MX2007015511A - Sales novedosas de farmacos sicotropicos conjugados y procesos para prepararlas. - Google Patents
Sales novedosas de farmacos sicotropicos conjugados y procesos para prepararlas.Info
- Publication number
- MX2007015511A MX2007015511A MX2007015511A MX2007015511A MX2007015511A MX 2007015511 A MX2007015511 A MX 2007015511A MX 2007015511 A MX2007015511 A MX 2007015511A MX 2007015511 A MX2007015511 A MX 2007015511A MX 2007015511 A MX2007015511 A MX 2007015511A
- Authority
- MX
- Mexico
- Prior art keywords
- acid
- residue
- chemical
- addition salt
- conjugate
- Prior art date
Links
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- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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| US68785105P | 2005-06-07 | 2005-06-07 | |
| US79450106P | 2006-04-25 | 2006-04-25 | |
| PCT/IL2006/000666 WO2006131923A2 (en) | 2005-06-07 | 2006-06-07 | Novel salts of conjugated psychotropic drugs and processes of preparing same |
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| ES (1) | ES2400772T3 (enExample) |
| MX (1) | MX2007015511A (enExample) |
| WO (1) | WO2006131923A2 (enExample) |
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| US7544681B2 (en) * | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| WO2007148341A2 (en) * | 2006-06-22 | 2007-12-27 | Ramot At Tel Aviv University Ltd. | Novel serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity |
| US9278947B2 (en) | 2006-06-22 | 2016-03-08 | Ramot At Tel-Aviv University Ltd. | Serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity |
| CN101511388B (zh) * | 2006-07-17 | 2012-10-24 | 特拉维夫大学拉莫特有限公司 | 含有精神药物或gaba激动剂和有机酸的缀合物以及它们在治疗疼痛和其它cns疾病中的用途 |
| EP2252578B1 (en) | 2008-02-11 | 2012-08-01 | Ramot at Tel Aviv University Ltd. | Conjugates for treating neurodegenerative diseases and disorders |
| AU2010329440A1 (en) * | 2009-12-09 | 2012-08-09 | Bar-Ilan University | Methods of improving cognitive functions |
| CA2789654A1 (en) * | 2010-02-24 | 2011-09-01 | Ramot At Tel-Aviv University Ltd. | Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same |
| US8916610B2 (en) | 2010-09-22 | 2014-12-23 | Ramot At Tel-Aviv University Ltd. | Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| JOP20200296A1 (ar) * | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| AU2020258086A1 (en) | 2019-04-17 | 2021-11-11 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
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| US2944053A (en) * | 1960-07-05 | Uiiilcu | ||
| US2914528A (en) * | 1958-04-16 | 1959-11-24 | Smith Kline French Lab | Substituted phenothiazinyl trifluoro-methyl sulfones |
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| US3956492A (en) * | 1972-07-12 | 1976-05-11 | Boehringer Ingelheim Gmbh | Pharmaceutical compositions containing a 3-(amino-methylene)-5-phenyl-1,4-benzodiazepin-2-one and method of use |
| GB1460713A (en) * | 1973-06-08 | 1977-01-06 | Kefalas As | 7-fluoro substituted phenothiazines method for preparation thereof and compositions bladed rotor for a gas turbine engine |
| US3978216A (en) * | 1974-06-03 | 1976-08-31 | Nelson Research & Development Company | Method for treating schizophrenia and method and composition for potentiating neuroleptic drugs |
| US3947579A (en) * | 1974-06-03 | 1976-03-30 | Nelson Research & Development Company | Method and composition for potentiating neuroleptic drugs |
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2006
- 2006-06-07 ES ES06756205T patent/ES2400772T3/es active Active
- 2006-06-07 EP EP06756205A patent/EP1888120B1/en not_active Not-in-force
- 2006-06-07 MX MX2007015511A patent/MX2007015511A/es active IP Right Grant
- 2006-06-07 JP JP2008515378A patent/JP5284779B2/ja not_active Expired - Fee Related
- 2006-06-07 US US11/921,578 patent/US20090298814A1/en not_active Abandoned
- 2006-06-07 CA CA002610838A patent/CA2610838A1/en not_active Abandoned
- 2006-06-07 WO PCT/IL2006/000666 patent/WO2006131923A2/en not_active Ceased
- 2006-06-07 AU AU2006256369A patent/AU2006256369B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2400772T3 (es) | 2013-04-12 |
| EP1888120A2 (en) | 2008-02-20 |
| AU2006256369B2 (en) | 2012-08-02 |
| AU2006256369A8 (en) | 2006-12-14 |
| EP1888120B1 (en) | 2012-12-05 |
| JP2008545777A (ja) | 2008-12-18 |
| WO2006131923A2 (en) | 2006-12-14 |
| JP5284779B2 (ja) | 2013-09-11 |
| US20090298814A1 (en) | 2009-12-03 |
| CA2610838A1 (en) | 2006-12-14 |
| WO2006131923A3 (en) | 2007-08-02 |
| AU2006256369A1 (en) | 2006-12-14 |
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