JP5207386B2 - ピリミジン−２，４−ジアミンおよびその使用 - Google Patents

ピリミジン−２，４−ジアミンおよびその使用 Download PDF

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Publication number
JP5207386B2
JP5207386B2 JP2008554229A JP2008554229A JP5207386B2 JP 5207386 B2 JP5207386 B2 JP 5207386B2 JP 2008554229 A JP2008554229 A JP 2008554229A JP 2008554229 A JP2008554229 A JP 2008554229A JP 5207386 B2 JP5207386 B2 JP 5207386B2
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compound
salt
composition
group
aryl
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JP2009525353A5 (https=
JP2009525353A (ja
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ソマーセクハー バーミディパティ
ラジンダー シン
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ライジェル ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E10/00—Energy generation through renewable energy sources
    • Y02E10/50—Photovoltaic [PV] energy
    • Y02E10/549—Organic PV cells

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2008554229A 2005-12-06 2006-12-06 ピリミジン−２，４−ジアミンおよびその使用 Expired - Fee Related JP5207386B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/295,752 US7713987B2 (en) 2005-12-06 2005-12-06 Pyrimidine-2,4-diamines and their uses
US11/295,752 2005-12-06
PCT/US2006/046557 WO2008088303A1 (en) 2005-12-06 2006-12-06 Pyrimidine-2,4-diamines and their uses

Publications (3)

Publication Number Publication Date
JP2009525353A JP2009525353A (ja) 2009-07-09
JP2009525353A5 JP2009525353A5 (https=) 2011-02-03
JP5207386B2 true JP5207386B2 (ja) 2013-06-12

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JP2008554229A Expired - Fee Related JP5207386B2 (ja) 2005-12-06 2006-12-06 ピリミジン−２，４−ジアミンおよびその使用

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Country Link
US (2) US7713987B2 (https=)
EP (1) EP1968598B1 (https=)
JP (1) JP5207386B2 (https=)
CA (1) CA2630357C (https=)
ES (1) ES2463452T3 (https=)
WO (1) WO2008088303A1 (https=)

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AU2006206458B2 (en) 2005-01-19 2012-10-25 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
BRPI0610876B8 (pt) 2005-06-08 2021-05-25 Rigel Pharmaceuticals Inc composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel
US20070203161A1 (en) * 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US7713987B2 (en) * 2005-12-06 2010-05-11 Rigel Pharmaceuticals, Inc. Pyrimidine-2,4-diamines and their uses
US7659280B2 (en) * 2006-02-17 2010-02-09 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases
ES2622493T3 (es) * 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta de JAK
JP5161233B2 (ja) 2006-10-19 2013-03-13 ライジェル ファーマシューティカルズ， インコーポレイテッド 自己免疫疾患の処置のためのｊａｋキナーゼの阻害剤としての２，４−ピリミジンアミン誘導体
ATE540041T1 (de) 2006-11-21 2012-01-15 Rigel Pharmaceuticals Inc Prodrug-salze von 2,4-pyrimidindiaminverbindungen und anwendungen davon
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Also Published As

Publication number Publication date
US20070129360A1 (en) 2007-06-07
WO2008088303A1 (en) 2008-07-24
EP1968598A4 (en) 2010-09-01
JP2009525353A (ja) 2009-07-09
US7713987B2 (en) 2010-05-11
EP1968598A1 (en) 2008-09-17
ES2463452T3 (es) 2014-05-28
CA2630357A1 (en) 2007-06-06
CA2630357C (en) 2016-02-02
EP1968598B1 (en) 2014-02-19
US20070129362A1 (en) 2007-06-07

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