JP5138601B2 - 組換えウイルス安定化製剤 - Google Patents

組換えウイルス安定化製剤 Download PDF

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JP5138601B2
JP5138601B2 JP2008541555A JP2008541555A JP5138601B2 JP 5138601 B2 JP5138601 B2 JP 5138601B2 JP 2008541555 A JP2008541555 A JP 2008541555A JP 2008541555 A JP2008541555 A JP 2008541555A JP 5138601 B2 JP5138601 B2 JP 5138601B2
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virus
formulation
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JP2009516519A (ja
JP2009516519A5 (enExample
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シガリニ，サンドリーヌ
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Sanofi Pasteur Ltd
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Sanofi Pasteur Ltd
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JP2008541555A 2005-11-21 2006-11-15 組換えウイルス安定化製剤 Expired - Fee Related JP5138601B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59728005P 2005-11-21 2005-11-21
US60/597,280 2005-11-21
PCT/CA2006/001855 WO2007056847A1 (en) 2005-11-21 2006-11-15 Stabilizing formulations for recombinant viruses

Publications (3)

Publication Number Publication Date
JP2009516519A JP2009516519A (ja) 2009-04-23
JP2009516519A5 JP2009516519A5 (enExample) 2010-03-25
JP5138601B2 true JP5138601B2 (ja) 2013-02-06

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JP2008541555A Expired - Fee Related JP5138601B2 (ja) 2005-11-21 2006-11-15 組換えウイルス安定化製剤

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US (2) US20090169581A1 (enExample)
EP (1) EP1951865A4 (enExample)
JP (1) JP5138601B2 (enExample)
KR (1) KR101357685B1 (enExample)
CN (2) CN104984352A (enExample)
AU (1) AU2006315026B2 (enExample)
BR (1) BRPI0618850A2 (enExample)
CA (1) CA2630349A1 (enExample)
IL (1) IL191595A (enExample)
WO (1) WO2007056847A1 (enExample)
ZA (1) ZA200804356B (enExample)

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* Cited by examiner, † Cited by third party
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CN105944095B (zh) 2008-03-05 2021-04-02 赛诺菲巴斯德有限公司 一种使含佐剂的疫苗组合物稳定的方法
EP2143440A1 (fr) * 2008-07-09 2010-01-13 Sanofi Pasteur Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués
CN101407788B (zh) * 2008-11-26 2012-01-11 中国兽医药品监察所 一种促进狂犬病病毒增殖的方法
US20130058965A1 (en) * 2009-12-31 2013-03-07 Mannkind Corporation Injectable formulations for parenteral administration
SI3409289T1 (sl) 2010-02-26 2020-12-31 Novo Nordisk A/S Stabilni sestavki, ki vsebujejo protitelo
PT2542257T (pt) 2010-03-01 2017-10-09 Bayer Healthcare Llc Anticorpos monoclonais otimizados contra inibidor da via do fator tecidual (tfpi)
WO2011121306A1 (en) 2010-03-31 2011-10-06 Stabilitech Ltd. Stabilisation of viral particles
DK2552410T3 (en) 2010-03-31 2019-02-18 Stabilitech Biopharma Ltd PROCEDURE FOR THE CONSERVATION OF ALUNADUVANCES AND VACCINES WITH ALUNADUVANCES
JP5869553B2 (ja) 2010-03-31 2016-02-24 スタビリテック リミテッド ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤
RU2012153786A (ru) 2010-05-28 2014-07-10 Ново Нордиск А/С Стабильные многодозовые композиции, содержащие антитело и консервант
FR2960781B1 (fr) * 2010-06-07 2013-11-22 Sanofi Pasteur Preparation d'un vaccin oral sec stabilise, compose d'un virus vivant attenue
GB201016471D0 (en) * 2010-09-30 2010-11-17 Isis Innovation Viral vector immunogenic compositions
WO2012065164A2 (en) * 2010-11-12 2012-05-18 The Trustees Of The University Of Pennsylvania Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same
PH12013502442A1 (en) * 2011-05-26 2018-03-21 Glaxo Smithkline Biologicals Sa Inactivated dengue virus vaccine
EP3744833A1 (en) 2011-06-28 2020-12-02 Leukocare Ag Stabilisation method for viruses
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
KR20150036592A (ko) * 2012-07-24 2015-04-07 사노피 파스퇴르 백신 조성물
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
TWI690322B (zh) * 2012-10-02 2020-04-11 法商傳斯堅公司 含病毒的調配物及其使用
US9480739B2 (en) * 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
CA2923837A1 (en) * 2013-09-13 2015-03-19 Wake Forest University Health Sciences Methods and compositions for treatment of chlamydial infection and related diseases and disorders
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente
EP3087188A1 (en) 2013-12-23 2016-11-02 Theravectys Lyophilized lentiviral vector particles, compositions and methods
AR099470A1 (es) * 2014-02-17 2016-07-27 Intervet Int Bv Vacunas de virus de aves de corral líquidas
TWI670085B (zh) * 2014-02-19 2019-09-01 荷蘭商英特威國際公司 液體穩定之豬病毒疫苗
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
WO2015175961A1 (en) * 2014-05-16 2015-11-19 Stc.Unm Vaccination compositions, methods of making, and methods of use
DK3552615T3 (da) 2014-07-16 2022-02-14 Transgene Onkolytisk virus til ekspression af immun-checkpoint-modulatorer
TWI852899B (zh) 2014-09-02 2024-08-21 法商賽諾菲巴斯德公司 疫苗組合物
CA2975432A1 (en) 2015-02-13 2016-08-18 Transgene Sa Immunotherapeutic vaccine and antibody combination therapy
WO2016131945A1 (en) 2015-02-20 2016-08-25 Transgene Sa Combination product with autophagy modulator
AU2016242460B2 (en) * 2015-03-27 2019-04-18 Cadila Healthcare Limited Recombinant mumps virus Jeryl Lynn 2 based vaccine
EP3316905A1 (en) 2015-07-03 2018-05-09 Sanofi Pasteur Concomitant dengue and yellow fever vaccination
CA3023022A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
TW201825511A (zh) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 表現免疫檢查點調節子的溶瘤病毒
US11510871B2 (en) 2016-09-16 2022-11-29 Leukocare Ag Method for producing low viscous and highly concentrated biopharmaceutical drug products in liquid formulation
EP3512939B1 (en) 2016-09-16 2026-06-17 Leukocare AG A novel method for obtaining efficient viral vector-based compositions for vaccination or gene therapy
WO2018069316A2 (en) 2016-10-10 2018-04-19 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
WO2018091680A1 (en) 2016-11-18 2018-05-24 Transgene Sa Cowpox-based oncolytic vectors
CA3045228C (en) 2016-12-28 2024-01-02 Transgene Sa Oncolytic viruses and therapeutic molecules
US11110163B2 (en) 2017-02-14 2021-09-07 Inventprise, Llc Heat stable vaccines
KR102722153B1 (ko) 2017-02-14 2024-10-24 인벤트프라이즈 인크. 열 안정성 액체 로타바이러스 백신
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
KR20240113607A (ko) 2017-06-21 2024-07-22 트랜스진 개인 맞춤형 백신
WO2019020543A1 (en) 2017-07-28 2019-01-31 Transgene Sa ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS
JP7313345B2 (ja) 2017-10-05 2023-07-24 サノフィ・パスツール デング熱に対するブースターワクチン接種のための組成物
CA3093093A1 (en) 2018-03-07 2019-09-12 Transgene Parapoxvirus vectors
MX2020011257A (es) 2018-04-27 2021-01-15 Krystal Biotech Inc Ácidos nucleicos recombinantes que codifican una o más proteínas cosméticas para usos estéticos.
WO2020011754A1 (en) 2018-07-09 2020-01-16 Transgene Chimeric vaccinia viruses
EP3847246A1 (en) 2018-09-06 2021-07-14 Bavarian Nordic A/S Storage improved poxvirus compositions
EP3856914A1 (en) 2018-09-26 2021-08-04 Krystal Biotech, Inc. Compositions and methods for the treatment of skin diseases
EP3875119A4 (en) 2018-10-30 2022-08-31 The University of Tokyo ONCOLYTIC VIRUS FOR CANCER THERAPY
EP3890505A4 (en) * 2018-12-05 2022-11-02 Seres Therapeutics, Inc. COMPOSITIONS FOR STABILIZING BACTERIA AND THEIR USES
WO2020136232A1 (en) 2018-12-28 2020-07-02 Transgene Sa Immunosuppressive m2 protein
CA3124773A1 (en) 2018-12-28 2020-07-02 Transgene M2-defective poxvirus
CN113613664B (zh) 2019-03-01 2025-11-18 阿奇洛伊斯生物制药公司 在抗原特异性免疫细胞中调节cd160功能的方法及其用途
JP7712284B2 (ja) 2020-03-12 2025-07-23 バヴァリアン・ノルディック・アクティーゼルスカブ ポックスウイルスの安定性を改善する組成物
CN111707512A (zh) * 2020-06-15 2020-09-25 深圳市瑞赛生物技术有限公司 即用型维生素标准品及其制备方法、使用方法和贮存稳定剂
KR20230038496A (ko) 2020-07-13 2023-03-20 트랜스진 면역 억제의 치료
CN114617972B (zh) * 2020-12-11 2023-12-01 康希诺生物股份公司 一种药物组合物及其应用
WO2023025899A2 (en) 2021-08-26 2023-03-02 Transgene Delivery system for targeting genes of the interferon pathway
WO2023213763A1 (en) 2022-05-02 2023-11-09 Transgene Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab
WO2023213764A1 (en) 2022-05-02 2023-11-09 Transgene Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf
CN119654339A (zh) 2022-07-01 2025-03-18 特兰斯吉恩股份有限公司 包含表面活性蛋白-d和tnfsf成员的融合蛋白
KR20250052416A (ko) 2022-08-18 2025-04-18 트랜스진 키메라 폭스바이러스
WO2026041811A1 (en) 2024-08-23 2026-02-26 Transgene Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429965A (en) * 1966-08-01 1969-02-25 Sterling Drug Inc Avian pox virus vaccine and process of preparing same
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
US5833975A (en) * 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
JPS60193925A (ja) * 1984-03-13 1985-10-02 Chemo Sero Therapeut Res Inst 凍結乾燥製剤化ワクチン
FR2633518B1 (fr) * 1988-06-30 1991-03-22 Merieux Inst Procede de stabilisation des vaccins et associations de vaccins a virus attenues conserves sous forme lyophilisee, et compositions obtenues
US5869306A (en) 1995-03-17 1999-02-09 Hisamitsu Pharmaceutical Co., Inc. Gene transfer preparation
US6616931B1 (en) * 1996-09-26 2003-09-09 Merck & Co., Inc. Rotavirus vaccine formulations
EP1133316B1 (en) 1998-11-16 2009-01-21 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6689600B1 (en) * 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US6225289B1 (en) * 1998-12-10 2001-05-01 Genvec, Inc. Methods and compositions for preserving adenoviral vectors
FR2814957B1 (fr) * 2000-10-06 2002-12-20 Aventis Pasteur Composition vaccinale et procede de stabilisation
JP4475561B2 (ja) * 2001-10-11 2010-06-09 メルク・シャープ・エンド・ドーム・コーポレイション Ｃ型肝炎ウイルスワクチン
US7094412B2 (en) * 2001-12-10 2006-08-22 Bavarian Nordic A/S Poxvirus containing formulations and process for preparing stable poxvirus containing compositions
WO2005066333A1 (en) * 2003-12-30 2005-07-21 Aventis Pasteur, Inc. Stabilizing compositions for recombinant viruses
US10446282B2 (en) * 2011-12-23 2019-10-15 Ge-Hitachi Nuclear Energy Americas Llc Methods, systems, and computer program products for generating fast neutron spectra

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