JP5140225B2 - 置換ピラゾール - Google Patents
置換ピラゾール Download PDFInfo
- Publication number
- JP5140225B2 JP5140225B2 JP2002519454A JP2002519454A JP5140225B2 JP 5140225 B2 JP5140225 B2 JP 5140225B2 JP 2002519454 A JP2002519454 A JP 2002519454A JP 2002519454 A JP2002519454 A JP 2002519454A JP 5140225 B2 JP5140225 B2 JP 5140225B2
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- tetrahydro
- pyrazolo
- piperazin
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 C*(CN(*[n]1nc(*)c(*)c1*)C(*)C1)C(*)N1C=* Chemical compound C*(CN(*[n]1nc(*)c(*)c1*)C(*)C1)C(*)N1C=* 0.000 description 2
- LOGSFQPBBYQSSH-UHFFFAOYSA-N CC(CC=C1)(C(N2CCN(CCC[n](c(CC3)c4CN3S(C)(=O)=O)nc4-c3ccc(C(F)(F)F)cc3)CC2)=C1Cl)N Chemical compound CC(CC=C1)(C(N2CCN(CCC[n](c(CC3)c4CN3S(C)(=O)=O)nc4-c3ccc(C(F)(F)F)cc3)CC2)=C1Cl)N LOGSFQPBBYQSSH-UHFFFAOYSA-N 0.000 description 1
- GADLKTANNWUGMK-UHFFFAOYSA-N CC(N(CC1)Cc2c1[n](CC(CN(CC1)CCN1c(c(C(OC)=O)ccc1)c1[N+]([O-])=O)O)nc2-c1ccc(C(F)(F)F)cc1)=O Chemical compound CC(N(CC1)Cc2c1[n](CC(CN(CC1)CCN1c(c(C(OC)=O)ccc1)c1[N+]([O-])=O)O)nc2-c1ccc(C(F)(F)F)cc1)=O GADLKTANNWUGMK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22513800P | 2000-08-14 | 2000-08-14 | |
US60/225,138 | 2000-08-14 | ||
PCT/US2001/025289 WO2002014314A2 (en) | 2000-08-14 | 2001-08-10 | Substituted pyrazoles |
US09/928,122 | 2001-08-10 | ||
US09/928,122 US7309703B2 (en) | 2000-08-14 | 2001-08-10 | Substituted pyrazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004512272A JP2004512272A (ja) | 2004-04-22 |
JP5140225B2 true JP5140225B2 (ja) | 2013-02-06 |
Family
ID=26919335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002519454A Expired - Lifetime JP5140225B2 (ja) | 2000-08-14 | 2001-08-10 | 置換ピラゾール |
Country Status (17)
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
ES2281434T3 (es) * | 2000-08-14 | 2007-10-01 | Ortho-Mcneil Pharmaceutical, Inc. | Pirazoles sustituidos. |
US20070105841A1 (en) * | 2000-08-14 | 2007-05-10 | Breitenbucher J G | Method for treating allergies using substituted pyrazoles |
US7332494B2 (en) * | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
WO2002051983A2 (en) * | 2000-12-22 | 2002-07-04 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as cathepsin inhibitors |
US20040147503A1 (en) * | 2002-06-04 | 2004-07-29 | Sheila Zipfeil | Novel compounds and compositions as cathepsin inhibitors |
US20030073672A1 (en) * | 2001-09-05 | 2003-04-17 | Breitenbucher J. Guy | Method for treating allergies using substituted pyrazoles |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
CN1867336B (zh) * | 2002-06-12 | 2010-05-12 | 凯莫森特里克斯股份有限公司 | 1-芳基-4-取代的哌嗪衍生物及其制药用途 |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
GB0220214D0 (en) * | 2002-08-30 | 2002-10-09 | Novo Pharmaceuticals De Ltd | Compounds and their use |
PL375053A1 (en) | 2002-09-24 | 2005-11-14 | Novartis Ag | Sphingosine-1-phosphate receptor agonists in the treatment of demyelinating disorders |
US7384970B2 (en) | 2003-03-24 | 2008-06-10 | Irm Llc | Inhibitors of cathepsin S |
US7109243B2 (en) | 2003-03-24 | 2006-09-19 | Irm Llc | Inhibitors of cathepsin S |
US7173051B2 (en) | 2003-06-13 | 2007-02-06 | Irm, Llc | Inhibitors of cathepsin S |
US7256207B2 (en) | 2003-08-20 | 2007-08-14 | Irm Llc | Inhibitors of cathepsin S |
EA200801812A1 (ru) | 2003-09-17 | 2009-06-30 | Янссен Фармацевтика Н.В. | Сопряженные гетероциклические соединения |
EP1715921B1 (en) * | 2003-09-25 | 2013-04-24 | Abraxis BioScience, Inc. | Tetrahydroindolone derivatives for treatment of neurological conditions |
AU2005219438B2 (en) * | 2004-03-03 | 2011-02-17 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US7745491B2 (en) * | 2004-08-12 | 2010-06-29 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
US7777035B2 (en) | 2005-06-22 | 2010-08-17 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
US7598255B2 (en) | 2005-08-04 | 2009-10-06 | Janssen Pharmaceutica Nv | Pyrimidine compounds as serotonin receptor modulators |
US20080207683A1 (en) * | 2007-02-15 | 2008-08-28 | Darin Allen | Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20080200454A1 (en) * | 2007-02-15 | 2008-08-21 | Ameriks Michael K | Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20080269241A1 (en) * | 2007-02-15 | 2008-10-30 | Darin Allen | Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20090118274A1 (en) * | 2007-02-15 | 2009-05-07 | Darin Allen | Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20090099157A1 (en) * | 2007-02-15 | 2009-04-16 | Ameriks Michael K | Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s |
US20100046516A1 (en) * | 2007-06-26 | 2010-02-25 | Media Patents, S.L. | Methods and Devices for Managing Multicast Traffic |
EP2276198B1 (en) * | 2007-06-26 | 2012-01-18 | Media Patents, S. L. | Device for managing multicast groups |
WO2009062134A1 (en) * | 2007-11-09 | 2009-05-14 | Cenomed Biosciences, Llc | Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds |
WO2009102937A1 (en) * | 2008-02-14 | 2009-08-20 | Sunesis Pharmaceuticals, Inc. | Processes for the preparation of carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20090264443A1 (en) * | 2008-04-18 | 2009-10-22 | David Helton | Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds |
EP3011958A1 (en) | 2008-06-20 | 2016-04-27 | Novartis AG | Paediatric compositions for treating multiple sclerosis |
US8829011B2 (en) | 2008-10-29 | 2014-09-09 | Janssen Pharmaceutica Nv | 2-aminopyrimidine compounds as serotonin receptor modulators |
CA2740193A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
CA2740195A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
WO2010120935A1 (en) | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
SI2628481T1 (sl) | 2009-06-11 | 2016-08-31 | Abb Vie Bahamas Limited | Trisubstituirani heterocikli kot inhibitorji replikacije HCV virusa hepatitisa C |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
US9527845B2 (en) | 2014-12-30 | 2016-12-27 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis B infections |
EP3377060B1 (en) | 2015-11-20 | 2020-08-19 | Lundbeck La Jolla Research Center, Inc. | Pyrazole derivatives, processes for their preparation and uses thereof |
WO2017087863A1 (en) | 2015-11-20 | 2017-05-26 | Abide Therapeutics, Inc. | Pyrazole compounds and methods of making and using same |
US10385057B2 (en) | 2015-11-20 | 2019-08-20 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
US10583137B2 (en) | 2015-12-02 | 2020-03-10 | The Scripps Research Institute | Triazole DAGLα inhibitors |
TW201806956A (zh) | 2016-06-29 | 2018-03-01 | 諾維拉治療公司 | 二氮呯酮衍生物及治療b型肝炎感染之方法 |
CA3029566A1 (en) | 2016-06-29 | 2018-01-04 | Novira Therapeutics, Inc. | Diazepinone derivatives and their use in the treatment of hepatitis b infections |
EP3630744B1 (en) | 2017-05-23 | 2023-01-25 | H. Lundbeck A/S | Pyrazole magl inhibitors |
US10927105B1 (en) | 2017-05-23 | 2021-02-23 | Lundbeck La Jolla Research Center, Inc. | Pyrazole MAGL inhibitors |
JOP20190267A1 (ar) | 2017-05-23 | 2019-11-18 | Lundbeck La Jolla Research Center Inc | مثبطات بيرازول magl |
EP3884948A1 (en) * | 2020-03-26 | 2021-09-29 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Cathepsin inhibitors and uses thereof |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3914340A (en) * | 1970-06-02 | 1975-10-21 | Gen Tire & Rubber Co | Block copolymerization with azoamidino compounds as initiator |
JPS5720663B2 (US07772236-20100810-C00042.png) * | 1973-06-11 | 1982-04-30 | ||
US3994890A (en) * | 1974-01-31 | 1976-11-30 | Chugai Seiyaku Kabushiki Kaisha | 1-Aminoalkyl, 3-phenyl indazoles |
JPS5640714B2 (US07772236-20100810-C00042.png) * | 1974-03-04 | 1981-09-22 | ||
JPS5944312B2 (ja) * | 1974-11-22 | 1984-10-29 | 中外製薬株式会社 | インダゾ−ル誘導体の製法 |
JPS5936627B2 (ja) | 1975-07-25 | 1984-09-05 | 中外製薬株式会社 | インダゾ−ル誘導体の製法 |
US4523928A (en) * | 1980-04-28 | 1985-06-18 | Battelle Development Corporation | Gasohol production from thermochemical conversion of biomass to ethanol |
US4401823A (en) * | 1981-05-18 | 1983-08-30 | Uop Inc. | Hydrogenolysis of polyhydroxylated compounds |
US4364745A (en) * | 1981-06-26 | 1982-12-21 | Standard Oil Company (Indiana) | Plant hydrocarbon recovery process |
DE3132915A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DK27383A (da) * | 1982-02-17 | 1983-08-18 | Lepetit Spa | Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner |
JPH0615542B2 (ja) * | 1986-07-22 | 1994-03-02 | 吉富製薬株式会社 | ピラゾロピリジン化合物 |
US4925540A (en) * | 1988-10-04 | 1990-05-15 | Delphi Research Inc. | Method for treating organic waste material and an oxidation catalyst/cocatalyst composition useful therefor |
FR2642759B1 (fr) | 1989-02-09 | 1991-05-17 | Laboratorios Esteve Sa | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
US5177169A (en) * | 1989-04-03 | 1993-01-05 | Colorado State University Research Foundation | Method for recovering and using lignin in adhesive resins |
FR2673628B1 (fr) | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
US5186722A (en) * | 1991-06-25 | 1993-02-16 | Cantrell Research, Incorporated | Hydrocarbon-based fuels from biomass |
JP2818061B2 (ja) * | 1991-12-10 | 1998-10-30 | 三菱電機株式会社 | 放電加工装置 |
US5264576A (en) | 1992-10-22 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrazolo[4,3-c]pyridines which are intermediates |
US5599815A (en) | 1993-02-04 | 1997-02-04 | Meiji Seika Kabushiki Kaisha | Antipsychotic benzoisothiazolyl piperazine derivatives |
FR2712808B1 (fr) | 1993-11-25 | 1996-02-16 | Esteve Labor Dr | Utilisation des dérivés de 1-{4-[4-aryl(ou hétéroaryl)-1-pipérazinyl]-butyl}-1-H-azole pour la préparation de médicaments destinés au traitement des troubles de la sécrétion gastrique . |
IL112759A0 (en) | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
US5516960A (en) * | 1994-08-02 | 1996-05-14 | Board Of Regents, The University Of Texas System | Process for producing hydrocarbon fuels |
US5776718A (en) | 1995-03-24 | 1998-07-07 | Arris Pharmaceutical Corporation | Reversible protease inhibitors |
PL322409A1 (en) | 1995-03-24 | 1998-01-19 | Arris Pharm Corp | Reversible protease inhibitors |
TW438591B (en) | 1995-06-07 | 2001-06-07 | Arris Pharm Corp | Reversible cysteine protease inhibitors |
WO1996041633A1 (en) | 1995-06-08 | 1996-12-27 | Eli Lilly And Company | Methods of treating cold and allergic rhinitis |
FR2742052B1 (fr) | 1995-12-12 | 1998-04-10 | Esteve Labor Dr | Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports |
DE19602505A1 (de) | 1996-01-25 | 1997-07-31 | Merck Patent Gmbh | 1-(Pyrazol-4-Indol-3-yl)-Piperidine |
DK0912601T4 (da) | 1996-04-22 | 2009-03-09 | Massachusetts Inst Technology | Suppression af immunrespons ved inhibering af cathepsin S |
TW575583B (en) | 1996-04-24 | 2004-02-11 | Akzo Nobel Nv | Novel peptides suitable for use in antigen specific immunosuppressive therapy |
US5830850A (en) * | 1996-08-28 | 1998-11-03 | Mount Sinai School Of Medicine Of The City Of New York | Methods for the treatment of bone resorption disorders, including osteoporosis |
GB9626643D0 (en) * | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
AU7553198A (en) | 1997-06-12 | 1998-12-30 | Sumitomo Pharmaceuticals Company, Limited | Pyrazole derivatives |
FR2767827A1 (fr) | 1997-09-03 | 1999-02-26 | Adir | Nouveaux derives de l'indole et de l'indazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
PL202226B1 (pl) | 1997-11-05 | 2009-06-30 | Novartis Ag | Nitryl dipeptydowy, jego zastosowanie lecznicze i zawierająca go kompozycja farmaceutyczna |
GB9806287D0 (en) | 1998-03-24 | 1998-05-20 | Synphar Lab Inc | Monobactam enzyme inhibitors |
WO1999058153A1 (en) | 1998-05-08 | 1999-11-18 | Brigham & Women's Hospital | Methods of diagnosing and modulating autoimmunity |
AU2560000A (en) | 1999-02-20 | 2000-09-04 | Astrazeneca Ab | Di- and tripeptide nitrile derivatives as inhibitors of cathepsin l and cathepsin |
EP1159273A1 (en) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cathepsin s |
TW200404789A (en) | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
JP2003506364A (ja) | 1999-07-30 | 2003-02-18 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | システインプロテアーゼインヒビターとして有益な新規スクシネート誘導体化合物 |
AU7490900A (en) | 1999-09-16 | 2001-04-17 | Axys Pharmaceuticals, Inc. | Chemical compounds and compositions and their use as cathepsin s inhibitors |
AU1650501A (en) | 1999-12-03 | 2001-06-12 | Ono Pharmaceutical Co. Ltd. | 1,3,4-oxadiazoline derivatives and drugs containing these derivatives as the active ingredient |
US6214813B1 (en) * | 2000-04-07 | 2001-04-10 | Kinetek Pharmaceuticals, Inc. | Pyrazole compounds |
AU8645401A (en) * | 2000-08-14 | 2002-02-25 | Ortho Mcneil Pharm Inc | Substituted pyrazoles |
ES2281434T3 (es) * | 2000-08-14 | 2007-10-01 | Ortho-Mcneil Pharmaceutical, Inc. | Pirazoles sustituidos. |
US20070105841A1 (en) * | 2000-08-14 | 2007-05-10 | Breitenbucher J G | Method for treating allergies using substituted pyrazoles |
US7332494B2 (en) * | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
EP1184443A1 (en) * | 2000-09-04 | 2002-03-06 | Biofuel B.V. | Process for the production of liquid fuels from biomass |
PT1315491E (pt) * | 2000-09-06 | 2006-10-31 | Ortho Mcneil Pharm Inc | Utilizacao de pirazoles substituidos para o fabrico de um medicamento para o tratamento de alergias |
-
2001
- 2001-08-10 ES ES01959731T patent/ES2281434T3/es not_active Expired - Lifetime
- 2001-08-10 US US11/517,062 patent/US7589202B2/en not_active Expired - Lifetime
- 2001-08-10 DK DK01959731T patent/DK1309591T3/da active
- 2001-08-10 US US09/928,122 patent/US7309703B2/en not_active Expired - Lifetime
- 2001-08-10 PT PT01959731T patent/PT1309591E/pt unknown
- 2001-08-10 WO PCT/US2001/025289 patent/WO2002014314A2/en active IP Right Grant
- 2001-08-10 MX MXPA03001421A patent/MXPA03001421A/es active IP Right Grant
- 2001-08-10 AU AU2001281255A patent/AU2001281255B2/en not_active Expired
- 2001-08-10 EP EP01959731A patent/EP1309591B1/en not_active Expired - Lifetime
- 2001-08-10 DE DE60126286T patent/DE60126286T2/de not_active Expired - Lifetime
- 2001-08-10 AU AU8125501A patent/AU8125501A/xx active Pending
- 2001-08-10 AT AT01959731T patent/ATE352552T1/de not_active IP Right Cessation
- 2001-08-10 JP JP2002519454A patent/JP5140225B2/ja not_active Expired - Lifetime
- 2001-08-10 CA CA002419540A patent/CA2419540A1/en not_active Abandoned
- 2001-08-10 NZ NZ524193A patent/NZ524193A/xx unknown
- 2001-08-10 CN CNB018170692A patent/CN1329392C/zh not_active Expired - Lifetime
- 2001-08-14 AR ARP010103883A patent/AR035714A1/es unknown
-
2003
- 2003-07-04 HK HK03104770.5A patent/HK1052509B/zh not_active IP Right Cessation
-
2006
- 2006-09-07 US US11/517,171 patent/US7388011B2/en not_active Expired - Lifetime
- 2006-09-07 US US11/517,212 patent/US7393850B2/en not_active Expired - Lifetime
- 2006-09-07 US US11/517,040 patent/US7452890B2/en not_active Expired - Lifetime
- 2006-09-07 US US11/517,145 patent/US7417046B2/en not_active Expired - Lifetime
- 2006-09-07 US US11/517,518 patent/US7429591B2/en not_active Expired - Lifetime
-
2007
- 2007-02-20 CY CY20071100223T patent/CY1106032T1/el unknown
-
2008
- 2008-07-24 US US12/220,516 patent/US20080300255A1/en not_active Abandoned
- 2008-07-24 US US12/220,539 patent/US7772236B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5140225B2 (ja) | 置換ピラゾール | |
AU2001281255A1 (en) | Substituted pyrazoles | |
JP4911864B2 (ja) | 置換ピラゾール | |
US6953793B2 (en) | Substituted pyrazoles | |
ZA200302630B (en) | Method for treating allergies using substituted pyrazoles. | |
US20030073672A1 (en) | Method for treating allergies using substituted pyrazoles | |
US7332494B2 (en) | Method for treating allergies using substituted pyrazoles | |
RU2286343C2 (ru) | Замещенные пиразолы | |
US20070105841A1 (en) | Method for treating allergies using substituted pyrazoles | |
AU2001288730B2 (en) | Method for treating allergies using substituted pyrazoles | |
AU2001288730A1 (en) | Method for treating allergies using substituted pyrazoles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20080427 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080808 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20110803 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110816 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111115 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20111122 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111122 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20111130 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111219 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120403 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120703 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120713 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120823 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20121113 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20121119 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5140225 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20151122 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |