JP5143082B2 - 液液抽出システム - Google Patents
液液抽出システム Download PDFInfo
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- JP5143082B2 JP5143082B2 JP2009123683A JP2009123683A JP5143082B2 JP 5143082 B2 JP5143082 B2 JP 5143082B2 JP 2009123683 A JP2009123683 A JP 2009123683A JP 2009123683 A JP2009123683 A JP 2009123683A JP 5143082 B2 JP5143082 B2 JP 5143082B2
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- liquid
- oscillation source
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- ultrasonic
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- 238000000622 liquid--liquid extraction Methods 0.000 title claims description 73
- 238000000638 solvent extraction Methods 0.000 title claims description 73
- 230000010355 oscillation Effects 0.000 claims description 148
- 238000004945 emulsification Methods 0.000 claims description 119
- 238000000926 separation method Methods 0.000 claims description 113
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 79
- 230000010356 wave oscillation Effects 0.000 claims description 50
- 239000007788 liquid Substances 0.000 claims description 41
- 230000001804 emulsifying effect Effects 0.000 claims description 19
- 238000005191 phase separation Methods 0.000 claims description 11
- 239000012071 phase Substances 0.000 description 243
- 238000000605 extraction Methods 0.000 description 39
- 238000000034 method Methods 0.000 description 26
- 238000001514 detection method Methods 0.000 description 17
- 239000000463 material Substances 0.000 description 15
- 239000003814 drug Substances 0.000 description 14
- 229940079593 drug Drugs 0.000 description 13
- 239000000839 emulsion Substances 0.000 description 13
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 13
- 239000000203 mixture Substances 0.000 description 10
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000011521 glass Substances 0.000 description 8
- 239000012521 purified sample Substances 0.000 description 8
- 229910001220 stainless steel Inorganic materials 0.000 description 8
- 239000010935 stainless steel Substances 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- 238000004811 liquid chromatography Methods 0.000 description 5
- 238000011084 recovery Methods 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- -1 phthalate ester Chemical class 0.000 description 3
- 239000000523 sample Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000005501 phase interface Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0261—Solvent extraction of solids comprising vibrating mechanisms, e.g. mechanical, acoustical
- B01D11/0265—Applying ultrasound
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
- B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
- B01F31/87—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations transmitting the vibratory energy by means of a fluid, e.g. by means of air shock waves
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Extraction Or Liquid Replacement (AREA)
Description
102 分散相
103 溶質
104,205 容器
105 水
106,206 水槽
107 乳化用超音波発振源
108 分離用超音波発振源
109 超音波発振源駆動回路
110,208,404,503 制御部
111 移動機構
201 シリンジ
202 シリンジポンプ
203 乳化液
204 マイクロリアクタ
207 駆動回路
401,502 液液抽出部
402 固相抽出部
403 LC/MS部
405 回収用シリンジ
406 固相抽出カラム
407 三方弁
408 液体クロマトグラフィーカラム
409 検出部
501 マイクロリアクタ部
504 温度調節ユニット
Claims (6)
- 互いに混ざり合わない液体である連続相と分散相との何れかに溶解した溶質を他方へ移動させて液液抽出を行う液液抽出システムにおいて、
前記連続相及び前記分散相と、少なくとも前記連続相と前記分散相の何れかに溶解した溶質とが収められた容器と、
前記容器が収容され、前記容器の周囲に水を有する水槽と、
前記水槽の外側であって、前記連続相と前記分散相との相分離後に形成される界面と略平行な面に配置された乳化用超音波発振源と、
前記水槽の外側に配置された分離用超音波発振源と、
前記乳化用超音波発振源と前記分離用超音波発振源とを駆動させる超音波発振源駆動回路と、
前記乳化用超音波発振源,前記分離用超音波発振源の順番で、前記乳化用超音波発振源と前記分離用超音波発振源とを駆動させることにより、容器内の連続相及び分散相をさらに乳化させ、その後に、相分離させる前記超音波発振源駆動回路を制御する制御部とを備えた液液抽出システム。 - 請求項1に記載の液液抽出システムにおいて、
前記分離用超音波発振源は、前記連続相と前記分散相との相分離後に形成される界面と略直交する面に配置された液液抽出システム。 - 請求項1に記載の液液抽出システムにおいて、
前記水槽を、前記連続相と前記分散相との相分離後に形成される界面と略平行な方向に移動させる移動機構を備え、
前記分離用超音波発振源は、前記連続相と前記分散相の界面と略平行な面に設けられた液液抽出システム。 - 請求項1に記載の液液抽出システムにおいて、
前記容器の壁面が、前記乳化用超音波発振源と相分離後に形成される界面と略平行及び略直交となるように配置され、
前記容器の壁面の厚さは、前記乳化用超音波発振源又は前記分離用超音波発振源から発せられた超音波の半波長の整数倍である液液抽出システム。 - 請求項1に記載の液液抽出システムにおいて、
前記水槽の壁面の厚さは、前記乳化用超音波発振源又は前記分離用超音波発振源から発せられた超音波の半波長の整数倍である液液抽出システム。 - 互いに混ざり合わない液体である連続相と分散相との何れかに溶解した溶質を他方へ移動させて液液抽出を行う液液抽出システムであって、
前記連続相の中に前記分散相の油滴を生成して、乳化するマイクロ流路を有するマイクロリアクタと、
前記マイクロリアクタからの前記連続相と前記分散相と前記溶質とが収められた容器と、
前記容器を収容し、前記容器の周囲に水を有する水槽と、
前記水槽の外側に配置された分離用超音波発振源と、
前記乳化が終了した後に、前記分離用超音波発振源を動作させる制御部とを備えた液液抽出システムにおいて、
前記水槽の外側であって、前記連続相と前記分散相との相分離後に形成される界面と略平行な面に配置された乳化用超音波発振源を備え、
前記制御部は、前記乳化用超音波発振源,前記分離用超音波発振源の順で、前記乳化用超音波発振源と前記分離用超音波発振源とを駆動させる液液抽出システム。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009123683A JP5143082B2 (ja) | 2009-05-22 | 2009-05-22 | 液液抽出システム |
EP10005287A EP2260916A1 (en) | 2009-05-22 | 2010-05-20 | Liquid-liquid extraction system |
US12/783,924 US8252239B2 (en) | 2009-05-22 | 2010-05-20 | Liquid-liquid extraction system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009123683A JP5143082B2 (ja) | 2009-05-22 | 2009-05-22 | 液液抽出システム |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010269256A JP2010269256A (ja) | 2010-12-02 |
JP5143082B2 true JP5143082B2 (ja) | 2013-02-13 |
Family
ID=42729432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009123683A Expired - Fee Related JP5143082B2 (ja) | 2009-05-22 | 2009-05-22 | 液液抽出システム |
Country Status (3)
Country | Link |
---|---|
US (1) | US8252239B2 (ja) |
EP (1) | EP2260916A1 (ja) |
JP (1) | JP5143082B2 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011058881A1 (ja) * | 2009-11-13 | 2011-05-19 | 国立大学法人岡山大学 | 超微小液滴調製装置 |
JP5470186B2 (ja) * | 2010-07-30 | 2014-04-16 | 日本発條株式会社 | 被検査物の清浄度検査装置と、清浄度検査方法 |
RU2479346C1 (ru) * | 2011-08-29 | 2013-04-20 | Андрей Александрович Геталов | Способ одновременной ультразвуковой кавитационной обработки различных по составу жидких сред |
CN102943177B (zh) * | 2012-10-29 | 2014-03-26 | 浙江特力再生资源有限公司 | 一种从有机硅废渣中回收铜和硅粉的方法 |
CN103041609A (zh) * | 2012-12-26 | 2013-04-17 | 淮安万邦香料工业有限公司 | 油水两相间歇萃取专用装置及其萃取方法 |
GB201310214D0 (en) * | 2013-06-07 | 2013-07-24 | Medical Res Council | Separation and Analysis Systems and Methods |
CN104083894B (zh) * | 2014-06-20 | 2016-07-06 | 金峰 | 一种超声波及微波提取系统及工艺 |
WO2016065249A1 (en) | 2014-10-24 | 2016-04-28 | Life Technologies Corporation | Acoustically settled liquid-liquid sample purification system |
JP6501557B2 (ja) * | 2015-02-25 | 2019-04-17 | 学校法人早稲田大学 | ホウ素除去装置及びホウ素除去方法 |
CN109060396B (zh) * | 2018-08-29 | 2021-06-01 | 深圳技术大学 | 一种消费品化学成分检测分析用超声波萃取仪的超声萃取性能核查装置及方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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DE886884C (de) * | 1951-10-30 | 1953-08-17 | Siemens Ag | Verfahren und Einrichtung zum Trennen von Wasser und OEl |
JPS59169505A (ja) * | 1983-03-15 | 1984-09-25 | Gunma Daigaku | 超音波乳化による液−液抽出分離装置 |
JPH0665382B2 (ja) | 1991-03-20 | 1994-08-24 | 雪印乳業株式会社 | リポソーム調製装置とその装置を使用するリポソーム調製方法 |
FR2694705B1 (fr) | 1992-08-12 | 1994-09-23 | Commissariat Energie Atomique | Procédé d'extraction par solvant en continu avec traitement par ultrasons et colonne pour la mise en Óoeuvre de ce procédé. |
JPH0810509A (ja) | 1994-06-30 | 1996-01-16 | Mitsubishi Kakoki Kaisha Ltd | 船舶廃油の処理方法 |
US5463177A (en) * | 1994-08-23 | 1995-10-31 | General Electric Company | Solvent extraction process |
US7687039B2 (en) * | 1998-10-28 | 2010-03-30 | Covaris, Inc. | Methods and systems for modulating acoustic energy delivery |
US7128840B2 (en) * | 2002-03-26 | 2006-10-31 | Idaho Research Foundation, Inc. | Ultrasound enhanced process for extracting metal species in supercritical fluids |
DE602004009681T2 (de) | 2003-05-16 | 2008-08-14 | Velocys, Inc., Plain City | Verfahren zur erzeugung einer emulsion durch verwendung einer mikrokanalverfahrentechnologie |
DE10333921B4 (de) | 2003-07-25 | 2005-10-20 | Wella Ag | Extraktionsverfahren unter Verwendung eines statischen Mikromischers |
JP2005169186A (ja) * | 2003-12-08 | 2005-06-30 | Horiba Ltd | エマルジョン消去方法、測定方法及び土壌試料浄化方法 |
JP2006320772A (ja) * | 2005-05-17 | 2006-11-30 | Hitachi Plant Technologies Ltd | マイクロ流体デバイス |
JP2007136271A (ja) | 2005-11-15 | 2007-06-07 | Koike Seisakusho:Kk | 水油分離装置 |
JP5023902B2 (ja) | 2007-09-06 | 2012-09-12 | 株式会社日立プラントテクノロジー | 乳化装置 |
JP4798174B2 (ja) | 2008-05-21 | 2011-10-19 | 株式会社日立プラントテクノロジー | 乳化装置 |
-
2009
- 2009-05-22 JP JP2009123683A patent/JP5143082B2/ja not_active Expired - Fee Related
-
2010
- 2010-05-20 EP EP10005287A patent/EP2260916A1/en not_active Withdrawn
- 2010-05-20 US US12/783,924 patent/US8252239B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2010269256A (ja) | 2010-12-02 |
US20100296976A1 (en) | 2010-11-25 |
US8252239B2 (en) | 2012-08-28 |
EP2260916A1 (en) | 2010-12-15 |
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