WO2006131923A3 (en) 2007-08-02
AU2006256369A1 (en) 2006-12-14

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