JP5213270B2 - 制御された治療薬送達のためのナノ多孔質コーティングを含む医療デバイス - Google Patents
制御された治療薬送達のためのナノ多孔質コーティングを含む医療デバイス Download PDFInfo
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/146—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/37512—Pacemakers
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Description
100s:ステント支柱
110:ステント基板
110d:窪み
120、120a、120b:多孔質貯槽
120e:端部
120t、120ta、および120tb:治療薬含有貯槽
130、130a、130b:ナノ多孔質層
140:栓−形成材料、栓
a、a1、a2:開口
Claims (37)
- 医療デバイスであって、基板、該基板上に配置された、治療薬を含む多孔質貯槽、該多孔質貯槽上に配置されたナノ多孔質層、および該基板内および該ナノ多孔質層内に位置する、複数の有栓開口部を含み、該医療デバイスが、該治療薬をインビボにて放出し、前記有栓開口部の少なくとも一つが、前記基板内に位置し、かつ前記有栓開口部の少なくとも一つが、前記ナノ多孔質層内に位置することを特徴とする、前記医療デバイス。
- 前記基板内に位置する有栓開口部における該栓を形成する材料が、前記基板の表面を覆っている、請求項1記載の医療デバイス。
- 更に、前記ナノ多孔質層上に配置された追加の多孔質貯槽および該追加の多孔質貯槽上に配置された追加のナノ多孔質層を含む、請求項1記載の医療デバイス。
- 前記基板において有栓開口部を、および前記追加のナノ多孔質層において有栓開口部を含む、請求項3記載の医療デバイス。
- 前記有栓開口部における該栓の幅が、該開口の外側表面における、該開口の幅の1〜4倍なる範囲内にある、請求項1記載の医療デバイス。
- 前記有栓開口部における該栓が、生物学的に安定なものである、請求項1記載の医療デバイス。
- 前記有栓開口部における該栓が、生分解性のものである、請求項1記載の医療デバイス。
- 前記有栓開口部における該栓が、生物学的に安定なポリマーを含む、請求項1記載の医療デバイス。
- 前記有栓開口部における該栓が、生分解性のポリマーを含む、請求項1記載の医療デバイス。
- 前記有栓開口部における該栓が、水-膨潤性ポリマーを含む、請求項1記載の医療デバイス。
- 前記有栓開口部における該栓が、前記ナノ多孔質層材料で作られている、請求項1記載の医療デバイス。
- 追加の有栓開口部が、前記基板内に位置し、かつ前記有栓開口部における該栓が、前記基板の材料で作られている、請求項1記載の医療デバイス。
- 前記多孔質貯槽が、少なくとも部分的に前記基板の窪み内に配置されている、請求項1記載の医療デバイス。
- 複数の多孔質貯槽を含む、請求項1記載の医療デバイス。
- 単一のナノ多孔質層によって覆われた、複数の多孔質貯槽を含む、請求項1記載の医療デバイス。
- 各々が、異なるナノ多孔質層によって覆われた、複数の多孔質貯槽を含む、請求項1記載の医療デバイス。
- 複数のナノ多孔質層を含む、請求項1記載の医療デバイス。
- 孔径において異なり、あるいは厚みにおいて異なっている、複数のナノ多孔質層を含む、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、生物学的に安定なものである、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、生分解性のものである、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、ポリマー製である、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、金属製である、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、セラミックス製である、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、ポリマー-セラミックスハイブリッド材料製である、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、平行な孔構造を含む、請求項1記載の医療デバイス。
- 前記ナノ多孔質層が、相互に連結した孔構造を含む、請求項1記載の医療デバイス。
- 前記ナノ多孔質層の、前記多孔質貯槽に隣接する側の孔径が、その反対側における該層の孔径よりも大きい、請求項1記載の医療デバイス。
- 前記基板材料が、生物学的に安定である、請求項1記載の医療デバイス。
- 前記基板材料が、生分解性である、請求項1記載の医療デバイス。
- 前記基板材料が、金属である、請求項1記載の医療デバイス。
- 前記基板が、ポリマー-セラミックスハイブリッド材料製である、請求項1記載の医療デバイス。
- ステントおよび動脈瘤治療デバイスから選択される、請求項1記載の医療デバイス。
- 前記医療デバイスが、脈管構造、泌尿生殖器系、消化器系および胆道内に移植または挿入するのに適したものである、請求項1記載の医療デバイス。
- 複数の異なる治療薬を含む、請求項1記載の医療デバイス。
- 前記放出が、ゼロ次の放出である、請求項1記載の医療デバイス。
- 前記治療薬が、抗-血栓症薬剤、増殖抑制薬、抗-炎症薬、移動抑制剤、細胞外マトリックス製造並びに組織化に影響を及ぼす薬剤、抗-新生物剤、細胞分裂阻害剤、麻酔薬、抗-凝血薬、血管(上皮)細胞増殖促進剤、血管(上皮)細胞増殖阻害剤、コレステロール低下薬、血管拡張剤、TGF-β-上昇剤および内因性血管作用メカニズムに影響を及ぼす薬剤からなる群から選択される、少なくとも1種である、請求項1記載の医療デバイス。
- 請求項1記載の医療デバイスの製法であって、(a) 前記基板上に前記多孔質貯槽を形成する工程;(b) 該多孔質貯槽上に、前記ナノ多孔質層を形成する工程;(c) 該基板内および該ナノ多孔質層内に、前記開口を形成する工程;(d) 該多孔質貯槽を、該開口を介して前記治療薬で満たす工程;および(d)該開口を閉鎖する工程を含むことを特徴とする、前記方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/701,768 US8187255B2 (en) | 2007-02-02 | 2007-02-02 | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US11/701,768 | 2007-02-02 | ||
PCT/US2008/001153 WO2008097452A2 (en) | 2007-02-02 | 2008-01-29 | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
Publications (3)
Publication Number | Publication Date |
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JP2010517620A JP2010517620A (ja) | 2010-05-27 |
JP2010517620A5 JP2010517620A5 (ja) | 2012-07-26 |
JP5213270B2 true JP5213270B2 (ja) | 2013-06-19 |
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Application Number | Title | Priority Date | Filing Date |
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JP2009548280A Expired - Fee Related JP5213270B2 (ja) | 2007-02-02 | 2008-01-29 | 制御された治療薬送達のためのナノ多孔質コーティングを含む医療デバイス |
Country Status (5)
Country | Link |
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US (1) | US8187255B2 (ja) |
EP (1) | EP2131882B1 (ja) |
JP (1) | JP5213270B2 (ja) |
CA (1) | CA2679727A1 (ja) |
WO (1) | WO2008097452A2 (ja) |
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