JP5139618B2 - Mycobacteriumtuberculosisの融合タンパク質 - Google Patents

Mycobacteriumtuberculosisの融合タンパク質 Download PDF

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Publication number
JP5139618B2
JP5139618B2 JP2002504609A JP2002504609A JP5139618B2 JP 5139618 B2 JP5139618 B2 JP 5139618B2 JP 2002504609 A JP2002504609 A JP 2002504609A JP 2002504609 A JP2002504609 A JP 2002504609A JP 5139618 B2 JP5139618 B2 JP 5139618B2
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seq
antigen
fusion polypeptide
sequence
amino acid
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Expired - Fee Related
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Japanese (ja)
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JP2004526405A5 (https=
JP2004526405A (ja
Inventor
ヤシル スカイキー,
スティーブン リード,
マーク アルダーソン,
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コリクサ コーポレイション
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Priority claimed from US09/597,796 external-priority patent/US7186412B1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002504609A 2000-06-20 2001-06-20 Mycobacteriumtuberculosisの融合タンパク質 Expired - Fee Related JP5139618B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/597,796 US7186412B1 (en) 1998-04-07 2000-06-20 Fusion proteins of Mycobacterium tuberculosis
US09/597,796 2000-06-20
US26573701P 2001-02-01 2001-02-01
US60/265,737 2001-02-01
PCT/US2001/019959 WO2001098460A2 (en) 2000-06-20 2001-06-20 Fusion proteins of mycobacterium tuberculosis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011187390A Division JP2012034695A (ja) 2000-06-20 2011-08-30 Mycobacteriumtuberculosisの融合タンパク質

Publications (3)

Publication Number Publication Date
JP2004526405A JP2004526405A (ja) 2004-09-02
JP2004526405A5 JP2004526405A5 (https=) 2008-08-07
JP5139618B2 true JP5139618B2 (ja) 2013-02-06

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002504609A Expired - Fee Related JP5139618B2 (ja) 2000-06-20 2001-06-20 Mycobacteriumtuberculosisの融合タンパク質
JP2011187390A Pending JP2012034695A (ja) 2000-06-20 2011-08-30 Mycobacteriumtuberculosisの融合タンパク質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011187390A Pending JP2012034695A (ja) 2000-06-20 2011-08-30 Mycobacteriumtuberculosisの融合タンパク質

Country Status (13)

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US (7) US7083796B2 (https=)
EP (2) EP2133100B1 (https=)
JP (2) JP5139618B2 (https=)
AT (2) ATE442866T1 (https=)
AU (2) AU2001268678B2 (https=)
CA (1) CA2413959C (https=)
CY (2) CY1109531T1 (https=)
DE (1) DE60139963D1 (https=)
DK (2) DK1542732T3 (https=)
ES (2) ES2374620T3 (https=)
PT (2) PT1542732E (https=)
SI (1) SI1542732T1 (https=)
WO (1) WO2001098460A2 (https=)

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US6592877B1 (en) 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US7083796B2 (en) * 2000-06-20 2006-08-01 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
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US7026465B2 (en) * 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
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DK2457926T3 (da) 2005-04-29 2015-01-05 Glaxosmithkline Biolog Sa Ny fremgangsmåde til forebyggelse eller behandling af M. tuberkulose-infektion
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KR20100098602A (ko) * 2007-10-13 2010-09-08 코넬 유니버시티 마이코박테리움 아비움 아종 파라투베르쿨로시스에 대한 면역 응답을 유발하기 위한 조성물
KR101378240B1 (ko) * 2008-02-22 2014-03-28 포항공과대학교 산학협력단 결핵 예방용 조성물
AU2009273132B2 (en) 2008-07-25 2015-09-03 Glaxo Group Limited The tuberculosis Rv2386c protein, compositions and uses thereof
AU2009273130B2 (en) * 2008-07-25 2014-10-16 Glaxo Group Limited Novel compositions and methods
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BR112012018669A2 (pt) 2010-01-27 2017-09-05 Glaxosmithkline Biologicals Sa Proteína rv3616c modificada, uso de uma proteína rv3616c modificada, polinucleotídeo, uso de um polinucleotídeo, composição farmacêutica, composição imunogênica, proteína de fusão, e, polipeptídeo.
CN106822883A (zh) 2010-12-14 2017-06-13 葛兰素史密丝克莱恩生物有限公司 分枝杆菌抗原组合物
WO2013063059A1 (en) * 2011-10-24 2013-05-02 University Of Central Florida Research Foundation, Inc. Plastid-expressed mycobacterium tuberculosis vaccine antigens esat-6 and mtb72f fused to cholera toxin b subunit
EP2812704A4 (en) * 2012-02-07 2016-03-23 Intuitive Biosciences Inc MYCOBACTERIUM STUBERCULOSIS-SPECIFIC PEPTIDES FOR DETECTING INFECTION OR IMMUNIZATION OF NON-MUSCLE PRIMATES
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