JP5274464B2 - Ｔｎｆスーパーファミリー融合タンパク質 - Google Patents
Ｔｎｆスーパーファミリー融合タンパク質 Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
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- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP06017891A EP1894940A1 (en) | 2006-08-28 | 2006-08-28 | TNF superfamily fusion proteins |
| EP06017891.0 | 2006-08-28 | ||
| PCT/EP2007/007517 WO2008025516A2 (en) | 2006-08-28 | 2007-08-28 | Tnf superfamily fusion proteins |
Publications (3)
| Publication Number | Publication Date |
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| JP2010501191A JP2010501191A (ja) | 2010-01-21 |
| JP2010501191A5 JP2010501191A5 (cg-RX-API-DMAC7.html) | 2010-07-15 |
| JP5274464B2 true JP5274464B2 (ja) | 2013-08-28 |
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| JP2009525967A Expired - Fee Related JP5274464B2 (ja) | 2006-08-28 | 2007-08-28 | Ｔｎｆスーパーファミリー融合タンパク質 |
Country Status (8)
| Country | Link |
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| EP (2) | EP1894940A1 (cg-RX-API-DMAC7.html) |
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| AU (1) | AU2007291490A1 (cg-RX-API-DMAC7.html) |
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| DE (1) | DE602007013920D1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008025516A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2657801T3 (es) | 2007-07-10 | 2018-03-06 | Apogenix Ag | Proteínas de fusión de colectina de la superfamilia de TNF |
| US8592557B2 (en) * | 2008-06-17 | 2013-11-26 | Apogenix Gmbh | Multimeric TNF receptor fusion proteins and nucleic acids encoding same |
| US20110189194A1 (en) * | 2008-07-14 | 2011-08-04 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Use of cd95 inhibitors for the treatment of inflammatory disorders |
| DK2604693T3 (en) | 2008-07-21 | 2016-05-30 | Apogenix Gmbh | Single-chain TNFSF molecules |
| EP2829550B1 (en) | 2009-01-09 | 2016-11-16 | Apogenix AG | Fusion proteins forming trimers |
| TWI476001B (zh) | 2011-12-26 | 2015-03-11 | Ind Tech Res Inst | 三倍體Ｆｃ融合蛋白及其用途 |
| WO2014018858A2 (en) | 2012-07-26 | 2014-01-30 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Multimeric fusion protein vaccine and immunotherapeutic |
| WO2014100913A1 (en) * | 2012-12-24 | 2014-07-03 | Beijing Anxinhuaide Biotech. Co., Ltd | Improving the half life of a therapeutic polypeptide by fusing with a trimeric scaffold protein via a spacer |
| NO2776305T3 (cg-RX-API-DMAC7.html) | 2014-04-23 | 2018-01-27 | ||
| BR102014031185A8 (pt) * | 2014-12-12 | 2021-05-04 | Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp | proteína recombinante indutora da apoptose; processo de obtenção da dita proteína e o seu uso no tratamento do câncer |
| IL284430B2 (en) | 2015-01-20 | 2024-04-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
| EP3076179A1 (en) | 2015-03-30 | 2016-10-05 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Diagnosis and treatment of low grade gliomas |
| CA2999116A1 (en) | 2015-09-23 | 2017-03-30 | Apogenix Ag | Anti-cd95l antibody |
| EP4582098A3 (en) * | 2015-11-09 | 2025-12-24 | CureVac SE | Optimized nucleic acid molecules |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| WO2018129332A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (tils) with tumor necrosis factor receptor superfamily (tnfrsf) agonists and therapeutic combinations of tils and tnfrsf agonists |
| US11357841B2 (en) | 2017-01-06 | 2022-06-14 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| EP3622055A1 (en) | 2017-05-10 | 2020-03-18 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| WO2018226714A1 (en) | 2017-06-05 | 2018-12-13 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| JP7744621B2 (ja) * | 2017-08-11 | 2025-09-26 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ | 切断されたモルモットｌ－アスパラギナーゼバリアントおよび使用の方法 |
| CR20200251A (es) | 2017-11-17 | 2020-07-17 | Iovance Biotherapeutics Inc | Expansión de til de aspirados con aguja fina y biopsias por punción |
| CA3083118A1 (en) | 2017-11-22 | 2019-05-31 | Iovance Biotherapeutics, Inc. | Expansion of peripheral blood lymphocytes (pbls) from peripheral blood |
| WO2019118873A2 (en) | 2017-12-15 | 2019-06-20 | Iovance Biotherapeutics, Inc. | Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
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| AU2018415814B2 (en) | 2018-03-29 | 2025-08-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
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| US20220275043A1 (en) | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
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| KR20210064269A (ko) | 2018-09-20 | 2021-06-02 | 이오반스 바이오테라퓨틱스, 인크. | 동결보존된 종양 샘플로부터의 til의 확장 |
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| WO2024098024A1 (en) | 2022-11-04 | 2024-05-10 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
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| ATE505481T1 (de) | 2011-04-15 |
| CA2661599C (en) | 2015-06-09 |
| US8580273B2 (en) | 2013-11-12 |
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| CA2860945C (en) | 2015-12-29 |
| US8147843B2 (en) | 2012-04-03 |
| JP2010501191A (ja) | 2010-01-21 |
| AU2007291490A1 (en) | 2008-03-06 |
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| US20120148527A1 (en) | 2012-06-14 |
| DE602007013920D1 (de) | 2011-05-26 |
| EP1894940A1 (en) | 2008-03-05 |
| CA2661599A1 (en) | 2008-03-06 |
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